Endocrine Disruption and the Gut Microbiome

There is mounting evidence that the gut microbiome has a profound impact on human health and disease. In this chapter, we discuss interactions between endocrine disrupting chemicals (EDCs) and gut microbiota. We consider how the gut microbiota, through cross-talk with the guteliver and gutebrain axes, can mediate the outcome of EDC exposure. In addition, evidence is provided for the sex-specific, transgenerational effects of early EDC exposure, primarily through disruption of the vertical transfer of maternal gut microbiota. Furthermore, the potential role of gut microbiota dysbiosis in inflammatory, autoimmune, and anxiety-related C H A P T E R 355 Endocrine Disruption and Human Health, Second Edition https://doi.org/10.1016/B978-0-12-821985-0.00015-3 © 2022 Elsevier Inc. All rights reserved. diseases caused by EDC exposure is presented. Finally, evidence is provided that gut microbiota could be considered a therapeutic target for mitigating some of the effects of EDC on human health and disease. More specifically, inherent individual differences in gut microbiota can be used as a tool in developing a personalized microbiome-modifying approach to treating EDC-induced disorders.

• Publication year

  2022

• Venue

  Endocrine Disruption and Human Health

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/b978-0-12-821985-0.00015-3
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

  2021cited by this paper
• Ontogeny

  2021cited by this paper
• Perinatal exposure to bisphenol A at the intersection of stress, anxiety, and depression.

  2020cited by this paper
• Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

  2020cited by this paper
• Immunology

  2020cited by this paper
• The maternal microbiome modulates fetal neurodevelopment in mice

  2020cited by this paper
• Update on the health effects of bisphenol A: Overwhelming evidence of harm.

  2020cited by this paper
• Association of Exposure to Endocrine-Disrupting Chemicals During Adolescence With Attention-Deficit/Hyperactivity Disorder–Related Behaviors

  2020cited by this paper
• Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour

  2020cited by this paper
• Analysis of reports of unintended pregnancies associated with the combined use of non-enzyme-inducing antibiotics and hormonal contraceptives

  2020cited by this paper
• Endocrine-disrupting chemicals: economic, regulatory, and policy implications.

  2020cited by this paper
• Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse.

  2020cited by this paper
• Association Between Bisphenol A Exposure and Risk of All-Cause and Cause-Specific Mortality in US Adults

  2020cited by this paper
• 17β-Estradiol supplementation changes gut microbiota diversity in intact and colorectal cancer-induced ICR male mice

  2020cited by this paper
• Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes

  2020cited by this paper
• Unwitting Accomplices: Endocrine Disruptors Confounding Clinical Care

  2020cited by this paper
• A pneumonia outbreak associated with a new coronavirus of probable bat origin

  2020cited by this paper
• Interaction between microbiota and immunity in health and disease

  2020cited by this paper
• Gut microbiota and Covid-19- possible link and implications

  2020cited by this paper
• Transgenerational epigenetic effects from male exposure to endocrine-disrupting compounds: a systematic review on research in mammals

  2020cited by this paper
• High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients

  2020cited by this paper
• IgA and the intestinal microbiota: the importance of being specific

  2019cited by this paper
• Environmental Chemical Diethylhexyl Phthalate Alters Intestinal Microbiota Community Structure and Metabolite Profile in Mice

  2019cited by this paper
• Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns.

  2019cited by this paper
• Host–microbiota interactions in rheumatoid arthritis

  2019cited by this paper
• Estradiol and high fat diet associate with changes in gut microbiota in female ob/ob mice

  2019cited by this paper
• Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.

  2019cited by this paper
• Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract

  2019cited by this paper
• The gut–liver axis and the intersection with the microbiome

  2018cited by this paper
• The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus

  2018cited by this paper
• Steroids, stress and the gut microbiome‐brain axis

  2018cited by this paper
• Drug interactions between rifamycin antibiotics and hormonal contraception: a systematic review

  2018cited by this paper
• US Immigration Westernizes the Human Gut Microbiome.

  2018cited by this paper
• Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice

  2018influential reference
• Host diet and evolutionary history explain different aspects of gut microbiome diversity among vertebrate clades

  2018cited by this paper
• Bisphenol-A alters microbiota metabolites derived from aromatic amino acids and worsens disease activity during colitis

  2018cited by this paper
• β-Glucuronidases of opportunistic bacteria are the major contributors to xenobiotic-induced toxicity in the gut

  2018cited by this paper
• Long-Term Administration of Conjugated Estrogen and Bazedoxifene Decreased Murine Fecal β-Glucuronidase Activity Without Impacting Overall Microbiome Community

  2018cited by this paper
• Antibiotic-Induced Alterations in Gut Microbiota Are Associated with Changes in Glucose Metabolism in Healthy Mice

  2017cited by this paper
• Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior

  2017cited by this paper
• Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis

  2017cited by this paper
• Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells.

