The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Nature Genetics

• Publication date

  1997-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/NG1197-309PMID 9354795
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A topogenic role for the oncogenic N-terminus of TLS: nucleolar localization when transcription is inhibited

  1997cited by this paper
• Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer.

  1996cited by this paper
• Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.

  1995cited by this paper
• Genetically modified human epidermis overexpressing PDGF-A directs the development of a cellular and vascular connective tissue stroma when transplanted to athymic mice--implications for the use of genetically modified keratinocytes to modulate dermal regeneration.

  1995cited by this paper
• Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis

  1995cited by this paper
• Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing.

  1995cited by this paper
• Cellular Factors Binding to a Novel cis-Acting Element Mediate Steroid Hormone Responsiveness of Mouse Mammary Tumor Virus Promoter (*)

  1995cited by this paper
• WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.

  1995cited by this paper
• The Transcriptional Effect of WT1 Is Modulated by Choice of Expression Vector (*)

  1995cited by this paper
• Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor.

  1995cited by this paper
• Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site.

  1994cited by this paper
• A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG

  1994cited by this paper
• The role of platelet-derived growth factor production by tumor-associated macrophages in tumor stroma formation in lung cancer.

  1994cited by this paper
• Chromosomal translocations in human cancer

  1994cited by this paper
• Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor.

  1994cited by this paper
• Intra‐Abdominal Desmoplastic Small Round Cell Tumor

  1993cited by this paper
• Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

  1993cited by this paper
• Combinatorial generation of variable fusion proteins in the Ewing family of tumours.

  1993cited by this paper
• The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1

  1993cited by this paper
• EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts

  1993cited by this paper
• A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1.

  1993cited by this paper
• Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

  1993cited by this paper
• WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.

  1993cited by this paper
• The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor

  1993cited by this paper
• Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1.

  1992cited by this paper
• Structural and functional studies on platelet‐derived growth factor.

  1992cited by this paper
• The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene.

  1992cited by this paper
• Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

  1992cited by this paper
• Platelet-derived growth factor (PDGF) A-chain mRNA heterogeneity generated by the use of alternative promoters and alternative polyadenylation sites.

  1992cited by this paper
• Oncogenic conversion of transcription factors by chromosomal translocations.

  1991cited by this paper
• Intra‐abdominal Desmoplastic Small Round‐Cell Tumor: Report of 19 Cases of a Distinctive Type of High‐Grade Polyphenotypic Malignancy Affecting Young Individuals

  1991cited by this paper
• Promoter region of the human platelet-derived growth factor A-chain gene.

  1991cited by this paper
• Platelet-derived growth factor in chemotactic for fibroblasts

  1982cited by this paper

• IGF2BP2 stabilized by USP7 promotes cancer-associated fibroblast activation and attenuates gemcitabine sensitivity in PDAC.

  2025cites this paper
• RNF114 Interacts with EWSR1 to Regulate VEGFR2 in HER2-positive Breast Cancer

  2025cites this paper
• Multiple Desmoplastic Small Round Cell Tumor in the Intestine: A Case Report

  2025influential citation
• Desmoplastic Small Round Cell Tumors and the Role of Androgen Receptors

  2025cites this paper
• Desmoplastic small round cell tumor: clinical case and literature review

  2024cites this paper
• Desmoplastic Small Round Cell Tumor in a Young Adult: A Case Report Highlighting Diagnostic Challenges and Treatment Approaches

  2024cites this paper
• EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors

  2024cites this paper
• Desmoplastic small round cell tumor: from state of the art to future clinical prospects

  2023cites this paper
• Desmoplastic small round cell tumor of the liver: diagnosing a rare case on liver biopsy

  2023cites this paper
• Combination of Genomic Landsscape and 3D Culture Functional Assays Bridges Sarcoma Phenotype to Target and Immunotherapy

  2023cites this paper
• Mesenchymal tumours of the pleura: review and update

  2023cites this paper
• EWSR1::WT1 fusions in neoplasms other than conventional desmoplastic small round cell tumor: three tumors occurring outside the female genital tract.

