Polyelectrolyte Multilayered Capsules as Biomedical Tools

Polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method have become powerful tools for different biomedical applications, which include drug delivery, theranosis or biosensing. However, the exploitation of PEMUCs in the biomedical field requires a deep understanding of the most fundamental bases underlying their assembly processes, and the control of their properties to fabricate novel materials with optimized ability for specific targeting and therapeutic capacity. This review presents an updated perspective on the multiple avenues opened for the application of PEMUCs to the biomedical field, aiming to highlight some of the most important advantages offered by the LbL method for the fabrication of platforms for their use in the detection and treatment of different diseases.

• Publication year

  2022

• Venue

  Polymers

• Publication date

  2022-01-25

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.3390/polym14030479PMID 35160468PMCID 8838751
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field

  2021cited by this paper
• Polyelectrolyte Multilayers on Soft Colloidal Nanosurfaces: A New Life for the Layer-By-Layer Method

  2021influential reference
• Physico-chemical study of polymer mixtures formed by a polycation and a zwitterionic copolymer in aqueous solution and upon adsorption onto negatively charged surfaces

  2021cited by this paper
• New sight at the organization of layers of multilayer polyelectrolyte microcapsules

  2021cited by this paper
• A microwave-triggered opening of the multifunctional polyelectrolyte capsules with nanodiamonds in the shell composition

  2021cited by this paper
• Mimicking natural strategies to create multi-environment enzymatic reactors: From natural cell compartments to artificial polyelectrolyte reactors.

  2021cited by this paper
• Supramolecular dendrimer-containing layer-by-layer nanoassemblies for bioapplications: current status and future prospects

  2021cited by this paper
• Tailored gentamicin release from silica nanocarriers coated with polyelectrolyte multilayers

  2021cited by this paper
• Multifunctional nanostructured drug delivery carriers for cancer therapy: Multimodal imaging and ultrasound-induced drug release.

  2021cited by this paper
• Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment

  2021cited by this paper
• Biodegradable polyelectrolyte/magnetite capsules for MR imaging and magnetic targeting of tumors

  2021cited by this paper
• An investigation of calcium carbonate core-shell particles for incorporation of 225Ac and sequester of daughter radionuclides: In vitro and in vivo studies.

  2021cited by this paper
• Histopathological analysis of zebrafish after introduction of non-biodegradable polyelectrolyte microcapsules into the circulatory system

  2021cited by this paper
• Fabrication of Robust Capsules by Sequential Assembly of Polyelectrolytes onto Charged Liposomes

  2021cited by this paper
• Calcium Carbonate Core-Shell Particles for Incorporation of 225Ac and Their Application in Local α-Radionuclide Therapy.

  2021cited by this paper
• Multilayer Dextran Derivative Based Capsules Fighting Bacteria Resistant to Antibiotic: Case of Kanamycin-Resistant Escherichia coli.

  2021cited by this paper
• Layer-by-Layer assembled nano-drug delivery systems for cancer treatment

  2021cited by this paper
• Boosting transfection efficiency: A systematic study using layer-by-layer based gene delivery platform.

  2021cited by this paper
• Optimally designed theranostic system based folic acids and chitosan as a promising mucoadhesive delivery system for encapsulating curcumin LbL nano-template against invasiveness of breast cancer.

  2021cited by this paper
• Layer-by-Layer technique as a versatile tool for gene delivery applications

  2021cited by this paper
• There is still plenty of room for layer-by-layer assembly for constructing nanoarchitectonics-based materials and devices.

  2021cited by this paper
• Hollow microcapsule with pH-sensitive chitosan/polymer shell for in vitro delivery of curcumin and gemcitabine

  2021cited by this paper
• Formulation of Folate-Modified Raltitrexed-Loaded Nanoparticles for Colorectal Cancer Theranostics

  2020cited by this paper
• In Vitro Bioeffects of Polyelectrolyte Multilayer Microcapsules Post-Loaded with Water-Soluble Cationic Photosensitizer

  2020cited by this paper
• Multilayer Microcapsules with Shell-Chelated 89Zr for PET Imaging and Controlled Delivery.

  2020cited by this paper
• Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy

  2020cited by this paper
• Multilayer Capsules Encapsulating Nimbin and Doxorubicin for Cancer Chemo-Photothermal Therapy.

