Knockdown of mTOR by lentivirus‑mediated RNA interference suppresses atherosclerosis and stabilizes plaques via a decrease of macrophages by autophagy in apolipoprotein E‑deficient mice.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  International Journal of Molecular Medicine

• Publication date

  2013-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/ijmm.2013.1494PMID 24043133
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Everolimus Triggers Cytokine Release by Macrophages: Rationale for Stents Eluting Everolimus and a Glucocorticoid

  2012cited by this paper
• Local Gene Silencing of Monocyte Chemoattractant Protein-1 Prevents Vulnerable Plaque Disruption in Apolipoprotein E-Knockout Mice

  2012cited by this paper
• Serum C-reactive protein (CRP) and procalcitonin (PCT) levels and kinetics in patients with leptospirosis

  2011cited by this paper
• Inflammation and the development of atherosclerosis.

  2011cited by this paper
• Targeting S100P Inhibits Colon Cancer Growth and Metastasis by Lentivirus-Mediated RNA Interference and Proteomic Analysis

  2011cited by this paper
• Autophagy: Renovation of Cells and Tissues

  2011cited by this paper
• Metalloproteinase and stroke infarct size: role for anti‐inflammatory treatment?

  2010cited by this paper
• Eaten alive: a history of macroautophagy

  2010cited by this paper
• Expression of cytokine genes in the aorta is altered by the deficiency in MCP-1: effect of a high-fat, high-cholesterol diet.

  2010cited by this paper
• [Molecular mechanisms of coronary atherosclerotic plaque formation and rupture].

  2010cited by this paper
• Sirolimus inhibits endogenous cholesterol synthesis induced by inflammatory stress in human vascular smooth muscle cells.

  2010cited by this paper
• Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications.

  2009influential reference
• Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

  2009cited by this paper
• Lentivirus‐mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down‐regulation of stathmin

  2007cited by this paper
• Selective Clearance of Macrophages in Atherosclerotic Plaques by the Protein Synthesis Inhibitor Cycloheximide

  2007cited by this paper
• Anti-atherosclerotic effects of sirolimus on human vascular smooth muscle cells.

  2007cited by this paper
• The Mammalian Target of Rapamycin Signaling Pathway: Twists and Turns in the Road to Cancer Therapy

  2007cited by this paper
• Pathology of the vulnerable plaque.

  2007cited by this paper
• Tissue Factor: A Critical Role in Inflammation and Cancer

  2007cited by this paper
• Selective clearance of macrophages in atherosclerotic plaques by autophagy.

  2007influential reference
• The pharmacodynamic effects of sirolimus and sirolimus-calcineurin inhibitor combinations on macrophage scavenger and nuclear hormone receptors.

  2007cited by this paper
• Pathology of the Vulnerable Plaque

  2006cited by this paper
• Relevance of tissue factor in cardiovascular disease.

  2005cited by this paper
• Macrophage activation in atherosclerosis: pathogenesis and pharmacology of plaque rupture.

  2005cited by this paper
• High-density lipoprotein as a therapeutic target: clinical evidence and treatment strategies.

  2005cited by this paper
• Development by self-digestion: molecular mechanisms and biological functions of autophagy.

  2004influential reference
• Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

  2004cited by this paper
• Methods for monitoring autophagy.

  2004cited by this paper
• Challenges for RNAi in vivo.

  2004cited by this paper
• Therapeutic potential of target of rapamycin inhibitors

  2004cited by this paper
• Protective Effect of the Immunosuppressant Sirolimus Against Aortic Atherosclerosis In Apo E‐Deficient Mice

  2003cited by this paper
• RNA interference targeting Fas protects mice from fulminant hepatitis

  2003cited by this paper
• Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression.

  2003cited by this paper
• Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1).

  2003cited by this paper
• Stent-based delivery of sirolimus reduces neointimal formation in a porcine coronary model

  2003cited by this paper
• Inflammation and Atherosclerosis

  2002cited by this paper
• Simvastatin Promotes Atherosclerotic Plaque Stability in ApoE-Deficient Mice Independently of Lipid Lowering

  2002cited by this paper
• Regulation of APG14 Expression by the GATA-type Transcription Factor Gln3p*

  2001cited by this paper
• Stent-Based Delivery of Sirolimus Reduces Neointimal Formation in a Porcine Coronary Model

  2001cited by this paper
• Induction of Rapid Atherogenesis by Perivascular Carotid Collar Placement in Apolipoprotein E–Deficient and Low-Density Lipoprotein Receptor–Deficient Mice

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• The Itinerary of a Vesicle Component, Aut7p/Cvt5p, Terminates in the Yeast Vacuole via the Autophagy/Cvt Pathways*

  2000cited by this paper
• The role of plaque rupture and thrombosis in coronary artery disease.

