Differential regulation of tumor angiogenesis by distinct ErbB homo- and heterodimers.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Molecular Biology of the Cell

• Publication date

  2002-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.E02-02-0084PMID 12429844PMCID PMC133612
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells

  2004cited by this paper
• Transcriptional Regulation of the TFIIH Transcription Repair Components XPB and XPD by the Hepatitis B Virus x Protein in Liver Cells and Transgenic Liver Tissue*

  2001cited by this paper
• HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

  2001influential reference
• Expression of proangiogenic chemokine Gro 1 in low and high metastatic variants of Pam murine squamous cell carcinoma is differentially regulated by IL-1alpha, EGF and TGF-beta1 through NF-kappaB dependent and independent mechanisms.

  2001cited by this paper
• Angiogenesis: regulators and clinical applications.

  2001cited by this paper
• Untangling the ErbB signalling network

  2001influential reference
• FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition.

  2001cited by this paper
• Expression of proangiogenic chemokine Gro 1 in low and high metastatic variants of Pam murine squamous cell carcinoma is differentially regulated by IL‐1α, EGF and TGF‐β1 through NF‐κB dependent and independent mechanisms

  2001cited by this paper
• Mammary gland specific hEGF receptor transgene expression induces neoplasia and inhibits differentiation

  2000cited by this paper
• The ErbB signaling network: receptor heterodimerization in development and cancer

  2000cited by this paper
• Expression of c‐erbB receptors, heregulin and oestrogen receptor in human breast cell lines

  2000cited by this paper
• Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

  2000cited by this paper
• Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide.

  2000cited by this paper
• Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis

  2000influential reference
• Vesicular stomatitis virus G pseudotyped retrovector mediates effective in vivo suicide gene delivery in experimental brain cancer.

  1999influential reference
• Neu Differentiation Factor Stimulates Phosphorylation and Activation of the Sp1 Transcription Factor

  1999cited by this paper
• Molecular and biological properties of vascular endothelial growth factor

  1999cited by this paper
• Elevated expression of activated forms of Neu/ErbB‐2 and ErbB‐3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

  1999cited by this paper
• Structure, expression and receptor-binding properties of novel vascular endothelial growth factors.

  1999cited by this paper
• HIF‐1α is required for solid tumor formation and embryonic vascularization

  1998cited by this paper
• Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

  1998cited by this paper
• HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

  1998cited by this paper
• p42/p44 MAP Kinase Module Plays a Key Role in the Transcriptional Regulation of the Vascular Endothelial Growth Factor Gene in Fibroblasts*

  1998influential reference
• Angiogenesis and tumor metastasis.

  1998cited by this paper
• Dual effect of erbB-2 depletion on the regulation of DNA repair and cell cycle mechanisms in non-small cell lung cancer cells

  1998influential reference
• Specificity within the EGF family/ErbB receptor family signaling network

  1998influential reference
• The hypoxic response: huffing and HIFing.

  1997cited by this paper
• The Hypoxic Response: Minireview Huffing and HIFing

  1997cited by this paper
• Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors.

  1997cited by this paper
• ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

  1997cited by this paper
• The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand‐receptor interactions

  1997cited by this paper
• The biology of vascular endothelial growth factor.

  1997cited by this paper
• Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

  1996influential reference
• ErbB‐2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.

  1996cited by this paper
• Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells.

  1996cited by this paper
• An Immunological Approach Reveals Biological Differences between the Two NDF/Heregulin Receptors, ErbB-3 and ErbB-4 (*)

  1996cited by this paper
• The Relationship between Human Epidermal Growth-like Factor Receptor Expression and Cellular Transformation in NIH3T3 Cells*

  1996influential reference
• Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.

  1996cited by this paper
• Transformation of NIH 3T3 Cells by HER3 or HER4 Receptors Requires the Presence of HER1 or HER2 (*)

  1996cited by this paper
• A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor

  1996cited by this paper
• Growth regulation of human breast and ovarian tumor cells by heregulin: Evidence for the requirement of ErbB2 as a critical component in mediating heregulin responsiveness.

  1996cited by this paper
• Epidermal growth factor-related peptides and their receptors in human malignancies.

  1995cited by this paper
• Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells (*)

  1995cited by this paper
• Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2

  1995influential reference
• Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.

  1995influential reference
• c‐erbb growth‐factor‐receptor proteins in ovarian tumours

  1995cited by this paper
• Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling

  1995cited by this paper
• The cellular response to neuregulins is governed by complex interactions of the erbB receptor family

  1995cited by this paper
• Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

  1995cited by this paper
• Heregulin‐dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3.

  1995cited by this paper
• Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

  1995cited by this paper
• NDF/heregulin activates MAP kinase and p70/p85 S6 kinase during proliferation or differentiation of mammary epithelial cells.

  1995influential reference
• Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

  1994cited by this paper
• Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

  1994influential reference
• Hypoxia regulatory elements of the human vascular endothelial growth factor gene.

  1994cited by this paper
• The biology of erbB-2/neu/HER-2 and its role in cancer.

  1994cited by this paper
• A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling.

  1994cited by this paper
• Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology.

  1993cited by this paper
• Prognostic significance of co-expression of c-erbB-2 oncoprotein and epidermal growth factor receptor in breast cancer patients.

  1992cited by this paper
• Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu

  1992cited by this paper
• A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.

  1991cited by this paper
• Oncogenic potential of erbB-2 in human mammary epithelial cells.

  1991cited by this paper
• Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

  1990cited by this paper
• What is the evidence that tumors are angiogenesis dependent?

  1990cited by this paper
• Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function.

  1990cited by this paper
• Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts.

  1989influential reference
• erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells.

  1987cited by this paper
• Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells.

  1987cited by this paper
• [The mammary gland].

  1966cited by this paper

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