Characterization of the mechanisms of the increase in PPARδ expression induced by digoxin in the heart using the H9c2 cell line

No abstract is available for this paper.

• Publication year

  2011

• Venue

  British Journal of Pharmacology

• Publication date

  2011-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1476-5381.2011.01212.xPMID 21232041PMCID PMC3087139
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro

  2011cited by this paper
• The Decreased Expression of Peroxisome Proliferator-activated Receptors δ (PPARδ) is Reversed by Digoxin in the Heart of Diabetic Rats

  2010cited by this paper
• Mortality and morbidity during a five-year follow-up of diabetics with myocardial infarction.

  2009cited by this paper
• [Diagnosis and treatment of peripheral nerve injury in Wenchuan earthquake: a report of 14 cases].

  2008cited by this paper
• Decrease of peroxisome proliferator-activated receptor delta expression in cardiomyopathy of streptozotocin-induced diabetic rats.

  2008cited by this paper
• Troponin: regulatory function and disorders.

  2008influential reference
• Effects of digoxin at low serum concentrations on mortality and hospitalization in heart failure: a propensity-matched study of the DIG trial.

  2008cited by this paper
• Calcineurin Regulates Skeletal Muscle Metabolism via Coordinated Changes in Gene Expression*

  2007cited by this paper
• Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure.

  2007cited by this paper
• Roles of PPARs on regulating myocardial energy and lipid homeostasis

  2007influential reference
• PPARδ expression is influenced by muscle activity and induces slow muscle properties in adult rat muscles after somatic gene transfer

  2007cited by this paper
• PPARδ: a dagger in the heart of the metabolic syndrome

  2006cited by this paper
• Diabetic cardiomyopathy: the search for a unifying hypothesis.

  2006cited by this paper
• Transfer and Tunneling of Ca2+ from Sarcoplasmic Reticulum to Mitochondria in Skeletal Muscle*

  2006cited by this paper
• Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB.

  2006cited by this paper
• PPAR delta: a dagger in the heart of the metabolic syndrome.

  2006cited by this paper
• Is digoxin a drug of the past?

  2006cited by this paper
• Regulation of cardiac contractile function by troponin I phosphorylation.

  2005influential reference
• Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation.

  2004influential reference
• Attenuation of Mouse Mesangial Cell Contractility by High Glucose and Mannitol: Involvement of Protein Kinase C and Focal Adhesion Kinase

  2004cited by this paper
• Calcineurin and Calcium/Calmodulin-dependent Protein Kinase Activate Distinct Metabolic Gene Regulatory Programs in Cardiac Muscle*

  2004influential reference
• Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy

  2004cited by this paper
• Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes.

  2004cited by this paper
• Phosphorylation of Troponin I Controls Cardiac Twitch Dynamics: Evidence From Phosphorylation Site Mutants Expressed on a Troponin I-Null Background in Mice

  2002cited by this paper
• Phosphorylation of phospholamban and troponin I in beta-adrenergic-induced acceleration of cardiac relaxation.

  2000cited by this paper
• Stimulation of Slow Skeletal Muscle Fiber Gene Expression by Calcineurin in Vivo *

  2000cited by this paper
• CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo.

  2000cited by this paper
• Diabetes and cardiovascular disease.

  1999influential reference
• Troponin I phosphorylation in heart homogenate from diabetic rat.

  1996cited by this paper
• The elemental principles of calcium signaling.

  1995cited by this paper
• Double-blind placebo-controlled study of ibopamine and digoxin in patients with mild to moderate heart failure: results of the Dutch Ibopamine Multicenter Trial (DIMT).

  1993cited by this paper
• The Role of Calcium in the Energetics of Contracting Skeletal Muscle

  1991cited by this paper
• Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

  1990cited by this paper
• Positive inotropic effects of the endogenous Na+/K(+)-transporting ATPase inhibitor from the hypothalamus.

  1989cited by this paper
• Myocardial infarction in patients with diabetes mellitus.

  1988cited by this paper
• Reversibility of Diabetic Cardiomyopathy with Insulin in Rats

  1981cited by this paper
• Altered Myocardial Mechanics in Diabetic Rats

  1980cited by this paper
• Diabetes and cardiovascular disease. The Framingham study.

