Serum and Immunoglobulin G from the Mother of a Child with Congenital Heart Block Induce Conduction Abnormalities and Inhibit L-Type Calcium Channels in a Rat Heart Model

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Pediatric Research

• Publication date

  1998-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1203/00006450-199807000-00002PMID 9667364
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Isolated congenital complete heart block: longterm outcome of mothers, maternal antibody specificity and immunogenetic background.

  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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