Multi-Omics for Biomarker Discovery and Target Validation in Biofluids for Amyotrophic Lateral Sclerosis Diagnosis

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Omics

• Publication date

  2018-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/omi.2017.0183PMID 29356625
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Parkinson's disease].

  2022cited by this paper
• A Case-Control Study

  2019cited by this paper
• Poly‐GP in cerebrospinal fluid links C9orf72‐associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD

  2017influential reference
• Essential trace elements in amyotrophic lateral sclerosis (ALS): Results in a population of a risk area of Italy

  2017cited by this paper
• TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis

  2017cited by this paper
• Proteomic studies in the discovery of cerebrospinal fluid biomarkers for amyotrophic lateral sclerosis

  2017cited by this paper
• Biomarkers in Neurodegenerative Diseases.

  2017cited by this paper
• Inhibition of human endogenous retrovirus-K by antiretroviral drugs

  2017cited by this paper
• Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72‐associated amyotrophic lateral sclerosis

  2017cited by this paper
• Specific biomarkers for C9orf72 FTD/ALS could expedite the journey towards effective therapies

  2017cited by this paper
• Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease

  2017cited by this paper
• Cerebrospinal Fluid TAR DNA-Binding Protein 43 Combined with Tau Proteins as a Candidate Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Spectrum Disorders

  2017cited by this paper
• Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

  2017cited by this paper
• Diagnostic and Prognostic Biomarkers in Amyotrophic Lateral Sclerosis: Neurofilament Light Chain Levels in Definite Subtypes of Disease

  2017cited by this paper
• Blood trace metals in a sporadic amyotrophic lateral sclerosis geographical cluster

  2017influential reference
• More Is Better: Recent Progress in Multi-Omics Data Integration Methods

  2017cited by this paper
• Healing of Amyotrophic Lateral Sclerosis: A Case Report

  2017cited by this paper
• TDP‐43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing

  2017cited by this paper
• Poly(Gp) Proteins Are A Useful Pharmacodynamic Marker For C9Orf72-Associated Amyotrophic Lateral Sclerosis

  2017influential reference
• Amyotrophic Lateral Sclerosis.

  2017cited by this paper
• Neurofilaments and Neurofilament Proteins in Health and Disease.

  2017cited by this paper
• Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

  2017cited by this paper
• Cerebrospinal fluid levels of chromogranin A and phosphorylated neurofilament heavy chain are elevated in amyotrophic lateral sclerosis

  2017cited by this paper
• Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS)

  2017cited by this paper
• Amyotrophic lateral sclerosis

  2017cited by this paper
• Metals and neurodegenerative diseases. A systematic review

  2017cited by this paper
• Elevated Levels of Selenium Species in Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients with Disease-Associated Gene Mutations

  2017influential reference
• Blood hemoglobin A1c levels and amyotrophic lateral sclerosis survival

  2017cited by this paper
• The 'Omics' of Amyotrophic Lateral Sclerosis.

  2016cited by this paper
• Emerging molecular biomarker targets for amyotrophic lateral sclerosis.

  2016cited by this paper
• TDP-43 regulates endogenous retrovirus-K viral protein accumulation.

  2016cited by this paper
• Comparative Analysis of VOCs in Exhaled Breath of Amyotrophic Lateral Sclerosis and Cervical Spondylotic Myelopathy Patients

  2016cited by this paper
• Aberration of miRNAs Expression in Leukocytes from Sporadic Amyotrophic Lateral Sclerosis

  2016cited by this paper
• Circulating microRNAs as biomarkers of muscle differentiation and atrophy in ALS.

  2016cited by this paper
• A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients

  2016cited by this paper
• Identification of miRNAs as Potential Biomarkers in Cerebrospinal Fluid from Amyotrophic Lateral Sclerosis Patients

  2016cited by this paper
• Blood levels of trace metals and amyotrophic lateral sclerosis.

  2016cited by this paper
• Methods for the integration of multi-omics data: mathematical aspects

  2016cited by this paper
• Neurofilaments as Biomarkers for Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

  2016cited by this paper
• Assessment of a multiple biomarker panel for diagnosis of amyotrophic lateral sclerosis

  2016cited by this paper
• Phosphorylated neurofilament heavy chain levels in paired plasma and CSF of amyotrophic lateral sclerosis.

  2016cited by this paper
• Identification of erythrocyte biomarkers in amyotrophic lateral sclerosis

  2016cited by this paper
• An electronic nose may sniff out amyotrophic lateral sclerosis.

