A Randomized Controlled Pilot Trial of Modified Whole Blood versus Component Therapy in Severely Injured Patients Requiring Large Volume Transfusions

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Annals of Surgery

• Publication date

  2013-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/SLA.0b013e3182a4ffa0PMID 23979267
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fresh whole blood use by forward surgical teams in Afghanistan is associated with improved survival compared to component therapy without platelets

  2013cited by this paper
• Lack of effect of unrefrigerated young whole blood transfusion on patient outcomes after massive transfusion in a civilian setting

  2011cited by this paper
• Multicenter validation of a simplified score to predict massive transfusion in trauma.

  2010cited by this paper
• Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries.

  2009cited by this paper
• A massive transfusion protocol to decrease blood component use and costs.

  2008cited by this paper
• Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization.

  2008cited by this paper
• Damage control resuscitation: directly addressing the early coagulopathy of trauma.

  2007cited by this paper
• The use of fresh whole blood in massive transfusion.

  2006cited by this paper
• THE EFFECTS OF LEUKOREDUCED BLOOD TRANSFUSION ON INFECTION RISK FOLLOWING INJURY: A RANDOMIZED CONTROLLED TRIAL

  2006cited by this paper
• THE CELLULAR, METABOLIC, AND SYSTEMIC CONSEQUENCES OF AGGRESSIVE FLUID RESUSCITATION STRATEGIES

  2006cited by this paper
• Leukoreduction before red blood cell transfusion has no impact on mortality in trauma patients.

  2006cited by this paper
• Wound Shock: A History of Its Study and Treatment by Military Surgeons.

  2004cited by this paper
• Wound shock: a history of its study and treatment by military surgeons.

  2004influential reference
• United States Army Rangers in Somalia: an analysis of combat casualties on an urban battlefield.

  2000cited by this paper
• Postinjury multiple organ failure: a bimodal phenomenon.

  1996cited by this paper
• Postinjury multiple organ failure: a bimodal phenomenon.

  1996cited by this paper
• Plasma supplementation is beneficial for coagulation during severe hemorrhagic shock.

  1996cited by this paper
• American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis

  1992cited by this paper
• Definitions for sepsis and organ failure.

  1992cited by this paper
• Intra-abdominal compartment syndrome as a complication of ruptured abdominal aortic aneurysm repair.

  1989cited by this paper
• The hemostatic effect of transfusing fresh whole blood versus platelet concentrates after cardiac operations.

  1988cited by this paper
• Prophylactic platelet administration during massive transfusion. A prospective, randomized, double-blind clinical study.

  1986cited by this paper
• Fresh Frozen Plasma: Indications and Risks

  1985cited by this paper
• Use of physiologic monitoring to predict outcome and to assist in clinical decisions in critically ill postoperative patients.

  1983cited by this paper
• Management of the Major Coagulopathy with Onset during Laparotomy

  1983cited by this paper
• Altered Coagulation Protein Content After Albumin Resuscitation

  1982cited by this paper
• Whole Blood Versus Packed‐cell Transfusions: A Physiologic Comparison

  1981cited by this paper
• Hemostasis in Massively Transfused Trauma Patients

  1979cited by this paper
• Fluid resuscitation following injury: rationale for the use of balanced salt solutions

  1976cited by this paper
• Fluid resuscitation following injury: rationale for the use of balanced salt solutions.

  1976cited by this paper
• Blood Transfusions in Elective Operations: Comparison of Whole Blood versus Packed Red Cells

  1975cited by this paper
• The effect of cold on platelets. I. Cold-induced platelet aggregation.

  1971cited by this paper
• Should blood be whole or in parts?

  1969influential reference
• Whole blood versus packed red cells for preoperative transfusions.

  1969cited by this paper
• Whole blood versus packed red cells for preoperative transfusions.

  1969cited by this paper
• HISTORY OF BLOOD BANKING IN THE UNITED STATES.

  1965influential reference
• The Nature and Treatment of Wound Shock and Allied Conditions.

  1920cited by this paper
• THE INITIATION OF WOUND SHOCK

  1918cited by this paper

• Equivalent and resource-saving: Whole blood versus component therapy for trauma resuscitation.

