Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cancer Research

• Publication date

  2006-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-06-0139PMID 16740722
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells.

  2006cited by this paper
• Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent.

  2005cited by this paper
• Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.

  2005cited by this paper
• Sulforaphane-induced Cell Death in Human Prostate Cancer Cells Is Initiated by Reactive Oxygen Species*

  2005influential reference
• The molecular machinery of autophagy: unanswered questions

  2005cited by this paper
• Autophagy in metazoans: cell survival in the land of plenty

  2005cited by this paper
• Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.

  2005cited by this paper
• Sulforaphane-induced G2/M Phase Cell Cycle Arrest Involves Checkpoint Kinase 2-mediated Phosphorylation of Cell Division Cycle 25C*

  2004cited by this paper
• Pivotal Role of the Cell Death Factor BNIP3 in Ceramide-Induced Autophagic Cell Death in Malignant Glioma Cells

  2004cited by this paper
• Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype.

  2004cited by this paper
• Sulforaphane-Induced G 2 /M Phase Cell Cycle Arrest Involves Checkpoint Kinase 2 Mediated Phosphorylation of Cdc25C *

  2004cited by this paper
• Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention.

  2004cited by this paper
• Autophagy: Many paths to the same end

  2004cited by this paper
• A Novel Mechanism of Chemoprotection by Sulforaphane

  2004cited by this paper
• Regulation and role of autophagy in mammalian cells.

  2004cited by this paper
• Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

  2004cited by this paper
• Autophagy: a barrier or an adaptive response to cancer.

  2003cited by this paper
• Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo.

  2003cited by this paper
• Endostatin induces autophagic cell death in EAhy926 human endothelial cells.

  2003cited by this paper
• Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization.

  2003cited by this paper
• Induction of autophagic cell death in malignant glioma cells by arsenic trioxide.

  2003cited by this paper
• Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

  2002cited by this paper
• Corrigendum to “The chemical diversity and distribution of glucosinolates and isothiocyanates among plants” [Phytochemistry 56 (2001) 5–51]☆

  2002cited by this paper
• Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane.

  2002cited by this paper
• DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death

  2002cited by this paper
• Beclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network

  2001cited by this paper
• Potent induction of phase 2 enzymes in human prostate cells by sulforaphane.

  2001cited by this paper
• A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.

  2001cited by this paper
• The chemical diversity and distribution of glucosinolates and isothiocyanates among plants.

  2001cited by this paper
• Ubiquitin and proteasomes: Molecular dissection of autophagy: two ubiquitin-like systems

  2001cited by this paper
• LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

  2000influential reference
• Erk1/2-dependent Phosphorylation of Gα-interacting Protein Stimulates Its GTPase Accelerating Activity and Autophagy in Human Colon Cancer Cells*

  2000cited by this paper
• Fruit and vegetable intakes and prostate cancer risk.

  2000cited by this paper
• Dissection of Autophagosome Biogenesis into Distinct Nucleation and Expansion Steps

  2000cited by this paper
• Intakes of fruits, vegetables, and related nutrients and the risk of non-Hodgkin's lymphoma among women.

  2000cited by this paper
• Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells.

  2000cited by this paper
• INHIBITION OF CARCINOGENESIS BY ISOTHIOCYANATES*

  2000cited by this paper
• Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate.

  2000cited by this paper
• Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells

  1999cited by this paper
• Essential role of p53 in phenethyl isothiocyanate-induced apoptosis.

  1998cited by this paper
• Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein

  1998cited by this paper
• The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.

  1998cited by this paper
• A proposed refinement of the mitochondrial free radical theory of aging

  1997cited by this paper
• Inhibition of autophagy abrogates tumour necrosis factor α induced apoptosis in human T‐lymphoblastic leukaemic cells

  1997cited by this paper
• A proposed refinement of the mitochondrial free radical theory of aging.

  1997cited by this paper
• Epidemiological studies on brassica vegetables and cancer risk.

  1996cited by this paper
• Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy.

  1996cited by this paper
• CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane.

  1996cited by this paper
• Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.

