Phosphorylation of topoisomerase II by casein kinase II and protein kinase C: effects on enzyme-mediated DNA cleavage/religation and sensitivity to the antineoplastic drugs etoposide and 4'-(9-acridinylamino)methane-sulfon-m-anisidide.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Cancer Research

• Publication date

  1992-04-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 1313738
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Catalytic function of DNA topoisomerase II

  1991influential reference
• Effect of the calmodulin inhibitor trifluoperazine on phosphorylation of P-glycoprotein and topoisomerase II: relationship to modulation of subcellular distribution, DNA damage and cytotoxicity of doxorubicin in multidrug resistant L1210 mouse leukemia cells.

  1991cited by this paper
• Aberrant DNA topoisomerase II activity, radioresistance and inherited susceptibility to cancer.

  1991cited by this paper
• Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells.

  1991cited by this paper
• Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage.

  1991cited by this paper
• Phosphorylation of DNA topoisomerase II in a human tumor cell line.

  1991cited by this paper
• Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.

  1991influential reference
• Evidence that a protein kinase enhances amsacrine mediated formation of topoisomerase II-DNA complexes in murine mastocytoma cell nuclei.

  1991cited by this paper
• Alteration of DNA topoisomerase II activity during infection of H9 cells by human immunodeficiency virus type 1 in vitro: a target for potential therapeutic agents.

  1990influential reference
• DNA topoisomerases as anticancer drug targets.

  1990cited by this paper
• Segregation of recombined chromosomes in meiosis I requires DNA topoisomerase II.

  1990cited by this paper
• Phorbol ester effects on topoisomerase II activity and gene expression in HL-60 human leukemia cells with different proclivities toward monocytoid differentiation.

  1990cited by this paper
• Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.

  1990cited by this paper
• Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.

  1990cited by this paper
• The role of DNA topoisomerases in recombination and genome stability: a double-edged sword?

  1990cited by this paper
• Uncoupling the DNA cleavage and religation activities of topoisomerase II with a single-stranded nucleic acid substrate: evidence for an active enzyme-cleaved DNA intermediate.

  1990cited by this paper
• Topoisomerase II as a target of antileukemia drugs: a review of controversial areas.

  1989cited by this paper
• Regulation of casein kinase II activity by epidermal growth factor in human A-431 carcinoma cells.

  1989cited by this paper
• Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs.

  1989cited by this paper
• Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.

  1989cited by this paper
• Biochemical basis for the interactions of type I and type II topoisomerases with DNA.

  1989influential reference
• Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate.

  1989cited by this paper
• In vivo phosphorylation of the 170-kDa form of eukaryotic DNA topoisomerase II. Cell cycle analysis.

  1989cited by this paper
• Phosphorylation of DNA topoisomerase II in vivo and in total homogenates of Drosophila Kc cells. The role of casein kinase II.

  1988cited by this paper
• Regulation of Xenopus laevis DNA topoisomerase I activity by phosphorylation in vitro.

  1988cited by this paper
• Nuclear topoisomerase II levels correlate with the sensitivity of mammalian cells to intercalating agents and epipodophyllotoxins.

  1988cited by this paper
• Structure and phosphorylation of eukaryotic initiation factor 2. Casein kinase 2 and protein kinase C phosphorylate distinct but adjacent sites in the beta-subunit.

  1988cited by this paper
• DNA topoisomerases in cancer therapy.

  1987cited by this paper
• The influence of basic residues on the substrate specificity of protein kinase C.

  1987cited by this paper
• Role of the divalent cation in topoisomerase II mediated reactions.

  1987cited by this paper
• Specific phosphorylation of proteins in pore complex‐laminae from the sponge Geodia cydonium by the homologous aggregation factor and phorbol ester. Role of protein kinase C in the phosphorylation of DNA topoisomerase II.

  1987cited by this paper
• Role of proliferation in determining sensitivity to topoisomerase II-active chemotherapy agents.

  1987cited by this paper
• Protein serine/threonine kinases.

  1987cited by this paper
• Substrate specificity determinants for casein kinase II as deduced from studies with synthetic peptides.

  1987cited by this paper
• Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form.

  1987cited by this paper
• DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe.

  1987cited by this paper
• The organisation of chromatin loops: characterization of a scaffold attachment site

  1986cited by this paper
• Metaphase chromosome structure. Involvement of topoisomerase II.

  1986cited by this paper
• Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.