  2023cites this paper
• EWSR1 prevents the induction of aneuploidy through direct regulation of Aurora B

  2023cites this paper
• Salt-Inducible Kinase 1 is a potential therapeutic target in Desmoplastic Small Round Cell Tumor

  2022cites this paper
• Multi-site desmoplastic small round cell tumors are genetically related and immune-cold

  2022cites this paper
• CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma

  2022cites this paper
• Case Report: A pericardial effusion secondary to cardiac desmoplastic small round cell tumor

  2022cites this paper
• Plexiform fibrohistiocytic tumor: a clinicopathological and immunohistochemical study of 39 tumors, with evidence for a CSF1-producing “null cell” population

  2022cites this paper
• EWSR1 prevents the induction of aneuploidy by regulating the localization of Aurora B at inner centromere

  2022cites this paper
• Lurbinectedin inhibits the EWS-WT1 transcription factor in desmoplastic small round cell tumor.

  2022cites this paper
• Immunotherapy and Radioimmunotherapy for Desmoplastic Small Round Cell Tumor

  2021cites this paper
• Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling

  2021cites this paper
• Primary desmoplastic small round cell tumor of the submandibular gland: a case report and literature review

  2021cites this paper
• Generation of human embryonic stem cell models to exploit the EWSR1-CREB fusion promiscuity as a common pathway of transformation in human tumors

  2021cites this paper
• Molecular mechanisms underpinning sarcomas and implications for current and future therapy

  2021cites this paper
• Desmoplastic small round cell tumour presenting as cervical lymph nodes metastases with solid pattern morphology and novel EWSR1-WT1 fusion transcript.

  2021cites this paper
• Prognostic Role of Ultrasound Imaging in Desmoplastic Small Round Cell Tumor: A Retrospective Study and Literature Review

  2021cites this paper
• Genetic drivers and cells of origin in sarcomagenesis

  2021cites this paper
• RNA-binding proteins of COSMIC importance in cancer.

  2021cites this paper
• Hyperthermic intraperitoneal chemotherapy (HIPEC) as another treatment modality for desmoplastic round cell tumour patients: first paediatric experience from UK

  2021cites this paper
• Intra-Abdominal Desmoplastic Small Round Cell Tumor: Current Treatment Options and Perspectives

  2021cites this paper
• Primary Desmoplastic Small Round Cell Tumor of the Mandible: A Case Report and Literature Review

  2021cites this paper
• Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children’s Oncology Group

  2020cites this paper
• Establishment of multiple novel patient-derived models of desmoplastic small round cell tumor enabling functional characterization of ERBB pathway signaling and pre-clinical evaluation of a novel targeted therapy approach

  2020cites this paper
• Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor

  2020cites this paper
• Desmoplastic Small Round Cell Tumors: A review with focus on clinical management and therapeutic options.

  2020cites this paper
• Desmoplastic Small Round Cell Tumor: A Review of Main Molecular Abnormalities and Emerging Therapy

  2020cites this paper
• Desmoplastic small round cell tumor is dependent on the EWS-WT1 transcription factor

  2020cites this paper
• Mini-Review on Targeted Treatment of Desmoplastic Small Round Cell Tumor

  2020cites this paper
• Desmoplastic small round cell tumor (DSRCT): emerging therapeutic targets and future directions for potential therapies

  2020cites this paper
• Mesenchymal Tumors with EWSR1 Gene Rearrangements.

  2019cites this paper
• Soft Tissue Sarcomas

  2019cites this paper
• Expression profiles of exosomal miRNAs isolated from plasma of patients with desmoplastic small round cell tumor.

  2019cites this paper
• Dysregulated mitogen‐activated protein kinase signalling as an oncogenic basis for clear cell sarcoma of the kidney

  2018cites this paper
• Round Cell Sarcomas

  2018cites this paper
• Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer

  2018cites this paper
• [Desmoplastic small round cell tumor in children, adolescents and young adults].

  2018cites this paper
• Uncommon Tumors of Soft Tissue

  2017cites this paper
• CRISPR-Cas9–guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells

  2017cites this paper
• Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma

  2017cites this paper
• New transcriptional-based insights into the pathogenesis of desmoplastic small round cell tumors (DSRCTs)

  2017influential citation
• Desmoplastic small round cell tumor: evaluation of reverse transcription-polymerase chain reaction and fluorescence in situ hybridization as ancillary molecular diagnostic techniques

  2017cites this paper
• Desmoplastic Small Round Blue Cell Tumor: A Review of Treatment and Potential Therapeutic Genomic Alterations

  2017cites this paper
• Imatinib mesylate in desmoplastic small round cell tumors.

  2017cites this paper
• Molecular Pathology of Bone and Soft Tissue Tumors

  2017cites this paper
• Desmoplastic Small Round Cell Tumor

  2016cites this paper
• Gastric carcinosarcoma with rhabdomyosarcomatous differentiation: a case report and review

  2016cites this paper
• Undifferentiated Small Cell Tumors of the Hepatobiliary Tract

  2016cites this paper
• A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease

  2016cites this paper
• Desmoplastic Small Round Cell Tumor of the Pleura Successfully Treated with a Lower Dose of Pazopanib.

