Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Science Signaling

• Publication date

  2016-11-08

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1126/scisignal.aaf8566PMID 27919027
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014influential reference
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  2014influential reference
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  2014influential reference
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  2013cited by this paper
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  2013cited by this paper
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  2012influential reference
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• JAK mutations in high-risk childhood acute lymphoblastic leukemia

  2009cited by this paper
• AMPK in Health and Disease.

  2009influential reference
• AMPK phosphorylation of raptor mediates a metabolic checkpoint.

  2008influential reference
• Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

  2008cited by this paper
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  2008cited by this paper
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  2005cited by this paper
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  2000influential reference
• Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display.

  1999cited by this paper
• Interleukin-6-Specific Activation of the C/EBPδ Gene in Hepatocytes Is Mediated by Stat3 and Sp1

  1998cited by this paper
• Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

  1997cited by this paper
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  1996cited by this paper
• Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase*

  1996influential reference
• A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin‐6.

  1995cited by this paper
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  1993cited by this paper
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  2017cites this paper
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