Mitochondria Determine Response to Anti-programmed Cell Death Protein 1 (Anti-PD-1) Immunotherapy: An Evidence-based Hypothesis.

Immunotherapy based on programmed cell death protein-1 (PD-1) is a promising approach in oncology. However, a significant fraction of patients remain unresponsive. Therefore, it is imperative to clarify the relevant predictive factors. A decrease in cellular adenosine triphosphate (c-ATP) level can predispose to cellular dysfunction. ATP is a prerequisite for proper T cell migration and activation. Therefore, a decrease in the c-ATP level impairs T cell function and promotes cancer progression. This article gives an overview of the potential predictive factors of PD-1 blockade. Besides, it highlights the pivotal role of mitochondria in response to anti-PD-1 therapies.

• Publication year

  2021

• Venue

  Mitochondrion (Amsterdam. Print)

• Publication date

  2021-12-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mito.2021.12.001PMID 34890822
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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