Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Allergy and Clinical Immunology

• Publication date

  2014-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.jaci.2013.10.006PMID 24315502
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aspirin-exacerbated respiratory disease: burden of disease.

  2012cited by this paper
• Characterization of Asthma Exacerbations in Primary Care Using Cluster Analysis

  2012cited by this paper
• Cigarette Smoke Exposure-Associated Alterations to Non-Coding RNA

  2012cited by this paper
• Perinatal Gene-Gene and Gene-Environment Interactions on IgE Production and Asthma Development

  2012cited by this paper
• A large subgroup of mild-to-moderate asthma is persistently noneosinophilic.

  2012cited by this paper
• Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study.

  2012cited by this paper
• Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples.

  2011cited by this paper
• Identifying adult asthma phenotypes using a clustering approach

  2011cited by this paper
• Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program.

  2011cited by this paper
• Exhaled nitric oxide and clinical phenotypes of childhood asthma

  2011cited by this paper
• Medication use, emergency hospital care utilization, and quality-of-life outcome disparities by race/ethnicity among adults with asthma.

  2010cited by this paper
• Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study.

  2010cited by this paper
• Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program.

  2010cited by this paper
• Allergy Frontiers: Diagnosis and Health Economics

  2009cited by this paper
• Distinct clinical phenotypes of airways disease defined by cluster analysis

  2009cited by this paper
• The irreversible component of persistent asthma.

  2009cited by this paper
• Distinguishing phenotypes of childhood wheeze and cough using latent class analysis

  2008cited by this paper
• Outcome Measures in Asthma Management

  2008cited by this paper
• Cluster analysis and clinical asthma phenotypes.

  2008cited by this paper
• Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma

  2007cited by this paper
• Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007.

  2007cited by this paper
• Demographic and clinical characteristics of children and adolescents with severe or difficult-to-treat asthma.

  2006cited by this paper
• Asthma: defining of the persistent adult phenotypes.

  2006cited by this paper
• Aspirin sensitivity and severity of asthma: evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthma.

  2005cited by this paper
• Severe asthma in adults.

  2005cited by this paper
• Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma.

  2004influential reference
• The relationship of sex to asthma prevalence, health care utilization, and medications in a large managed care organization.

  2003cited by this paper
• Association of asthma control with health care utilization: a prospective evaluation.

  2002cited by this paper
• Racial/ethnic variation in asthma status and management practices among children in managed medicaid.

  2002cited by this paper
• The relation of socioeconomic factors and racial/ethnic differences in US asthma mortality.

  2000cited by this paper
• Pathophysiology of severe asthma.

  2000cited by this paper
• Development and validation of the Mini Asthma Quality of Life Questionnaire.

  1999cited by this paper
• Characteristics of patients with asthma within a large HMO: a comparison by age and gender.

  1998cited by this paper
• Standardization of Spirometry, 1994 Update. American Thoracic Society.

  1995cited by this paper
• Hierarchical Grouping to Optimize an Objective Function

  1963cited by this paper

• Global, Regional, and National Burden of Asthma from 1990 to 2021: A Comprehensive Analysis of Gender and Region-Level Disparities.

  2026cites this paper
• Lysophosphatidylcholine 18:2 exacerbates Th17-dominant inflammation in obese asthma.

  2026cites this paper
• Asthma Phenotypes and Biomarkers

  2025influential citation
• Phenotypes and endotypes of asthma in children

  2025cites this paper
• High Serum Thymic Stromal Lymphopoietin (TSLP) Is Characteristic of Late‐Onset, Long‐Duration, Eosinophilic Asthma

  2025cites this paper
• Tirzepatide improves neutrophilic inflammation in obese asthmatic mice by downregulating Th17 cell differentiation

  2025cites this paper
• Obesity-Associated Metabolomic and Functional Reprogramming in Neutrophils from Horses with Asthma

  2025cites this paper
• Management of patients with comorbid asthma and obesity: A large language model evaluation of clinical documentation.

  2025cites this paper
• Enhancing Phenotype Discovery in Electronic Health Records through Prior Knowledge-Guided Unsupervised Learning

  2025cites this paper
• Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry

  2025cites this paper
• Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study

  2025cites this paper
• Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review

  2025cites this paper
• Dietary Habits and Their Impact on Pediatric Obesity and Asthma: A Narrative Review with Emphasis on the Mediterranean Diet

  2025cites this paper
• Fungal immunomodulatory protein FIP-fve mitigates airway inflammation and metabolic dysfunction in an obese allergic asthma model

  2025cites this paper
• Treatable Traits in Asthma: The importance of extra- pulmonary traits - GERD, CRSwNP, Atopic Dermatitis, and Depression/Anxiety.

  2024cites this paper
• Phenotypes of occupational bronchial asthma: external respiration status and quality of life

  2024cites this paper
• Novel Machine Learning Identifies Five Asthma Phenotypes Using Cluster Analysis of Real-World Data.