  2016cites this paper
• WT1 Mutation in Childhood Cancer.

  2016cites this paper
• Sister Mary Joseph nodule caused by metastatic desmoplastic small round cell tumor: A clinicopathological report.

  2016cites this paper
• Myeloablative Chemotherapy with Autologous Stem Cell Transplant for Desmoplastic Small Round Cell Tumor

  2015cites this paper
• Desmoplastic small round cell tumor 20 years after its discovery.

  2015cites this paper
• Primary intra-renal desmoplastic small round cell tumor: expanding the histologic spectrum, with special emphasis on the differential diagnostic considerations.

  2014cites this paper
• Molecular Testing in Paediatric Tumours

  2014cites this paper
• Pazopanib in advanced desmoplastic small round cell tumours: a multi-institutional experience

  2014cites this paper
• Round cell sarcomas - biologically important refinements in subclassification.

  2014cites this paper
• The diversity of soft tissue tumours with EWSR1 gene rearrangements: a review

  2014cites this paper
• Desmoplastic small round cell tumor with atypical immunohistochemical profile and rhabdoid-like differentiation.

  2014cites this paper
• EWS-WT1 oncoprotein activates neuronal reprogramming factor ASCL1 and promotes neural differentiation.

  2014cites this paper
• Ewing family tumours: a paediatric perspective

  2014cites this paper
• Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors

  2013cites this paper
• Targeting Treatment of Soft Tissue Sarcomas

  2013cites this paper
• The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts

  2013influential citation
• EWS-WT1 Chimeric Protein in Desmoplastic Small Round Cell Tumor is a Potent Transactivator of FGFR4

  2012cites this paper
• Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor and Related Tumors

  2012influential citation
• Soft Tissue “Small Round Blue Cell Tumors” of Childhood

  2012cites this paper
• Desmoplastický kulatobuněčný tumor

  2011cites this paper
• Multicenter Phase II trial assessing effectiveness of imatinib mesylate on relapsed or refractory KIT-positive or PDGFR-positive sarcoma

  2010cites this paper
• The Predominant WT1 Isoform (+KTS) Encodes a DNA-Binding Protein Targeting the Planar Cell Polarity Gene Scribble in Renal Podocytes

  2010cites this paper
• Imatinib mesylate in children and adolescents with cancer

  2010cites this paper
• Soft tissue tumors associated with EWSR1 translocation

  2010influential citation
• The Clinical Relevance of Molecular Genetics in Soft Tissue Sarcomas

  2010cites this paper
• NF-kappaB regulates androgen receptor expression and prostate cancer growth.

  2009cites this paper
• Genetics and Molecular Biology of Bone and Soft Tissue Tumors

  2009cites this paper
• Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors

  2009cites this paper
• Cytogenetic and Molecular Pathology of Pediatric Cancer

  2009cites this paper
• Meta-coexpression conservation analysis of microarray data: a "subset" approach provides insight into brain-derived neurotrophic factor regulation

  2009cites this paper
• Analyses of Akt and PDGF receptor expression and activation in human tumors

  2009cites this paper
• Molecular pathology of sarcomas.

  2009cites this paper
• Nonrhabdomyosarcomas and Other Soft Tissue Tumors

  2009cites this paper
• A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: A Children's Oncology Group study

  2008cites this paper
• Phase II, Open-Label Study Evaluating the Activity of Imatinib in Treating Life-Threatening Malignancies Known to Be Associated with Imatinib-Sensitive Tyrosine Kinases

  2008cites this paper
• Adenosine Transporter ENT4 Is a Direct Target of EWS/WT1 Translocation Product and Is Highly Expressed in Desmoplastic Small Round Cell Tumor

  2008cites this paper
• Oncogenic and Angiogenic Growth Factors Accumulate during Routine Storage of Apheresis Platelet Concentrates

  2008cites this paper
• Comparative proteomic analysis of livers from ketotic cows

  2008cites this paper
• Genetic Markers in Sporadic Tumors

  2008cites this paper
• Adenosine Transporter ENT 4 Is a Direct Target of EWS / WT 1 Translocation Product and Is Highly Expressed in Desmoplastic Small Round Cell Tumor

  2008cites this paper
• Adult human sarcomas. II. Medical oncology

  2007cites this paper