Aldosterone: a forgotten mediator of the relationship between psychological stress and heart disease.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Neuroscience and Biobehavioral Reviews

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neubiorev.2009.07.005PMID 19631234PMCID PMC3099453
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Emotional triggering of cardiac events.

  2009cited by this paper
• Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes.

  2009cited by this paper
• Novel insights into glucocorticoid‐mediated diabetogenic effects: towards expansion of therapeutic options?

  2009cited by this paper
• Reconsidering the Roles of the Mineralocorticoid Receptor

  2009cited by this paper
• Aldosterone and its Cardiovascular Effects

  2009cited by this paper
• Textbook of nephro-endocrinology

  2009cited by this paper
• Aldosterone induces superoxide generation via Rac1 activation in endothelial cells.

  2008cited by this paper
• Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptor.

  2008cited by this paper
• Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.

  2008cited by this paper
• A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function.

  2008cited by this paper
• Chronic treatment with the mineralocorticoid hormone aldosterone results in increased anxiety-like behavior.

  2008cited by this paper
• Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-&ggr;, and Proinflammatory Adipokines

  2008cited by this paper
• Psychological stress and cardiovascular disease.

  2008cited by this paper
• Aldosterone impairs baroreflex sensitivity in healthy adults.

  2007cited by this paper
• Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity

  2007cited by this paper
• Glucocorticoids and cardiovascular disease.

  2007cited by this paper
• Baroreflex sensitivity predicts long-term cardiovascular mortality after myocardial infarction even in patients with preserved left ventricular function.

  2007cited by this paper
• Body mass index predicts aldosterone production in normotensive adults on a high-salt diet.

  2007cited by this paper
• Angiotensin II, corticosteroids, type II diabetes and the metabolic syndrome.

  2007cited by this paper
• Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus.

  2007cited by this paper
• Psychological stress and disease.

  2007cited by this paper
• Sick at heart: the pathophysiology of negative emotions.

  2007cited by this paper
• Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.

  2007cited by this paper
• Aldosterone as a cardiovascular risk hormone.

  2007cited by this paper
• Pivotal role of the mineralocorticoid receptor in corticosteroid‐induced adipogenesis

  2007cited by this paper
• Intra-vascular glucocorticoid metabolism as a modulator of vascular structure and function

  2006cited by this paper
• Sadness and broken hearts: neurohumoral mechanisms and co-morbidity of ischemic heart disease and psychological depression.

  2006cited by this paper
• Novel Effect of Mineralocorticoid Receptor Antagonism to Reduce Proinflammatory Cytokines and Hypothalamic Activation in Rats With Ischemia-Induced Heart Failure

  2006cited by this paper
• Mineralocorticoid receptors and cardiovascular damage: it's not just aldosterone.

  2006cited by this paper
• Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats.

  2006cited by this paper
• Diurnal Cortisol Decline is Related to Coronary Calcification: CARDIA Study

  2006cited by this paper
• Angiotensin II Induces Interleukin-6 in Humans Through a Mineralocorticoid Receptor–Dependent Mechanism

  2006cited by this paper
• Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats.

  2006cited by this paper
• Aldosterone Target Neurons in the Nucleus Tractus Solitarius Drive Sodium Appetite

  2006cited by this paper
• Insulin sensitivity in patients with primary aldosteronism: a follow-up study.

  2006cited by this paper
• Sadness and broken hearts: neurohumoral mechanisms and co-morbidity of ischemic heart disease and psychological depression.

  2006influential reference
• Psychological Aspects of Primary Aldosteronism

  2006cited by this paper
• Weight Loss and the Renin-Angiotensin-Aldosterone System

  2005cited by this paper
• Effect of Aldosterone and Mineralocorticoid Receptor Blockade on Vascular Inflammation

  2005cited by this paper
• The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: the emerging field of behavioral cardiology.

  2005cited by this paper
• Psychosocial factors and cardiovascular diseases.

  2005cited by this paper
• Anti-stress and anti-anxiety effects of centrally acting angiotensin II AT1 receptor antagonists.

  2005cited by this paper
• Inhibition of cortisol production with metyrapone prevents mental stress-induced endothelial dysfunction and baroreflex impairment.

  2005cited by this paper
• Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes.

  2005cited by this paper
• Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism.

