Antidepressant-like effects of Perilla frutescens seed oil during a forced swimming test.

Unipolar depressive disorder may become one of the major leading causes of disease burden by 2030 according to the World Health Organization (WHO). Thus, the discovery of antidepressive foods is attractive and could have considerable impacts worldwide. We investigated the antidepressant-like effects of Perilla frutescens seed oil on adult male rats subjected to a forced swimming test (FST). Forty Sprague-Dawley rats were housed and fed various diets, including soybean oil-rich, eicosapentaenoic acid (EPA)-rich, and P. frutescens seed oil-rich diets for 6 weeks. After the dietary intervention, animals were tested using an FST and were sacrificed after the test. We analyzed the fatty acid profiles of red blood cells (RBCs) and the brain prefrontal cortex (PFC). Levels of brain-derived neurotrophic factor (BDNF), serotonin, and dopamine in the PFC were also determined. After the FST, the imipramine, EPA-rich, and P. frutescens seed oil-rich groups showed significant shorter immobility time and longer struggling time than the control group (p < 0.05). Levels of BDNF in the P. frutescens seed oil-rich group and levels of serotonin in the EPA-rich group were significantly (p < 0.05) higher than those of the control group. Moreover, the BDNF concentration in the PFC was significantly positively correlated with the struggling time. However, there were no significant differences in dopamine levels between the intervention groups and the control group. In conclusion, a P. frutescens seed oil-rich diet exhibited antidepressant-like properties through modulation of fatty acid profiles and BDNF expression in the brain during an FST.

• Publication year

  2014

• Venue

  Food & Function

• Publication date

  2014-04-25

• Fields of study

  Agricultural and Food Sciences, Medicine, Biology

• Identifiers
  DOI 10.1039/c3fo60717hPMID 24651157
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of Long-Chain Omega-3 Fatty Acids in Psychiatric Practice.

  2013cited by this paper
• Factors influencing behavior in the forced swim test.

  2013cited by this paper
• Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice.

  2012cited by this paper
• Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression.

  2012cited by this paper
• N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test.

  2012cited by this paper
• Chronic ω-3 fatty acids supplementation promotes beneficial effects on anxiety, cognitive and depressive-like behaviors in rats subjected to a restraint stress protocol.

  2011cited by this paper
• Dietary intake of n-3 and n-6 fatty acids and the risk of clinical depression in women: a 10-y prospective follow-up study.

  2011cited by this paper
• Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover.

  2010cited by this paper
• Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet: Neurotrophin content and protein kinase activity.

  2010cited by this paper
• The hypothalamic-pituitary-adrenal axis and serotonin abnormalities: a selective overview for the implications of suicide prevention

  2010cited by this paper
• Anatomical and functional correlates in major depressive disorder: The contribution of neuroimaging studies

  2010cited by this paper
• High Levels of Depressive Symptoms in Pregnancy With Low Omega-3 Fatty Acid Intake From Fish

  2009cited by this paper
• L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications

  2009cited by this paper
• Omega-3 fatty acids in major depressive disorder.

  2009cited by this paper
• Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects.

  2009cited by this paper
• PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus.

  2009cited by this paper
• Omega-3 fatty acids on the forced-swimming test.

  2008cited by this paper
• n-3 Polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism

  2007cited by this paper
• Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex

  2007cited by this paper
• Essential Fatty acids - a review.

  2006cited by this paper
• Cross-national comparisons of seafood consumption and rates of bipolar disorders.

  2003cited by this paper
• Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus Published, JLR Papers in Press, May 16, 2003. DOI 10.1194/jlr.M300079-JLR200

  2003cited by this paper
• Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial.

  2003cited by this paper
• Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+

  2003cited by this paper
• Cytokine-induced sickness behaviour: mechanisms and implications.

  2002cited by this paper
• Recent studies on interactions between n-3 and n-6 polyunsaturated fatty acids in brain and other tissues

  2002cited by this paper
• A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs.

  2002cited by this paper
• Comparison of antidepressant activity in 4- and 40-week-old male mice in the forced swimming test: involvement of 5-HT1A and 5-HT1B receptors in old mice

  2001cited by this paper
• Fish Consumption, Depression, and Suicidality in a General Population

  2001cited by this paper
• Fish consumption, depression, and suicidality in a general population.

  2001cited by this paper
• Group-specific assays that distinguish between the four major types of mammalian phospholipase A2.

  1999cited by this paper
• Fish consumption and major depression.

  1998cited by this paper
• Neurotrophins: a family of proteins supporting the survival of neurons.

