Role of Iron in Inducing Oxidative Stress in Thalassemia: Can It Be Prevented by Inhibition of Absorption and by Antioxidants?

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Annals of the New York Academy of Sciences

• Publication date

  2005-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1196/annals.1345.014PMID 16339657
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• mRNA expression of iron regulatory genes in β‐thalassemia intermedia and β‐thalassemia major mouse models

  2006cited by this paper
• Intracellular kinetics of iron in reticulocytes: evidence for endosome involvement in iron targeting to mitochondria.

  2005cited by this paper
• Iron chelation therapy.

  2005cited by this paper
• Iron trafficking in the mitochondrion: novel pathways revealed by disease.

  2005cited by this paper
• Decreased hepcidin mRNA expression in thalassemic mice

  2004cited by this paper
• Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia/HbE patients treated with an oral chelator.

  2004cited by this paper
• Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis.

  2004cited by this paper
• Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

  2004cited by this paper
• Effects of N‐acetylcysteine on dense cell formation in sickle cell disease

  2003cited by this paper
• Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.

  2003cited by this paper
• Labile plasma iron in iron overload: redox activity and susceptibility to chelation.

  2003cited by this paper
• Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein.

  2003cited by this paper
• A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer.

  2003cited by this paper
• Hepcidin, a new iron regulatory peptide.

  2002cited by this paper
• A Review of the Molecular Diagnosis of Thalassemia

  2002cited by this paper
• The labile iron pool: characterization, measurement, and participation in cellular processes(1).

  2002cited by this paper
• Oxidative status and malondialdehyde in beta-thalassaemia patients.

  2002cited by this paper
• A review of fluorescence methods for assessing labile iron in cells and biological fluids.

  2002cited by this paper
• Oxidative status and malondialdehyde in β‐thalassaemia patients

  2002cited by this paper
• A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload*

  2001cited by this paper
• Oral supplements of vitamin E improve measures of oxidative stress in plasma and reduce oxidative damage to LDL and erythrocytes in β-thalassemia intermedia patients

  2001cited by this paper
• Secondary iron overload.

  2001cited by this paper
• Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver*

  2001cited by this paper
• Diagnosing myocardial iron overload.

  2001cited by this paper
• The importance of non-transferrin bound iron in disorders of iron metabolism.

  2000cited by this paper
• LEAP‐1, a novel highly disulfide‐bonded human peptide, exhibits antimicrobial activity

  2000cited by this paper
• Iron regulatory proteins and the molecular control of mammalian iron metabolism.

  2000cited by this paper
• Deferiprone therapy in homozygous human beta-thalassemia removes erythrocyte membrane free iron and reduces KCl cotransport activity.

  1999cited by this paper
• Quantification of non-transferrin-bound iron in the presence of unsaturated transferrin.

  1999cited by this paper
• [Secondary iron overload].

  1998cited by this paper
• Deferiprone (L1) chelates pathologic iron deposits from membranes of intact thalassemic and sickle red blood cells both in vitro and in vivo.

  1995cited by this paper
• Iron chelation therapy

  1995cited by this paper
• Auto-oxidation and a membrane-associated 'Fenton reagent': a possible explanation for development of membrane lesions in sickle erythrocytes.

  1985cited by this paper
• Molecular basis for mild forms of homozygous beta-thalassaemia.

  1981cited by this paper
• PATHOPHYSIOLOGY OF THALASSEMIA

  1980cited by this paper
• Vitamin E deficiency in beta-thalassemia major: changes in hematological and biochemical parameters after a therapeutic trial with alpha-tocopherol.

  1979cited by this paper
• Non‐Specific Serum Iron in Thalassaemia: an Abnormal Serum Iron Fraction of Potential Toxicity

  1978cited by this paper
• Immunostimulants in primary hepatomas

  1975cited by this paper

• The effect of aqueous extract of Iranian oak (Quercus brantii) on lipid profile and liver enzymes in beta-thalassemia patients: a randomized controlled trial, double-blind, placebo-controlled

  2025cites this paper
• The Relationship Between Non-Transferrin-Bound Iron (NTBI), Labile Plasma Iron (LPI), and Iron Toxicity

  2025cites this paper
• Antioxidative effects of N‐acetylcysteine in patients with β–thalassemia: A quick review on clinical trials

  2024cites this paper
• Can N-acetylcysteine reduce red blood cell transfusion burden in patients with transfusion-dependent β-thalassemia?

  2023cites this paper
• Impact on oxidative stress of oral, high-dose, iron supplementation for management of iron deficiency after bariatric surgery, a preliminary study.

  2023cites this paper
• Free radical as a double-edged sword in disease: Deriving strategic opportunities for nanotherapeutics

  2023cites this paper
• Is the Role of Hepcidin and Erythroferrone in the Pathogenesis of Beta Thalassemia the Key to Developing Novel Treatment Strategies?

