The frequent failure of the host's immunologic responses to impose restraints on tumor growth and dissemination has led to the realization that a number of factors, both immunologic and nonimmunologic, may act in concert to affect tumorigenesis. Immunologic mechanisms involved in tumor cell destruction are predicated principally on in vitro procedures, but the relevancy of these experimental observations to the actual events in vivo remains unclear and unresolved. The macrophage has been shown to be an integral segment of the immune response and to constitute an important element of the host defense against tumors. In this connection, interferon may be implicated in tumor cell destruction through macrophage activation to cytotoxicity. Studies of agerelated susceptibility of New Zealand Black mice to three different carcinogens, ie, 3-methylcholanthrene, x-irradiation, and murine leukemia virus, have further emphasized the multifactorial determinants which may be operational in oncogenesis. Advances in our knowledge of tumor immunology have suggested a number of possible modalities for preventing tumors from escaping immunologic destruction and should continue to contribute to further elucidation of neoplastic mechanisms. (Am J Pathol 93:515-524, 1978)
ABSTRACT
PUBLICATION RECORD
- Publication year
2020
- Venue
Definitions
- Publication date
2020-02-02
- Fields of study
Not labeled
- Identifiers
- External record
- Source metadata
Semantic Scholar
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- 3-methylcholanthrene
A chemical carcinogen named in the abstract as one of the exposures tested in New Zealand Black mice.
Aliases: 3-MC
- age-related susceptibility
Variation in susceptibility to carcinogenic exposures as a function of age.
- interferon
A signaling protein considered here as a possible activator of macrophage-mediated tumor cell killing.
- macrophage
A phagocytic immune cell that is discussed here as part of the host defense against tumors.
- macrophage activation to cytotoxicity
The process by which macrophages are induced to become cytotoxic toward target cells.
- murine leukemia virus
A murine virus named in the abstract as one of the carcinogenic exposures tested in New Zealand Black mice.
Aliases: MLV
- new zealand black mice
An inbred mouse strain used in the abstract as an example of age-related variation in carcinogen susceptibility.
Aliases: NZB mice
- tumor immunity
The host immune response directed against tumor cells and tumor growth.
Aliases: tumor immunology
- x-irradiation
Ionizing radiation named in the abstract as one of the carcinogenic exposures tested in New Zealand Black mice.
REFERENCES
Showing 1-33 of 33 references · Page 1 of 1
CITED BY
Showing 1-31 of 31 citing papers · Page 1 of 1