Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Cellular Signalling

• Publication date

  2014-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cellsig.2014.05.007PMID 24835978PMCID PMC4305345
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alpha-1–Adrenergic Receptors in Heart Failure: The Adaptive Arm of the Cardiac Response to Chronic Catecholamine Stimulation

  2014cited by this paper
• β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt.

  2014cited by this paper
• Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography.

  2012influential reference
• Angiotensin II Induces Epithelial-to-Mesenchymal Transition in Renal Epithelial Cells through Reactive Oxygen Species/Src/Caveolin-Mediated Activation of an Epidermal Growth Factor Receptor–Extracellular Signal-Regulated Kinase Signaling Pathway

  2012cited by this paper
• β2‐adrenergic receptor Thr164IIe polymorphism, blood pressure and ischaemic heart disease in 66 750 individuals

  2012cited by this paper
• Adrenergic Alpha-1 Pathway Is Associated with Hypertension among Nigerians in a Pathway-focused Analysis

  2012cited by this paper
• β2‐Adrenergic receptor‐induced transactivation of epidermal growth factor receptor and platelet‐derived growth factor receptor via Src kinase promotes rat cardiomyocyte survival

  2012cited by this paper
• Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway

  2011cited by this paper
• Cardiac and neuroprotection regulated by α1-adrenergic receptor subtypes

  2011cited by this paper
• The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro

  2011cited by this paper
• Characterization of the mechanisms of the increase in PPARδ expression induced by digoxin in the heart using the H9c2 cell line

  2011cited by this paper
• Transactivated EGFR mediates α₁-AR-induced STAT3 activation and cardiac hypertrophy.

  2011cited by this paper
• Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis

  2011influential reference
• Essential role of EGFR in cardioprotection and signaling responses to A1 adenosine receptors and ischemic preconditioning.

  2011cited by this paper
• Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure.

  2011cited by this paper
• Alpha-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in Black adolescents and young adults.

  2010cited by this paper
• Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling.

  2009cited by this paper
• p66Shc Links &agr;1-Adrenergic Receptors to a Reactive Oxygen Species–Dependent AKT-FOXO3A Phosphorylation Pathway in Cardiomyocytes

  2009cited by this paper
• A new G(q)-initiated MAPK signaling pathway in the heart.

  2009cited by this paper
• Matrix Metalloproteinase-7 and ADAM-12 (a Disintegrin and Metalloproteinase-12) Define a Signaling Axis in Agonist-Induced Hypertension and Cardiac Hypertrophy

  2009cited by this paper
• Suppression of Collagen Production in Norepinephrine Stimulated Cardiac Fibroblasts Culture: Differential Effect of α and β-Adrenoreceptor Antagonism

  2009cited by this paper
• Cardiac alpha 1-adrenergic drive in pathological remodelling.

  2008cited by this paper
• STAT3 Activation in Pressure-Overloaded Feline Myocardium: Role for Integrins and the Tyrosine Kinase BMX

  2008cited by this paper
• Heparin Binding‐Epidermal Growth Factor and Src Family Kinases in Proliferation of Renal Epithelial Cells

  2008cited by this paper
• Cardiac α1-adrenergic drive in pathological remodelling

  2007cited by this paper
• Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells.

  2007cited by this paper
• When a G protein-coupled receptor does not couple to a G protein.

  2007cited by this paper
• Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

  2007cited by this paper
• ROLES OF α1A‐ AND α1B‐ADRENOCEPTORS IN HEART: INSIGHTS FROM STUDIES OF GENETICALLY MODIFIED MICE

  2007cited by this paper
• Roles of alpha1A- and alpha1B-adrenoceptors in heart: insights from studies of genetically modified mice.

  2007cited by this paper
• β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection

  2007cited by this paper
• An Angiotensin II Type 1 Receptor Mutant Lacking Epidermal Growth Factor Receptor Transactivation Does Not Induce Angiotensin II–Mediated Cardiac Hypertrophy

  2006cited by this paper
• Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload.

  2006cited by this paper
• Selective Loss of Fine Tuning of Gq/11 Signaling by RGS2 Protein Exacerbates Cardiomyocyte Hypertrophy*

  2006cited by this paper
• Structural and functional characterisation of cardiac fibroblasts.

  2005cited by this paper
• Many good reasons to have STAT3 in the heart.