  2016cited by this paper
• MicroRNAs-424 and 206 are potential prognostic markers in spinal onset amyotrophic lateral sclerosis.

  2016cited by this paper
• NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5′ Long Terminal Repeat

  2016cited by this paper
• Serial measurements of phosphorylated neurofilament-heavy in the serum of subjects with amyotrophic lateral sclerosis.

  2015cited by this paper
• Identification of plasma microRNAs as a biomarker of sporadic Amyotrophic Lateral Sclerosis

  2015cited by this paper
• C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

  2015cited by this paper
• Serum microRNAs in sporadic amyotrophic lateral sclerosis.

  2015influential reference
• Neurofilament light chain

  2015cited by this paper
• Measuring Compounds in Exhaled Air to Detect Alzheimer's Disease and Parkinson’s Disease

  2015cited by this paper
• Human endogenous retrovirus-K contributes to motor neuron disease

  2015influential reference
• Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

  2015cited by this paper
• Level of neurotoxic metals in amyotrophic lateral sclerosis: A population-based case-control study.

  2015cited by this paper
• Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients

  2015cited by this paper
• TUBA4A gene analysis in sporadic amyotrophic lateral sclerosis: identification of novel mutations

  2015influential reference
• miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients

  2014cited by this paper
• miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients

  2014cited by this paper
• Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS.

  2014cited by this paper
• Genome-wide analysis of the heritability of amyotrophic lateral sclerosis.

  2014cited by this paper
• Blood Volatile Organic Compounds as Potential Biomarkers for Amyotrophic Lateral Sclerosis: an Animal Study in the SOD1 G93A Mouse

  2014cited by this paper
• Blood Biomarkers for Amyotrophic Lateral Sclerosis: Myth or Reality?

  2014cited by this paper
• Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers.

  2014influential reference
• MicroRNA-206: A Potential Circulating Biomarker Candidate for Amyotrophic Lateral Sclerosis

  2014cited by this paper
• Blood Lead, Manganese, and Aluminum Levels in a Regional Italian Cohort of ALS Patients: Does Aluminum Have an Influence?

  2014cited by this paper
• Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS.

  2014influential reference
• Differential diagnosis of amyotrophic lateral sclerosis from Guillain–Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid

  2014influential reference
• Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study

  2014influential reference
• How do C9ORF72 repeat expansions cause ALS and FTD: can we learn from other non-coding repeat expansion disorders?

  2014cited by this paper
• Amyotrophic lateral sclerosis outcome measures and the role of albumin and creatinine: a population-based study.

  2014cited by this paper
• Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice.

  2013cited by this paper
• Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis

  2013influential reference
• Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

  2013cited by this paper
• Detection of Alzheimer's and Parkinson's disease from exhaled breath using nanomaterial-based sensors.

  2013cited by this paper
• RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.

  2013cited by this paper
• State of play in amyotrophic lateral sclerosis genetics

  2013cited by this paper
• Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood

  2013cited by this paper
• Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite.

  2013cited by this paper
• Relationships between disease progression and serum levels of lipid, urate, creatinine and ferritin in Japanese patients with amyotrophic lateral sclerosis: a cross-sectional study.

  2012cited by this paper
• Differential expression of TAR DNA-binding protein (TDP-43) in the central nervous system of horses afflicted with equine motor neuron disease (EMND): a preliminary study of a potential pathologic marker

  2012cited by this paper
• Metal Concentrations in Cerebrospinal Fluid and Blood Plasma from Patients with Amyotrophic Lateral Sclerosis

  2012cited by this paper
• TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

  2012cited by this paper
• Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: a possible marker of disease severity and progression

  2012cited by this paper
• How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia: can we learn from other noncoding repeat expansion disorders?

  2012cited by this paper
• EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

  2012cited by this paper
• A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis.

  2012cited by this paper
• Amyotrophic lateral sclerosis.

  2012cited by this paper
• TDP-43 in aging and Alzheimer's disease - a review.

  2011cited by this paper
• Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

  2011influential reference
• MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice

  2009influential reference
• Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

  2009cited by this paper
• TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

  2008cited by this paper
• Highly selective artificial gel antibodies for detection and quantification of biomarkers in clinical samples. II. Albumin in body fluids of patients with neurological disorders.

