Antidepressant-like effect of scopoletin, a coumarin isolated from Polygala sabulosa (Polygalaceae) in mice: evidence for the involvement of monoaminergic systems.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  European Journal of Pharmacology

• Publication date

  2010-09-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ejphar.2010.06.043PMID 20599906
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bupropion

  2012cited by this paper
• Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: evidence for the involvement of the monoaminergic system.

  2010cited by this paper
• Ascorbic acid administration produces an antidepressant-like effect: evidence for the involvement of monoaminergic neurotransmission.

  2009cited by this paper
• Coumarin, Anthroquinone and Stilbene Derivatives with Anticholinesterase Activity

  2008cited by this paper
• Interaction of zinc with antidepressants in the tail suspension test.

  2008cited by this paper
• Antinociceptive effect of the Polygala sabulosa hydroalcoholic extract in mice: evidence for the involvement of glutamatergic receptors and cytokine pathways.

  2008cited by this paper
• Bupropion: a review of its use in the management of major depressive disorder.

  2008cited by this paper
• Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: in vitro and in vivo interactions with benzodiazepine binding sites

  2008cited by this paper
• Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems.

  2008cited by this paper
• Estudo taxonômico de Polygala subgênero Ligustrina (Chodat) Paiva (Polygalaceae)

  2007cited by this paper
• Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test.

  2007cited by this paper
• Evaluation of antidepressant-like activity of aqueous and ethanolic extracts of Terminalia bellirica Roxb. fruits in mice.

  2007cited by this paper
• Antidepressant-like effect of the extract from leaves of Schinus molle L. in mice: evidence for the involvement of the monoaminergic system.

  2007influential reference
• Antidepressant-like effect of lamotrigine in the mouse forced swimming test: evidence for the involvement of the noradrenergic system.

  2007influential reference
• HPA and Immune Axes in Stress: Involvement of the Serotonergic System

  2007cited by this paper
• Involvement of dopamine D1 receptors and alpha1-adrenoceptors in the antidepressant-like effect of chlorpheniramine in the mouse tail suspension test.

  2007cited by this paper
• A neurotrophic model for stress-related mood disorders.

  2006cited by this paper
• Antinociceptive properties of coumarins, steroid and dihydrostyryl‐2‐pyrones from Polygala sabulosa (Polygalaceae) in mice

  2006cited by this paper
• Evaluation of the antithyroid, antioxidative and antihyperglycemic activity of scopoletin from Aegle marmelos leaves in hyperthyroid rats

  2006cited by this paper
• Immobility stress induces depression-like behavior in the forced swim test in mice: effect of magnesium and imipramine.

  2006influential reference
• The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice.

  2005cited by this paper
• Large-scale observational studies of hypericum extracts in patients with depressive disorders--a systematic review.

  2005cited by this paper
• The HPA and immune axes in stress: the involvement of the serotonergic system

  2005cited by this paper
• Hypouricemic action of scopoletin arising from xanthine oxidase inhibition and uricosuric activity.

  2005cited by this paper
• Can stress cause depression?

  2005cited by this paper
• The therapeutic role of 5-HT1A and 5-HT2A receptors in depression.

  2004cited by this paper
• The tail suspension test: A new method for screening antidepressants in mice

  2004cited by this paper
• Central monoamines and their role in major depression.

  2004cited by this paper
• Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells.

  2004cited by this paper
• Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT1A-Receptor Agonist

  2004cited by this paper
• Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders.

  2004cited by this paper
• Is there a role for 5-HT1A agonists in the treatment of depression?

  2003cited by this paper
• Drug Information Sources and Antidepressant Adherence

  2003cited by this paper
• Efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis

  2003cited by this paper
• Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

  2003cited by this paper
• Assessing antidepressant activity in rodents: recent developments and future needs.

  2002cited by this paper
• Neurobiology of depression.

  2002cited by this paper
• Effect of scopoletin on PC3 cell proliferation and apoptosis.

  2001cited by this paper
• Selective imidazoline I2 ligands do not show antidepressant-like activity in the forced swim test in mice

  2001cited by this paper
• Intra- and interstrain differences in models of "behavioral despair".

  2001cited by this paper
• Pharmacology of antidepressants.

  2001cited by this paper
• Research and treatment approaches to depression

  2001cited by this paper
• Pharmacology of antidepressants.

  2001cited by this paper
• The role of dopamine in the mechanism of action of antidepressant drugs.

  2000cited by this paper
• Single restraint stress sensitizes acute chewing movements induced by haloperidol, but not if the 5-HT1A agonist 8-OH-DPAT is given prior to stress.

