Some biotransformation enzymes responsible for polycyclic aromatic hydrocarbon metabolism in rat nasal turbinates: effects on enzyme activities of in vitro modifiers and intraperitoneal and inhalation exposure of rats to inducing agents.

No abstract is available for this paper.

• Publication year

  1983

• Venue

  Cancer Research

• Publication date

  1983-10-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  PMID 6309378
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• N-Demethylation of aminopyrine by the nasal mucosa in mice and rats.

  2009cited by this paper
• The role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis.

  2006cited by this paper
• Rat nasal tissue activation of benzo(a)pyrene and 2-aminoanthracene to mutagens in Salmonella typhimurium.

  1983cited by this paper
• Distribution and retention of benzo(A)pyrene in rats after inhalation.

  1982cited by this paper
• Localization and binding of N'-nitrosonornicotine metabolites in the nasal region and in some other tissues of Sprague-Dawley rats.

  1982cited by this paper
• Cytochrome P-450-dependent monooxygenases in olfactory epithelium of dogs: possible role in tumorigenicity.

  1982cited by this paper
• Cytochrome P-450 dependent monooxygenase activity in rat nasal epithelial membranes.

  1982cited by this paper
• Induction of nasal tumors in rats exposed to hexamethylphosphoramide by inhalation.

  1982cited by this paper
• 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity.

  1982cited by this paper
• Cytochrome P450 dependent monooxygenases in nasal epithelial membranes: effect of phenobarbital and benzo(A)pyrene.

  1982cited by this paper
• The isolated perfused lung--a critical evaluation.

  1981cited by this paper
• Mechanisms of chemical carcinogenesis

  1981cited by this paper
• Xenobiotic metabolism by alveolar type II cells isolated from rabbit lung.

  1981cited by this paper
• Inhalation studies with benzo[a]pyrene in Syrian golden hamsters.

  1981cited by this paper
• The influence of disulfiram and other inhibitors of oxidative metabolism on the formation of 2-hydroxyethyl-mercapturic acid from 1,2-dibromoethane by the rat.

  1981cited by this paper
• Formation of tissue-bound N'-nitrosonornicotine metabolites by the target tissues of Sprague-Dawley and Fisher rats.

  1981cited by this paper
• Constitutive and induced hepatic microsomal cytochrome P-450 monooxygenase activities in male Fischer-344 and CD rats. A comparative study.

  1980cited by this paper
• Metabolism and activation of chemical carcinogens

  1980cited by this paper
• Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane.

  1980cited by this paper
• Comparative metabolism of benzo(a)pyrene in organ and cell cultures derived from rat tracheas.

  1979cited by this paper
• Kinetics, activation, and induction of aortic mono-oxygenases--biotransformation of benzo[a]pyrene.

  1979cited by this paper
• A class of strong inhibitors of microsomal monooxygenases: the ellipticines.

  1979cited by this paper
• Benzo(a)pyrene oxidation, conjugation and disposition in the isolated perfused rabbit lung: role of the glutathione S-transferases.

  1979cited by this paper
• Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats.

  1978cited by this paper
• Metabolism of [3H]benzo[a]pyrene by cultured human bronchus and cultured human pulmonary alveolar macrophages.

  1978cited by this paper
• Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase induction.

  1977cited by this paper
• Chemical carcinogenesis

  1977cited by this paper
• A comparison of benzo(a)pyrene metabolism by liver and lung microsomal enzymes from 3-methylcholanthrene-treated rhesus monkeys and rats.

  1977cited by this paper
• SKF 525-A inhibition, induction, and 452-nm complex formation.

  1976cited by this paper
• Chemical carcinogenesis.

  1975cited by this paper
• The interactions of inducers, inhibitors, and substrates of drug-metabolizing enzymes with rat liver cytochrome P-450.

  1974cited by this paper
• Urban Aerosol Toxicity: The Influence of Particle Size

  1974cited by this paper
• Metabolism of xenobiotics by the isolated perfused lung. Comparison with in vitro incubations.

  1974cited by this paper
• 1,4-Dioxane. I. Results of a 2-year ingestion study in rats

  1974cited by this paper
• An improved apparatus for acute inhalation exposure of rodents to radioactive aerosols.

  1973cited by this paper
• A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide.

  1971cited by this paper
• Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.

  1966cited by this paper
• A fluorometric assay for glutathione.

  1966cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.

  2016cites this paper
• Biotransformation (Metabolism) of Pesticides

  2012cites this paper
• The ability of polycyclic aromatic hydrocarbons to alter physiological factors underlying drug disposition

  2011cites this paper
• Metabolism of Pesticides

  2010cites this paper
• Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet).

