Effect of caloric restriction on depression

Recently, most of evidence shows that caloric restriction could induce antidepressant‐like effects in animal model of depression. Based on studies of the brain–gut axis, some signal pathways were common between the control of caloric restriction and depression. However, the specific mechanism of the antidepressant‐like effects induced by caloric restriction remains unclear. Therefore, in this article, we summarized clinical and experimental studies of caloric restriction on depression. This review may provide a new therapeutic strategy for depression.

• Publication year

  2018

• Venue

  Journal of Cellular and Molecular Medicine

• Publication date

  2018-02-21

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/jcmm.13418PMID 29465826PMCID 5908110
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2015cited by this paper
• Effects of Intermittent Fasting, Caloric Restriction, and Ramadan Intermittent Fasting on Cognitive Performance at Rest and During Exercise in Adults

  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
• BDNF signaling and survival of striatal neurons

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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• Fasting in mood disorders: neurobiology and effectiveness. A review of the literature.

  2013influential reference
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  2013cited by this paper
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  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• The combined effects of exercise and foods in preventing neurological and cognitive disorders.

  2011cited by this paper
• Ghrelin mediates stress-induced food-reward behavior in mice.

  2011cited by this paper
• Glucocorticoids, cytokines and brain abnormalities in depression.

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  2010cited by this paper
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  2010influential reference
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  2009cited by this paper
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  2009cited by this paper
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  2008influential reference
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  2008cited by this paper
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  2008cited by this paper
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  2005influential reference
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