Malaria Prophylaxis: A Comprehensive Review

The flow of international travellers to and from malaria-endemic areas, especially Africa, has increased in recent years. Apart from the very high morbidity and mortality burden imposed on malaria-endemic areas, imported malaria is the main cause of fever possibly causing severe disease and death in travellers coming from tropical and subtropical areas, particularly Sub-Saharan Africa. The importance of behavioural preventive measures (bed nets, repellents, etc.), adequate chemoprophylaxis and, in selected circumstances, stand-by emergency treatment may not be overemphasized. However, no prophylactic regimen may offer complete protection. Expert advice is needed to tailor prophylactic advice according to traveller (age, baseline clinical conditions, etc.) and travel (destination, season, etc.) characteristics in order to reduce malaria risk.

• Publication year

  2010

• Venue

  Pharmaceuticals

• Publication date

  2010-10-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.3390/ph3103212PMCID 4034089
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• WHO Guidelines for the treatment of malaria

  2011cited by this paper
• Lower atovaquone and proguanil concentrations in patients taking efavirenz, lopinavir + ritonavir or atazanavir + ritonavir

  2011cited by this paper
• pfmdr1 Amplification and Fixation of pfcrt Chloroquine Resistance Alleles in Plasmodium falciparum in Venezuela

  2010cited by this paper
• Epidemiologic Features Impacting the Presentation of Malaria in Children in Houston

  2010cited by this paper
• Expert review of the evidence base for arthropod bite avoidance.

  2010cited by this paper
• Imported malaria in children: incidence and risk factors for severity.

  2010cited by this paper
• [Malaria prophylaxis in the traveler].

  2010cited by this paper
• Severe Malaria in Immigrant Population: A Retrospective Review

  2010cited by this paper
• [Pregnancy and travelling].

  2010cited by this paper
• HIV protease inhibitors, indinavir or nelfinavir, augment antimalarial action of artemisinin in vitro.

  2010cited by this paper
• Profilaxis de la malaria en el viajero

  2010cited by this paper
• Susceptibility of Plasmodium falciparum isolates to doxycycline is associated with pftetQ sequence polymorphisms and pftetQ and pfmdt copy numbers.

  2010cited by this paper
• Guidelines for the treatment of malaria

  2010cited by this paper
• Plasmodium infection and its risk factors in eastern Uganda

  2010cited by this paper
• [A fifth plasmodium that can cause malaria].

  2010cited by this paper
• [Impact of malaria during pregnancy in the Amazon region].

  2009cited by this paper
• [Retinal damage by (hydroxy)chloroquine intake: published evidence for an efficient ophthalmological follow-up].

  2009cited by this paper
• The risk of malaria in travelers to India.

  2009cited by this paper
• Imported Malaria in Children in Industrialized Countries, 1992–2002

  2009cited by this paper
• Randomized, Double-Blind Study of the Safety, Tolerability, and Efficacy of Tafenoquine versus Mefloquine for Malaria Prophylaxis in Nonimmune Subjects

  2009cited by this paper
• Clinical and laboratory features of human Plasmodium knowlesi infection.

  2009cited by this paper
• Effectiveness of malaria chemoprophylaxis against Plasmodium falciparum infection in UK travellers: retrospective observational data.

  2009cited by this paper
• Resistance to Therapies for Infection by Plasmodium vivax

  2009cited by this paper
• Epileptogenic potential of mefloquine chemoprophylaxis: a pathogenic hypothesis

  2009cited by this paper
• Effect of two different house screening interventions on exposure to malaria vectors and on anaemia in children in The Gambia: a randomised controlled trial.

  2009cited by this paper
• The standard of malaria prevention advice in UK primary care.

  2009cited by this paper
• Modeling the risk of malaria for travelers to areas with stable malaria transmission

  2009cited by this paper
• Malária durante a gravidez: efeito sobre o curso da gestação na região amazônica

  2009cited by this paper
• Illness in Long-Term Travelers Visiting GeoSentinel Clinics

  2009influential reference
• Evaluation of mood profiles during malaria chemoprophylaxis: a randomized, double-blind, four-arm study.

