Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  International Journal of Molecular Medicine

• Publication date

  2012-09-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3892/ijmm.2012.1020PMID 22692588
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nuclear factor high‐mobility group box1 mediating the activation of toll‐like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice

  2011cited by this paper
• Insulin resistance in obesity as the underlying cause for the metabolic syndrome.

  2010cited by this paper
• Cannabinoid Receptor Stimulation Impairs Mitochondrial Biogenesis in Mouse White Adipose Tissue, Muscle, and Liver

  2010cited by this paper
• Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-{kappa}B.

  2010cited by this paper
• Curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling.

  2009cited by this paper
• Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells.

  2009cited by this paper
• Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway.

  2009cited by this paper
• N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes.

  2009cited by this paper
• The effect of capillarisin on glycochenodeoxycholic acid-induced apoptosis and heme oxygenase-1 in rat primary hepatocytes

  2009cited by this paper
• Curcumin: potential for hepatic fibrosis therapy?

  2008cited by this paper
• Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes

  2008cited by this paper
• Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity.

  2008cited by this paper
• Nonalcoholic fatty liver disease and mitochondrial dysfunction.

  2008cited by this paper
• Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB.

  2008cited by this paper
• Curcumin Protects the Rat Liver from CCl4-Caused Injury and Fibrogenesis by Attenuating Oxidative Stress and Suppressing Inflammation

  2008cited by this paper
• High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo

  2008cited by this paper
• Mitochondrial Reactive Oxygen Species Signal Hepatocyte Steatosis by Regulating the Phosphatidylinositol 3-Kinase Cell Survival Pathway*

  2007cited by this paper
• NF-κB activation as a pathological mechanism of septic shock and inflammation

  2006cited by this paper
• Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor.

  2006cited by this paper
• NF-kappa B activation as a pathological mechanism of septic shock and inflammation.

  2006cited by this paper
• Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease.

  2006cited by this paper
• NASH: a mitochondrial disease.

  2005cited by this paper
• PPARalpha in the pathogenesis of fatty liver disease.

  2004influential reference
• PPARα in the pathogenesis of fatty liver disease

  2004cited by this paper
• Curcumin (Diferuloylmethane) Inhibits Receptor Activator of NF-κB Ligand-Induced NF-κB Activation in Osteoclast Precursors and Suppresses Osteoclastogenesis1

  2004cited by this paper
• Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis.

  2004cited by this paper
• Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis.

  2003cited by this paper
• Lipotoxicity: when tissues overeat

  2003cited by this paper
• Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis

  2003influential reference
• Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice.

  2003cited by this paper
• Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

  2002cited by this paper
• Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice.

  2002cited by this paper
• Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.

  2002cited by this paper
• Role of the Mitochondrial Permeability Transition Pore in Apoptosis

  1997influential reference
• A simple method for the isolation and purification of total lipides from animal tissues.

  1957cited by this paper

• Advances and Perspectives in Curcumin Regulation of Systemic Metabolism: A Focus on Multi-Organ Mechanisms

  2026cites this paper
• Effects of Short-Term Garcinia kola and Prolonged Curcumin Treatment on Pancreatic Morphology and Function in Diabetic Rats with Sciatic Nerve Transection

  2025cites this paper
• Curcumin mitigates obesity-driven dysbiosis and liver steatosis while promoting browning and thermogenesis in white adipose tissue of high-fat diet-fed mice.

  2025cites this paper
• Reactive Oxygen Species-Mediated Mitochondrial-Targeted Therapeutics in Hepatic Disorders: Current Progress and Future Opportunities.

  2025cites this paper
• Natural Autophagy Activators to Fight Age-Related Diseases

  2024cites this paper
• Targeting Mitochondrial Dysfunction for the Prevention and Treatment of Metabolic Disease by Bioactive Food Components

  2024influential citation
• Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

  2024cites this paper
• Puerarin Modulates Hepatic Farnesoid X Receptor and Gut Microbiota in High-Fat Diet-Induced Obese Mice

  2024cites this paper
• Involvement of mitochondria in Alzheimer's disease pathogenesis and their potential as targets for phytotherapeutics.

  2024cites this paper
• Components from Curcuma longa (Turmeric) Against Hepatobiliary Diseases Based on Gut-Liver Axis: Pharmacotherapeutic Properties and Potential Clinical Applications.

  2024cites this paper
• Multifaceted physiological and therapeutical impact of curcumin on hormone‐related endocrine dysfunctions: A comprehensive review

  2024cites this paper
• Chinese herbal medicines: The modulator of nonalcoholic fatty liver disease targeting oxidative stress.

  2023cites this paper
• Natural Products for the Treatment of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

  2023cites this paper
• The role of curcumin in the liver-gut system diseases: from mechanisms to clinical therapeutic perspective

  2023cites this paper
• The Beneficial Effects of Curcumin on Lipids: Possible Effects on Dyslipidemia-Induced Cardiovascular Complications.