  2010cites this paper
• UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function

  2010cites this paper
• Polycyclic aromatic hydrocarbons and amiodarone pharmacokinetics

  2010cites this paper
• Nasal Cytotoxic and Carcinogenic Activities of Systemically Distributed Organic Chemicals

  2006cites this paper
• Benzo(fl)pyrene Disposition and Metabolism in Rats following Intratracheal Instillation1

  2006cites this paper
• An approach to investigating the importance of high potency polycyclic aromatic hydrocarbons (PAHs) in the induction of lung cancer by air pollution.

  2005cites this paper
• Regulation of cytochrome P450 gene expression in the olfactory mucosa.

  2004cites this paper
• Glutathione transferases in human nasal mucosa

  2004cites this paper
• Drug Metabolism in the Nasal Mucosa

  2004cites this paper
• Approaches to carcinogenic risk assessment for polycyclic aromatic hydrocarbons: a UK perspective.

  2004cites this paper
• The role of carboxylesterase in organophosphorus pesticide toxicity at the olfactory epithelium of coho salmon(Oncorhynchus kisutch)

  2004cites this paper
• Gene expression profiling in respiratory tissues from rats exposed to mainstream cigarette smoke.

  2003cites this paper
• Drug Transport into the Mammalian Brain: The Nasal Pathway and its Specific Metabolic Barrier

  2002cites this paper
• Cellular activation and neuronal transport of intranasally instilled benzo(a)pyrene in the olfactory system of rats.

  2002cites this paper
• Health Risks Associated with Inhaled Nasal Toxicants

  2001cites this paper
• Kinetics of propylene oxide metabolism in microsomes and cytosol of different organs from mouse, rat, and humans.

  2001cites this paper
• Bioavailability and Pharmacokinetics of Lorazepam after Intranasal, Intravenous, and Intramuscular Administration

  2001cites this paper
• TOXICOKINETICS OF INHALED BENZO[a]PYRENE: Plasma and Lung Bioavailability

  2001cites this paper
• CHAPTER 23 – Metabolism of Pesticides

  2001cites this paper
• Toxicokinetics of inhaled benzo[a]pyrene: plasma and lung bioavailability.

  2001cites this paper
• Induction of mouse CYP2J by pyrazole in the eye, kidney, liver, lung, olfactory mucosa, and small intestine, but not in the heart.

  2000cites this paper
• Target cells for methylsulphonyl-2,6-dichlorobenzene in the olfactory mucosa in mice.

  2000cites this paper
• Effect of cigarette smoke on CYP1A1, CYP1A2 and CYP2B1/2 of nasal mucosae in F344 rats.

  1998cites this paper
• Prodrugs for nasal drug delivery.

  1998cites this paper
• Metabolic capacity of nasal tissue interspecies comparisons of xenobiotic-metabolizing enzymes.

  1997cites this paper
• Distribution of microsomal epoxide hydrolase and glutathione S-transferase in the rat olfactory mucosa: relevance to distribution of lesions caused by systemically-administered olfactory toxicants.

  1995cites this paper
• The stability of peptides in nasal enzymic systems

  1995cites this paper
• Cytochrome P450 2a of nasal epithelium: Regulation and role in carcinogen metabolism

  1995cites this paper
• Toxicity of an anthraquinone violet dye mixture following inhalation exposure, intratracheal instillation, or gavage.

  1994cites this paper
• Effects of P450 inhibition and induction on the olfactory toxicity of beta,beta'-iminodipropionitrile (IDPN) in the rat.

  1994cites this paper
• Acetone-dependent regulation of cytochromes P4502E1 and P4502B1 in rat nasal mucosa.

  1993cites this paper
• Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the beagle dog. II. The conducting airways.

  1993cites this paper
• Glutathione S-transferases in rat olfactory epithelium: purification, molecular properties and odorant biotransformation.

  1993cites this paper
• Drug metabolism in the nasal cavity: relevance to toxicology.

  1993cites this paper
• Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa.

  1993cites this paper
• Olfaction.

  1992cites this paper
• The accumulation and metabolism of 3-trifluoromethylpyridine by rat olfactory and hepatic tissues.

  1992cites this paper
• alpha-Naphthyl butyrate carboxylesterase activity in human and rat nasal tissue.

  1992cites this paper
• Olfactory toxicity of beta,beta'-iminodipropionitrile in the rat.

  1992cites this paper
• Drug-metabolizing enzymes in respiratory nasal mucosa and liver of cynomolgus monkey.

  1992cites this paper
• Nasal cavity enzymes involved in xenobiotic metabolism: effects on the toxicity of inhalants.

  1991cites this paper
• Xenobiotic-metabolizing enzymes in human respiratory nasal mucosa.