  2009cited by this paper
• Imported malaria among African immigrants: is there still a relationship between developed countries and their ex-colonies?

  2009cited by this paper
• Managing insecticide resistance in malaria vectors by combining carbamate-treated plastic wall sheeting and pyrethroid-treated bed nets

  2009cited by this paper
• Efficacy of four insect repellents against mosquito bites: a double‐blind randomized placebo‐controlled field study in Senegal

  2009cited by this paper
• [Prevention with repellent in children].

  2009cited by this paper
• Schwangerschaft und Reisen

  2009cited by this paper
• Drugs for preventing malaria in travellers

  2009cited by this paper
• Updates

  2009influential reference
• [Febrile torticollis: an atypical presentation of Kawasaki disease].

  2009cited by this paper
• Human Plasmodium knowlesi infections in young children in central Vietnam

  2009cited by this paper
• Quality of anti-malarial drugs provided by public and private healthcare providers in south-east Nigeria

  2009cited by this paper
• An Advisory Committee Statement (ACS)

  2009cited by this paper
• House screening for malaria control.

  2009cited by this paper
• Mixture for Controlling Insecticide-Resistant Malaria Vectors

  2008cited by this paper
• Identification and geographic distribution of the ACE-1R mutation in the malaria vector Anopheles gambiae in south-western Burkina Faso, West Africa.

  2008cited by this paper
• Clinical practice. Malaria prevention in short-term travelers.

  2008cited by this paper
• Declining incidence of malaria imported into the UK from West Africa

  2008cited by this paper
• Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening.

  2008cited by this paper
• Assessment of acceptability and ease of use of atovaquone/proguanil medication in subjects undergoing malaria prophylaxis

  2008cited by this paper
• Prevalence of contraindications to mefloquine use among USA military personnel deployed to Afghanistan

  2008cited by this paper
• Performance of self-diagnosis and standby treatment of malaria in international oilfield service employees in the field

  2008cited by this paper
• Transfer of chloroquine and desethylchloroquine across the placenta and into milk in Melanesian mothers.

  2008cited by this paper
• Plasmodium knowlesi: the fifth human malaria parasite.

  2008cited by this paper
• Imported schistosomiasis in Europe: preliminary data for 2007 from TropNetEurop.

  2008cited by this paper
• Imported falciparum malaria in Europe: 2007 data from TropNetEurop.

  2008cited by this paper
• Neuromuscular training and the risk of leg injuries in female floorball players: cluster randomised controlled study

  2008cited by this paper
• Chapter 26 – The Traveler with HIV

  2008cited by this paper
• Failure of atovaquone/proguanil to prevent Plasmodium ovale malaria in traveler returning from Cameroon.

  2008influential reference
• Malaria Chemoprophylaxis: Strategies for Risk Groups

  2008influential reference
• In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand

  2008influential reference
• International travel and health: situation as on 1 January 2007

  2007cited by this paper
• Prevention of malaria in long-term travelers.

  2007influential reference
• Chloroquine prophylaxis against vivax malaria in pregnancy: a randomized, double‐blind, placebo‐controlled trial

  2007cited by this paper
• [Chloroquine/hydroxychloroquine: variability of retinotoxic cumulative doses].

  2007cited by this paper
• Malaria chemoprophylaxis: what do the travelers choose, and how does pretravel consultation influence their final decision.

  2007cited by this paper
• Malaria risk perception, knowledge and prophylaxis practices among travellers of African ethnicity living in Paris and visiting their country of origin in sub-Saharan Africa.

  2007cited by this paper
• Prevention of malaria in travellers.

  2007cited by this paper
• Atovaquone-proguanil: report from the CDC expert meeting on malaria chemoprophylaxis (II).

  2007cited by this paper
• Reversible hearing loss in temporal association with chemoprophylactic mefloquine use.

  2007cited by this paper
• Chloroquine-induced recurrent psychosis.

  2007cited by this paper
• The safety and tolerance of atovaquone/proguanil for the long-term prophylaxis of plasmodium falciparum malaria in non-immune travelers and expatriates [corrected].