  2000cited by this paper
• Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation.

  1999cited by this paper
• Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast*

  1998cited by this paper
• TOR signalling and control of cell growth.

  1997cited by this paper
• Coronary plaque disruption.

  1995cited by this paper
• Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture.

  1995cited by this paper
• Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content.

  1993cited by this paper
• Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.

  1985cited by this paper

• mTOR Signaling in Macrophages: All Depends on the Context

  2025cites this paper
• Foam cells: tracing the diverse cellular origins and their linked signaling pathways

  2025cites this paper
• Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

  2024cites this paper
• Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets

  2024cites this paper
• Comprehensive view of macrophage autophagy and its application in cardiovascular diseases

  2023cites this paper
• Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets

  2023cites this paper
• Neuropeptide Y Promotes Human M2 Macrophage Polarization and Enhances p62/SQSTM1-Dependent Autophagy and NRF2 Activation

  2022cites this paper
• Interactive contribution of hyperinsulinemia, hyperglycemia, and mammalian target of rapamycin signaling to valvular interstitial cell differentiation and matrix remodeling

  2022cites this paper
• Tuning macrophages for atherosclerosis treatment

  2022cites this paper
• Laminaria japonica Polysaccharide Suppresses Atherosclerosis via Regulating Autophagy-Mediated Macrophage Polarization.

  2022cites this paper
• New insight into dyslipidemia‐induced cellular senescence in atherosclerosis

  2022cites this paper
• Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds.

  2021cites this paper
• mTOR kinase is a therapeutic target for respiratory syncytial virus and coronaviruses

  2021cites this paper
• Gypenoside inhibits ox-LDL uptake and foam cell formation through enhancing Sirt1-FOXO1 mediated autophagy flux restoration.

  2020cites this paper
• Shen-Yuan-Dan Capsule Attenuates Atherosclerosis and Foam Cell Formation by Enhancing Autophagy and Inhibiting the PI3K/Akt/mTORC1 Signaling Pathway

  2019cites this paper
• ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of Atherosclerosis

  2019cites this paper
• Macrophage Death as a Pharmacological Target in Atherosclerosis

  2019cites this paper
• Therapeutic potency of mTOR signaling pharmacological inhibitors in the treatment of proinflammatory diseases, current status, and perspectives

  2018cites this paper
• Overexpression of CTRP9 attenuates the development of atherosclerosis in apolipoprotein E-deficient mice

  2018cites this paper
• mTOR pathway activation in large vessel vasculitis.

  2018cites this paper
• Folic acid delays development of atherosclerosis in low‐density lipoprotein receptor‐deficient mice

  2018cites this paper
• mTOR drives cerebral blood flow and memory deficits in LDLR−/− mice modeling atherosclerosis and vascular cognitive impairment

  2018cites this paper
• The role of autophagy in advanced glycation end product-induced proliferation and migration in rat vascular smooth muscle cells

  2018cites this paper
• Potential therapeutic effects of mTOR inhibition in atherosclerosis.

  2016cites this paper
• Autophagy: An Exposing Therapeutic Target in Atherosclerosis

  2016cites this paper
• Correlation between CX 3 CR 1 249 V / I polymorphism and premature coronary heart disease & blood lipid ratio

  2016cites this paper
• Plasma microRNA-100 is associated with coronary plaque vulnerability.

  2015cites this paper
• Autophagy in Vascular Disease

  2015cites this paper
• Mammalian target of rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway.

  2015cites this paper
• 7‐Ketocholesterol‐induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress

  2015cites this paper
• mTOR inhibition: a promising strategy for stabilization of atherosclerotic plaques.

  2014cites this paper
• Current siRNA targets in atherosclerosis and aortic aneurysm.

  2014cites this paper
• An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice

  2014cites this paper