  1997cited by this paper
• Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study.

  1997cited by this paper
• Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test.

  1997cited by this paper
• Role of the serotonergic system in the forced swimming test.

  1995cited by this paper
• Chromones and coumarins from skimmia laureola

  1987cited by this paper
• Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: most antidepressants selectively block norepinephrine uptake.

  1984cited by this paper
• Involvement of α- and β1-adrenergic mechanisms in the immobility-reducing action of desipramine in the forced swimming test

  1983cited by this paper
• Involvement of alpha- and beta 1-adrenergic mechanisms in the immobility-reducing action of desipramine in the forced swimming test.

  1983cited by this paper
• Behavioral despair in mice: a primary screening test for antidepressants.

  1977influential reference
• The Biochemistry of Affective Disorders

  1967cited by this paper
• The catecholamine hypothesis of affective disorders: a review of supporting evidence.

  1965cited by this paper

• Bioactive compounds with antidepressant potential in rodents: A narrative review

  2025cites this paper
• A review about invitro anti-diabetic activity of scopoletin

  2025cites this paper
• Resveratrol Ameliorates Chronic Stress in Kennel Dogs and Mice by Regulating Gut Microbiome and Metabolome Related to Tryptophan Metabolism

  2025cites this paper
• Scopoletin mitigates maternal separation-induced anxiety-like and depression-like behaviors in male mice through modulation of the Sirt1/NF-κB pathway

  2024cites this paper
• Dual Approach to Depression: The Combined Efficacy of Intermittent Hypoxia and Fluoxetine in Modulating Behavioral and Inflammatory Responses

  2024cites this paper
• Paeonol prevents sepsis-associated encephalopathy via regulating the HIF1A pathway in microglia.

  2024cites this paper
• Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity

  2024cites this paper
• Ferulago Angulata methanolic extract ameliorates scopolamine-induced memory impairment through the inhibition of hippocampal monoamine oxidase activity

  2024cites this paper
• ANTIDEPRESSIVE EFFECT OF NEW COUMARIN DERIVATIVES

  2024cites this paper
• AN OVERVIEW OF SOME HERBAL ANTIDEPRESSANT PLANTS

  2024cites this paper
• Anti-Aging Effect of Traditional Plant-Based Food: An Overview

  2024cites this paper
• Locomotor-Reducing, Sedative, and Antidepressant-Like Effects of Confectionery Flavours Coumarin and Vanillin.

  2024cites this paper
• Antiplasmodial activity of coumarins isolated from Polygala boliviensis: in vitro and in silico studies

  2023cites this paper
• FeCl3-catalyzed regioselective ring-opening of aryl oxirane with 4-hydroxycoumarin for the synthesis of furo[3,2-c]coumarins.

  2023cites this paper
• Antidepressant effects of coumarins and their derivatives: A critical analysis of research advances.

  2023cites this paper
• Novel Coumarin-furo[2,3-d]pyrimidinone Hybrid derivatives as anticancer agents: Synthesis, biological evaluation and Molecular Docking.

  2023cites this paper
• Antidepressant-like active ingredients and their related mechanisms of functional foods or medicine and food homologous products

  2023cites this paper
• Plant-derived chelators and ionophores as potential therapeutics for metabolic diseases.

  2023cites this paper
• An Underutilized Food “Miwu”: Diet History, Nutritional Evaluations, and Countermeasures for Industrial Development

  2023cites this paper
• Systematic Analysis of the Mechanism of Polygoni Multiflori Caulis in Improving Depressive Disorder in Mice via Network Pharmacology Combined with Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Exactive Orbitrap Mass Spectrometer.

  2023cites this paper
• Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update

  2022cites this paper
• Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression

  2022cites this paper
• A review of monoamine oxidase (MAO) inhibitors in tobacco or tobacco smoke.

  2022cites this paper
• Comparative evaluation of natural neuroprotectives and their combinations on chronic immobilization stress-induced depression in experimental mice

  2022cites this paper
• Adera: A drug repurposing workflow for neuro-immunological investigations using neural networks

  2022cites this paper
• Natural Products for the Treatment of Post-stroke Depression

  2022cites this paper
• Scopoletin protects retinal ganglion cells 5 from high glucose-induced injury in a cellular model of diabetic retinopathy via ROS-dependent p38 and JNK signaling cascade

  2022cites this paper
• Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways.

