Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals

Abstract—The authors examined the association of total plasma homocysteine (Hcy) levels with measures of atrophy and white matter disease on MRI scans in 36 healthy elderly individuals. Hcy had a significant positive relationship with lateral ventricle–brain ratios in the anterior (r = 0.49) and middle (r = 0.43) ventricular regions as measures of central atrophy, but not with cortical atrophy or white matter hyperintensities. In a logistic regression analysis, elevated Hcy was a significant determinant of increased anterior ventricle–brain ratio (≥0.34) after controlling for age, folate, B12, creatinine, and white matter disease (OR = 2.3; CI, 1.03–5.09).

• Publication year

  2002

• Venue

  Neurology

• Publication date

  2002-05-28

• Fields of study

  Medicine

• Identifiers
  DOI 10.1212/wnl.58.10.1539PMID 12034795
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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