Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2007-09-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.0701311104PMID 17726112PMCID PMC1964831
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

  2006cited by this paper
• Loss of autophagy in the central nervous system causes neurodegeneration in mice

  2006cited by this paper
• Generation of cell lines with tetracycline‐regulated autophagy and a role for autophagy in controlling cell size

  2006cited by this paper
• Induction of Autophagy in Axonal Dystrophy and Degeneration

  2006cited by this paper
• Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

  2005cited by this paper
• Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

  2005cited by this paper
• Macrophages Rapidly Transfer Pathogens from Lipid Raft Vacuoles to Autophagosomes

  2005cited by this paper
• Subsurface cisterna-lined axonal invaginations and double-walled vesicles at the axonal-myelin sheath interface.

  2005cited by this paper
• Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

  2005cited by this paper
• Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair

  2005cited by this paper
• p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

  2005cited by this paper
• Axon degeneration mechanisms: commonality amid diversity

  2005cited by this paper
• Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism.

  2005cited by this paper
• Development by self-digestion: molecular mechanisms and biological functions of autophagy.

  2004cited by this paper
• Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt-Jakob disease: a brain biopsy study.

  2004cited by this paper
• Two ubiquitin-like conjugation systems essential for autophagy.

  2004cited by this paper
• In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker.

  2003cited by this paper
• Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau

  2003cited by this paper
• Axon pathology in neurological disease: a neglected therapeutic target.

  2002cited by this paper
• Huntingtin Aggregate-Associated Axonal Degeneration is an Early Pathological Event in Huntington's Disease Mice

  2001cited by this paper
• FEBS Lett

  2000cited by this paper
• Cre recombinase expression in cerebellar Purkinje cells

  2000cited by this paper
• LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

  2000cited by this paper
• Endocytotic Formation of Vesicles and Other Membranous Structures Induced by Ca2+ and Axolemmal Injury

  1998cited by this paper
• Conformational changes of the smooth endoplasmic reticulum are facilitated by L‐glutamate and its receptors in rat Purkinje cells

  1998cited by this paper
• Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

  1997cited by this paper
• Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease

  1996cited by this paper
• Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transport

  1993cited by this paper
• Genesis

  1985cited by this paper
• The neuronal endoplasmic reticulum: Its cytochemistry and contribution to the endomembrane system. II. Axons and terminals

  1984cited by this paper
• Electron microscope and enzyme studies in cerebral biopsies of Huntington's chorea.

  1974cited by this paper
• A light and electron microscopic study of the cellular response to axonal injury in the superior cervical ganglion of the rat

  1972cited by this paper
• “Phagocytic” Lysosomes in Chromatolytic Neurones

  1967cited by this paper
• Non-central forces in the nuclear two-body problem

  1942cited by this paper

• Salvia plebeia R. Br. extract delays cellular senescence and promotes healthy aging via Atg7-dependent autophagy, with rosmarinic acid as a major bioactive constituent.

  2026cites this paper
• Autophagy Induction in Wistar Rat Lens by Organophosphate Pesticide

  2026cites this paper
• New perspective on neurodegenerative diseases: Focusing on the interaction between autophagy and oxidative stress and targeted strategies.

  2026cites this paper
• Establishment of spinocerebellar ataxia type 34 model mice accompanied by early glial activation and degeneration of cerebellar neurons

  2025cites this paper
• Autophagy Modulation by Antidepressants: Mechanisms and Implications

  2025cites this paper
• Dynamic regulation of autophagy during Semliki Forest virus infection of neuroblastoma cells

  2025cites this paper
• Tailoring UPS-to-autophagy transition to restore RGC prosperity and functionality in a rodent traumatic optic neuropathy model.

  2025cites this paper
• The Interplay between Autophagy and Adult Hippocampal Neurogenesis

  2025cites this paper
• Pathophysiological Mechanisms Fostering Developmental and Epileptic Encephalopathies (DEE): a Complex Interplay between Genetics, Inflammation and Neurodegeneration

  2025cites this paper
• Chronic administration of the hydrogen sulfide prodrug SG1002 partially protects against erectile dysfunction resulting from long-term androgen deprivation.