  2022cites this paper
• Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

  2022cites this paper
• Adera2.0: A Drug Repurposing Workflow for Neuroimmunological Investigations Using Neural Networks

  2022cites this paper
• Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy

  2022cites this paper
• Lewis‐Acid‐Mediated One‐Pot Tandem Reactions for Synthesis of Structurally Diverse Furo[3,2‐c]coumarins

  2021cites this paper
• Mechanisms of action of herbal antidepressants

  2021cites this paper
• Orchard biomass residues: Chemical composition, biological activity and wood characterization of apricot tree (Prunus armeniaca L.)

  2021cites this paper
• Convolvulus pluricaulis usage and depression

  2021cites this paper
• TCM Substances in Neuropsychopharmacotherapy: Basic Aspects with a Focus on Depression

  2021cites this paper
• Anti-depressant Activity of Hydroalcoholic Extract of Asperula odorata L. in Mice

  2021influential citation
• Polygala sabulosa A.W. Bennett extract mitigates motor and cognitive deficits in a mouse model of acute ischemia

  2021cites this paper
• Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies

  2021cites this paper
• Myrsinoic acid B from Myrsine coriacea reverses depressive-like behavior and brain oxidative stress in streptozotocin-diabetic rats.

  2021cites this paper
• R (-)-methoxetamine exerts rapid and sustained antidepressant effects and fewer behavioral side effects relative to S (+)-methoxetamine.

  2021cites this paper
• Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties

  2020cites this paper
• Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies

  2020cites this paper
• Rapid action of mechanism investigation of Yixin Ningshen tablet in treating depression by combinatorial use of systems biology and bioinformatics tools.

  2020cites this paper
• Panaxynol attenuates CUMS-induced anxiety and depressive-like behaviors via regulating neurotransmitters, synapses and the HPA axis in mice.

  2020cites this paper
• Scopoletin ameliorates anxiety-like behaviors in complete Freund’s adjuvant-induced mouse model

  2020cites this paper
• Do We Build Similar Molecules for Comorbid Diseases? Tevarud in Drug Design, an Analysis for Depression and Inflammation.

  2020cites this paper
• Bioactive Compounds and Distinctive Pharmacological Activity Guided Review of Aegle marmelos: A Miraculous Plant of Indigenous Medicine System

  2020cites this paper
• Review of Scopoletin: Isolation, Analysis Process, and Pharmacological Activity

  2020cites this paper
• Dopaminergic system contribution to the antidepressant-like effect of 3-phenyl-4-(phenylseleno) isoquinoline in mice.

  2020cites this paper
• Ethylene is the key signal in the accumulation process of scopoletin in noni (Morinda citrifolia)

  2020cites this paper
• The protective effect of 5-O-methylvisammioside on LPS-induced depression in mice by inhibiting the over activation of BV-2 microglia through Nf-κB/IκB-α pathway.

  2020cites this paper
• Inhibitory effect of coumarin and its analogs on insulin fibrillation /cytotoxicity is depend on oligomerization states of the protein

  2020cites this paper
• Xanthotoxin reverses Parkinson’s disease-like symptoms in zebrafish larvae and mice models: a comparative study

  2020cites this paper
• Discovering the Potentials of Medicinal Mushrooms in Combating Depression - A Review.

  2020cites this paper
• Schisandrae Chinensis Fructus inhibits behavioral deficits induced by sleep deprivation and chronic unpredictable mild stress via increased signaling of brain‐derived neurotrophic factor

  2019cites this paper
• Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidβ aggregation, and lipid peroxidation.

  2019cites this paper
• Mapping the Biotransformation of Coumarins through Filamentous Fungi

  2019cites this paper
• EMERGING MECHANISMS AND POTENTIAL ANTIDEPRESSANT ACTION OF MEDICINAL PLANTS

  2019cites this paper
• Fluorescence of Scopoletin Including its Photoacidity and Large Stokes Shift

  2019cites this paper
• Effect of herbal and nutritional products on the central nervous system effects of haloperidol: a systematic review

  2019cites this paper
• Coumarin-piperazine derivatives as biologically active compounds

  2019cites this paper
• Protective effect of Convolvulus pluricaulis against neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat.