  2005cited by this paper
• Transduction of Receptor Signals by ß-Arrestins

  2005cited by this paper
• Novel human α1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function

  2005cited by this paper
• Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis

  2005cited by this paper
• "Ins and outs" of seven-transmembrane receptor signalling to ERK.

  2005cited by this paper
• Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function.

  2005cited by this paper
• Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human α1D- and α1B-adrenergic receptors

  2004cited by this paper
• Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors.

  2004cited by this paper
• Matrix metalloproteinase-dependent EGF receptor activation in hypertension and left ventricular hypertrophy.

  2004cited by this paper
• Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities

  2003cited by this paper
• Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2

  2003cited by this paper
• Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

  2003cited by this paper
• Seven-transmembrane-spanning receptors and heart function

  2002cited by this paper
• Knockout of the α1A/C-adrenergic receptor subtype: The α1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure

  2002cited by this paper
• Small artery remodeling in hypertension

  2002cited by this paper
• Novel regulation and function of Src tyrosine kinase

  2002cited by this paper
• (-)Epigallocatechin-3-Gallate Directly Inhibits MT1-MMP Activity, Leading to Accumulation of Nonactivated MMP-2 at the Cell Surface

  2002cited by this paper
• Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

  2002influential reference
• Catecholamines stimulate interleukin-6 synthesis in rat cardiac fibroblasts.

  2001cited by this paper
• Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

  2001cited by this paper
• Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group.

  2000cited by this paper
• Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)

  2000cited by this paper
• Fibrosis and hypertensive heart disease

  2000cited by this paper
• Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.

  1999cited by this paper
• Mechanism of biological synergy between cellular Src and epidermal growth factor receptor.

  1999influential reference
• EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

  1999influential reference
• Subtype Specific Regulation of Human Vascular α1-Adrenergic Receptors by Vessel Bed and Age

  1999cited by this paper
• Stat3 Activation Is Required for Cellular Transformation by v-src

  1998cited by this paper
• TGF-beta signal transduction.

  1998cited by this paper
• Selective activation of alpha1A-adrenergic receptors in neonatal cardiac myocytes is sufficient to cause hypertrophy and differential regulation of alpha1-adrenergic receptor subtype mRNAs.

  1998cited by this paper
• Comparison between alpha-1 adrenoceptor-mediated and beta adrenoceptor-mediated inotropic components elicited by norepinephrine in failing human ventricular muscle.

  1997cited by this paper
• Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

  1996cited by this paper
• Simultaneous expression of cardiac and skeletal muscle isoforms of the L‐type Ca2+ channel in a rat heart muscle cell line.

  1994cited by this paper
• Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.

  1994cited by this paper
• Effects of myocardial alpha 1-adrenergic receptor stimulation and blockade on contractility in humans.

  1991cited by this paper
• Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart.

  1991cited by this paper
• Effects of Myocardial α1‐Adrenergic Receptor Stimulation and Blockade on Contractility in Humans

  1991cited by this paper
• Properties of a clonal muscle cell line from rat heart.

  1976cited by this paper

• A Brief Description of the Cellular Mechanisms Involved in Cardiac Chemical Hypoxia

  2026cites this paper
• Adrenoceptors in GtoPdb v.2025.3

  2025cites this paper
• Electroacupuncture Ameliorates Acute Myocardial Ischemic Injury and Long QT Interval in Mice through the α1A-Adrenergic Receptor: Electrophysiological, Morphological, and Molecular Evidence

  2022cites this paper
• α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension

  2021cites this paper
• Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry

  2019cites this paper
• The α1-adrenoceptor-mediated human hyperplastic prostate cells proliferation is impaired by EGF receptor inhibition.

  2019cites this paper
• Cardiac GPCR–Mediated EGFR Transactivation: Impact and Therapeutic Implications

  2017cites this paper
• Cobalt chloride induces RhoA/ROCK activation and remodeling effect in H9c2 cardiomyoblasts: Involvement of PI3K/Akt and MAPK pathways.

  2017cites this paper
• Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway

  2015cites this paper
• Biased Signaling in Naturally Occurring Mutations in Human Melanocortin-3 Receptor Gene

  2015cites this paper
• Cell-Surface Receptors Transactivation Mediated by G Protein-Coupled Receptors

  2014cites this paper