  1994cited by this paper
• Autophagy and other vacuolar protein degradation mechanisms

  1992cited by this paper
• A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

  1992cited by this paper
• A qualitative and quantitative study of the ultrastructure of regenerating muscle fibres in Duchenne muscular dystrophy and polymyositis.

  1987cited by this paper

• The Role of Nutrition in Prostate Cancer Risk, Progression, and Mortality: A Comprehensive Review.

  2026cites this paper
• Sulforaphane in Cancer Prevention and Therapy: A State-of-the-Art Review of Epidemiological Evidence, Molecular Mechanisms, and Translational Challenges.

  2026cites this paper
• Benzyl isothiocyanate triggers apoptosis by initiating autophagy through the generation of ROS and modulating the MAPK and PI3K-AKT pathway in cervical cancer cells.

  2025cites this paper
• Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal

  2025cites this paper
• Alpha-lipoic acid alleviated intermittent hypoxia-induced myocardial injury in mice by promoting autophagy through Nrf2 signaling pathway.

  2025cites this paper
• Isothiocyanates from cruciferous plants as geroprotectors.

  2025cites this paper
• Sulforaphane regulates hepatic autophagy and apoptosis by modulating Kupffer cells’ polarization via Nrf2/HO-1 pathway in the murine hemorrhagic shock/resuscitation model

  2025cites this paper
• An in vitro investigation of 5-aminolevulinic acid and acridine orange as sensitizers in radiodynamic therapy for prostate and breast cancer

  2025cites this paper
• Combination of Low-Dose Sulforaphane and Docetaxel on Mitochondrial Function and Metabolic Reprogramming in Prostate Cancer Cell Lines

  2025cites this paper
• The roles of placental senescence, autophagy and senotherapeutics in the development and prevention of pre-eclampsia: A focus on ergothioneine.

  2025cites this paper
• Advancing Photodynamic Therapy with Nano-Conjugated Hypocrellin: Mechanisms and Clinical Applications

  2024cites this paper
• Sulforaphane and Benzyl Isothiocyanate Suppress Cell Proliferation and Trigger Cell Cycle Arrest, Autophagy, and Apoptosis in Human AML Cell Line

  2024cites this paper
• Isothiocyanates induce autophagy and inhibit protein synthesis in primary cells via modulation of AMPK-mTORC1-S6K1 signaling pathway, and protect against mutant huntingtin aggregation

  2024cites this paper
• Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2.

  2024cites this paper
• Glucosinolates and Their Hydrolytic Derivatives: Promising Phytochemicals With Anticancer Potential

  2024cites this paper
• The Dual Role of Sulforaphane-Induced Cellular Stress—A Systems Biological Study

  2024cites this paper
• Sulforaphane and Its Protective Role in Prostate Cancer: A Mechanistic Approach

  2023cites this paper
• Natural Compounds Targeting the Autophagy Pathway in the Treatment of Colorectal Cancer

  2023cites this paper
• Sulforaphane, a Chemopreventive Compound Induces Necrotic Behavior and Inhibits S-phase of Cell Cycle in Human Kidney Cells in Vitro

  2023cites this paper
• Glucosinolates in cancer prevention and treatment: experimental and clinical evidence

  2023cites this paper
• The role of proteasome inhibitor MG132 in cisplatin resistant ovarian cancer

  2023cites this paper
• Forkhead Box Q1 is a novel regulator of autophagy in breast cancer cells

  2023cites this paper
• Sulforaphane Reduces the Chronic Inflammatory Immune Response of Human Dendritic Cells

  2023cites this paper
• Sulforaphane Combined with Vitamin D Induces Cytotoxicity Mediated by Oxidative Stress, DNA Damage, Autophagy, and JNK/MAPK Pathway Modulation in Human Prostate Tumor Cells

  2023cites this paper
• Antiaging Mechanism of Natural Compounds: Effects on Autophagy and Oxidative Stress

  2022cites this paper
• Green Tea Epigallocatechin-3-Gallate Regulates Autophagy in Male and Female Reproductive Cancer

  2022cites this paper
• Decoding ceRNA regulatory network and autophagy-related genes in benign prostatic hyperplasia.