  2005cited by this paper
• Eplerenone Inhibits Atherosclerosis in Nonhuman Primates

  2005cited by this paper
• Increased plasma aldosterone in patients with clinical depression.

  2005cited by this paper
• Angiotensin II and Aldosterone Regulate Gene Transcription Via Functional Mineralocortocoid Receptors in Human Coronary Artery Smooth Muscle Cells

  2005cited by this paper
• Spironolactone in the treatment of polycystic ovary syndrome: Effects on clinical features, insulin sensitivity and lipid profile

  2005cited by this paper
• Anger, anxiety, and depression as risk factors for cardiovascular disease: the problems and implications of overlapping affective dispositions.

  2005cited by this paper
• Serum aldosterone and the incidence of hypertension in nonhypertensive persons.

  2004cited by this paper
• Comparison of efficacy of spironolactone with metformin in the management of polycystic ovary syndrome: an open-labeled study.

  2004cited by this paper
• Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study.

  2004cited by this paper
• Hormones and the stressed brain.

  2004cited by this paper
• Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research.

  2004influential reference
• Does altered glucocorticoid homeostasis increase cardiovascular risk?

  2004cited by this paper
• Brain mineralocorticoid receptors: orchestrators of hypertension and end-organ disease

  2004cited by this paper
• Hormones and the Stressed Brain

  2004cited by this paper
• The Renin-Angiotensin-Aldosterone system in patients with depression compared to controls – a sleep endocrine study

  2003cited by this paper
• Hypertension and Left Ventricular Hypertrophy : The 4 E Effects of Eplerenone , Enalapril , and Eplerenone / Enalapril in Patients With Essential

  2003cited by this paper
• Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction.

  2003cited by this paper
• Neural control of the kidney: past, present, and future.

  2003cited by this paper
• Eplerenone , a Selective Aldosterone Blocker , in Patients with Left Ventricular Dysfunction after Myocardial Infarction

  2003cited by this paper
• Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model.

  2002cited by this paper
• Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity

  2002cited by this paper
• Cardiac Damage Prevention by Eplerenone: Comparison With Low Sodium Diet or Potassium Loading

  2002cited by this paper
• Mineralocorticoid Receptor Antagonism in Experimental Atherosclerosis

  2002cited by this paper
• Aldosterone Antagonist Improves Diastolic Function in Essential Hypertension

  2002cited by this paper
• Aldosterone in congestive heart failure.

  2001cited by this paper
• Corticosteroids in relation to fear, anxiety and psychopathology.

  2001influential reference
• Central mineralocorticoid receptor blockade improves volume regulation and reduces sympathetic drive in heart failure.

  2001cited by this paper
• The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

  2000cited by this paper
• Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure.

  2000cited by this paper
• Stress and Body Shape: Stress-Induced Cortisol Secretion Is Consistently Greater Among Women With Central Fat

  2000cited by this paper
• The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.

  1999cited by this paper
• Differential hypothalamic-pituitary-adrenal axis reactivity to psychological and physical stress.

  1999cited by this paper
• Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women.

  1999cited by this paper
• Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome.

  1999cited by this paper
• Brain corticosteroid receptor balance in health and disease.

  1998cited by this paper
• Aldosterone in obesity.

  1998cited by this paper
• Body fat distribution, insulin resistance, and metabolic diseases.

  1997cited by this paper
• The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: evidence that androgens impair insulin action in women.

  1996cited by this paper
• Stress Reduction and Preventing Hypertension: Preliminary Support for a Psychoneuroendocrine Mechanism

  1995cited by this paper
• Relationships among plasma aldosterone, high-density lipoprotein cholesterol, and insulin in humans.

  1995cited by this paper
• Influence of arterial blood pressure and aldosterone on left ventricular hypertrophy in moderate essential hypertension.

  1993cited by this paper
• Central Nervous System and the Pathogenesis of Hypertension Sites and Mechanisms

  1991cited by this paper
• Role for aldosterone in blood pressure regulation of obese adolescents.

  1986cited by this paper
• Mechanisms of hypertension associated with obesity.

  1983cited by this paper
• Changes in Endocrine Activities Relative to Obesity in Patients with Essential Hypertension *

  1981cited by this paper
• Protection by a Steroid-Spirolactone Against Certain Types of Cardiac Necroses.∗

  1960cited by this paper
• Aldosterone in congestive heart failure.