  2007cited by this paper
• Tafenoquine: a promising new antimalarial agent

  2007cited by this paper
• Antimicrobial prevention and therapy for travelers’ infection

  2007cited by this paper
• Protection antivectorielle de l'enfant : insecticides et insectifuges

  2007cited by this paper
• Epidemiology and burden of malaria in pregnancy.

  2007cited by this paper
• Antimalarial drug quality in Africa

  2007cited by this paper
• A systematic review and meta-analysis of the effectiveness and safety of atovaquone proguanil (Malarone) for chemoprophylaxis against malaria.

  2007influential reference
• [Children arthropod bites protective measures: insecticides and repellents].

  2007cited by this paper
• Self-reported adverse events associated with antimalarial chemoprophylaxis in peace corps volunteers.

  2007cited by this paper
• Imported malaria in children: a national surveillance in the Netherlands and a review of European studies.

  2007cited by this paper
• The HIV-positive traveler.

  2007cited by this paper
• Variabilität der retinotoxischen Gesamtdosis Chloroquin/Hydroxychloroquin

  2007cited by this paper
• The immunocompromised traveller. An Advisory Committee Statement (ACS).

  2007cited by this paper
• Tertian malaria (Plasmodium vivax and Plasmodium ovale) in two travelers despite atovaquone-proguanil prophylaxis.

  2006cited by this paper
• Dual Infection with HIV and Malaria Fuels the Spread of Both Diseases in Sub-Saharan Africa

  2006cited by this paper
• Characterization of counterfeit artesunate antimalarial tablets from southeast Asia.

  2006influential reference
• Antimalarial drugs in pregnancy: a review.

  2006cited by this paper
• Do travelers really take their mefloquine malaria chemoprophylaxis? Estimation of adherence by an electronic pillbox.

  2006cited by this paper
• Problem pathogens: prevention of malaria in travellers.

  2006influential reference
• Primaquine: report from CDC expert meeting on malaria chemoprophylaxis I.

  2006cited by this paper
• Malaria prevention and stand-by emergency treatment among Japanese travelers.

  2006cited by this paper
• The impact of endemic and epidemic malaria on the risk of stillbirth in two areas of Tanzania with different malaria transmission patterns

  2006cited by this paper
• Acute hepatitis and atovaquone/proguanil.

  2006cited by this paper
• Long-term malaria prophylaxis for travelers.

  2006cited by this paper
• The safety of atovaquone/proguanil in long-term malaria prophylaxis of nonimmune adults.

  2006cited by this paper
• Knowledge, attitudes, and practices on malaria preventive measures of migrants attending a public health clinic in northern Italy.

  2006cited by this paper
• Imported malaria in an HIV-positive traveler: a case report with a fatal outcome.

  2006cited by this paper
• Malaria prophylaxis for aircrew: safety of atovaquone/proguanil in healthy volunteers under aircraft cabin pressure conditions.

  2006cited by this paper
• Reported side effects to chloroquine, chloroquine plus proguanil, and mefloquine as chemoprophylaxis against malaria in Danish travelers.

  2006cited by this paper
• The efficacy of chemoprophylaxis against malaria with chloroquine plus proguanil, mefloquine, and atovaquone plus proguanil in travelers from Denmark.

  2006cited by this paper
• Post-marketing surveillance: adverse events during long-term use of atovaquone/proguanil for travelers to malaria-endemic countries.

  2006cited by this paper

• Antiplasmodial and antipyretic activities of the Monodora myristica (Annonaceae) seeds

  2025cites this paper
• The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery

  2025cites this paper
• Antimalarial effects of Diospyros chamaethamnus and Guibourtia coleosperma extracts in mice with Plasmodium berghei malaria

  2025cites this paper
• Malaria in the Republic of Ireland; A retrospective review of the clinical epidemiology of malaria between 2016 and 2020

  2024cites this paper
• Characteristics and outcome of patients with malaria presented to a Hong Kong emergency department—A retrospective cohort analysis

  2024cites this paper
• Machine learning approach to identify malaria risk in travelers using real-world evidence

  2024cites this paper
• Nanotechnology-Driven Innovations in Malaria Treatment and Control: Current Challenges and Pharmaceutical Strategies