  2020cited by this paper
• Quantitative Assessment of Endosomal Escape of Various Endocytosed Polymer-Encapsulated Molecular Cargos upon Photothermal Heating.

  2020cited by this paper
• Layer-by-layer fabrication of 3D hydrogel structures using open microfluidics.

  2020cited by this paper
• Nanoparticles in Polyelectrolyte Multilayer Layer-by-Layer (LbL) Films and Capsules—Key Enabling Components of Hybrid Coatings

  2020cited by this paper
• Dual Transport of Active Substances with a Layer-by-Layer-Based Drug Delivery System to Terminate Inflammatory Processes.

  2020cited by this paper
• All‐Optical Nanoscale Heating and Thermometry with Resonant Dielectric Nanoparticles for Controllable Drug Release in Living Cells

  2020cited by this paper
• Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

  2020cited by this paper
• Layer-by-Layer Biomaterials for Drug Delivery.

  2020cited by this paper
• A closer physico-chemical look to the Layer-by-Layer electrostatic self-assembly of polyelectrolyte multilayers.

  2020influential reference
• Layer‐by‐Layer‐Assembled Capsule Size Affects the Efficiency of Packaging and Delivery of Different Genetic Cargo

  2020cited by this paper
• Layer-by-layer coated nanoliposomes for oral delivery of insulin.

  2020cited by this paper
• Adsorption of Mixtures of a Pegylated Lipid with Anionic and Zwitterionic Surfactants at Solid/Liquid

  2020cited by this paper
• Enhanced cytotoxicity caused by AC magnetic field for polymer microcapsules containing packed magnetic nanoparticles.

  2020cited by this paper
• Development of Gene Therapy Vectors: Remaining Challenges.

  2020cited by this paper
• The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Möhwald.

  2019cited by this paper
• Influence of Heat Treatment on Loading of Polymeric Multilayer Microcapsules with Rhodamine B.

  2019cited by this paper
• Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing.

  2019cited by this paper
• Layer-by-Layer Fabrication of 3D Hydrogel Structures Using Open Microfluidics

  2019cited by this paper
• Magnetically targetable microcapsules display subtle changes in permeability and drug release in response to a biologically compatible low frequency alternating magnetic field.

  2019cited by this paper
• Focused ultrasound-mediated fluorescence of composite microcapsules loaded with magnetite nanoparticles: In vitro and in vivo study.

  2019cited by this paper
• Doxorubicin-loaded biodegradable capsules: Temperature induced shrinking and study of cytotoxicity in vitro

  2019cited by this paper
• Recent Developments in Layer-by-Layer Technique for Drug Delivery Applications.

  2019cited by this paper
• Confining iron oxide nanocubes inside submicrometric cavities as a key strategy to preserve magnetic heat losses in an intracellular environment.

  2019cited by this paper
• Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition.

  2019cited by this paper
• Hyaluronic acid/poly(ethylenimine) polyelectrolyte multilayer coatings for siRNA-mediated local gene silencing

  2019cited by this paper
• Bioelectrochemical Properties of Enzyme-Containing Multilayer Polyelectrolyte Microcapsules Modified with Multiwalled Carbon Nanotubes

  2019cited by this paper
• Liposome Crosslinked Polyacrylamide/DNA Hydrogel: a Smart Controlled-Release System for Small Molecular Payloads.

  2018cited by this paper
• Layer-by-layer hollow photosensitizer microcapsule design via a manganese carbonate hard template for photodynamic therapy in cells.

  2018cited by this paper
• Internal Structure of Matrix-Type Multilayer Capsules Templated on Porous Vaterite CaCO3 Crystals as Probed by Staining with a Fluorescence Dye

  2018cited by this paper
• Layer-by-layer DNA films incorporating highly transfecting bioreducible poly(amido amine) and polyethylenimine for sequential gene delivery

  2018cited by this paper
• Multilayer Hydrogel Capsules of Interpenetrated Network for Encapsulation of Small Molecules.

  2018cited by this paper
• Chitosan–alginate BSA-gel-capsules for local chemotherapy against drug-resistant breast cancer

  2018cited by this paper
• Controlled rupture of magnetic LbL polyelectrolyte capsules and subsequent release of contents employing high intensity focused ultrasound

  2018cited by this paper
• Intracellular Delivery of Antioxidant CeO2 Nanoparticles via Polyelectrolyte Microcapsules.

