Kinetics of propylene oxide metabolism in microsomes and cytosol of different organs from mouse, rat, and humans.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Toxicology and Applied Pharmacology

• Publication date

  2001-04-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1006/TAAP.2001.9135PMID 11264024
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The closed chamber technique — uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors

  2006cited by this paper
• Microsomal glutathione S-transferase. Purification, initial characterization and demonstration that it is not identical to the cytosolic glutathione S-transferases A, B and C.

  2005cited by this paper
• Enzyme specific kinetics of 1,2-epoxybutene-3 in microsomes and cytosol from livers of mouse, rat, and man

  2005cited by this paper
• In vitro kinetics of styrene and styrene oxide metabolism in rat, mouse, and human

  2005cited by this paper
• Cytosolic epoxide hydrolase in humans: development and tissue distribution

  2004cited by this paper
• Kinetic and chemical mechanism of epoxide hydrolase.

  1999cited by this paper
• Methods for biological monitoring of propylene oxide exposure in Fischer 344 rats.

  1999cited by this paper
• Tissue distribution of DNA adducts in male Fischer rats exposed to 500 ppm of propylene oxide: quantitative analysis of 7-(2-hydroxypropyl)guanine by 32P-postlabelling.

  1998cited by this paper
• Pharmacokinetics and metabolism of vinyl fluoride in vivo and in vitro.

  1997cited by this paper
• Epoxide hydrolase-dependent metabolism of butadiene monoxide to 3-butene-1,2-diol in mouse, rat, and human liver.

  1997cited by this paper
• Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen.

  1997cited by this paper
• Propylene oxide: mutagenesis, carcinogenesis and molecular dose.

  1997cited by this paper
• In vivo and in vitro kinetics of ethylene oxide metabolism in rats and mice.

  1996cited by this paper
• A gas-liquid system for enzyme kinetic studies of volatile organic chemicals. Determination of enzyme kinetic constants and partition coefficients of trichloroethylene.

  1996cited by this paper
• In vivo dosimetry of ethylene oxide and propylene oxide in the cynomolgus monkey.

  1996cited by this paper
• Cytochrome P450 2a of nasal epithelium: Regulation and role in carcinogen metabolism

  1995cited by this paper
• Olfactory toxicity of diethyldithiocarbamate (DDTC) and disulfiram and the protective effect of DDTC against the olfactory toxicity of dichlobenil.

  1995cited by this paper
• An Introduction to the Bootstrap

  1995cited by this paper
• Metabolic activation of the olfactory toxicant, dichlobenil, in rat olfactory microsomes: comparative studies with p-nitrophenol.

  1995cited by this paper
• Benzene metabolism by human liver microsomes in relation to cytochrome P450 2E1 activity.

  1994cited by this paper
• Nasal Diagrams: A Tool for Recording the Distribution of Nasal Lesions in Rats and Mice

  1994cited by this paper
• Biochemical and histopathological changes in nasal epithelium of rats after 3-day intermittent exposure to formaldehyde and ozone alone or in combination.

  1994cited by this paper
• Glutathione S-transferases: structure and mechanism of an archetypical detoxication enzyme.

  1994cited by this paper
• The characterization of glutathione S-transferases from rat olfactory epithelium.

  1993cited by this paper
• Kinetic analysis of furan biotransformation by F-344 rats in vivo and in vitro.

  1993cited by this paper
• Drug metabolism in the nasal cavity: relevance to toxicology.

  1993cited by this paper
• Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice.

  1992cited by this paper
• Species and tissue differences in the microsomal oxidation of 1,3-butadiene and the glutathione conjugation of butadiene monoxide in mice and rats. Possible role in 1,3-butadiene-induced toxicity.

  1992cited by this paper
• Direct measurement of melphalan conjugation with glutathione: studies with human melanoma cells and mammalian liver.

  1992cited by this paper
• Estimating error limits in parametric curve fitting

  1989cited by this paper
• Biotransformation enzymes in nasal mucosa and liver of Sprague-Dawley rats.