  2022cites this paper
• Redox Balance in β-Thalassemia and Sickle Cell Disease: A Love and Hate Relationship

  2022cites this paper
• EVALUATION OF ZINC, SELENIUM AND LIVER ENZYMES IN CHILDREN AND TEENAGERS WITH THALASSEMIA DISEASE

  2021cites this paper
• The Effectiveness of Vitamin C as an Antioxidant Against the Pulse of Recovery After Physical Activity in the New Normal

  2021cites this paper
• Iron and zinc ions, potent weapons against multidrug-resistant bacteria

  2020cites this paper
• Leukocyte telomere length in patients with transfusion-dependent thalassemia

  2020cites this paper
• Effects of three months of treatment with vitamin E and N-acetyl cysteine on the oxidative balance in patients with transfusion-dependent β-thalassemia

  2020influential citation
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  2020cites this paper
• Specific Mechanisms and Protective Antioxidant Systems Playing Role in Occurring Oxidative Stress in Erythrocytes

  2020cites this paper
• Protective Effects of Osthole against Free Radical-Induced Hemolysis of Erythrocytes

  2020cites this paper
• Randomized controlled trial of effect of N-acetylcysteine as an antioxidant on iron overload 2 in children with thalassemia major 3 Running title : N-acetylcysteine as an antioxidant in thalassemia major 4 5

  2020cites this paper
• Melatonin is a potential therapeutic molecule for oxidative stress induced red blood cell (RBC) injury : A review

  2020cites this paper
• Implications of SARSr-CoV 2 infection in thalassemias: Do patients fall into the “high clinical risk” category?

  2020cites this paper
• Telomere Length in Patients with Transfusion-Dependent Thalassemia

  2019cites this paper
• Abnormal red blood cell morphological changes in thalassaemia associated with iron overload and oxidative stress

  2019cites this paper
• Factors associated with insulin-like growth factor-1 in children with thalassemia major

  2019cites this paper
• The Effect of Transfusion-Dependent Thalassemia Patient’s Serum on Peripheral Blood Mononuclear Cell Viability

  2019cites this paper
• Impact of red blood cell transfusion dose density on progression-free survival in patients with lower-risk myelodysplastic syndromes

  2019cites this paper
• Labile iron pool as a parameter to monitor iron overload and oxidative stress status in β‐thalassemic erythrocytes

  2018cites this paper
• the Radboud University Nijmegen

  2018cites this paper
• Effects of the Usage of l-Cysteine (l-Cys) on Human Health

  2018cites this paper
• Polyneuropathy and myopathy in beta-thalassemia major patients

  2018cites this paper
• Low IL-2 Expressing T Cells in Thalassemia Major Patients: Is It Immune Aging

  2018cites this paper
• Cardiac complications in beta-thalassemia: From mice to men

  2017cites this paper
• Nonmalignant Hematologic Diseases

  2017cites this paper
• Chapter 19 Green Tea : Just a Drink or Nutraceutical

  2017cites this paper
• Iron overload in hematological disorders.

  2017cites this paper
• Labile plasma iron levels predict survival in patients with lower-risk myelodysplastic syndromes

  2017cites this paper
• Oxidative stress and age-related changes in T cells: is thalassemia a model of accelerated immune system aging?

  2016cites this paper
• Evaluation of In Vitro Antioxidant Potential of Cordia retusa

  2016influential citation
• Correlation between Serum Ferritin and Cardiac Troponin I in Major Beta Thalassemia Children

  2016cites this paper
• Oxidative stress in β-thalassaemia and sickle cell disease

  2015cites this paper
• Current and future treatment strategies for iron overload cardiomyopathy.

  2015cites this paper
• STUDY OF ANTIOXIDANT POTENTIAL OF CADABA FRUTICOSA BY USING VARIOUS IN VITRO MODELS

  2014cites this paper
• Assessment of Labile Plasma Iron in Patients Who Undergo Hematopoietic Stem Cell Transplantation

  2014cites this paper
• Effect of zinc supplementation on serum antibody titers to heat shock protein 27 in patients with thalassemia major

  2014cites this paper
• Running exercise alleviates trabecular bone loss and osteopenia in hemizygous β-globin knockout thalassemic mice.

  2014cites this paper
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  2014influential citation
• FORMULATION AND IN VITRO EVALUATION OF DEFERASIROX ORO-DISPERSIBLE TABLETS

  2014cites this paper
• USE OF TRANSFERRIN RECEPTOR ANTAGONIST FOR THE TREATMENT OF THALASSEMIA FIELD OF THE INVENTION

  2014cites this paper
• Green Tea: Just a Drink or Nutraceutical

  2014cites this paper
• Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage.

  2014cites this paper
• Effect of zinc supplementation on serum mlondealdehyde and lipid profiles on beta thalassemia major patients

  2014cites this paper
• In vitro screening of Fe2+-chelating effect by a Fenton's reaction-luminol chemiluminescence system.

  2014cites this paper
• Assessment of Labile Plasma Iron in Patients Who Undergo Hematopoietic Stem Cell Transplantation

  2013cites this paper
• Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload

  2013cites this paper
• Beta-Thalassemia Major and Female Fertility: The Role of Iron and Iron-Induced Oxidative Stress

  2013influential citation
• Molecular and Biochemical Study on β-Thalassemia Patients in Iraq

  2013cites this paper
• Cancer cells with irons in the fire.

