Blood MALT1, Th1, and Th17 cells are dysregulated, inter‐correlated, and correlated with disease activity in rheumatoid arthritis patients; meanwhile, MALT1 decline during therapy relates to treatment outcome

Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) participates in inflammatory and autoimmune diseases via activating various signaling pathways and promoting the differentiation of T‐helper (Th) 1 and Th17 cells; however, it is rarely reported in rheumatoid arthritis (RA). This study aimed to assess the correlation of MALT1 with Th1 and Th17 cells and evaluate its potential as a biomarker for evaluating disease activity and treatment outcomes in RA patients.

• Publication year

  2021

• Venue

  Journal of clinical laboratory analysis (Print)

• Publication date

  2021-11-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jcla.24112PMID 34788483PMCID 8761436
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by Fc&ggr;R signaling

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  2018cited by this paper
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• Immunopathogenesis of Rheumatoid Arthritis.

  2017cited by this paper
• Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis

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• Novel treatment strategies in rheumatoid arthritis.

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• Advances in the Treatment of Rheumatoid Arthritis

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• Rheumatoid arthritis

  2016cited by this paper
• 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

  2016cited by this paper
• The Paracaspase MALT1.

  2016cited by this paper
• The role of Th1 and Th17 cells in glomerulonephritis

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• Role of Th1 and Th17 cells in the development and complexity of coronary artery disease: comparison analysis by the methods of flow cytometry and SYNTAX score

  2015cited by this paper
• American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

  2015cited by this paper
• Alternative Expression Pattern of MALT1-A20-NF-κB in Patients with Rheumatoid Arthritis

  2014cited by this paper
• Safety of synthetic and biological DMARDs: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis

  2014cited by this paper
• Advances in the treatment of rheumatoid arthritis

  2014cited by this paper
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  2012cited by this paper
• Treatment Strategies in Early Rheumatoid Arthritis and Prevention of Rheumatoid Arthritis

  2012cited by this paper
• The pathogenesis of rheumatoid arthritis.

  2011cited by this paper
• Regulation of NF-κB signaling by caspases and MALT1 paracaspase

  2011cited by this paper
• Rheumatoid arthritis classifi cation criteria : an American College of Rheumatology / European League Against Rheumatism collaborative initiative

  2010cited by this paper
• 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.

  2010cited by this paper
• Role of Th17 cells in human autoimmune arthritis.

  2010cited by this paper
• The nuclear factor NF-kappaB pathway in inflammation.

  2009cited by this paper
• Th17 cytokines and their emerging roles in inflammation and autoimmunity

  2008cited by this paper
• Multifunctional roles for MALT1 in T-cell activation

  2008cited by this paper
• Rheumatoid arthritis.

  2001cited by this paper
• Rheumatoid arthritis

  2001influential reference
• Th1/Th2 cells.

  1999cited by this paper
• Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism Criteria.

  1996cited by this paper
• [Rheumatoid arthritis].

  1983influential reference

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