  2023cites this paper
• The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals

  2022cites this paper
• Role of Liv.52 in Non-Infectious Chronic Liver Disease

  2022cites this paper
• Management of Alzheimer’s Disease with nutraceuticals

  2021cites this paper
• Therapeutic Screening of Herbal Remedies for the Management of Diabetes

  2021cites this paper
• Curcumin Alleviates Palmitic Acid-Induced LOX-1 Upregulation by Suppressing Endoplasmic Reticulum Stress in HUVECs

  2021cites this paper
• Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

  2020influential citation
• Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson's disease: significance of SIRT3-mediated FOXO3 deacetylation

  2020cites this paper
• Curcumin suppressed proliferation and migration of human retinoblastoma cells through modulating NF-κB pathway

  2020cites this paper
• Metabolic and transcriptome responses of RNAi-mediated AMPKα knockdown in Tribolium castaneum

  2020cites this paper
• Biochemical and Histological Study on the Effects of Curcumin and/or Yellow Bean on Rats Drinking Ethanol Alcohol

  2019cites this paper
• Potential Therapeutic Impacts of Curcumin in Treating Epilepsy

  2019cites this paper
• Dietary Polyphenols Protect Against Oleic Acid-Induced Steatosis in an in Vitro Model of NAFLD by Modulating Lipid Metabolism and Improving Mitochondrial Function

  2019cites this paper
• Ursodeoxycholic Acid Regulates Hepatic Energy Homeostasis and White Adipose Tissue Macrophages Polarization in Leptin-Deficiency Obese Mice

  2019cites this paper
• Protection by different classes of dietary polyphenols against palmitic acid-induced steatosis, nitro-oxidative stress and endoplasmic reticulum stress in HepG2 hepatocytes

  2018cites this paper
• Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues.

  2017cites this paper
• Comparison of dietary polyphenols for protection against molecular mechanisms underlying nonalcoholic fatty liver disease in a cell model of steatosis.

  2017cites this paper
• Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells.

  2017cites this paper
• Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice

  2017cites this paper
• Nutrient sensing by absorptive and secretory progenies of small intestinal stem cells

  2017cites this paper
• The Effects of Gestational and Lactational Bisphenol A Exposure on Rat Pup Morphometric Measurements and on Adrenal Gland Glucocorticoid Receptor Gene Expression

  2017cites this paper
• Is There a Role for Curcumin Supplementation in the Treatment of Non-Alcoholic Fatty Liver Disease? The Data Suggest Yes.

  2017cites this paper
• Curcumin exerts antitumor effects in retinoblastoma cells by regulating the JNK and p38 MAPK pathways.

  2016cites this paper
• Boron nitride nanotubes as vehicles for intracellular delivery of fluorescent drugs and probes.

  2016cites this paper
• Curcumin prevents muscle damage by regulating NF-κB and Nrf2 pathways and improves performance: an in vivo model

  2016cites this paper
• Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.

  2016cites this paper
• Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

  2016cites this paper
• Curcumin in hepatic stellate cell activation in health

  2016cites this paper
• Curcumin Effects on Hepatic Steatosis and Histopathology in an Obese Mouse Mode

  2015cites this paper
• Natural Compounds Modulating Mitochondrial Functions

  2015influential citation
• Curcumin Targets Multiple Pathways to Halt Hepatic Stellate Cell Activation: Updated Mechanisms In Vitro and In Vivo

  2015cites this paper
• Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism

  2015cites this paper
• Flavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease Therapy.

  2015cites this paper
• Integrated Metabolomics, Transcriptomics and Proteomics Identifies Metabolic Pathways Affected by Anaplasma phagocytophilum Infection in Tick Cells*

  2015cites this paper
• Multifunctional effects of honokiol as an anti-inflammatory and anti-cancer drug in human oral squamous cancer cells and xenograft.

  2015cites this paper
• Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels.

  2015cites this paper
• Nuclear respiratory factor-2α and adenosine triphosphate synapses in rat primary cortical neuron cultures: The key role of adenosine monophosphate-activated protein kinase.

  2015cites this paper
• Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells

  2014cites this paper
• Nutraceuticals in the Prevention and Treatment of Fatty Liver Disease

  2014cites this paper
• Glycyrrhetinic acid suppressed NF-κB activation in TNF-α-induced hepatocytes.

  2014cites this paper
• [Recent advances in curcumin and its derivatives for treatment of liver diseases].

  2014cites this paper
• Lipid Replacement Therapy: a natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function.

  2014cites this paper
• Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds.

  2014cites this paper
• Mild obesity reduces survival and adiponectin sensitivity in endotoxemic rats.

  2013cites this paper
• Selective impairment on the proliferation of neural progenitor cells by oxidative phosphorylation disruption.

  2013cites this paper
• A Current Update on the Rule of Alternative and Complementary Medicine in the Treatment of Liver Diseases

  2013cites this paper
• AMPK Targets Involved in Energy Homeostasis and Epigenetic Regulation of Mitochondrial Function-related Genes

  2013cites this paper
• ANTI-DIABETIC EFFECTS OF TURMERIC IN ALLOXAN INDUCED DIABETIC RATS. JEEVANGI SANTOSHKUMAR ET AL.

  2013cites this paper
• ANTI-DIABETIC EFFECTS OF TURMERIC IN ALLOXAN INDUCED DIABETIC RATS.

  2013cites this paper
• Mechanisms of Membrane Repair and the Novel Role of Oral Phospholipids (Lipid Replacement Therapy®) and Antioxidants to Improve Membrane Function.

  2012cites this paper
• Efficacy of Herbal Remedies in The Treatment of Nonalcholic Fatty Liver Disease/Hepatic Steatosis in Human and Animals

  2012cites this paper
• Efficacy of Herbal Remedies in The Treatment of Nonalcholic Fatty Liver Disease/Hepatic Steatosis in Human and Animals

  2012cites this paper