  2026cites this paper
• Whole Blood versus Components for Transfusion in Trauma and Life-Threatening Hemorrhage-Unresolved Issues.

  2026cites this paper
• Time-dependent coagulation declines in cold-stored whole blood: a paired in-vitro comparison of rotational thromboelastometry and SEER sonorheometry.

  2026cites this paper
• Association of Whole Blood on Mortality and Inhospital Complications: A Statewide Analysis.

  2025cites this paper
• Leveraging the Multifaceted Platelet Storage Lesion to Advance Precision Platelet Transfusion Medicine.

  2025cites this paper
• Female patients receiving massive transfusion are less likely to receive whole blood despite survival benefit.

  2025cites this paper
• What we do matters

  2025cites this paper
• Use of Whole Blood in Trauma Patients on Anticoagulation or Antiplatelet Therapy.

  2025cites this paper
• Trauma resuscitation with Low-Titer Group O Whole Blood Or Products: study protocol for a randomized clinical trial (the TROOP trial)

  2025cites this paper
• The impact of pathological factors on the structure and function of erythrocyte membranes: from the molecular level to clinical consequences

  2025cites this paper
• Advances in resuscitation and deresuscitation

  2025cites this paper
• Blood transfusion strategies for major bleeding in trauma.

  2025cites this paper
• Intent Vs Execution: Failure To Achieve Balanced Resuscitation In Bleeding Trauma Patients.

  2025cites this paper
• Expanding the Blood Donor Pool: An Update to Initiatives to Increase New Donor Participation.

  2025cites this paper
• Analysis of Outcomes after Whole Blood Transfusion vs Balanced Component Therapy.

  2025cites this paper
• Association between whole blood versus balanced component therapy and survival in isolated severe traumatic brain injury

  2025cites this paper
• Association between whole blood ratio and risk of mortality in massively transfused trauma patients

  2025cites this paper
• Impact of Whole Blood Resuscitation on Infection Risk in Trauma Patients Undergoing Hemorrhage Control Laparotomy.

  2025cites this paper
• Clinical evaluation of novel blood collection and storage bags containing alternative plasticizers to DEHP: Recommendations from the BEST collaborative

  2025cites this paper
• Pragmatic O-Positive Whole-blood RandoMizaTion in male trauma Patients (POWeR-MTP)

  2025influential citation
• Transfusion of modified whole blood versus blood components therapy in patients with severe trauma: Randomized controlled trial protocol (WEBSTER trial).

  2025cites this paper
• Prehospital Whole Blood Administration Not Associated with Increased Transfusion Reactions: The Experience of a Metropolitan EMS Agency

  2025cites this paper
• Prehospital Blood Administration in Traumatic Hemorrhagic Shock

  2025cites this paper
• The use of whole blood transfusion in emergency medicine

  2025cites this paper
• Evaluating the safety outcomes of whole blood versus component transfusion in trauma: A meta-analysis of 59,213 patients.

  2025cites this paper
• Storage damage of cold-stored whole blood in CPDA maintenance fluid during the whole effective storage period

  2025cites this paper
• Can heroic roadside care save lives?

  2025cites this paper
• A narrative review: Resuscitation of older adults with hemorrhagic shock

  2025cites this paper
• Mitigating the risk of low-titer group O-positive whole blood resuscitation in females of childbearing potential: toward a systems-based approach

  2024cites this paper
• An Analysis of the Association of Whole Blood Transfusion With the Development of Acute Respiratory Distress Syndrome

  2024cites this paper
• Evolution of whole blood trauma resuscitation in childbearing age females: practice patterns and trends

  2024cites this paper
• Sex-based utilization and outcomes of cold-stored whole blood for trauma resuscitation: Analysis of a prospective multicenter study

  2024cites this paper
• The effect of whole blood resuscitation on in-hospital mortality: A propensity score weighted analysis of patients treated at a Level I trauma center

  2024cites this paper
• Does early transfusion of cold-stored whole blood reduce the need for component therapy in civilian trauma patients? A systematic review

  2024cites this paper
• Optimizing damage control resuscitation through early patient identification and real‐time performance improvement