  2022cites this paper
• Sulforaphane Acts Through NFE2L2 to Prevent Hypoxia-Induced Apoptosis in Porcine Granulosa Cells via Activating Antioxidant Defenses and Mitophagy.

  2022cites this paper
• Anticancer Activity, Mechanism, and Delivery of Allyl Isothiocyanate

  2022cites this paper
• The Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases

  2022cites this paper
• Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes.

  2022cites this paper
• Effects of Sulforaphane-Induced Cell Death upon Repeated Passage of Either P-Glycoprotein-Negative or P-Glycoprotein-Positive L1210 Cell Variants

  2022cites this paper
• Sulforaphane inhibits blue light-induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial cells.

  2021cites this paper
• Sulforaphane as a Promising Natural Molecule for Cancer Prevention and Treatment

  2021cites this paper
• A review of dietary phytochemicals and their relation to oxidative stress and human diseases.

  2021cites this paper
• S6K1 Is Indispensible for Stress-Induced Microtubule Acetylation and Autophagic Flux

  2021cites this paper
• Targeting Drug Chemo-Resistance in Cancer Using Natural Products

  2021cites this paper
• Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential

  2021influential citation
• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

  2021cites this paper
• Study the effect of turnip leaves on tumor cells in vitro and in vivo

  2021cites this paper
• Molecular Effectors of Photodynamic Therapy-Mediated Resistance to Cancer Cells

  2021cites this paper
• Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics.

  2021cites this paper
• Autophagy-Dependent Apoptosis Induced by Apoferritin-Cu(II) Nanoparticles in Multidrug-Resistant Colon Cancer Cells.

  2021cites this paper
• Rapeseed (Brassica napus): Processing, Utilization, and Genetic Improvement

  2021cites this paper
• Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review.

  2021cites this paper
• Noncoding RNAs: New regulatory code in chondrocyte apoptosis and autophagy

  2020cites this paper
• How autophagy can restore proteostasis defects in multiple diseases?

  2020cites this paper
• Health Benefits of Organosulfur Compounds

  2020cites this paper
• Sulforaphane in broccoli: The green chemoprevention!! Role in cancer prevention and therapy

  2020cites this paper
• Role of Bcl-2 Family Proteins in Photodynamic Therapy Mediated Cell Survival and Regulation

  2020cites this paper
• Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

  2020cites this paper
• Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway

  2020cites this paper
• Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention

  2020cites this paper
• The dual functions of α-tubulin acetylation in cellular apoptosis and autophage induced by tanespimycin in lung cancer cells

  2020cites this paper
• Autophagy-Inducing Inhalable Co-crystal Formulation of Niclosamide-Nicotinamide for Lung Cancer Therapy

  2020cites this paper
• Epigenetics/Epigenomics and Prevention of Early Stages of Cancer by Isothiocyanates

  2020cites this paper
• The Role of Lysosome-associated Membrane Protein 2 in Prostate Cancer Chemopreventive Mechanisms of Sulforaphane

  2020cites this paper
• Sulforaphane and sulforaphene

  2020cites this paper
• Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B.

  2020cites this paper
• Sulforaphane exerts anticancer effects on human liver cancer cells via induction of apoptosis and inhibition of migration and invasion by targeting MAPK7 signalling pathway.

  2020cites this paper
• OP16 induces deadly autophagy and apoptosis of cells by inhibiting Akt in esophageal squamous cell carcinoma

  2020cites this paper
• Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma

  2020cites this paper
• Survivin and Telomerase as Radiotherapeutic Response Predictors of Subjects with Stage IIIB Cervical Squamous Cell Carcinoma

  2020cites this paper
• Autophagy Attenuation Hampers Progesterone Synthesis during the Development of Pregnant Corpus Luteum

  2019cites this paper
• The functional role of Bax/Bak in palmitate-induced lipoapoptosis.