  1994cited by this paper
• Protein quality, amino acid balance, utilization, and evaluation of diets containing amino acids as therapeutic agents.

  1993cited by this paper
• Protein quality, amino acid balance, utilization, and evaluation of diets containing amino acids as therapeutic agents.

  1993cited by this paper
• Behavioural despair in rats: a new model sensitive to antidepressant treatments.

  1978cited by this paper
• "Behavioural despair" in rats and mice: strain differences and the effects of imipramine.

  1978cited by this paper
• Depression: a new animal model sensitive to antidepressant treatments

  1977cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• A simple method for the isolation and purification of total lipides from animal tissues.

  1957cited by this paper

• Biomass Potential of Alkaline-Pretreated Perilla frutescens Residues and Isolation of their Degrading Bacteria

  2025cites this paper
• Comprehensive Characterisation of Perilla Seed Oil for Potential Applications as a Bioactive Food Ingredient - Review

  2024influential citation
• Development, basic information, classifications, pharmacological activities, and underlying mechanisms of medicine food homology: A review

  2024cites this paper
• Perilla frutescens: A traditional medicine and food homologous plant

  2023cites this paper
• Antidepressant-like Effects of Representative Types of Food and Their Possible Mechanisms

  2023cites this paper
• A comprehensive review of the botany, ethnopharmacology, phytochemistry, pharmacology, toxicity and quality control of Perillae Fructus.

  2022cites this paper
• Quantitative Comparison and Chemical Profile Analysis of Different Medicinal Parts of Perilla frutescens (L.) Britt. from Different Varieties and Harvest Periods.

  2022cites this paper
• PERILLA FRUTESCENS – A REVIEW ON PHARMACOLOGICAL ACTIVITIES, EXTRACTION PROCEDURE AND APPLICATIONS

  2022cites this paper
• New Insights into Depressive Disorder with Respect to Low-Grade Inflammation and Fish Oil Intake.

  2021cites this paper
• Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies

  2021cites this paper
• Glycoglycerolipids from the leaves of Perilla frutescens (L.) Britton (Labiatae) and their anti-inflammatory activities in lipopolysaccharide-stimulated RAW264.7 cells.

  2021cites this paper
• Assessment of genetic diversity and population structure among a collection of Korean Perilla germplasms based on SSR markers

  2020cites this paper
• Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice

  2020cites this paper
• Ultrasound pre-treatment combined with microwave-assisted hydrodistillation of essential oils from Perilla frutescens (L.) Britt. leaves and its chemical composition and biological activity

  2020cites this paper
• Oleogel-structured emulsion for enhanced oxidative stability of perilla oil: Influence of crystal morphology and cooling temperature

  2020cites this paper
• Perilla oil regulates intestinal microbiota and alleviates insulin resistance through the PI3K/AKT signaling pathway in type-2 diabetic KKAy mice.

  2019cites this paper
• A high linoleic acid diet exacerbates metabolic responses and gut microbiota dysbiosis in obese rats with diabetes mellitus.

  2019cites this paper
• Fatty acid composition and oil content of seeds from perilla (Perilla frutescens (L.) var. frutescens) germplasm of Republic of Korea

  2019cites this paper
• Botanicals as modulators of depression and mechanisms involved

  2019cites this paper
• Effects of dietary perilla seed oil supplementation on lipid metabolism, meat quality, and fatty acid profiles in Yellow-feathered chickens.

  2019cites this paper
• Effect of caloric restriction on depression

  2018cites this paper
• n-3 polyunsaturated fatty acids prevent d-galactose-induced cognitive deficits in prediabetic rats.

  2018cites this paper
• Ethnomedicinal, Phytochemical and Pharmacological Investigations of Perilla frutescens (L.) Britt.

  2018cites this paper
• Perilla leaf " , " Perilla stalk " and " Perilla seed " corresponding to Folium

  2018cites this paper
• EPA and DHA, but not ALA, have antidepressant effects with 17β-estradiol injection via regulation of a neurobiological system in ovariectomized rats.

  2017cites this paper
• Botanicals as Modulators of Neuroplasticity: Focus on BDNF

  2017cites this paper
• Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China.

  2017cites this paper
• Anti-amyloidogenic effects of Perilla frutescens var. acuta on beta-amyloid aggregation and disaggregation

  2017cites this paper
• N-3 Polyunsaturated fatty acids ameliorate cognitive age-related impairments and depressive behaviour in unchallenged aged prediabetic rats

  2015cites this paper
• Cinnamic aldehyde treatment alleviates chronic unexpected stress-induced depressive-like behaviors via targeting cyclooxygenase-2 in mid-aged rats.

  2015cites this paper