  2018cited by this paper
• Ion distribution in dry polyelectrolyte multilayers: a neutron reflectometry study.

  2018cited by this paper
• Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

  2018cited by this paper
• Ultrasound‐Triggered Delivery of Anticancer Therapeutics from MRI‐Visible Multilayer Microcapsules

  2018cited by this paper
• Poly-L-ornithine/fucoidan-coated calcium carbonate microparticles by layer-by-layer self-assembly technique for cancer theranostics

  2018cited by this paper
• Layer-by-Layer polyelectrolyte assemblies for encapsulation and release of active compounds.

  2017cited by this paper
• Layer-by-layer assembled biopolymer microcapsule with separate layer cavities generated by gas-liquid microfluidic approach.

  2017cited by this paper
• Protein A Functionalized Polyelectrolyte Microcapsules as a Universal Platform for Enhanced Targeting of Cell Surface Receptors.

  2017cited by this paper
• Theranostic Multilayer Capsules for Ultrasound Imaging and Guided Drug Delivery.

  2017cited by this paper
• Novel polymeric micelles for insect pest control: encapsulation of essential oil monoterpenes inside a triblock copolymer shell for head lice control

  2017cited by this paper
• Engineering and Design of Polymeric Shells: Inwards Interweaving Polymers as Multilayer Nanofilm, Immobilization Matrix, or Chromatography Resins.

  2017cited by this paper
• Rethinking cancer nanotheranostics.

  2017cited by this paper
• Release from Polyelectrolyte Multilayer Capsules in Solution and on Polymeric Surfaces

  2017cited by this paper
• Insulin-loaded PLGA microspheres for glucose-responsive release

  2017cited by this paper
• Polyelectrolyte nanocapsules containing iron oxide nanoparticles as MRI detectable drug delivery system

  2017cited by this paper
• Highly efficient delivery of potent anticancer iminoquinone derivative by multilayer hydrogel cubes.

  2017cited by this paper
• Equilibrium Overcompensation in Polyelectrolyte Complexes

  2017cited by this paper
• 3D solid supported inter-polyelectrolyte complexes obtained by the alternate deposition of poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate)

  2016cited by this paper
• Comment on "Formation of polyelectrolyte multilayers: ionic strengths and growth regimes" by K. Tang and A. M. Besseling, Soft Matter, 2016, 12, 1032.

  2016cited by this paper
• Automatic Assembly of Ultra-Multilayered Nanotube-Nanoparticle Composites.

  2016cited by this paper
• Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin.

  2016cited by this paper
• Layer‐by‐Layer Assemblies for Cancer Treatment and Diagnosis

  2016cited by this paper
• Cellular uptake and intracellular fate of protein releasing bacterial amyloids in mammalian cells.

  2016cited by this paper
• Synthesis of polyelectrolyte nanocapsules with iron oxide (Fe3O4) nanoparticles for magnetic targeting

  2016cited by this paper
• Innovation in Layer-by-Layer Assembly.

  2016cited by this paper
• High Throughput Layer-by-Layer Films for Extracting Film Forming Parameters and Modulating Film Interactions with Cells.

  2016cited by this paper
• Fabrication of polyelectrolyte multilayered nano-capsules using a continuous layer-by-layer approach.

  2016influential reference
• Nanoemulsion-templated polylelectrolyte multifunctional nanocapsules for DNA entrapment and bioimaging.

  2016cited by this paper
• Layer-by-layer modification of high surface curvature nanoparticles with weak polyelectrolytes using a multiphase solvent precipitation process.

  2016cited by this paper
• Zero-order release of polyphenolic drugs from dynamic, hydrogen-bonded LBL films.

  2016cited by this paper
• Protein-Containing Multilayer Capsules by Templating on Mesoporous CaCO3 Particles: POST- and PRE-Loading Approaches.

  2016cited by this paper
• Thermoresponsive physical hydrogels of poly(lactic acid)/poly(ethylene glycol) stereoblock copolymers tuned by stereostructure and hydrophobic block sequence.

  2016cited by this paper
• Bacteria-triggered degradation of nanofilm shells for release of antimicrobial agents.