  1988cited by this paper
• Chronic inhalation toxicity and carcinogenicity study of propylene oxide in Wistar rats.

  1988cited by this paper
• Organ distribution of epoxide hydrolases in cytosolic and microsomal fractions of normal and nafenopin-treated male DBA/2 mice.

  1988cited by this paper
• Nasal cavity neoplasia in F344/N rats and (C57BL/6 x C3H)F1 mice inhaling propylene oxide for up to two years.

  1986cited by this paper
• Distribution and inducibility of cytosolic epoxide hydrolase in male Sprague-Dawley rats.

  1986cited by this paper
• Interindividual variations in the activities of cytosolic and microsomal epoxide hydrolase in human liver.

  1985cited by this paper
• p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol.

  1985cited by this paper
• Drug metabolism in man and its relationship to that in three rodent species: monooxygenase, epoxide hydrolase, and glutathione S-transferase activities in subcellular fractions of lung and liver.

  1984cited by this paper
• Inhalation pharmacokinetics based on gas uptake studies

  1984cited by this paper
• Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats.

  1984cited by this paper
• Differentiation between metabolic incorporation and covalent binding in the labeling of macromolecules in the rat nasal mucosa and bone marrow by inhaled [14C]- and [3H]formaldehyde.

  1984cited by this paper
• Microsomal glutathione transferase. Purification in unactivated form and further characterization of the activation process, substrate specificity and amino acid composition.

  1983cited by this paper
• Some biotransformation enzymes responsible for polycyclic aromatic hydrocarbon metabolism in rat nasal turbinates: effects on enzyme activities of in vitro modifiers and intraperitoneal and inhalation exposure of rats to inducing agents.

  1983cited by this paper
• Cytochrome P-450 dependent monooxygenase activity in rat nasal epithelial membranes.

  1982cited by this paper
• Inhalation pharmacokinetics based on gas uptake studies

  1981cited by this paper
• Genetic toxicity of some important epoxides.

  1981cited by this paper
• Tissue and species differences in enzymes of epoxide metabolism.

  1981cited by this paper
• Hepatic glutathione S-transferases: activities and cellular localization in rat, rhesus monkey, chimpanzee and man.

  1981cited by this paper
• Alcohol dehydrogenase-coupled spectrophotometric assay of epoxide hydratase activity.

  1980cited by this paper
• Xenobiotic metabolism in the human lung.

  1980cited by this paper
• A vial-equilibration method to evaluate the drug-metabolizing enzyme activity for volatile hydrocarbons.

  1979cited by this paper
• An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  1978cited by this paper
• Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.

  1974cited by this paper
• Enzymatic conjugation of epoxides with glutathione.

  1973cited by this paper
• Hepatic epoxide hydrase. Structure-activity relationships for substrates and inhibitors.

  1971cited by this paper
• Determination of serum proteins by means of the biuret reaction.

  1949cited by this paper
• Lehrbuch der Toxikologie

  year unknowncited by this paper

• Genetic Susceptibility and Physical Activity Modified the Long‐Term Effect of Propylene Oxide Exposure on Lung Function: A Repeated‐Measurement Cohort Study

  2025cites this paper
• Volatile organic compounds exposure in relation to glucose homeostasis and type 2 diabetes in older adults from the NHANES

  2024cites this paper
• Cross-sectional and longitudinal associations between propylene oxide exposure and lung function among Chinese community residents: Roles of oxidative DNA damage, lipid peroxidation, and protein carbonylation.

  2022cites this paper
• In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene.

  2022cites this paper
• Associations of propylene oxide exposure with fasting plasma glucose and diabetes: Roles of oxidative DNA damage and lipid peroxidation.

  2021cites this paper
• Olfactory Mucosa: Composition, Enzymatic Localization, and Metabolism

  2015cites this paper
• Novel and existing data for a future physiological toxicokinetic model of ethylene and its metabolite ethylene oxide in mouse, rat, and human.

