Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Obesity

• Publication date

  2010-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/oby.2009.510PMID 20111019PMCID PMC3984458
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.

  2009influential reference
• Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at?

  2009cited by this paper
• An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.

  2008cited by this paper
• Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

  2008influential reference
• Effects of Physical Activity and Weight Loss on Skeletal Muscle Mitochondria and Relationship With Glucose Control in Type 2 Diabetes

  2007cited by this paper
• Skeletal muscle fat oxidation: timing and flexibility are everything.

  2005cited by this paper
• Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency*

  2005cited by this paper
• Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics.

  2005cited by this paper
• Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes.

  2005cited by this paper
• Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

  2004cited by this paper
• Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns.

  2003cited by this paper
• Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction

  2002cited by this paper
• Acylcarnitine profiles in fibroblasts from patients with respiratory chain defects can resemble those from patients with mitochondrial fatty acid beta-oxidation disorders.

  2002influential reference
• Lipotoxic diseases.

  2002cited by this paper
• Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes.

  2002cited by this paper
• Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.

  2002cited by this paper
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  2001cited by this paper
• Rapid Diagnosis of Methylmalonic and Propionic Aci- Demias: Quantitative Tandem Mass Spectrometric Anal- Ysis of Propionylcarnitine in Filter-paper Blood Speci- Mens Obtained from Newborns

  2001cited by this paper
• The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis.

  1997cited by this paper
• Subcutaneous Abdominal Fat and Thigh Muscle Composition Predict Insulin Sensitivity Independently of Visceral Fat

  1997cited by this paper
• Metabolic propensity toward obesity in black vs white females: responses during rest, exercise and recovery.

  1996cited by this paper
• Impaired mitochondrial beta-oxidation in a patient with an abnormality of the respiratory chain. Studies in skeletal muscle mitochondria.

  1990cited by this paper
• Incomplete palmitate oxidation in cell-free systems of rat and human muscles.

  1983cited by this paper

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