  1986cited by this paper
• Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis

  1986cited by this paper
• Studies and perspectives of protein kinase C.

  1986cited by this paper
• Assay and purification of protein kinase C.

  1986cited by this paper
• Topoisomerase II is a structural component of mitotic chromosome scaffolds

  1985cited by this paper
• Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro.

  1985cited by this paper
• DNA topoisomerases.

  1985cited by this paper
• Localization of topoisomerase II in mitotic chromosomes

  1985cited by this paper
• In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction.

  1985cited by this paper
• A synthetic peptide substrate specific for casein kinase II.

  1985cited by this paper
• DNA topoisomerase II is required at the time of mitosis in yeast.

  1985cited by this paper
• Topoisomerase I phosphorylation in vitro and in rapidly growing Novikoff hepatoma cells.

  1985cited by this paper
• Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization.

  1984cited by this paper
• Yeast DNA topoisomerase II is encoded by a single-copy, essential gene.

  1984cited by this paper
• DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

  1984cited by this paper
• DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.

  1983cited by this paper
• Studies on transformation of Escherichia coli with plasmids.

  1983cited by this paper
• Cleavage of DNA by mammalian DNA topoisomerase II.

  1983cited by this paper
• Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster.

  1983cited by this paper
• DNA topoisomerase II from Drosophila melanogaster. Purification and physical characterization.

  1983cited by this paper
• Purification and characterization of a type II casein kinase from Drosophila melanogaster.

  1983cited by this paper
• Casein kinases--multipotential protein kinases.

  1982cited by this paper
• Purification and characterization of a nuclear DNA-binding phosphoprotein in fetal and tumor tissues.

  1981cited by this paper
• Construction and characterization of new cloning vehicles. II. A multipurpose cloning system.

  1977cited by this paper

• C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks.

  2024cites this paper
• The interplay between DNA topoisomerase 2α post-translational modifications and drug resistance

  2020cites this paper
• Casein kinase II–dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast

  2019cites this paper
• The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation*

  2016influential citation
• Études fonctionnelles et structurales de l'isoforme ɑ et de l'ADN topoisomérase humaine et ses complexes ciblés par des composés thérapeutiques

  2015cites this paper
• Structural Dynamics and Novel Biological Function of Topoisomerase 2

  2015cites this paper
• Etoposide resistance in MCF-7 breast cancer cell line is marked by multiple mechanisms.

  2014cites this paper
• Mechanisms regulating resistance to inhibitors of topoisomerase II

  2013cites this paper
• New mechanistic and functional insights into DNA topoisomerases.

  2013cites this paper
• [Molecular determinants of response to topoisomerase II inhibitors].

  2011cites this paper
• Mécanismes moléculaires et déterminants de la réponse aux inhibiteurs de topo-isomérases I

  2011cites this paper
• NUCLEAR FUNCTIONS OF ADENOMATOUS POLYPOSIS COLI: REGULATION OF THE G2-M CELL CYCLE TRANSITION & INTERMEDIATE FILAMENT INTERACTION

  2009cites this paper
• DNA topoisomerase II and its growing repertoire of biological functions

  2009cites this paper
• Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of &agr;-Synuclein

  2008cites this paper
• Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1.

  2008cites this paper
• Plk 3 phosphorylates topoisomerase II α at Thr 1342 , a site that is not recognized by Plk 1

  2008cites this paper
• A proteomic approach to identifying new drug targets (potentiating topoisomerase II poisons).

  2008cites this paper
• Plk3 phosphorylates topoisomerase IIα at Thr1342, a site that is not recognized by Plk1

  2008cites this paper
• The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer.

  2007influential citation
• DNA topoisomerase II, genotoxicity, and cancer.

  2007cites this paper
• The Influence of Hyaluronan-CD 44 Interaction on Topoisomerase II Activity and Etoposide Cytotoxicity in Head and Neck Cancer

  2007influential citation
• Cell cycle deregulation in breast cancer: insurmountable chemoresistance or Achilles' heel?

  2007cites this paper
• Topoisomerase II inhibitors.

  2006cites this paper
• Bursting on the Scene: How Thalamic Neurons Grab Your Attention

  2006cites this paper
• Role of protein kinases in antitumor drug resistance

  2005cites this paper
• Cyclic AMP-dependent Protein Kinase Type I Is Involved in Hypersensitivity of Human Breast Cells to Topoisomerase II Inhibitors 1

  2005cites this paper
• Topoisomerase II inhibitors.