  1959cited by this paper
• Stress and disease

  1955cited by this paper
• Stress and disease.

  1955cited by this paper
• [General adaptation syndrome and diseases of adaptation].

  1950cited by this paper
• The general adaptation syndrome and the diseases of adaptation.

  1946cited by this paper

• Ambient temperature and ovarian hyperstimulation syndrome: An observational study

  2025cites this paper
• Assessment of per- and poly-fluoroalkyl substances and physiological biomarkers in aquarium-based bottlenose dolphins and killer whales.

  2024cites this paper
• Association of mental health-related patient reported outcomes with blood pressure in adults and children with primary proteinuric glomerulopathies

  2024cites this paper
• Maternal sucrose consumption alters steroid levels in the mother, placenta, and fetus

  2024cites this paper
• Is your stress my stress? A standardized, randomized-controlled paradigm to study physiological stress contagion based on direct stress observation.

  2024cites this paper
• Increased daytime and awakening salivary free aldosterone in essential hypertensive men

  2024cites this paper
• Assessment of Phthalate Esters and Physiological Biomarkers in Bottlenose Dolphins (Tursiops truncatus) and Killer Whales (Orcinus orca)

  2024influential citation
• Steroid hormones in systemic sclerosis: associations with disease characteristics and modifications during scleroderma renal crisis.

  2023cites this paper
• A randomized vagus nerve stimulation study demonstrates that serum aldosterone levels decrease with age in women, but not in men

  2023cites this paper
• The cardiovascular subtleties of testosterone on gender-affirming hormone therapy.

  2023cites this paper
• Unraveling the phenotypic and genomic background of behavioral plasticity and temperament in North American Angus cattle

  2023cites this paper
• Naturally stressed? Glucocorticoid profiles in blubber of blue and gray whales in response to life history parameters.

  2022cites this paper
• Effectiveness of Multidomain Dormitory Environment and Roommate Intervention for Improving Sleep Quality of Medical College Students: A Cluster Randomised Controlled Trial in China

  2022cites this paper
• Stress, hypoglycemia, and the autonomic nervous system.

  2022cites this paper
• Impaired negative feedback and death following acute stress in glucocorticoid receptor knockout Xenopus tropicalis tadpoles.

  2022cites this paper
• Mental Stress and Cardiovascular Health—Part I

  2022cites this paper
• Genetic Differences between Physical Injury Patients With and Without Post-traumatic Syndrome: Focus on Secondary Findings and Potential Variants Revealed by Whole Exome Sequencing

  2021cites this paper
• Towards understanding the welfare of cetaceans in accredited zoos and aquariums

  2021cites this paper
• Behavioral diversity as a potential positive indicator of animal welfare in bottlenose dolphins

  2021cites this paper
• Reference intervals and values for fecal cortisol, aldosterone, and the ratio of cortisol to dehydroepiandrosterone metabolites in four species of cetaceans

  2021cites this paper
• Effect and Relationship of Seasons on the High Risk of Ovarian Hyperstimulation Syndrome After Oocyte Retrieval in Patients With Polycystic Ovary Syndrome

  2021cites this paper
• Primary aldosteronism is everywhere but does anyone see it?

  2021cites this paper
• Peak week recommendations for bodybuilders: an evidence based approach

  2021cites this paper
• Associations of trauma and posttraumatic stress disorder with aldosterone in women.

  2021cites this paper
• The effects of furosemide on cortisol concentrations when paired with exercise in Standardbred horses

  2021cites this paper
• Determinants and Mechanisms of the Renin-Aldosterone Stress Response

  2021cites this paper
• Steroid hormone secretion after stimulation of mineralocorticoid and NMDA receptors and cardiovascular risk in patients with depression

  2020cites this paper
• Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression

  2020cites this paper
• The potential pathophysiological role of aldosterone and the mineralocorticoid receptor in anxiety and depression - Lessons from primary aldosteronism.

  2020cites this paper
• CIA_A_259422 1271..1283

  2020cites this paper
• ACTH Infusion Impairs Baroreflex Sensitivity-Implications for Cardiovascular Hypoglycemia-Associated Autonomic Failure.