  2024cites this paper
• Importance of diet in children and adolescents with obesity and asthma

  2024cites this paper
• Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma

  2024cites this paper
• Metabolic and weight components' impact on incident asthma using a real-world cohort.

  2024cites this paper
• Clinical and pathogenetic features and polymorphic gene variants in various phenotypes of occupational bronchial asthma

  2024cites this paper
• The Role of Peptides in Asthma–Obesity Phenotype

  2024influential citation
• Targeting Lipid Metabolism in Obese Asthma: Perspectives and Therapeutic Opportunities

  2024cites this paper
• The Impact of High-Fructose Diet and Co-Sensitization to House Dust Mites and Ragweed Pollen on the Modulation of Airway Reactivity and Serum Biomarkers in Rats

  2024cites this paper
• Associations of advanced lung cancer inflammation index with all-cause and respiratory disease mortality in adults with asthma: NHANES, 1999–2018

  2024cites this paper
• Clinical and functional features and quality of life in various phenotypes of occupational asthma

  2024cites this paper
• What's new in pediatric asthma and rhinitis phenotypes and endotypes?

  2024cites this paper
• Obesity-related asthma and its relationship with microbiota

  2024cites this paper
• Cluster analysis of phenotypes, job exposure, and inflammatory patterns in elderly and nonelderly asthma patients.

  2024cites this paper
• Clinical characteristics of obese, fixed airway obstruction, exacerbation-prone phenotype and comorbidities among severe asthma patients: a single-center study

  2024cites this paper
• Targeted therapy for severe bronchial asthma: Phenotyping of patients and algorithm for selecting a genetically engineered biological drug

  2024cites this paper
• Childhood asthma phenotypes and endotypes: a glance into the mosaic

  2023cites this paper
• The Impact of Body Mass Index on Asthma Attacks Severity in Children with Asthma

  2023cites this paper
• Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma

  2023cites this paper
• Clinical impact of obesity on oscillometry lung mechanics in adult asthmatics.

  2023cites this paper
• Lung Function and Asthma Clinical Control in N-ERD Patients, Three-Year Follow-Up in the Context of Real-World Evidence

  2023cites this paper
• The profile of severe asthmatics: Results from a specialized asthma clinic

  2023influential citation
• Non-steroidal anti-inflammatory drugs exacerbated respiratory disease – a condition overlooked by anesthesiologist

  2023cites this paper
• Management of comorbidities in difficult and severe asthma

  2023influential citation
• The phenotypic heterogeneity of obese and nonobese patients with severe asthma and comparison of omalizumab–mepolizumab treatment efficiency in these patients

  2023cites this paper
• Effect of Azithromycin on Exacerbations in Asthma Patients with Obesity: Protocol for a Multi-Center, Prospective, Single-Arm Intervention Study

  2023cites this paper
• Comparing asthma control assessment using the Asthma Control Test and the Asthma APGAR in African American/Black and Hispanic/Latinx populations

  2023cites this paper
• Severity of adult-onset asthma - a matter of blood neutrophils and severe obesity.

  2023cites this paper
• Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma

  2022cites this paper
• Association of mold levels in urban children's homes with difficult- Association of mold levels in urban children's homes with difficult-to-control asthma to-control asthma

  2022cites this paper
• Obesity affects pulmonary function in Japanese adult patients with asthma, but not those without asthma

  2022cites this paper
• Determinants of Severe Asthma – A Long-Term Cohort Study in Northern Sweden

  2022cites this paper
• Mitoquinone mesylate attenuates pathologic features of lean and obese allergic asthma in mice.

  2022cites this paper
• Cluster Analysis of Patients with Chronic Rhinosinusitis and Asthma after Endoscopic Sinus Surgery.

  2022cites this paper
• Classifications of moderate to severe asthma phenotypes in Japan and analysis of serum biomarkers: A Nationwide Cohort Study in Japan (NHOM Asthma Study).

  2022cites this paper
• Allergic Polysensitization Clusters: Newly Recognized Severity Marker in Urban Asthmatic Adults

  2022cites this paper
• Body Composition-Specific Asthma Phenotypes: Clinical Implications

  2022cites this paper
• Leukocyte redistribution as immunological biomarker of corticosteroid resistance in severe asthma

  2022cites this paper
• [The diagnostic approach to difficult-to-treat asthma and severe asthma].

  2022cites this paper
• Neutrophils and Asthma

  2022cites this paper
• Therapeutic Ketosis Decreases Methacholine Hyperresponsiveness in Mouse Models of Inherent Obese Asthma.

