Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane.

Groups of 50 F344 rats of each sex sere exposed to 0.6 or 3.0 pts/10(6) of 1,2-dibromo-3-chloropropane (DBCP) by inhalation for 6 h/day, 5 days/week for 103 weeks. Fifty rats of each sex inhaling filtered air were used as unexposed controls. All survivors were killed at 104 weeks. Up to 93% of the male and female rats developed neoplasms of the nasal cavity. Most of the tumours were adenomas, squamous-cell papillomas, squamous-cell carcinomas, and adenocarcinomas. In the low-dose group 78% of the tumours in males and 66% in females were benign, whereas in the high-dose groups 89% in males and 76% in females were malignant. Invasion through the cribriform plate into the cerebrum or metastasis to the regional lymph nodes was found in 73% of the carcinomas in males and 51% in females. Electron-microscopic examination suggested that the basal cells of the olfactory epithelium were the site of origin of the poorly differentiated adenocarcinomas.

• Publication year

  1980

• Venue

  British Journal of Cancer

• Publication date

  1980-11-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1038/bjc.1980.311PMID 7459212PMCID 2010558
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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