  1979cited by this paper
• The positive inotropic effect of digitoxin: independence from sodium accumulation.

  1978cited by this paper
• Role of diabetes in congestive heart failure: the Framingham study.

  1974influential reference

• Roles of distinct nuclear receptors in diabetic cardiomyopathy

  2024cites this paper
• Qiliqiangxin: A multifaceted holistic treatment for heart failure or a pharmacological probe for the identification of cardioprotective mechanisms?

  2023cites this paper
• PTX3 from vascular endothelial cells contributes to trastuzumab-induced cardiac complications

  2023cites this paper
• Live cell screening identifies glycosides as enhancers of cardiomyocyte cell cycle activity

  2022cites this paper
• Etanercept Ameliorates Cardiac Fibrosis in Rats with Diet-Induced Obesity

  2021cites this paper
• Quantitative proteomic analysis reveals high interference on protein expression of H9c2 cells activated with glucose and cardiotonic steroids.

  2020cites this paper
• Transcriptomic analysis reveals common pathways and biomarkers associated with oxidative damage caused by mitochondrial toxicants in Chironomus dilutus.

  2020cites this paper
• Cardiac glycosides with target at direct and indirect interactions with nuclear receptors.

  2020cites this paper
• Toxicogenomics provides insights to toxicity pathways of neonicotinoids to aquatic insect, Chironomus dilutus.

  2020cites this paper
• TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells

  2019cites this paper
• GW0742 activates peroxisome proliferator‐activated receptor δ to reduce free radicals and alleviate cardiac hypertrophy induced by hyperglycemia in cultured H9c2 cells

  2018influential citation
• Molecular mechanisms regarding potassium bromate‑induced cardiac hypertrophy without apoptosis in H9c2 cells.

  2018cites this paper
• Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1‐like Diabetic Rats

  2017cites this paper
• Loperamide-induced Cardiac Depression Is Enhanced by Hyperglycemia: Evidence Relevant to Loperamide Abuse.

  2017cites this paper
• Ginsenoside Rh2 Improves Cardiac Fibrosis via PPARδ–STAT3 Signaling in Type 1-Like Diabetic Rats

  2017influential citation
• Lanatoside C Promotes Foam Cell Formation and Atherosclerosis

  2016cites this paper
• Ascribing novel functions to the sarcomeric protein, myosin binding protein H (MyBPH) in cardiac sarcomere contraction.

  2015cites this paper
• Ginseng Is Useful to Enhance Cardiac Contractility in Animals

  2014cites this paper
• Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways.

  2014cites this paper
• Role of peroxisome proliferator-activated receptors δ (PPARδ) in rats showing endotoxemic heart failure

  2014cites this paper
• The role of novel protein-protein interactions in the function and mechanism of the sarcomeric protein, myosin binding protein H (MyBPH)

  2014cites this paper
• Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats

  2014cites this paper
• Antihyperglycemic action of sinapic acid in diabetic rats.

  2013cites this paper
• Cardiac Peroxisome Proliferator-Activated Receptor δ (PPARδ) as a New Target for Increased Contractility without Altering Heart Rate

  2013cites this paper
• Increase of PPARδ by dopamine mediated via DA-1 receptor-linked phospholipase C pathway in neonatal rat cardiomyocytes.

  2013influential citation
• Activation of Receptors δ (PPARδ) by Agonist (GW0742) may Enhance Lipid Metabolism in Heart both In Vivo and In Vitro

  2013cites this paper
• Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats.

  2012cites this paper
• The involvement of CaMKII in myocardial ischaemia-reperfusion injury

  2012cites this paper
• Increase of Peroxisome Proliferator-activated Receptor δ (PPARδ) by Digoxin to Improve Lipid Metabolism in the Heart of Diabetic Rats

  2012cites this paper
• Oleic acid activates peroxisome proliferator-activated receptor δ to compensate insulin resistance in steatotic cells.

  2012cites this paper
• Abnormalities in renal dopamine signaling and hypertension : the role of GRK 4 Review

  2011cites this paper