  1991cites this paper
• Deposition of acetone vapor in the upper respiratory tract of the B6C3F1 mouse.

  1991cites this paper
• The cyanide-metabolizing enzyme rhodanese in human nasal respiratory mucosa.

  1991cites this paper
• Biotransformation enzymes in the rodent nasal mucosa: the value of a histochemical approach.

  1990cites this paper
• Induction of cytochrome P-450 isozyme 3a (P-450IIE1) in rabbit olfactory mucosa by ethanol and acetone.

  1990cites this paper
• Olfactory-specific cytochrome P-450 (P-450olf1; IIG1). Gene structure and developmental regulation.

  1990cites this paper
• Identification and biochemical analysis of novel olfactory-specific cytochrome P-450IIA and UDP-glucuronosyl transferase.

  1990cites this paper
• Promoting effect of polybrominated biphenyls on tracheal papillomas in Syrian golden hamsters.

  1989cites this paper
• Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception.

  1989cites this paper
• Drug-induced protoporphyria in the olfactory mucosa of the hamster.

  1989cites this paper
• Sites for xenobiotic activation and detoxication within the respiratory tract: implications for chemically induced toxicity.

  1988cites this paper
• The interaction of metyrapone and alpha-naphthoflavone with rat olfactory cytochrome P-450.

  1988cites this paper
• Effects of the respiratory tract on inhaled materials.

  1988cites this paper
• Distribution of microsomal monooxygenases in the rabbit respiratory tract.

  1988cites this paper
• XENOBIOTIC METABOLISM IN THE NASAL EPITHELIUM

  1988cites this paper
• Regional distribution of xenobiotic metabolizing enzymes in respiratory airways of dogs.

  1988cites this paper
• Ocular ketone reductase distribution and its role in the metabolism of ocularly applied levobunolol in the pigmented rabbit.

  1988cites this paper
• The Effect of Cytochrome P-450-Dependent Metabolism and Other Enzyme Activities on Olfaction

  1988cites this paper
• Comparative Metabolic Basis for the Disposition and Toxic Effects of Inhaled Materials

  1988cites this paper
• Olfactory cytochrome P-450. Studies with suicide substrates of the haemoprotein.

  1988cites this paper
• Biotransformation enzymes in nasal mucosa and liver of Sprague-Dawley rats.

  1988cites this paper
• The interaction of metyrapone and α-naphthoflavone with rat olfactory cytochrome P-450

  1988cites this paper
• In vivo metabolism of nasally instilled benzo[a]pyrene in dogs and monkeys.

  1988cites this paper
• In vivo metabolism of nasally instilled dihydrosafrole [1-(3,4-methylenedioxyphenyl)propane] in dogs and monkeys.

  1987cites this paper
• Uptake and specific binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the olfactory mucosa of mice and rats.

  1987cites this paper
• Evidence for an olfactory receptor which responds to nicotine — nicotine as an odorant

  1987cites this paper
• NADPH: cytochrome P-450 reductase in olfactory epithelium. Relevance to cytochrome P-450-dependent reactions.

  1986cites this paper
• Benzo(a)pyrene disposition and metabolism in rats following intratracheal instillation.

  1986cites this paper
• Activation of nitrosamines to mutagens by rat and rabbit nasal, lung and liver S-9 homogenates.

  1986cites this paper
• The metabolism of xenobiotics by certain extrahepatic organs and its relation to toxicity.

  1986cites this paper
• Metabolism of benzo[a]pyrene on the nasal mucosa of Syrian hamsters: comparison to metabolism by other extrahepatic tissues and possible role of nasally produced metabolites in carcinogenesis.

  1985cites this paper
• Metabolism of 1-[14C]nitropyrene in respiratory tract tissue of rats exposed to diesel exhaust.

  1985cites this paper
• Mutagenicity of some dialkylnitrosamines, cyclic nitrosamines and N,N-diethanolnitrosamine in Salmonella typhimurium with rat and rabbit nasal, lung and liver S9 homogenates.

  1985cites this paper
• Localization of a cytochrome P-450 isozyme (cytochrome P-450 PB-B) and NADPH-cytochrome P-450 reductase in rat nasal mucosa.

  1985cites this paper
• Disposition and metabolism of 2,3-[14C]dichloropropene in rats after inhalation.

  1985cites this paper
• Selective activation of carcinogens and other toxicants by nasal mucosae

  1984cites this paper
• The assessment of DNA damage and repair in rat nasal epithelial cells.

  1984cites this paper
• Bioactivation and biotransformation of 1-nitropyrene in liver, lung and nasal tissue of rats.

  1983cites this paper