Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Diabetologia

• Publication date

  2012-02-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00125-012-2494-4PMID 22349108
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action.

  2010cited by this paper
• AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3)

  2010cited by this paper
• Activation of AMP-Activated Protein Kinase by Interleukin-6 in Rat Skeletal Muscle

  2009cited by this paper
• AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

  2009cited by this paper
• AMPK: an emerging drug target for diabetes and the metabolic syndrome.

  2009cited by this paper
• Human IL6 enhances leptin action in mice

  2009cited by this paper
• Control of gluconeogenic genes during intense/prolonged exercise: hormone-independent effect of muscle-derived IL-6 on hepatic tissue and PEPCK mRNA.

  2009cited by this paper
• Fenofibrate differentially regulates plasminogen activator inhibitor‐1 gene expression via adenosine monophosphate–activated protein kinase–dependent induction of orphan nuclear receptor small heterodimer partner

  2009cited by this paper
• Hepatocyte Growth Factor Family Negatively Regulates Hepatic Gluconeogenesis via Induction of Orphan Nuclear Receptor Small Heterodimer Partner in Primary Hepatocytes*

  2009cited by this paper
• Activation of AMP-activated protein kinase (AMPK) by Interleukin-6 in rat skeletal muscle: Association with changes in cAMP, energy state, and endogenous fuel mobilization

  2009cited by this paper
• Sodium arsenite induces orphan nuclear receptor SHP gene expression via AMP-activated protein kinase to inhibit gluconeogenic enzyme gene expression.

  2008cited by this paper
• Insulin resistance, inflammation, and non-alcoholic fatty liver disease.

  2008cited by this paper
• Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP

  2008influential reference
• Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats.

  2008cited by this paper
• Cytokines in the Pathogenesis of Fatty Liver and Disease Progression to Steatohepatitis: Implications for Treatment

  2008cited by this paper
• Molecular basis of endocrine regulation by orphan nuclear receptor Small Heterodimer Partner.

  2008cited by this paper
• Structure and function of the atypical orphan nuclear receptor small heterodimer partner.

  2007cited by this paper
• The dual function of hepatic SOCS3 in insulin resistance in vivo

  2007influential reference
• Regulation of suppressor of cytokine signaling 3 (SOC3) by growth hormone in pro-B cells.

  2007cited by this paper
• Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

  2006cited by this paper
• Interleukin-6 and diabetes: the good, the bad, or the indifferent?

  2005cited by this paper
• Analysis of SOCS-3 Promoter Responses to Interferon γ*

  2004cited by this paper
• Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.

  2004cited by this paper
• Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms

  2004cited by this paper
• Suppressor of Cytokine Signaling-3 (SOCS-3), a Potential Mediator of Interleukin-6-dependent Insulin Resistance in Hepatocytes*

  2003cited by this paper
• Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice.

  2003cited by this paper
• Metformin modulates insulin post-receptor signaling transduction in chronically insulin-treated Hep G2 cells.

  2003cited by this paper
• Interleukin-6 induces cellular insulin resistance in hepatocytes.

  2002influential reference
• Interactions of STAT3 with Caveolin-1 and Heat Shock Protein 90 in Plasma Membrane Raft and Cytosolic Complexes

  2002cited by this paper
• Role of AMP-activated protein kinase in mechanism of metformin action.

  2001cited by this paper
• Metformin reverses fatty liver disease in obese, leptin-deficient mice

  2000cited by this paper
• Dose-dependent effects of recombinant human interleukin-6 on glucose regulation.

  1997cited by this paper
• Interleukin-6 stimulates gluconeogenesis in primary cultures of rat hepatocytes.

  1995influential reference
• Endocrine and carbohydrate responses to interleukin-6 in vivo.

  1994cited by this paper
• Interleukin 6 stimulates hepatic glucose release from prelabeled glycogen pools.

  1990influential reference

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• Stat3 activation-triggered transcriptional networks govern the early stage of HBV-induced hepatic inflammation

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• Research advances in the therapy of metabolic syndrome

  2024cites this paper
• Marine-Derived Phosphoeleganin and Its Semisynthetic Derivative Decrease IL6 Levels and Improve Insulin Signaling in Human Hepatocellular Carcinoma Cells

  2024cites this paper
• STAT3 as a therapeutic target in the metformin-related treatment.

  2023cites this paper
• Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion

  2022cites this paper
• Acute exercise reduces feeding by activating IL-6/Tubby axis in the mouse hypothalamus

  2022cites this paper
• Dietary supplementation of L-carnitine ameliorates metabolic syndrome independent of trimethylamine N-oxide produced by gut microbes in high-fat diet-induced obese mice.

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• Actions of Metformin in the Brain: A New Perspective of Metformin Treatments in Related Neurological Disorders

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• Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats.

  2022cites this paper
• The effects of metformin, pioglitazone, exenatide and exercise on fatty liver in obese diabetic rats: the role of IRS-1 and SOCS-3 molecules

  2022cites this paper
• A potential probiotic bacterium for antipsychotic-induced metabolic syndrome: mechanisms underpinning how Akkermansia muciniphila subtype improves olanzapine-induced glucose homeostasis in mice

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  2021cites this paper
• Suppressor of cytokine signalling-2 controls hepatic gluconeogenesis and hyperglycemia by modulating JAK2/STAT5 Signalling pathway.

  2021cites this paper
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  2021cites this paper
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• Platelet Measurements and Type 2 Diabetes: Investigations in Two Population-Based Cohorts

  2020cites this paper
• Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion

  2020cites this paper
• Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation

  2020cites this paper
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  2018cites this paper
• Pathophysiology of the metabolic syndrome.

  2018cites this paper
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  2018cites this paper
• Examination of potential mechanisms linking AMPK to inhibition of IL-6 signalling

  2017cites this paper
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  2017cites this paper
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• Association between IL-6 and related risk factors of metabolic syndrome and cardiovascular disease in young rats.

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• B-Cell Translocation Gene 2 Regulates Hepatic Glucose Homeostasis via Induction of Orphan Nuclear Receptor Nur77 in Diabetic Mouse Model

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• Metformin Suppresses Lipopolysaccharide (LPS)-induced Inflammatory Response in Murine Macrophages via Activating Transcription Factor-3 (ATF-3) Induction*

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• IL-17A plays an important role in induction of type 2 diabetes and its complications

  2014cites this paper
• Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes.

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• Regulation of metabolism and inflammation in liver and skeletal muscle

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• The roles of aerobic exercise training and suppression IL-6 gene expression by RNA interference in the development of insulin resistance.

  2013cites this paper
• Down-regulation of insulin signaling is involved in painful diabetic neuropathy in type 2 diabetes.

  2013cites this paper
• Proteomic analysis of liver mitochondria of apolipoprotein E knockout mice treated with metformin.

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• Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation

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• B-cell translocation gene-2 increases hepatic gluconeogenesis via induction of CREB.

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