  2024cites this paper
• Pregnancy and trauma: What you need to know

  2024cites this paper
• Barriers and Challenges to Implementing Whole Blood Transfusion Protocols in Civilian Hospitals: A Systematic Review and Meta-Analysis

  2024cites this paper
• Assessing the one‐month mortality impact of civilian‐setting prehospital transfusion: A systematic review and meta‐analysis

  2024cites this paper
• FINDING THE SWEET SPOT: THE ASSOCIATION BETWEEN WHOLE BLOOD TO RED BLOOD CELLS RATIO AND OUTCOMES OF HEMORRHAGING CIVILIAN TRAUMA PATIENTS

  2024cites this paper
• Early Fluid Is Less Fluid: Comparing Early Versus Late ICU Resuscitation in Severely Injured Trauma Patients

  2024cites this paper
• Whole blood versus balanced resuscitation in massive hemorrhage: Six of one or half dozen of the other?

  2024cites this paper
• A Guide to the Use of Vasopressors and Inotropes for Patients in Shock

  2024cites this paper
• Whole blood resuscitation for injured patients requiring transfusion: A systematic review, meta-analysis, and practice management guideline from the Eastern Association for the Surgery of Trauma

  2024influential citation
• The Role of Whole Blood Hemostatic Resuscitation in Bleeding Geriatric Trauma Patients.

  2024cites this paper
• Association between whole blood ratio and risk of mortality in massively transfused trauma patients: retrospective cohort study

  2024cites this paper
• The New Old Solution: Whole Blood for Nontraumatic Hemorrhage.

  2024cites this paper
• Whole Blood and Blood Component Resuscitation in Trauma

  2024cites this paper
• Resuscitation with pre-hospital blood products in adults with trauma-related haemorrhagic shock: the RePHILL RCT

  2024cites this paper
• Timing to First Whole Blood Transfusion and Survival Following Severe Hemorrhage in Trauma Patients.

  2024cites this paper
• What's new in whole blood resuscitation? In the trauma bay and beyond

  2024cites this paper
• Hospital variation in adoption of balanced transfusion practices among injured patients requiring blood transfusions.

  2024cites this paper
• Whole Blood Trauma Resuscitation in Community Trauma Centers Confers Survival Benefit Over Component Therapy

  2023cites this paper
• Low-titer O whole blood in management of massive bleeding

  2023cites this paper
• Delayed Leukoreduction of whole blood with a platelet‐sparing filter to increase low‐titer group O whole blood production in the United States

  2023cites this paper
• Whole blood transfusion in the treatment of acute hemorrhage, a systematic review and meta-analysis

  2023cites this paper
• What is the Role of Whole Blood Transfusions on Trauma Patients?

  2023cites this paper
• Outcomes of Transfusion With Whole Blood, Component Therapy, or Both in Adult Civilian Trauma Patients: A Systematic Review and Meta-Analysis.

  2023cites this paper
• Massive Trauma and Resuscitation Strategies.

  2023cites this paper
• Transfusion Management in Trauma: What is Current Best Practice?

  2023cites this paper
• Blood component resuscitative strategies to mitigate endotheliopathy in a murine hemorrhagic shock model

  2023cites this paper
• Use of Whole Blood in Civilian Trauma Resuscitation: Is It Better Than Component Therapy?

  2023cites this paper
• Association of Whole Blood With Survival Among Patients Presenting With Severe Hemorrhage in US and Canadian Adult Civilian Trauma Centers.

  2023cites this paper
• In Vitro Analysis of Platelet Adhesion, Aggregation, and Surface GP1bα Expression in Stored Refrigerated Whole Blood: A Pilot Study

  2023cites this paper
• Doing More with Less: Low-Titer Group O Whole Blood resulted in Less Total Transfusions and an Independent Association with Survival in Adults with Severe Traumatic Hemorrhage.

  2023cites this paper
• Resuscitation and Care in the Trauma Bay.

  2023cites this paper
• Use of Low-Titer O-Positive Whole Blood in Female Trauma Patients: A Literature Review, Qualitative Multidisciplinary Analysis of Risk/Benefit, and Guidelines for Its Use as a Universal Product in Hemorrhagic Shock.