  2005cites this paper
• Etoposide: discovery and medicinal chemistry.

  2004cites this paper
• Cytokinetic differences in the action ofN-[2-(dimethylamino)ethyl]acridine-4-carboxamide as compared with that of amsacrine and doxorubicin

  2004cites this paper
• In vitro assessment ofN-[2-(dimethylamino)ethyl]acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance

  2004cites this paper
• Reduced levels of topoisomerase IIα and IIβ in a multidrug-resistant lung-cancer cell line

  2004influential citation
• Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.

  2003cites this paper
• Phosphorylation of Serine 1106 in the Catalytic Domain of Topoisomerase IIα Regulates Enzymatic Activity and Drug Sensitivity*

  2003cites this paper
• Overexpression of the Atypical Protein Kinase C ζ Reduces Topoisomerase II Catalytic Activity, Cleavable Complexes Formation, and Drug-induced Cytotoxicity in Monocytic U937 Leukemia Cells*

  2002cites this paper
• Functional and Regulatory Characteristics of Eukaryotic Type II DNA Topoisomerase

  2001cites this paper
• Characterization of cell lines resistant to topoisomerase targeting drugs and mechanistic studies of Quinoxaline solid tumor drugs - a new chemical class of topoisomerase II poisons /

  2001cites this paper
• Differential responses of human neuroblastoma and glioblastoma to apoptosis.

  2001cites this paper
• Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice.

  2000cites this paper
• During both interphase and mitosis, DNA topoisomerase II interacts with DNA as well as RNA through the protein's C-terminal domain.

  2000cites this paper
• Cytotoxicity of Metallic Complexes of Furan Oximes in Murine and Human Tissue Cultured Cell Lines

  1999cites this paper
• Phosphorylation Mechanism Independent of through a α Activates Topoisomerase II Extracellular Signal-Regulated Kinase

  1999cites this paper
• Extracellular Signal-Regulated Kinase Activates Topoisomerase IIα through a Mechanism Independent of Phosphorylation

  1999cites this paper
• Synergistic Cytotoxicity, Apoptosis and Protein-linked DNA Breakage by Etoposide and Camptothecin in Human U87 Glioma Cells: Dependence on Tyrosine Phosphorylation

  1999cites this paper
• Effects of Alkyl Amine Carboxyboranes on L1210 DNA Fragmentation and Nucleic Acid Metabolism

  1998cites this paper
• Characterization of DNA topoisomerase II alpha/beta heterodimers in HeLa cells.

  1998cites this paper
• Hypersensitivity of Ku-Deficient Cells toward the DNA Topoisomerase II Inhibitor ICRF-193 Suggests a Novel Role for Ku Antigen during the G2 and M Phases of the Cell Cycle

  1998cites this paper
• Physiological regulation of eukaryotic topoisomerase II.

  1998cites this paper
• Sequence-specific poisons of type II DNA topoisomerases

  1998cites this paper
• Cellular resistance to topoisomerase-targeted drugs: from drug uptake to cell death.

  1998cites this paper
• Cytotoxicity of ferratricarbadecaboranyl complexes in murine and human tissue cultured cell lines.

  1998cites this paper
• Complex response of breast epithelial cell lines to topoisomerase inhibitors.

  1998cites this paper
• The N-terminal domain of human topoisomerase IIalpha is a DNA-dependent ATPase.

  1998cites this paper
• Reduced activity of topoisomerase II in an Adriamycin-resistant human stomach-adenocarcinoma cell line

  1998cites this paper
• Relationship between amine-carboxyboranes and TNF alpha for the regulation of cell growth in different tumor cell lines.

  1998cites this paper
• Synthesis and antitumor activity of boronated dipeptides containing aromatic amino acids.

  1997cites this paper
• Daidzein stimulation of bone resorption in pit formation assay.

  1997cites this paper
• Potentiation of etoposide-induced apoptosis by staurosporine in human tumor cells is associated with events downstream of DNA-protein complex formation

  1997influential citation
• DNA topoisomerase targeting drugs: mechanisms of action and perspectives.

  1997cites this paper
• Topoisomerase II levels and drug response in small cell lung cancer.