  2020cites this paper
• Juvenile Children’s Salivary Aldosterone and Cortisone Decrease during Informal Math and Table-Tennis Competitions

  2020cites this paper
• Salivary aldosterone and cortisone respond differently to high- and low-psychologically stressful soccer competitions

  2020cites this paper
• The potential link between inherited G6PD deficiency, oxidative stress, and vitamin D deficiency and the racial inequities in mortality associated with COVID-19

  2020cites this paper
• Sympathectomy-induced blood pressure reduction in adult normotensive and hypertensive rats is counteracted by enhanced cardiovascular sensitivity to vasoconstrictors

  2019cites this paper
• Damage-Fitness Model: the missing piece in integrative stress models

  2019cites this paper
• Kinetics and Interrelations of the Renin Aldosterone Response to Acute Psychosocial Stress: A Neglected Stress System

  2019influential citation
• Development of a biomarker panel for identifying stressed marine mammals

  2019cites this paper
• Classical steroids in a new fashion: Focus on testosterone and aldosterone.

  2019cites this paper
• Genome‐wide DNA methylation investigation of glucocorticoid exposure within buccal samples

  2019cites this paper
• Fungus Monascus-Fermented Red Yeast Rice (RYR): Natural Therapeutic Statin Source or Mycotoxin?

  2018cites this paper
• Genome-wide DNA methylation investigation of stress: from a mouse model of chronic stress to humans exposed to glucocorticoids

  2018cites this paper
• Effects of chronic exposure to 12‰ saltwater on the endocrine physiology of juvenile American alligator (Alligator mississippiensis)

  2018cites this paper
• Testing men's hormone responses to playing League of Legends: No changes in testosterone, cortisol, DHEA or androstenedione but decreases in aldosterone

  2018cites this paper
• Repeated adrenocorticotropic hormone administration alters adrenal and thyroid hormones in free-ranging elephant seals

  2018cites this paper
• Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance

  2018cites this paper
• Psychophysiological measurement of affective responses during speech perception

  2018cites this paper
• Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice

  2018cites this paper
• Hypertension linked to allostatic load: from psychosocial stress to inflammation and mitochondrial dysfunction

  2018cites this paper
• Effect of maternal renin-angiotensin-aldosterone system activation on social coping strategies and gene expression of oxytocin and vasopressin in the brain of rat offspring in adulthood.

  2017cites this paper
• Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies

  2017cites this paper
• Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies.

  2017cites this paper
• Adjunctive Steroid Therapy for Treatment of Pediatric Septic Shock.

  2017cites this paper
• Adrenal responses of large whales: Integrating fecal aldosterone as a complementary biomarker to glucocorticoids.

  2017cites this paper
• Evidence for Ancestral Programming of Resilience in a Two-Hit Stress Model

  2017cites this paper
• Pharmacokinetic and urinary profiling reveals the prednisolone/cortisol ratio as a valid biomarker for prednisolone administration

  2017cites this paper
• General Physiology and Biophysics Revised manuscript #1 Title: Effect of maternal renin-angiotensin-aldosterone system activation on social coping strategies and gene expression of oxytocin and vasopressin in the brain of rat offspring in adulthood Running title: Maternal RAAS activation and program

  2017cites this paper
• From Breakdowns to Breakthroughs

  2017cites this paper
• Effetti extra-renali dei mineralcorticoidi: non solo sale!

  2017cites this paper
• Souffrance au travail et enjeux de santé : le rôle charnière de l’inflammation et du stress oxydant

  2017cites this paper
• Enhanced nitric oxide generation from nitric oxide synthases as the cause of increased peroxynitrite formation during acute restraint stress: Effects on carotid responsiveness to angiotensinergic stimuli in type-1 diabetic rats.

  2016cites this paper
• Elevated plasma aldosterone is an independent risk factor for erectile dysfunction in men

  2016cites this paper
• Model approach for stress induced steroidal hormone cascade changes in severe mental diseases

  2016cites this paper
• Serum biochemistry reference intervals of live wild dugongs (Dugong dugon) from urban coastal Australia.

