Curcumin: potential for hepatic fibrosis therapy?

No abstract is available for this paper.

• Publication year

  2008

• Venue

  British Journal of Pharmacology

• Publication date

  2008-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.bjp.0707580PMID 18037917PMCID PMC2241785
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reversal of Liver Fibrosis

  2009cited by this paper
• Role of curcumin in cancer therapy.

  2007influential reference
• Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa.

  2007cited by this paper
• Curcumin Prevents Tumor-induced T Cell Apoptosis through Stat-5a-mediated Bcl-2 Induction*

  2007cited by this paper
• Clinical studies with curcumin.

  2007influential reference
• Effects of curcumin on peroxisome proliferator-activated receptor gamma expression and nuclear translocation/redistribution in culture-activated rat hepatic stellate cells.

  2007influential reference
• Prevention of liver cirrhosis in rats by curcumin

  2007cited by this paper
• De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation.

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• Curcumin: the Indian solid gold.

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• Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes.

  2006cited by this paper
• Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor.

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  2006influential reference
• Study on effects of extracts fromSalvia Miltiorrhiza andCurcuma Longa in inhibiting phosphorylated extracellular signal regulated kinase expression in rat’s hepatic stellate cells

  2006cited by this paper
• Chemopreventive and therapeutic effects of curcumin.

  2005cited by this paper
• Anti-oxidant activities of curcumin and related enones.

  2005cited by this paper
• The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis

  2005cited by this paper
• Curcumin: the story so far.

  2005influential reference
• Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases.

  2004cited by this paper
• Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth.

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  2000cited by this paper
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• Inhibition of tissue factor gene activation in cultured endothelial cells by curcumin. Suppression of activation of transcription factors Egr-1, AP-1, and NF-kappa B.

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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2010cites this paper
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