The metabolism of flubendazole and the activities of selected biotransformation enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Parasitology

• Publication date

  2012-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1017/S0031182012000595PMID 22717022
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enhancement of the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica using the metabolic inhibitor ketoconazole

  2010influential reference
• Flubendazole metabolism and biotransformation enzymes activities in healthy sheep and sheep with haemonchosis.

  2010cited by this paper
• Potentiation of triclabendazole sulphoxide-induced tegumental disruption by methimazole in a triclabendazole-resistant isolate of Fasciola hepatica

  2010influential reference
• Phase I biotransformation of albendazole in lancet fluke (Dicrocoelium dendriticum).

  2009cited by this paper
• Liquid chromatography/mass spectrometric identification of benzimidazole anthelminthics metabolites formed ex vivo by Dicrocoelium dendriticum.

  2009cited by this paper
• Xenobiotic metabolizing enzymes and metabolism of anthelminthics in helminths

  2009cited by this paper
• LC–MS–MS identification of albendazole and flubendazole metabolites formed ex vivo by Haemonchus contortus

  2008influential reference
• Inhibition of Polymorphic Human Carbonyl Reductase 1 (CBR1) by the Cardioprotectant Flavonoid 7-monohydroxyethyl Rutoside (monoHER)

  2008cited by this paper
• Biotransformation of flubendazole and selected model xenobiotics in Haemonchus contortus.

  2008cited by this paper
• LC with Fluorimetric Detection for Sensitive Analysis of Reduced Flubendazole in Biological Samples

  2008cited by this paper
• Hepatic and extra-hepatic metabolic pathways involved in flubendazole biotransformation in sheep.

  2008cited by this paper
• Understanding triclabendazole resistance.

  2007cited by this paper
• Altered drug influx/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes

  2005cited by this paper
• Triclabendazole biotransformation and comparative diffusion of the parent drug and its oxidized metabolites into Fasciola hepatica

  2004cited by this paper
• Genetic analysis of inbreeding of two strains of the parasitic nematode Haemonchus contortus.

  2004cited by this paper
• The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica

  2004cited by this paper
• In vitro metabolism of moxidectin in Haemonchus contortus adult stages

  2001cited by this paper
• Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1).

  2001cited by this paper
• Haemonchus contortus utilises catalase in defence against exogenous hydrogen peroxide in vitro.

  2001cited by this paper
• Comparative metabolism of albendazole and albendazole sulphoxide by different helminth parasites

  2001cited by this paper
• Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes.

  1997cited by this paper
• Haemonchus contortus: the uptake and metabolism of closantel.

  1997cited by this paper
• Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver.

  1995influential reference
• Resistance of field strains of Haemonchus contortus to ivermectin, closantel, rafoxanide and the benzimidazoles in South Africa

  1988cited by this paper
• Correlation of drug conjugative metabolism rates between in vivo and in vitro: glucuronidation and sulfation of p-nitrophenol as a model compound in rat.

  1982cited by this paper
• A technique for the recovery of nematodes from ruminants by migration from gastro-intestinal ingesta gelled in agar: large-scale application.

  1980cited by this paper

• Study on the effect of GCY-12 gene on albendazole sensitivity of Haemonchus contortus by RNA interference

  2025cites this paper
• In vitro analysis of the activities of commercial anthelmintics in the presence of inhibitors of xenobiotic detoxification pathways in Haemonchus contortus exsheathed L3 stage

  2025cites this paper
• Biotransformation of anthelmintics in nematodes in relation to drug resistance

  2025cites this paper
• Phylogenetic and transcriptomic study of aldo-keto reductases in Haemonchus contortus and their inducibility by flubendazole

  2024cites this paper
• Flubendazole carbonyl reduction in drug-susceptible and drug-resistant strains of the parasitic nematode Haemonchus contortus: changes during the life cycle and possible inhibition

  2024influential citation
• Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode

  2022cites this paper
• The role of UDP-glycosyltransferases in xenobioticresistance

  2022cites this paper
• The induction and inhibition of UDP-glycosyltransferases in Haemonchus contortus and their role in the metabolism of albendazole

  2022cites this paper
• UGT440A1 Is Associated With Motility, Reproduction, and Pathogenicity of the Plant-Parasitic Nematode Bursaphelenchus xylophilus

  2022cites this paper
• Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and recovery in a parasitic nematode

  2021cites this paper
• Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and recovery in a parasitic nematode Authors

  2021cites this paper
• Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults

  2020cites this paper
• Metabolism of the anthelmintic drug fenbendazole in Arabidopsis thaliana and its effect on transcriptome and proteome.

  2019cites this paper
• Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis

  2019cites this paper
• Similarities and differences in the biotransformation and transcriptomic responses of Caenorhabditis elegans and Haemonchus contortus to five different benzimidazole drugs

  2019cites this paper
• UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences

  2018cites this paper
• Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis

  2018cites this paper
• Biotransformation of flubendazole and fenbendazole and their effects in the ribwort plantain (Plantago lanceolata).

  2018cites this paper
• The transcription factor SKN-1 and detoxification gene ugt-22 alter albendazole efficacy in Caenorhabditis elegans

  2018cites this paper
• Metabolism of albendazole, ricobendazole and flubendazole in Haemonchus contortus adults: Sex differences, resistance-related differences and the identification of new metabolites

  2018cites this paper
• Strategies to Optimize the Efficacy of Anthelmintic Drugs in Ruminants.

  2018cites this paper
• Functional analysis of UGT201D3 associated with abamectin resistance in Tetranychus cinnabarinus (Boisduval)

  2018cites this paper
• Evaluation of drug uptake and deactivation in plant: Fate of albendazole in ribwort plantain (Plantago laceolata) cells and regenerants.

  2017cites this paper
• Metabolism of drugs and other xenobiotics in giant liver fluke (Fascioloides magna)

  2016cites this paper
• The Role of Xenobiotic-Metabolizing Enzymes in Anthelmintic Deactivation and Resistance in Helminths.

  2016cites this paper
• Metabolic pathways of benzimidazole anthelmintics in harebell (Campanula rotundifolia).

  2016cites this paper
• Haemonchus contortus: Applications in Drug Discovery.

  2016cites this paper
• Monepantel: the most studied new anthelmintic drug of recent years

  2014cites this paper
• Phenobarbital Induction and Chemical Synergism Demonstrate the Role of UDP-Glucuronosyltransferases in Detoxification of Naphthalophos by Haemonchus contortus Larvae

  2014cites this paper
• Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus).

  2014cites this paper
• Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa

  2014cites this paper
• Biotransformation of benzimidazole anthelmintics in reed (Phragmites australis) as a potential tool for their detoxification in environment.

  2013cites this paper
• Biotransformation of albendazole and activities of selected detoxification enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics.

  2013cites this paper