  2017cited by this paper
• Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis

  2017cited by this paper
• Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe

  2017influential reference
• Neurotransmitters: The Critical Modulators Regulating Gut–Brain Axis

  2017cited by this paper
• Perinatal Bisphenol A Exposure Induces Chronic Inflammation in Rabbit Offspring via Modulation of Gut Bacteria and Their Metabolites

  2017cited by this paper
• Perinatal exposure to endocrine disrupting compounds and the control of feeding behavior—An overview

  2017cited by this paper
• The Emerging Role of Epigenetics in the Regulation of Female Puberty.

  2016cited by this paper
• Intestinal Microbiota Is Influenced by Gender and Body Mass Index

  2016cited by this paper
• Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.

  2016cited by this paper
• Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice

  2016influential reference
• Sex-Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice

  2016cited by this paper
• The gut microbiota: a major player in the toxicity of environmental pollutants?

  2016cited by this paper
• Revised Estimates for the Number of Human and Bacteria Cells in the Body

  2016cited by this paper
• Neonatal Androgen Exposure Causes Persistent Gut Microbiota Dysbiosis Related to Metabolic Disease in Adult Female Rats.

  2016cited by this paper
• Effects of exposure to bisphenol A and ethinyl estradiol on the gut microbiota of parents and their offspring in a rodent model

  2016cited by this paper
• Pubertal development and regulation.

  2016cited by this paper
• Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans.

  2016cited by this paper
• Sex differences in the gut microbiome–brain axis across the lifespan

  2016cited by this paper
• Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?

  2016cited by this paper
• Sex differences and hormonal effects on gut microbiota composition in mice

  2016cited by this paper
• The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

  2016cited by this paper
• Inflammasomes: mechanism of action, role in disease, and therapeutics

  2015cited by this paper
• Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: a population-based case-control pilot study.

  2015cited by this paper
• Endocrine Disruption and Human Health

  2015cited by this paper
• Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

  2015cited by this paper
• Early infancy microbial and metabolic alterations affect risk of childhood asthma

  2015cited by this paper
• Ovariectomy results in differential shifts in gut microbiota in low versus high aerobic capacity rats

  2015cited by this paper
• The vocabulary of microbiome research: a proposal

  2015cited by this paper
• From Broad-Spectrum Biocides to Quorum Sensing Disruptors and Mussel Repellents: Antifouling Profile of Alkyl Triphenylphosphonium Salts

  2015cited by this paper
• Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks

  2015cited by this paper
• Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.

  2015cited by this paper
• Arsenic induces structural and compositional colonic microbiome change and promotes host nitrogen and amino acid metabolism.

  2015cited by this paper
• EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.

  2015cited by this paper
• Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats

  2015influential reference
• Dissemination of antibiotic resistance in methicillin-resistant Staphylococcus aureus and vancomycin-resistant S aureus strains isolated from hospital effluents.

  2015cited by this paper
• Chlorpyrifos Exposure During Perinatal Period Affects Intestinal Microbiota Associated With Delay of Maturation of Digestive Tract in Rats

  2015cited by this paper
• The effect of past antibiotic exposure on diabetes risk.

  2015cited by this paper
• Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes

  2015influential reference
• Gastrointestinal hormones and the dialogue between gut and brain

  2014cited by this paper
• Antibiotic resistance threats in the United States: stepping back from the brink.

  2014cited by this paper
• The Placenta Harbors a Unique Microbiome

  2014cited by this paper
• Microbiological effects of sublethal levels of antibiotics

  2014cited by this paper
• Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics.

  2014cited by this paper
• A novel role for maternal stress and microbial transmission in early life programming and neurodevelopment

  2014cited by this paper
• Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences.

  2014cited by this paper
• Metagenomic profiles and antibiotic resistance genes in gut microbiota of mice exposed to arsenic and iron.

  2014cited by this paper
• Minireview: Gut microbiota: the neglected endocrine organ.

  2014cited by this paper
• Bile acids and the gut microbiome

  2014cited by this paper
• Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

  2014cited by this paper
• Gut-brain axis: how the microbiome influences anxiety and depression.

  2013cited by this paper
• Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity

  2013cited by this paper
• Maternal intrapartum antibiotics and decreased vertical transmission of Lactobacillus to neonates during birth

  2013cited by this paper
• Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host.

  2013cited by this paper
• Presence of phthalates in gastrointestinal medications: is there a hidden danger?

  2013cited by this paper
• Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

  2013cited by this paper
• Gender bias in autoimmunity is influenced by microbiota.

  2013cited by this paper
• Welcome to the Microgenderome

  2013cited by this paper
• Hydroxysteroid dehydrogenases (HSDs) in bacteria: a bioinformatic perspective.

  2012cited by this paper
• Host remodeling of the gut microbiome and metabolic changes during pregnancy.

  2012cited by this paper

• Alterations in the gut microbiota of Eimeria infected broiler chickens fed diets supplemented with varying levels of dietary calcium and phosphorus, along with 25-hydroxycholecalciferol

  2024cites this paper
• Differential effects of Akkermansia-enriched fecal microbiota transplant on energy balance in female mice on high-fat diet

  2022cites this paper