Pathways and Mechanisms of Ocular Pain and Photophobia in Dry Eye Disease

No abstract is available for this paper.

• Publication year

  year unknown

• Venue

  Dry Eye Disease

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1016/b978-0-323-82753-9.00005-9
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Microglial activation in the trigeminal spinal subnucleus interpolaris/caudalis modulates orofacial incisional mechanical pain hypersensitivity associated with orofacial injury in infancy.

  2021cited by this paper
• Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study

  2021cited by this paper
• Neuropathic corneal pain and dry eye: a continuum of nociception

  2021cited by this paper
• Long‐Term Trigeminal Nerve Stimulation as a Treatment for Ocular Pain

  2021cited by this paper
• Corneal sub-basal nerve plexus microneuromas in individuals with and without dry eye

  2021cited by this paper
• Morphological and Functional Changes of Corneal Nerves and Their Contribution to Peripheral and Central Sensory Abnormalities

  2020cited by this paper
• TRPM8: A Therapeutic Target for Neuroinflammatory Symptoms Induced by Severe Dry Eye Disease

  2020cited by this paper
• Oral Gabapentinoids and Nerve Blocks for the Treatment of Chronic Ocular Pain.

  2020cited by this paper
• Imaging Biomarkers for Dry Eye Disease.

  2020cited by this paper
• Visualization of micro-neuromas by using in vivo confocal microscopy: An objective biomarker for the diagnosis of neuropathic corneal pain?

  2020cited by this paper
• Photophobia: shared pathophysiology underlying dry eye disease, migraine and traumatic brain injury leading to central neuroplasticity of the trigeminothalamic pathway

  2020cited by this paper
• Comparison of clinical characteristics of post-refractive surgery-related and post-herpetic neuropathic corneal pain

  2020cited by this paper
• Corneal nerve pathway function in individuals with dry eye symptoms.

  2020cited by this paper
• TRPV1, TRPA1, and TRPM8 are expressed in axon terminals in the cornea: TRPV1 axons contain CGRP and secretogranin II; TRPA1 axons contain secretogranin 3

  2020cited by this paper
• From astrocytes to satellite glial cells and back: a 25 year-long journey through the purinergic modulation of glial functions in pain and more.

  2020cited by this paper
• CGRP Modulates Orofacial Pain through Mediating Neuron-Glia Crosstalk

  2020cited by this paper
• Revisiting PNS Plasticity: How Uninjured Sensory Afferents Promote Neuropathic Pain

  2020cited by this paper
• Ocular Neuropathic Pain: An Overview Focusing on Ocular Surface Pains

  2020cited by this paper
• Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection

  2020cited by this paper
• Multi-dimensional role of the parabrachial nucleus in regulating pain-related affective disturbances in trigeminal neuropathic pain.

  2020cited by this paper
• Ocular Surface Pain: A Narrative Review

  2020cited by this paper
• Opioid receptors inhibit the spinal AMPA receptor Ca2+ permeability that mediates latent pain sensitization

  2019cited by this paper
• Pregabalin Failed to Prevent Dry Eye Symptoms after Laser-Assisted in Situ Keratomileusis (LASIK) in a Randomized Pilot Study

  2019cited by this paper
• C-Fiber Assays in the Cornea vs. Skin

  2019cited by this paper
• Efficacy of autologous serum tears for treatment of neuropathic corneal pain.

  2019cited by this paper
• Role of TRPM8 Channels in Altered Cold Sensitivity of Corneal Primary Sensory Neurons Induced by Axonal Damage

  2019cited by this paper
• Dysfunctional Coping Mechanisms Contribute to Dry Eye Symptoms

  2019cited by this paper
• TRPV1 activity and substance P release are required for corneal cold nociception

  2019cited by this paper
• Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem

  2019cited by this paper
• Molecular evidence for the role of inflammation in dry eye disease

  2019cited by this paper
• Modification of the Neuropathic Pain Symptom Inventory for use in eye pain (NPSI-Eye).

  2019cited by this paper
• Corneal Innervation and Sensation: The Eye and Beyond

  2018cited by this paper
• Antinociceptive effect of two novel transient receptor potential melastatin 8 antagonists in acute and chronic pain models in rat

  2018cited by this paper
• Neuropathic pain and dry eye.

  2018cited by this paper
• TRPM8 Channels and Dry Eye

  2018cited by this paper
• The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

  2017cited by this paper
• TFOS DEWS II pain and sensation report.

  2017cited by this paper
• Inhibitory Effect of Amitriptyline on the Impulse Activity of Cold Thermoreceptor Terminals of Intact and Tear-Deficient Guinea Pig Corneas

  2017cited by this paper
• Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation.

  2017cited by this paper
• Select noxious stimuli induce changes on corneal nerve morphology

  2017cited by this paper
• Neurochemical effects of photobiostimulation in the trigeminal ganglion after inferior alveolar nerve injury.

  2017cited by this paper
• TFOS DEWS II Definition and Classification Report.

  2017cited by this paper
• The Glutamatergic System in Primary Somatosensory Neurons and Its Involvement in Sensory Input-Dependent Plasticity

  2017cited by this paper
• Ocular inflammation induces trigeminal pain, peripheral and central neuroinflammatory mechanisms.

  2016cited by this paper
• What can photophobia tell us about dry eye?

  2016cited by this paper
• Understanding Neuropathic Corneal Pain—Gaps and Current Therapeutic Approaches

  2016cited by this paper
• Validity and Reliability of a Novel Ocular Pain Assessment Survey (OPAS) in Quantifying and Monitoring Corneal and Ocular Surface Pain.

