Detection of tissue pH with quantitative chemical exchange saturation transfer magnetic resonance imaging

Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has emerged as a novel means for sensitive detection of dilute labile protons and chemical exchange rates. By sensitizing to pH‐dependent chemical exchange, CEST MRI has shown promising results in monitoring tissue statuses such as pH changes in disorders like acute stroke, tumor, and acute kidney injury. This article briefly reviews the basic principles for CEST imaging and quantitative measures, from the simplistic asymmetry analysis to multipool Lorentzian decoupling and quasi‐steady‐state reconstruction. In particular, the advantages and limitations of commonly used quantitative approaches for CEST applications are discussed.

• Publication year

  2022

• Venue

  NMR in Biomedicine

• Publication date

  2022-02-10

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/nbm.4711PMID 35141979PMCID PMC10249910
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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