  2023cites this paper
• Volume replacement in the resuscitation of trauma patients with acute hemorrhage: an umbrella review

  2023cites this paper
• Nonsurgical management of major hemorrhage

  2023cites this paper
• An assessment of the safety, hemostatic efficacy, and clinical impact of low-titer group O whole blood in children and adolescents

  2023cites this paper
• Patients with both traumatic brain injury and hemorrhagic shock benefit from resuscitation with whole blood

  2023cites this paper
• Time to Whole Blood Transfusion in Hemorrhaging Civilian Trauma Patients: There Is Always Room for Improvement.

  2023cites this paper
• Prise en charge non chirurgicale de l’hémorragie majeure

  2023cites this paper
• Emergency transfusion with whole blood versus packed red blood cells: A study of 1400 patients

  2023cites this paper
• Early Fluid is Less Fluid: Comparing Early Versus Late Resuscitation in Severely Injured Trauma Patients

  2023cites this paper
• Platelet dysfunction after trauma: From mechanisms to targeted treatment

  2022cites this paper
• Low titer Group O whole blood utilization in pediatric trauma resuscitation: A National Survey

  2022cites this paper
• Use of Cold-Stored Whole Blood is Associated With Improved Mortality in Hemostatic Resuscitation of Major Bleeding

  2022cites this paper
• Whole blood for trauma resuscitation?

  2022cites this paper
• Transfusion-free Strategies in Liver and Pancreatic Surgery

  2022cites this paper
• Transfusion management in the trauma patient

  2022cites this paper
• Is Low-Titer Group O Whole Blood Truly a Universal Blood Product?

  2022cites this paper
• Impact of Incorporating Whole Blood into Hemorrhagic Shock Resuscitation: Analysis of 1,377 Consecutive Trauma Patients Receiving Emergency-Release Uncrossmatched Blood Products.

  2022cites this paper
• MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE

  2022cites this paper
• The National Blood Shortage -An Impetus for Change.

  2022cites this paper
• Prehospital low titer group O whole blood is feasible and safe: Results of a prospective randomized pilot trial

  2022cites this paper
• The Role of Prehospital REBOA for Hemorrhage Control in Civilian and Military Austere Settings: A Systematic Review

  2022cites this paper
• Primum, non nocere: Whole blood, prehospital transfusion and anti‐D hemolytic disease of the fetus and newborn

  2022cites this paper
• Whole Blood in Trauma Resuscitation: What is the Real Cost?

  2022cites this paper
• The Role of Whole Blood Transfusions in Civilian Trauma: A Review of Literature in Military and Civilian Trauma

  2022cites this paper
• National analysis of whole blood and component versus component transfusions in civilian trauma patients who underwent a thoracotomy or laparotomy: Toward improving patient outcomes and quality of care.

  2022cites this paper
• The Use of Whole Blood in Rural Trauma Leads to Decreased Resource Utilization

  2022cites this paper
• Impact of time to surgery on mortality in hypotensive patients with noncompressible torso hemorrhage: An AAST multicenter, prospective study

  2022cites this paper
• After 800 Mtp Events, Mortality Due to Hemorrhagic Shock Remains High and Unchanged Despite Several In-Hospital Hemorrhage Control Advancements

  2021cites this paper
• Adverse events after low titer group O whole blood versus component product transfusion in pediatric trauma patients: A propensity‐matched cohort study

  2021cites this paper
• Ranger O Low Titer (ROLO): Whole Blood Transfusion for Forward Deployed Units.

  2021cites this paper
• Whole truths but half the blood: Addressing the gap between the evidence and practice of pre‐hospital and in‐hospital blood product use for trauma resuscitation

  2021cites this paper
• Low Titer Group O Whole Blood In Injured Children Requiring Massive Transfusion

  2021cites this paper
• Hemorrhage control

  2021cites this paper
• Whole Blood Is Back

  2021cites this paper
• Difficult Decisions in Trauma Surgery: What Is the Clinical Impact of Whole Blood as Compared to Component Therapy in Civilian Trauma?

  2021cites this paper