  2016cited by this paper
• Effect of pH on the structure and drug release profiles of layer-by-layer assembled films containing polyelectrolyte, micelles, and graphene oxide

  2016cited by this paper
• Hybrid Polyelectrolyte/Fe3O4 Nanocapsules for Hyperthermia Applications.

  2016cited by this paper
• Biodegradable protein-based rockets for drug transportation and light-triggered release.

  2015cited by this paper
• Assembly-Controlled Permeability of Layer-by-Layer Polymeric Microcapsules Using a Tapered Fluidized Bed.

  2015cited by this paper
• Synthesis of biocompatible polymeric nano-capsules based on calcium carbonate: A potential cisplatin delivery system.

  2015cited by this paper
• Layer-by-layer engineered nanocapsules of curcumin with improved cell activity.

  2015cited by this paper
• Biocompatible long-sustained release oil-core polyelectrolyte nanocarriers: From controlling physical state and stability to biological impact.

  2015cited by this paper
• Technology-driven layer-by-layer assembly of nanofilms

  2015influential reference

• Multilayer nanoarchitectonics of polypeptide capsules with size-selective permeability.

  2026cites this paper
• Beyond slurry Systems: Chitosan thin film Fabrication, Mechanism, and reusability for sustainable textile effluent remediation

  2025cites this paper
• Intermolecular Interactions in the Formation of Polymer and Nanocomposite Microcapsules by Layer-by-Layer Assembly Method

  2025cites this paper
• Synergistic effect of DR5-targeted capsules loaded with doxorubicin in drug-resistant 3D tumour spheroids

  2025cites this paper
• A Novel Prednisolone-Loaded Layer-by-Layer Nanoparticles (LBL-NPs) for Rheumatoid Arthritis: Optimization and Therapeutic Evaluation

  2025cites this paper
• Control of the self-assembly and properties of quaternized dextran/heparin polyelectrolyte multilayer films by the degree of dextran substitution.

  2025cites this paper
• Microbially Inspired Calcium Carbonate Precipitation Pathway Integrated Polyelectrolyte Capsules (MICPC) for Biomolecules Release.

  2024cites this paper
• Chitosan/bovine serum albumin layer-by-layer assembled particles for non-invasive inhaled drug delivery to the lungs.

  2024cites this paper
• Cytostatic drug mitoxantrone delivery platform based on porous vaterite particles: Synthesis, characterization and release

  2024cites this paper
• Nanotechnology in medicine revolutionizing drug delivery for cancer and viral infection treatments.

  2024cites this paper
• Coating of liposomes with β-glucans from the king oyster mushroom (Pleurotus eryngii)

  2024cites this paper
• Polysaccharide-based polyelectrolyte multilayers fabricated via layer-by-layer approach: From preparation to applications

  2024cites this paper
• Chitosan-based layer-by-layer edible coatings application for the preservation of mandarin fruit bioactive compounds and organic acids

  2023cites this paper
• Probing the effect of the capping polyelectrolyte on the internal structure of Layer-by-Layer decorated nanoliposomes.

  2023cites this paper
• Doxorubicin-Loaded Polyelectrolyte Multilayer Capsules Modified with Antitumor DR5-Specific TRAIL Variant for Targeted Drug Delivery to Tumor Cells

  2023cites this paper
• Nylon-6-Coated Doxorubicin-Loaded Magnetic Nanoparticles and Nanocapsules for Cancer Treatment

  2023cites this paper
• Layer-by-Layer Nanoassemblies for Vaccination Purposes

  2023cites this paper
• Mineralization of Shells of Emulsion Polyelectrolyte Microcapsules by Calcium Carbonate

  2023cites this paper
• Polyelectrolyte Microcapsules: On the Formation and Possibilities of Regulating Multilayer Structures

  2022cites this paper
• A decade of developing applications exploiting the properties of polyelectrolyte multilayer capsules.

  2022cites this paper
• Stimuli-responsive polyelectrolyte multilayer films and microcapsules.

  2022cites this paper
• Advances in polysaccharide-based nano/microcapsules for biomedical applications: A review.

  2022cites this paper
• Layer-by-Layer Materials for the Fabrication of Devices with Electrochemical Applications

  2022cites this paper