  2025cites this paper
• The Dual Role of Autophagy in the Pathogenesis of Arboviruses With a Focus on JEV and DENV

  2025cites this paper
• Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

  2025cites this paper
• Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways

  2025cites this paper
• Autophagy regulates PVALB (parvalbumin) interneuron excitability and memory

  2025cites this paper
• The Role of Autophagy in Excitotoxicity, Synaptic Mitochondrial Stress and Neurodegeneration

  2025cites this paper
• Chronic administration of the hydrogen sulfide prodrug SG1002 partially protects against erectile dysfunction resulting from long-term androgen deprivation

  2025cites this paper
• Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

  2025cites this paper
• Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications

  2025cites this paper
• Differential response of neurons to autophagy modulation in Huntington’s disease

  2025cites this paper
• Neuronal autophagy in the control of synapse function.

  2025cites this paper
• Navigating the neuronal recycling bin: Another look at huntingtin in coordinating autophagy

  2025cites this paper
• Retinoic Acid Promotes Neuronal Differentiation While Increasing Proteins and Organelles Related to Autophagy

  2025cites this paper
• Autophagy in cancer and protein conformational disorders

  2025cites this paper
• Molecular hallmarks of neurodegeneration in polyglutamine spinocerebellar ataxias

  2025cites this paper
• Ligustilide inhibits Purkinje cell ferritinophagy via the ULK1/NCOA4 pathway to attenuate valproic acid-induced autistic features.

  2024cites this paper
• Spontaneously regenerative corticospinal neurons in mice

  2024cites this paper
• The effect of Neuropeptide Y Y2 receptor blockade on memory impairment and autophagy in a rat model of Alzheimer’s disease

  2024cites this paper
• Autophagy in the retina affects photoreceptor synaptic plasticity and behavior.

  2024cites this paper
• Autophagy in the nervous system: general principles and specific functions

  2024cites this paper
• Neuronal Autophagy: Regulations and Implications in Health and Disease

  2024cites this paper
• Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons

  2024cites this paper
• Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases

  2024cites this paper
• Transforming growth factor-β1 protects mechanically injured cortical murine neurons by reducing trauma-induced autophagy and apoptosis

  2024cites this paper
• High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia

  2024cites this paper
• Exosomes derived from human umbilical cord mesenchymal stem cells pretreated by monosialoteterahexosyl ganglioside alleviate intracerebral hemorrhage by down-regulating autophagy.

  2024cites this paper
• Genetic modeling of degenerative diseases and mechanisms of neuronal regeneration in the zebrafish cerebellum

  2024cites this paper
• Autophagy as a new player in the regulation of clock neurons physiology of Drosophila melanogaster

  2024cites this paper
• Adult-onset deactivation of autophagy leads to loss of synapse homeostasis and cognitive impairment, with implications for alzheimer disease

  2024cites this paper
• Last but not least: emerging roles of the autophagy-related protein ATG4D

  2024cites this paper
• The role of autophagy in brain health and disease: Insights into exosome and autophagy interactions

  2024cites this paper
• Amyotrophic Lateral Sclerosis Mechanism: Insights from the Caenorhabditis elegans Models

  2024cites this paper
• Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo

  2024cites this paper
• High-Content Small Molecule Screen Identifies a Novel Compound That Restores AP-4-Dependent Protein Trafficking in Neuronal Models of AP-4-Associated Hereditary Spastic Paraplegia

  2023cites this paper
• Role of lipids in the control of autophagy and primary cilium signaling in neurons

  2023cites this paper
• Preliminary Study on the Effect and Molecular Mechanism of Tetrandrine in Alleviating Pulmonary Inflammation and Fibrosis Induced by Silicon Dioxide

  2023cites this paper
• Genetic Polymorphism Detection of Pathophysiological Pathways of Ischemic Stroke in Asian.

  2023cites this paper
• Tuning gene expression to music: the compensatory effect of music on age-related cognitive disorders

  2023cites this paper
• Peroxisome and pexophagy in neurological diseases

  2023cites this paper
• Cathepsin D mediates prenatal caffeine exposure-caused NAFLD susceptibility in male rat offspring by regulating autophagy.

  2023cites this paper
• Deregulated mitochondrial quality control, the heel of Achilles in elucidating the role of autophagy in SARM1‐mediated axon degeneration

  2023cites this paper
• Epigenetic regulation of autophagy-related genes: Implications for neurodevelopmental disorders

  2023cites this paper
• Lentinan alleviates sciatic nerve injury by promoting autophagy to remove myelin fragments

  2023cites this paper
• Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies

  2023cites this paper
• Rhythms in barriers and fluids: Circadian clock regulation in the aging neurovascular unit.