  2008cited by this paper
• Colocalization of Transactivation-Responsive DNA-Binding Protein 43 and Huntingtin in Inclusions of Huntington Disease

  2008cited by this paper
• The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia

  2008cited by this paper
• Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate

  2008cited by this paper
• Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations

  2007cited by this paper
• A controlled study of reverse transcriptase in serum and CSF of HIV-negative patients with ALS

  2007cited by this paper
• Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies.

  2007cited by this paper
• Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases

  2007cited by this paper

• Multiomics approach identifies SERPINB1 as candidate biomarker for spinocerebellar ataxia type 2

  2025cites this paper
• Multivariate curve resolution-based data fusion approaches applied in 1H NMR metabolomic analysis of healthy cohorts.

  2024cites this paper
• Applications of multi‐omics analysis in human diseases

  2023cites this paper
• Genomic and transcriptomic advances in amyotrophic lateral sclerosis.

  2023cites this paper
• Screening and identification of key biomarkers associated with amyotrophic lateral sclerosis and depression using bioinformatics

  2023cites this paper
• Druggability of Targets for Diagnostic Radiopharmaceuticals.

  2023cites this paper
• A Diagnostic Gene-Expression Signature in Fibroblasts of Amyotrophic Lateral Sclerosis

  2023cites this paper
• Depicting the molecular features of suicidal behavior: a review from an "omics" perspective.

  2023cites this paper
• [Omics to serve myology].

  2023cites this paper
• Evolving markers in amyotrophic lateral sclerosis.

  2023cites this paper
• Synthetic biology tools: Engineering microbes for biotechnological applications

  2022cites this paper
• Diagnostic Circulating miRNAs in Sporadic Amyotrophic Lateral Sclerosis

  2022cites this paper
• Predicting mortality in cardiovascular diseases by Fourier-Transform Raman spectroscopy

  2022cites this paper
• A chemogenomic approach is required for effective treatment of amyotrophic lateral sclerosis

  2022cites this paper
• RNA Deregulation in Amyotrophic Lateral Sclerosis: The Noncoding Perspective

  2021cites this paper
• Studies on Novel Diagnostic and Predictive Biomarkers of Intrahepatic Cholestasis of Pregnancy Through Metabolomics and Proteomics

  2021cites this paper
• Precision Neurosurgery: A Path Forward

  2021cites this paper
• Metabolic Plasticity of Astrocytes

  2021cites this paper
• Breathomics: Review of Sample Collection and Analysis, Data Modeling and Clinical Applications

  2021cites this paper
• Micro-Fourier-transform infrared reflectance spectroscopy as tool for probing IgG glycosylation in COVID-19 patients

  2021cites this paper
• Tyrosine and Tryptophan vibrational bands as markers of kidney injury: a renocardiac syndrome induced by renal ischemia and reperfusion study

  2021cites this paper
• OMICS-BASED EXPLORATION AND FUNCTIONAL VALIDATION OF NEUROTROPHIC FACTORS AND HISTAMINE AS THERAPEUTIC TARGETS IN ALS.

  2020cites this paper
• Renocardiac Syndrome Induced by Renal Ischemia and Reperfusion: Vibrational Markers

  2020cites this paper
• Causal effects of serum metabolites on amyotrophic lateral sclerosis: A Mendelian randomization study.

  2020cites this paper
• From Multi-Omics Approaches to Precision Medicine in Amyotrophic Lateral Sclerosis

  2020cites this paper
• Pharmacometabolomics

  2019cites this paper
• New molecular diagnostic trends and biomarkers for amyotrophic lateral sclerosis

  2019cites this paper
• Neuroprotection in Amyotrophic Lateral Sclerosis

  2019cites this paper
• High-dimensionality Data Analysis of Pharmacological Systems Associated with Complex Diseases

  2019cites this paper
• How far have we come with contextual data integration in drug discovery?

  2018cites this paper
• Corrigendum: Dysregulation of MicroRNAs and Target Genes Networks in Peripheral Blood of Patients With Sporadic Amyotrophic Lateral Sclerosis

  2018cites this paper
• Metabolomics Biomarkers: A Strategy Toward Therapeutics Improvement in ALS

  2018cites this paper
• Machine Learning Reveals Protein Signatures in CSF and Plasma Fluids of Clinical Value for ALS

  2018cites this paper
• Dysregulation of MicroRNAs and Target Genes Networks in Peripheral Blood of Patients With Sporadic Amyotrophic Lateral Sclerosis

  2018cites this paper