Association between high serum alanine aminotransferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus‐associated cirrhosis

K. Tarao,Y. Rino,S. Ohkawa,A. Shimizu,S. Tamai,K. Miyakawa,Hiroharu Aoki,T. Imada,K. Shindo,N. Okamoto,Shinichi Totsuka

Published 1999 in Cancer

ABSTRACT

Many studies have demonstrated in animal experiments that persistent inflammation may accelerate the development of carcinoma. In this article, the question of whether the persistent elevation of serum alanine aminotransferase (ALT) levels (which represents the inflammatory necrosis of hepatocytes) correlates with the development of hepatocellular carcinoma (HCC) was studied in patients with early stage hepatitis C virus (HCV)‐associated cirrhosis.

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