  2023cites this paper
• An Update on Autophagy as a Target in the Treatment of Alzheimer's Disease.

  2023cites this paper
• “Dirty Dancing” of Calcium and Autophagy in Alzheimer’s Disease

  2023cites this paper
• NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin

  2023cites this paper
• CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells

  2023cites this paper
• The Multiple Roles of Autophagy in Neural Function and Diseases

  2023cites this paper
• Music compensates for altered gene expression in age-related cognitive disorders

  2023cites this paper
• Pathogenic Aspects and Therapeutic Avenues of Autophagy in Parkinson’s Disease

  2023cites this paper
• Targeting SARM1 improves autophagic stress-induced axonal neuropathy

  2023influential citation
• Inhibition of Wnt/β-catenin signaling attenuates axonal degeneration in models of Parkinson's disease.

  2022cites this paper
• Organization of the autophagy pathway in neurons.

  2022cites this paper
• BDNF stimulates the retrograde pathway for axonal autophagy

  2022cites this paper
• Alternative autophagy: mechanisms and roles in different diseases

  2022cites this paper
• Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration

  2022cites this paper
• Dynamics of Metabolic Pathways and Stress Response Patterns during Human Neural Stem Cell Proliferation and Differentiation

  2022cites this paper
• ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiation

  2022cites this paper
• Molecular Mechanism and Regulation of Autophagy and Its Potential Role in Epilepsy

  2022cites this paper
• NDR1/2 kinases regulate membrane trafficking, enable efficient autophagy and prevent neurodegeneration

  2022cites this paper
• Organization of Presynaptic Autophagy-Related Processes

  2022cites this paper
• Macroautophagy in CNS health and disease

  2022cites this paper
• Nutrition in Brain Aging: Its Relevance to Age-Associated Neurodegeneration

  2022cites this paper
• Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

  2022cites this paper
• Integrated proteomics reveals the landscape of autophagy degradation in human neurons and autophagy receptors regulating neuronal activity

  2022cites this paper
• PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux

  2022cites this paper
• Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

  2022cites this paper
• Brain-derived neurotrophic factor stimulates the retrograde pathway for axonal autophagy

  2022cites this paper
• The tissue-specific autophagic response to nutrient deprivation

  2022cites this paper
• ATG5: A central autophagy regulator implicated in various human diseases

  2022cites this paper
• Pharmacological mTOR-inhibition facilitates clearance of AD-related tau aggregates in the mouse brain.

  2022cites this paper
• Neurodegeneration and convergent factors contributing to the deterioration of the cytoskeleton in Alzheimer's disease, cerebral ischemia and multiple sclerosis (Review)

  2022cites this paper
• Autophagy in parvalbumin interneurons is required for inhibitory transmission and memory via regulation of synaptic proteostasis

  2022cites this paper
• Aging Differentially Affects Axonal Autophagosome Formation and Maturation

  2022cites this paper
• Autophagy status as a gateway for stress-induced catecholamine interplay in neurodegeneration.

  2021cites this paper
• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

  2021cites this paper
• Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration

  2021cites this paper
• Characterization of the role of autophagy in retinal ganglion cell survival over time using a rat model of chronic ocular hypertension

  2021cites this paper
• From Metabolic Syndrome to Neurological Diseases: Role of Autophagy

  2021cites this paper
• Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans

  2021cites this paper
• Presynaptic Autophagy and the Connection With Neurotransmission

  2021cites this paper
• Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles

  2021cites this paper
• Different Roles of Beclin1 in the Interaction Between Glia and Neurons after Exposure to Morphine and the HIV- Trans-Activator of Transcription (Tat) Protein

  2021cites this paper
• Autophagy in α-Synucleinopathies—An Overstrained System

  2021cites this paper
• Autophagy: a multifaceted player in the fate of sperm

  2021cites this paper
• The Homeostasis of p62/SQSTM1 Short Isoform Regulates Selective Autophagy

  2021cites this paper
• Lanthanum chloride induces autophagy in primary cultured rat cortical neurons through Akt/mTOR and AMPK/mTOR signaling pathways.

  2021cites this paper
• The SZT2 Interactome Unravels New Functions of the KICSTOR Complex

  2021cites this paper
• Live Imaging of Autophagosome Biogenesis and Maturation in Primary Neurons

  2021cites this paper