  2015cites this paper
• The runner-up: On the role of the mineralocorticoid receptor in human cognition

  2015cites this paper
• Is flourishing good for the heart? Relationships between positive psychology characteristics and cardiorespiratory health

  2015cites this paper
• Autonomic and inflammatory consequences of posttraumatic stress disorder and the link to cardiovascular disease.

  2015cites this paper
• Acute restraint stress increases carotid reactivity in type-I diabetic rats by enhancing Nox4/NADPH oxidase functionality.

  2015cites this paper
• Anesthesia with sevoflurane in neonatal rats: Developmental neuroendocrine abnormalities and alleviating effects of the corticosteroid and Cl(-) importer antagonists.

  2015cites this paper
• Chronic intermittent mental stress promotes atherosclerotic plaque vulnerability, myocardial infarction and sudden death in mice.

  2015cites this paper
• Regulation of aldosterone synthesis and secretion.

  2014cites this paper
• New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine

  2014influential citation
• Childhood social disadvantage, cardiometabolic risk, and chronic disease in adulthood.

  2014cites this paper
• Endocrine and Neurobehavioral Abnormalities Induced by Propofol Administered to Neonatal Rats

  2014cites this paper
• Entwicklung von Teststrategien zur selektiven Hemmung von Enzymen der adrenalen Steroidsynthese unter besonderer Berücksichtigung von Speziesunterschieden

  2014cites this paper
• The influence of psychological stress on arginine vasopressin concentration in the human plasma and cerebrospinal fluid.

  2014cites this paper
• A marked proportional rise in IVC aldosterone following cosyntropin administration during AVS is a signal to the presence of adrenal hyperplasia in primary aldosteronism

  2014cites this paper
• A kardiovaszkuláris rizikó és a C4B gén hiányos haplotípusok közötti kapcsolat mechanizmusának vizsgálata

  2013cites this paper
• Transgenerational programming of brain and behaviour by prenatal stress

  2013cites this paper
• Serotonin – 100 words

  2013cites this paper
• Cardiovascular and metabolic risk profile in young people at familial risk of depression

  2013cites this paper
• The use of health impact assessment for a community undergoing natural gas development.

  2013cites this paper
• Hyperreninemic Hypoaldosteronism in Combat-Related Posttraumatic Stress Disorder

  2013cites this paper
• POTENTIALLY TRAUMATIC EVENTS AND THE RISK OF SIX PHYSICAL HEALTH CONDITIONS IN A POPULATION‐BASED SAMPLE

  2013cites this paper
• The information provided by the adrenal cortical steroids: a hypothesis.

  2012cites this paper
• Childhood adversity and immune and inflammatory biomarkers associated with cardiovascular risk in youth: a systematic review.

  2012cites this paper
• Aldosterone synergizes with peripheral inflammation to induce brain IL-1β expression and depressive-like effects.

  2012cites this paper
• Physiological Consequences of Repeated Exposures to Conditioned Fear

  2012cites this paper
• The heart's content: the association between positive psychological well-being and cardiovascular health.

  2012cites this paper
• Perceived stress correlates with disturbed sleep: A link connecting stress and cardiovascular disease

  2012cites this paper
• ACTH‐induced cortisol release is related to the copy number of the C4B gene encoding the fourth component of complement in patients with non‐functional adrenal incidentaloma

  2012cites this paper
• A prospective study of positive psychological well-being and coronary heart disease.

  2011cites this paper
• Episodic Rage Associated with Primary Aldosteronism Resolved with Adrenalectomy

  2011cites this paper
• Psychological assessment of primary aldosteronism: a controlled study.

  2011cites this paper
• Lower Frequency of Antidepressant Use in Patients on Renin-Angiotensin-Aldosterone System Modifying Medications

  2011cites this paper
• Aldosterone and stress-dependent arterial hypertension

  2011cites this paper
• Does affective commitment decrease the level of stress reported in teachers? A comparison of primary and secondary school teachers

  2010influential citation
• Erwerbsminderung bei Holocaustopfern: eine langzeitkatamnestische Betrachtung somatischer und psychiatrischer Diagnosen unter Berücksichtigung des Gesamtschauaspekts

  2010cites this paper
• Pathophysiologic mechanisms linking impaired cardiovascular health and neurologic dysfunction: The year in review

  2010cites this paper
• The Plymouth Student Scientist The Plymouth Student Scientist

  year unknowninfluential citation