  2021cites this paper
• Heterogeneity of Mild to Moderate Persistent Asthma in Children: Confirmation by Latent Class Analysis and Association With 1-Year Outcomes

  2021cites this paper
• Stratified approaches for using biomarkers in phenotyping for the management of severe asthma in India

  2021cites this paper
• Evaluating the glucagon-like peptide-1 receptor in managing asthma

  2021cites this paper
• Central airway collapse is related to obesity independent of asthma phenotype

  2021cites this paper
• The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions

  2021cites this paper
• FASE-CPHG Study: identification of asthma phenotypes in the French Severe Asthma Study using cluster analysis

  2021cites this paper
• Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma

  2021cites this paper
• EFFECTS OF PATIENT COUNSELING ON DRUG DOSE REGIME AND MEDICATION COMPLIANCE IN ASTHMA PATIENTS: A PROSPECTIVE STUDY

  2021cites this paper
• Trajectories of asthma and allergy symptoms from childhood to adulthood

  2021cites this paper
• Cluster modelling of longitudinal disease data: asthma and potential clinical phenotypes

  2021cites this paper
• Association Between Environmental Factors and Asthma Using Mendelian Randomization: Increased Effect of Body Mass Index on Adult-Onset Moderate-to-Severe Asthma Subtypes

  2021cites this paper
• Asthma clustering methods: a literature-informed application to the children’s health study data

  2021cites this paper
• Association of Mold Levels in Urban Children's Homes with Difficult-to-Control Asthma.

  2021cites this paper
• Metformin prevents airway hyperreactivity in rats with dietary obesity.

  2021cites this paper
• Novel therapeutic approaches targeting endotypes of severe airway disease

  2021cites this paper
• Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry (ISAR).

  2021cites this paper
• Aspirin desensitization in NSAID-exacerbated respiratory disease and its outcomes in the clinical course of asthma: A systematic review of the literature and meta-analysis

  2021cites this paper
• Combined unsupervised-supervised machine learning for phenotyping complex diseases with its application to obstructive sleep apnea

  2021cites this paper
• Asthma Exacerbations in Patients with Type 2 Diabetes and Asthma on Glucagon-like Peptide-1 Receptor Agonists

  2021cites this paper
• Diagnosing, Monitoring and Treating Asthma

  2021cites this paper
• A Systematic Review of Asthma Phenotypes Derived by Data-Driven Methods

  2021influential citation
• Pioglitazone prevents obesity-related airway hyperreactivity and neuronal M2 receptor dysfunction.

  2021cites this paper
• Asthme et obésité de l’adulte

  2021cites this paper
• Heterogeneity of Childhood Asthma in Korea: Cluster Analysis of the Korean Childhood Asthma Study Cohort

  2020cites this paper
• Monoclonal antibodies for the treatment of severe asthma

  2020cites this paper
• Higher body mass index is associated with increased lung stiffness and less airway obstruction in individuals with asthma and fixed airflow obstruction

  2020cites this paper
• The Possible Dual Role of the ACE2 Receptor in Asthma and Coronavirus (SARS-CoV2) Infection

  2020cites this paper
• Clinical phenotypes of patients hospitalized for an asthma exacerbation: prognostic implications.

  2020cites this paper
• Asthma in Children and Adults – What are The Differences and What Can They Tell us About Asthma?

  2020cites this paper
• Evolving phenotypes to endotypes: is precision medicine achievable in asthma?

  2020cites this paper
• Asthma Exacerbations in Type 2 Diabetics with Asthma on Glucagon-like Peptide-1 Receptor Agonists.

  2020cites this paper
• Bronchodilator dose responsiveness in children and adolescents: Clinical features and association with future asthma exacerbations.

  2020cites this paper
• Contribution of systemic and airway immune responses to pediatric obesity-related asthma.

  2020cites this paper
• Early Higher BMI is associated with increased lung stiffness and less airway obstruction in individuals with asthma and fixed airflow obstruction

  2020cites this paper
• eNose breathprints as a surrogate biomarker for classifying asthma patients by atopy.

  2020cites this paper
• Comorbid Obesity and Depressive Symptoms in Childhood Asthma: A Harmful Synergy.

  2020cites this paper
• The Nonantibiotic Macrolide EM900 Attenuates House Dust Mite-Induced Airway Inflammation in a Mouse Model of Obesity-Associated Asthma

  2020cites this paper
• Neutrophilic asthma: a complex phenotype of severe asthma

  2020cites this paper
• Latent Class Analysis of School-Age Children at Risk for Asthma Exacerbation.

  2020cites this paper
• eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy

  2020cites this paper
• Outlooks of bronchial provocation pattern in obesity

  2020cites this paper
• Are We meeting the Promise of Endotypes and Precision Medicine in Asthma.

  2020cites this paper
• Mepolizumab effectiveness and identification of super-responders in severe asthma

  2020cites this paper
• Contribution of IL-17 in Steroid Hyporesponsiveness in Obese Asthmatics Through Dysregulation of Glucocorticoid Receptors α and β

  2020cites this paper