  2024cites this paper
• Individual- and community-level correlates of intermittent preventive treatment of malaria in pregnancy in Ghana: further analysis of the 2019 Malaria Indicator Survey

  2024cites this paper
• Antimalarial prophylaxis failure: Malaria in a returning traveler despite mefloquine prophylaxis

  2024cites this paper
• Malaria: An Overview

  2023cites this paper
• Synthesis, spectral characterization, DFT studies, and computational screening of 4‐amino‐3‐mercapto‐5‐methyl‐1,2,4‐triazole and its cadmium(II) mixed ligands complexes as potential antimalaria drug

  2023cites this paper
• Lyophilized solid dispersions of artemisinin to improve saturation solubility and dissolution

  2022cites this paper
• Adherence to antimalarial chemoprophylaxis among Israeli travelers visiting malaria-endemic areas.

  2021cites this paper
• Biguanides: Species with versatile therapeutic applications.

  2021cites this paper
• A proteomic glimpse into the effect of antimalarial drugs on Plasmodium falciparum proteome towards highlighting possible therapeutic targets.

  2020cites this paper
• The Use of Antimalarial Drugs against Viral Infection

  2020cites this paper
• The use of proteomics for the identification of promising vaccine and diagnostic biomarkers in Plasmodium falciparum

  2020cites this paper
• Population genomics identifies a distinct Plasmodium vivax population on the China-Myanmar border of Southeast Asia

  2020cites this paper
• Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug-resistant parasites.

  2020cites this paper
• COVID-19 and Malaria: A Fatal Attraction for SARS CoV-2?

  2020cites this paper
• Effectiveness of medicine Malaria Off 200 as mass prophylaxis against Malaria in the high-risk villages of Shahdol, Madhya Pradesh

  2019cites this paper
• Early transmission of sensitive strain slows down emergence of drug resistance in Plasmodium vivax

  2019cites this paper
• Epidemiologic Trends in Malaria Incidence Among Travelers Returning to Metropolitan France, 1996-2016

  2019cites this paper
• Improvement of solubility, dissolution and stability profile of artemether solid dispersions and self emulsified solid dispersions by solvent evaporation method

  2018cites this paper
• Stand-by emergency treatment (SBET) of malaria in Spanish travellers: a cohort study

  2018cites this paper
• Investigating calcium channel blockers as antimalarials

  2018cites this paper
• Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status

  2017cites this paper
• Prophylactic efficacy of primaquine for preventing Plasmodium falciparum and Plasmodium vivax parasitaemia in travelers: A meta-analysis and systematic review.

  2017cites this paper
• Epidemiological and clinical features of imported malaria at the three main hospitals of the Friuli-Venezia Giulia Region, Italy.

  2017cites this paper
• Antimalarial drug discovery using triazoles to overcome chloroquine resistance

  2015cites this paper
• Preparation and Characterization of Solid Dispersions of Artemether by Freeze-Dried Method

  2015cites this paper
• Evaluation of Agrobacterium-mediated Transformation of Chlamydomonas reinhardtii Using a Synthetic Amorpha-4, 11-diene Synthase Gene

  2015cites this paper
• Recrudescence of Plasmodium falciparum malaria in a primigravid woman with anaemia as the only sign of disease

  2014cites this paper
• EVALUATION OF THE EFFECTIVENESS OF ANTIMALARIAL INTERVENTIONS DURING PREGNANCY IN BLANTYRE, MALAWI

  2014influential citation
• Psychiatric Aspects of Infectious Diseases

  2014cites this paper
• "Recycling" classical drugs for malaria.

  2014cites this paper
• Malaria and haematologic parameters of pupils at different altitudes along the slope of Mount Cameroon: a cross-sectional study

  2013cites this paper
• Feasibility study exploring the spatial distribution of Plasmodium falciparum

  2013cites this paper
• when the Parasite Runs into the Virus

  2012cites this paper
• Malaria Chemoprophylaxis for the International Traveler, Current Options and Future Possibilities

  2012cites this paper
• Mefloquine derivatives : synthesis, mechanisms of action, antimicrobial activities.

  2011cites this paper
• Mediterranean Journal of Hematology and Infectious Diseases Malaria and Hiv in Adults: W

  year unknowncites this paper