  2019cites this paper
• Magnetic Fe3O4-supported sulfonic acid-functionalized graphene oxide (Fe3O4@GO-naphthalene-SO3H): a novel and recyclable nanocatalyst for green one-pot synthesis of 5-oxo-dihydropyrano[3,2-c]chromenes and 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-ones

  2019cites this paper
• Biotransformation of Coumarins by Filamentous Fungi: An Alternative Way for Achievement of Bioactive Analogs

  2019cites this paper
• A Convenient Synthesis of Bipyrido‐Fused Coumarins and Their Biological Evaluation

  2019cites this paper
• DFT/TD-DFT calculations, spectroscopic characterizations (FTIR, NMR, UV-vis), molecular docking and enzyme inhibition study of 7-benzoyloxycoumarin

  2018cites this paper
• Antidepressant and anxiolytic like effects of Urtica dioica leaves in streptozotocin induced diabetic mice

  2018cites this paper
• Biomolecules from Plants as an Adaptogen

  2018cites this paper
• Phytochemical, Botanical and Biological Paradigm of Astavarga Plants- The Ayurvedic Rejuvenators

  2018cites this paper
• Persistent Lin28 Expression Impairs Neurite Outgrowth and Cognitive Function in the Developing Mouse Neocortex

  2018cites this paper
• In Silico Prediction of the Anti-Depression Mechanism of a Herbal Formula (Tiansi Liquid) Containing Morinda officinalis and Cuscuta chinensis

  2017cites this paper
• Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models

  2017cites this paper
• Scopoletin Supplementation Ameliorates Steatosis and Inflammation in Diabetic Mice

  2017cites this paper
• 3-Substituted-7-(diethylamino)coumarins as molecular scaffolds for the bottom-up self-assembly of solids with extensive π-stacking

  2017cites this paper
• Involvement of the dopaminergic system in the antidepressant-like effect of the lectin isolated from the red marine alga Solieria filiformis in mice.

  2017cites this paper
• Neurotoxicity of fragrance compounds: A review.

  2017cites this paper
• Antitumor screening of crude extracts of ten medicinal plants of Polygala genus from Southern Brazil

  2017cites this paper
• Theoretical evaluation of ADMET properties for coumarin derivatives as compounds with therapeutic potential

  2017cites this paper
• Neurotoxic effects of silver nanoparticles and the protective role of rutin.

  2017cites this paper
• Antidepressants: Mechanism of Action, Toxicity and Possible Amelioration

  2017cites this paper
• Citrus Coumarins and Their Health Properties

  2017cites this paper
• Monoaminergic neurotransmission is mediating the antidepressant-like effects of Passiflora edulis Sims fo. edulis.

  2017cites this paper
• Effect of scopoletin on monoamine oxidases and brain amines.

  2016cites this paper
• Attenuation of acute restraint stress-induced depressive like behavior and hippocampal alterations with protocatechuic acid treatment in mice

  2016cites this paper
• Hypothalamic Proteomic Analysis Reveals Dysregulation of Glutamate Balance and Energy Metabolism in a Mouse Model of Chronic Mild Stress-Induced Depression

  2016cites this paper
• Biphasic Effects of α-Asarone on Immobility in the Tail Suspension Test: Evidence for the Involvement of the Noradrenergic and Serotonergic Systems in Its Antidepressant-Like Activity

  2016cites this paper
• Inhibition of the NF-κB and p38 MAPK pathways by scopoletin reduce the inflammation caused by carrageenan in the mouse model of pleurisy

  2016cites this paper
• Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice.

  2016cites this paper
• Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation.

  2016cites this paper
• Urtica dioica leaves modulates hippocampal smoothened-glioma associated oncogene-1 pathway and cognitive dysfunction in chronically stressed mice.

  2016cites this paper
• Implication of coumarins towards central nervous system disorders.

  2016cites this paper
• Brain‐derived Neurotrophic Factor Signaling Mediates the Antidepressant‐like Effect of the Total Flavonoids of Alpiniae Oxyphyllae Fructus in Chronic Unpredictable Mild Stress Mice

  2016cites this paper
• Age-dependent effects of esculetin on mood-related behavior and cognition from stressed mice are associated with restoring brain antioxidant status.

  2016cites this paper
• Evidence for the involvement of the monoaminergic system in the antidepressant-like activity of methanolic extract of Bacopa monnieri in albino mice

  2016cites this paper
• Role of medicinal plants with antidepressant action and its mechanism: A Review

  2016cites this paper
• Phytochemical constituents as future antidepressants: a comprehensive review

  2015cites this paper
• In vitro and in vivo characterization of PA01, a novel promising triple reuptake inhibitor.

  2015cites this paper
• Microwave-assisted clean synthesis of xanthenes and chromenes in [bmim][PF6] and their antioxidant studies

  2015cites this paper
• Eletrochemical characterization of Scopoletin, a 7-hydroxy-6-methoxy-coumarin

  2015cites this paper