  2016cited by this paper
• The potential role of neuropathic mechanisms in dry eye syndromes

  2016cited by this paper
• What Causes Eye Pain?

  2015cited by this paper
• Effect of environment on the long-term consequences of chronic pain

  2015cited by this paper
• Sensitization of trigeminal brainstem pathways in a model for tear deficient dry eye

  2015cited by this paper
• Transient receptor potential cation channel subfamily V member 1 expressing corneal sensory neurons can be subdivided into at least three subpopulations

  2015cited by this paper
• Neuropathic ocular pain: an important yet underevaluated feature of dry eye

  2015cited by this paper
• Burning Eye Syndrome: Do Neuropathic Pain Mechanisms Underlie Chronic Dry Eye?

  2015cited by this paper
• Ocular neuropathic pain

  2015cited by this paper
• Tear fluid hyperosmolality increases nerve impulse activity of cold thermoreceptor endings of the cornea

  2014cited by this paper
• Dry eye symptom severity and persistence are associated with symptoms of neuropathic pain

  2014cited by this paper
• Corneal nerves in health and disease.

  2014cited by this paper
• Dry eye modifies the thermal and menthol responses in rat corneal primary afferent cool cells.

  2013cited by this paper
• Glia and pain: is chronic pain a gliopathy?

  2013cited by this paper
• The role of calcitonin gene-related peptide on the increase in transient receptor potential vanilloid-1 levels in trigeminal ganglion and trigeminal nucleus caudalis activation of rat.

  2013cited by this paper
• Corneal afferents differentially target thalamic- and parabrachial-projecting neurons in spinal trigeminal nucleus caudalis.

  2013cited by this paper
• The development of chronic pain: physiological CHANGE necessitates a multidisciplinary approach to treatment

  2013cited by this paper
• The corneal pain system. Part I: the missing piece of the dry eye puzzle.

  2012cited by this paper
• Shedding light on photophobia.

  2012cited by this paper
• Satellite glial cell P2Y12 receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats

  2012cited by this paper
• An Approach to Localizing Corneal Pain Representation in Human Primary Somatosensory Cortex

  2012cited by this paper
• Calcitonin gene-related peptide promotes cellular changes in trigeminal neurons and glia implicated in peripheral and central sensitization

  2011cited by this paper
• The Economic Burden of Dry Eye Disease in the United States: A Decision Tree Analysis

  2011cited by this paper
• Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea

  2010cited by this paper
• Validation of the 5-Item Dry Eye Questionnaire (DEQ-5): Discrimination across self-assessed severity and aqueous tear deficient dry eye diagnoses.

  2010cited by this paper
• Predicted phenotypes of dry eye: proposed consequences of its natural history.

  2009cited by this paper
• Cerebral cortex modulation of pain

  2009cited by this paper
• Cellular and molecular mechanisms of pain.

  2009cited by this paper
• The thalamic nucleus submedius and ventrolateral orbital cortex are involved in nociceptive modulation: a novel pain modulation pathway.

  2009cited by this paper
• Sodium channel blockers for the treatment of neuropathic pain

  2009cited by this paper
• Neuropathic pain: a maladaptive response of the nervous system to damage.

  2009cited by this paper
• Neuropathic pain: a clinical perspective.

  2009cited by this paper
• Calcitonin receptor‐like receptor (CLR), receptor activity‐modifying protein 1 (RAMP1), and calcitonin gene‐related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution

  2008cited by this paper
• Sodium channels and mechanisms of neuropathic pain.

  2006cited by this paper
• Noradrenergic Activation Amplifies Bottom-Up and Top-Down Signal-to-Noise Ratios in Sensory Thalamus

  2006cited by this paper
• Regulation of Ca2+-permeable AMPA receptors: synaptic plasticity and beyond.

  2006cited by this paper
• Terminating Migraine With Allodynia and Ongoing Central Sensitization Using Parenteral Administration of COX1/COX2 Inhibitors

  2005cited by this paper
• Injured versus uninjured afferents: Who is to blame for neuropathic pain?

  2005cited by this paper
• Sodium channel blockers in neuropathic pain.

  2005cited by this paper
• Hyperalgesia and allodynia: peripheral mechanisms.

  2005cited by this paper
• Neural basis of sensation in intact and injured corneas.

  2004cited by this paper
• Calcitonin gene-related peptide receptor activation produces PKA- and PKC-dependent mechanical hyperalgesia and central sensitization.

  2004cited by this paper
• Corneal nerves: structure, contents and function.

  2003cited by this paper
• Can we conquer pain?

  2002cited by this paper
• Comparative analysis of the chemical neuroanatomy of the mammalian trigeminal ganglion and mesencephalic trigeminal nucleus.

  2002cited by this paper
• Pain Pathways and Parabrachial Circuits in the Rat

  2002cited by this paper
• Mechanisms of neuropathic pain.

  2001cited by this paper
• Mechanisms of pain

  2001cited by this paper
• Spinal nerve ligation: what to blame for the pain and why.

  2000cited by this paper
• Reliability and validity of the Ocular Surface Disease Index.

  2000cited by this paper
• Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers

  2000cited by this paper
• Central nervous system plasticity and persistent pain.

  1999cited by this paper
• Neural Mechanisms and Pathways in Craniofacial Pain

  1999cited by this paper
• Neuropathic pain: aetiology, symptoms, mechanisms, and management.

  1999cited by this paper

• TFOS lifestyle: Impact of lifestyle challenges on the ocular surface.

  2023cites this paper
• The environment and dry eye—manifestations, mechanisms, and more

  2023cites this paper