  1997cites this paper
• Calcium signaling in the cell nucleus

  1997cites this paper
• DNA Topoisomerase II Inhibitors

  1997cites this paper
• Comparison of topoisomerase I and II expression in primary brain tumor and lung cancer.

  1997cites this paper
• Decreased levels of topoisomerase IIα in human renal cell carcinoma lines resistant to etoposide

  1997cites this paper
• Topoisomerase activities in undifferentiated acute myeloblastic leukemias and monocytic differentiated leukemias.

  1997cites this paper
• Cytotoxicity of copper complexes of 2-furaldehyde oxime derivatives in murine and human tissue cultured cell lines.

  1997cites this paper
• MULTIDRUG RESISTANCE IN LEUKAEMIA

  1997cites this paper
• Topoisomerase II Activities in Human Leukemic Cells and Their Sensitivity to Anthracyclines and Podophyllotoxines

  1997cites this paper
• Protein kinase C and its substrates.

  1996cites this paper
• Phosphorylation-independent stimulation of DNA topoisomerase II alpha activity.

  1996cites this paper
• Protein kinase C and its substrates.

  1996cites this paper
• Human DNA topoisomerase II: biochemistry and role in chemotherapy resistance (review).

  1996cites this paper
• In vitro induction of micronuclei and chromosome aberrations by quinolones: possible mechanisms.

  1996cites this paper
• Ectopic expression of inactive forms of yeast DNA topoisomerase II confers resistance to the anti-tumour drug, etoposide.

  1996cites this paper
• Topoisomerase II activities in AML blasts and their correlation with cellular sensitivity to anthracyclines and epipodophyllotoxines.

  1996cites this paper
• Resistance to etoposide in human leukemia HL-60 cells: reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides.

  1996cites this paper
• Analysis of eukaryotic DNA topoisomerases and topoisomerase-directed drug effects.

  1996cites this paper
• Epidermal Growth Factor Regulates Topoisomerase II Activity and Drug Sensitivity in Human KB Cells

  1996cites this paper
• 20 DNA Topoisomerases

  1996cites this paper
• Separation and functional analysis of eukaryotic DNA topoisomerases by chromatography and electrophoresis.

  1996cites this paper
• Protein gates in DMA topoisomerase II

  1996cites this paper
• Topoisomerase II activities in AML and their correlation with cellular sensitivity to anthracyclines and epipodophyllotoxines.

  1996cites this paper
• Protein gates in DNA topoisomerase II.

  1996cites this paper
• Mechanisms of resistance of human small cell lung cancer lines selected in VP‐16 and cisplatin

  1996cites this paper
• Cellular resistance to topoisomerase poisons.

  1996cites this paper
• Development and partial characterization of a human T-lymphoblastic leukemic (CCRF-CEM) cell line resistant to etoposide. Analysis of possible circumventing approaches.

  1996cites this paper
• The clinical pharmacology of etoposide: an update.

  1996cites this paper
• Lessons from immunological, biochemical, and molecular pathways of the activation mediated by IL-2 and IL-4.

  1996cites this paper
• Ultrastructural features and P-glycoprotein immunolocalization in Saos-2/DX580 multidrug-resistant human osteosarcoma cells.

  1996cites this paper
• Chemotherapeutic drug cytotoxicity enhancement in human cells in culture

  1996cites this paper
• Phosphorylation-independent Stimulation of DNA Topoisomerase II Activity (*)

  1996cites this paper
• The antitumor activity of doxorubicin against drug-resistant murine carcinoma is enhanced by oral administration of a synthetic staurosporine analogue, CGP 41251.

  1995cites this paper
• Topoisomerases II alpha and beta as therapy targets in breast cancer.

  1995cites this paper
• Topoisomerases in Multidrug Resistance

  1995cites this paper
• Nuclear Calcium-Binding Proteins and Their Functions

  1995cites this paper
• Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene.

  1995cites this paper
• Selective use of an alternative stop codon and polyadenylation signal within intron sequences leads to a truncated topoisomerase II alpha messenger RNA and protein in human HL-60 leukemia cells selected for resistance to mitoxantrone.

  1995cites this paper
• Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents.

  1995cites this paper
• The Contribution of Protein Kinase C to Multiple Drug Resistance in Cancer

  1995cites this paper
• Cyclic AMP-dependent protein kinase type I is involved in hypersensitivity of human breast cells to topoisomerase II inhibitors.

  1995cites this paper
• Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution.

  1995cites this paper