  2015cites this paper
• Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation

  2014cites this paper
• DMD056341 872..884

  2014cites this paper
• In vivo formation of N7-guanine DNA adduct by safrole 2',3'-oxide in mice.

  2012cites this paper
• Connecting the chemical and biological reactivity of epoxides.

  2012cites this paper
• Epoxy Compounds—Olefin Oxides, Aliphatic Glycidyl Ethers and Aromatic Monoglycidyl Ethers

  2012cites this paper
• Kinetics of Ethylene and Ethylene Oxide in Subcellular Fractions of Lungs and Livers of Male B6C3F1 Mice and Male Fischer 344 Rats and of Human Livers

  2011influential citation
• Kinetics and mechanism of the catalytic hydration of propylene oxide

  2010cites this paper
• Kinetics and mechanism of the catalytic hydration of 2-methylbutene-2 oxide

  2010cites this paper
• STATUS REPORT : Advances in Inhalation Dosimetry of Gases and Vapors with Portal of Entry Effects in the Upper Respiratory Tract

  2009cites this paper
• Genetic Polymorphism in Glutathione Transferases (GST): Population Distribution of GSTM1, T1, and P1 Conjugating Activity

  2009influential citation
• Is propylene oxide induced cell proliferation in rat nasal respiratory epithelium mediated by a severe depletion of water-soluble non-protein thiol?

  2009cites this paper
• Advances in Inhalation Dosimetry of Gases and Vapors with Portal of Entry Effects in the Upper Respiratory Tract

  2009cites this paper
• Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: Example of a threshold carcinogen

  2009cites this paper
• Concentrations of the propylene metabolite propylene oxide in blood of propylene-exposed rats and humans--a basis for risk assessment.

  2008cites this paper
• Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: the first steps.

  2008cites this paper
• Evaluation of effects from repeated inhalation exposure of F344 rats to high concentrations of propylene.

  2007cites this paper
• A physiological toxicokinetic model for inhaled propylene oxide in rat and human with special emphasis on the nose.

  2007influential citation
• Nasal NPSH depletion and propylene oxide uptake in the upper respiratory tract of the mouse.

  2006influential citation
• Kinetic modeling of beta-chloroprene metabolism: I. In vitro rates in liver and lung tissue fractions from mice, rats, hamsters, and humans.

  2004influential citation
• Propylene oxide in blood and soluble nonprotein thiols in nasal mucosa and other tissues of male Fischer 344/N rats exposed to propylene oxide vapors--relevance of glutathione depletion for propylene oxide-induced rat nasal tumors.

  2004influential citation
• In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1.

  2004cites this paper
• Dose-dependent transitions in mechanisms of toxicity: case studies.

  2004cites this paper
• Inhibition of the benzo[a]pyrene-induced toxicity by allyl sulfides in human epidermal keratinocytes

  2004cites this paper
• Metabolism and mutagenicity of source water contaminants 1,3-dichloropropane and 2,2-dichloropropane.

  2004influential citation
• Uptake of inspired propylene oxide in the upper respiratory tract of the f344 rat.

  2004influential citation
• Biokinetic and Toxicodynamic Modelling and its Role in Toxicological Research and Risk Assessment

  2003cites this paper
• The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic as modelling a tool in hazard and risk assessment. A commentary.

  2003cites this paper
• Tissue dosimetry expansion and cross-validation of rat and mouse physiologically based pharmacokinetic models for trichloroethylene.

  2003cites this paper
• Molecular dosimetry of N7-(2-hydroxypropyl)guanine in tissues of F344 rats after inhalation exposure to propylene oxide.

  2003cites this paper
• Drug Transport into the Mammalian Brain: The Nasal Pathway and its Specific Metabolic Barrier

  2002cites this paper
• The toxicity of styrene to the nasal epithelium of mice and rats: studies on the mode of action and relevance to humans.

  2001cites this paper