  2019cites this paper
• Sulforaphane metabolites inhibit migration and invasion via microtubule-mediated Claudins dysfunction or inhibition of autolysosome formation in human non-small cell lung cancer cells

  2019cites this paper
• Autophagy modulator scoring system: a user-friendly tool for quantitative analysis of methodological integrity of chemical autophagy modulator studies

  2019cites this paper
• Protects the Liver against CdSe Quantum Dot-Induced Cytotoxicity. Research

  2019cites this paper
• THE PREVENTION OF OBESITY-ASSOCIATED COLORECTAL CANCER VIA DIETARY SUPPRESSION OF INFLAMMATION-DRIVEN WNT-SIGNALING

  2019cites this paper
• The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents

  2019cites this paper
• HIF1α promotes prostate cancer progression by increasing ATG5 expression

  2019cites this paper
• Phytochemicals as potent modulators of autophagy for cancer therapy.

  2018cites this paper
• The Prevention of a High Dose of Vitamin D or Its Combination with Sulforaphane on Intestinal Inflammation and Tumorigenesis in Apc1638N Mice Fed a High‐Fat Diet

  2018cites this paper
• Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cells following treatment with sulforaphane.

  2018cites this paper
• Allyl Isothiocyanate Induces Autophagy through the Up-Regulation of Beclin-1 in Human Prostate Cancer Cells.

  2018cites this paper
• Antiproliferative, Proapoptotic, Antioxidant and Antimicrobial Effects of Sinapis nigra L. and Sinapis alba L. Extracts

  2018cites this paper
• The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review

  2018influential citation
• Cyclocommunol induces apoptosis in human oral squamous cell carcinoma partially through a Mcl-1-dependent mechanism.

  2018cites this paper
• The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts

  2018cites this paper
• Co-delivery of doxorubicin and shRNA of Beclin1 by folate receptor targeted pullulan-based multifunctional nanomicelles for combinational cancer therapy

  2018cites this paper
• Raddeanin a Suppresses Glioblastoma Growth by Inducing ROS Generation and Subsequent JNK Activation to Promote Cell Apoptosis

  2018cites this paper
• Sulforaphane-N-Acetyl-Cysteine inhibited autophagy leading to apoptosis via Hsp70-mediated microtubule disruption.

  2018cites this paper
• xorubicin and shRNA of Beclin 1 by folate receptor targeted pullulan-based multifunctional nanomicelles for combinational cancer therapy

  2018cites this paper
• Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund’s Adjuvant-Induced Mono-Arthritis

  2018cites this paper
• Inhibiting autophagy overcomes docetaxel resistance in castration-resistant prostate cancer cells

  2018cites this paper
• Roles of ROS, Nrf2, and autophagy in cadmium‐carcinogenesis and its prevention by sulforaphane

  2018cites this paper
• Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism

  2018cites this paper
• Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway

  2018cites this paper
• Activation of autophagy by stress‐activated signals as a cellular self‐defense mechanism against the cytotoxic effects of MBIC in human breast cancer cells in vitro

  2018cites this paper
• Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells

  2017influential citation
• Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells

  2017cites this paper
• Anticancer Activity of Curcumin-Loaded PLGA Nanoparticles on PC3 Prostate Cancer Cells

  2017cites this paper
• Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

  2017cites this paper
• Anticancer effect of Saussurea lappa extract via dual control of apoptosis and autophagy in prostate cancer cells

  2017cites this paper
• Apoptosis and injuries of heavy ion beam and x-ray radiation on malignant melanoma cell

  2017cites this paper
• A Combination of Pterostilbene with Autophagy Inhibitors Exerts Efficient Apoptotic Characteristics in Both Chemosensitive and Chemoresistant Lung Cancer Cells.

  2017cites this paper
• Glucosinolates and Isothiocyanates: Cancer Preventive Effects

  2017cites this paper
• Suberoylanilide hydroxamic acid sensitizes neuroblastoma to paclitaxel by inhibiting thioredoxin‐related protein 14‐mediated autophagy

  2017cites this paper
• The effects of sulforaphane on canine osteosarcoma proliferation and invasion

  2017cites this paper
• Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells.

  2017cites this paper