  2013cites this paper
• Increased Serum Heat Shock Protein 27 Antibody Titers and Prooxidant-Antioxidant Balance in Patients with Beta-Thalassemia Major

  2012cites this paper
• Combined Therapy with Deferiprone and Desferrioxamine as Compared to Desferasirox on Ventricular Function in Thalassemia Major Patients

  2012cites this paper
• Normalized coagulation markers and anticoagulation proteins in children with severe β-thalassemia disease after stem cell transplantation.

  2012cites this paper
• [Relation analysis between intracellular distribution of nanomateriarls, ROS generation and DNA damage].

  2012cites this paper
• Vitamin E supplement improves erythrocyte membrane fluidity of thalassemia: an ESR spin labeling study.

  2012cites this paper
• Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients.

  2012cites this paper
• Disorders of Red Cell Production and the Iron-Loading Anemias

  2012cites this paper
• Special Effects of Oral Therapeutic Supplementation of Antioxidants on Attenuation of Iron Overload in Homozygous Beta Thalassemia

  2012cites this paper
• Iron Balance in β-thalassemia: Maintaining an Antioxidant / Oxidant Ratio

  2012cites this paper
• Effect of exogenous antioxidants on erythrocyte redox status and hepcidin content in disorders of iron metabolism regulation

  2012cites this paper
• Hubungan antara Stres Oksidatif dengan Kadar Hemoglobin pada Penderita Thalassemia /Hbe Correlation between Stres Oxidatif and Hemoglobine Level of Thalassemia /Hbe

  2012cites this paper
• Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial iron overload

  2011cites this paper
• Oxidative stress contributes to hemolysis in patients with hereditary spherocytosis and can be ameliorated by fermented papaya preparation

  2011cites this paper
• Chelators to the rescue: different horses for different courses!

  2011cites this paper
• Pro‐oxidative/antioxidative imbalance: a key indicator of adverse outcome in hematopoietic stem cell transplantation

  2011cites this paper
• Intravenous Iron Treatment in Patients with Chronic Renal Disease, Oxidative Stress and the Effect of N-acetylcysteine

  2011cites this paper
• The role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia

  2010cites this paper
• Protein C levels in β-thalassemia major patients in the east Nile delta of Egypt

  2010cites this paper
• Erythrocytes anion transport and oxidative change in β‐thalassaemias

  2010cites this paper
• Protein C levels in beta-thalassemia major patients in the east Nile delta of Egypt.

  2010cites this paper
• The Effect of Iron(III) on the Activity of Selenoenzymes and Oxidative Damage in the Liver of Rats. Interaction with Natural Antioxidants and Deferiprone

  2010cites this paper
• Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids.

  2010cites this paper
• Efficacy of Deferasirox in Preventing Complications of Iron Overload in the Iron Overloaded Gerbil

  2009cites this paper
• Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers

  2009cites this paper
• Abnormal iron uptake and liver cancer

  2009cites this paper
• Hepcidin in acute iron toxicity.

  2009cites this paper
• Premature senescence of T lymphocytes from patients with beta-thalassemia major.

  2009cites this paper
• Ineffective erythropoiesis and thalassemias

  2009cites this paper
• Combined therapy of silymarin and desferrioxamine in patients with β‐thalassemia major: a randomized double‐blind clinical trial

  2009cites this paper
• Vitamin E Supplementation Reduces Oxidative Stress in Beta Thalassaemia Intermedia

  2009cites this paper
• Deferasirox removes cardiac iron and attenuates oxidative stress in the iron‐overloaded gerbil

  2009cites this paper
• Modification of platelet shape change parameter by oxidized lipoprotein from beta-thalassemia/Hemoglobin E.

  2009cites this paper
• Regulation of iron absorption in hemoglobinopathies.

  2008cites this paper
• Inflammation and oxidant-stress in β-thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial

  2008cites this paper
• Toxicity evaluation in a paper recycling mill effluent by coupling bioindicator of aging with the toxicity identification evaluation method in nematode Caenorhabditis elegans.

  2008cites this paper
• Phenotypic and behavioral defects induced by iron exposure can be transferred to progeny in Caenorhabditis elegans.

  2008cites this paper
• Effect of green tea on iron status and oxidative stress in iron-loaded rats.

  2008cites this paper
• Thromboembolic complications in beta-thalassemia: Beyond the horizon.

  2007cites this paper
• Thromboembolic complications in β-thalassemia: Beyond the horizon

  2007cites this paper
• Heterozygous beta-globin gene mutations as a risk factor for iron accumulation and liver fibrosis in chronic hepatitis C.

  2007cites this paper
• Heterozygous b -globin gene mutations as a risk factor for iron accumulation and liver fibrosis in chronic hepatitis C

  2007cites this paper
• Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions.

  2006cites this paper
• Suppression of hepcidin during anemia requires erythropoietic activity.

  2006cites this paper
• Heterozygous β-globin gene mutations as a risk factor for iron accumulation and liver fibrosis in chronic hepatitis C

  2006cites this paper
• Beta-thalassemia.

  2005cites this paper