Regulation of angiogenesis by vascular endothelial growth factor and angiopoietin-1 in the rat aorta model: distinct temporal patterns of intracellular signaling correlate with induction of angiogenic sprouting.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  American Journal of Pathology

• Publication date

  2002-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0002-9440(10)64242-3PMID 12213710PMCID PMC1867259
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion.

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  2000cited by this paper
• Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathway.

  2000cited by this paper
• Regulation of angiogenesis via vascular endothelial growth factor receptors.

  2000cited by this paper
• Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt.

  2000influential reference
• Mekk3 is essential for early embryonic cardiovascular development

  2000cited by this paper
• A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration*

  1999cited by this paper
• Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.

  1999cited by this paper
• Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the Angiopoietin receptor Tie-2

  1999cited by this paper
• VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling.

  1999cited by this paper
• A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration.

  1999cited by this paper
• Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.

  1999cited by this paper
• MAP kinases, phosphatidylinositol 3‐kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor

  1999influential reference
• Vascular endothelial growth factor and the angiopoietins: working together to build a better blood vessel.

  1998cited by this paper
• Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models.

  1998cited by this paper
• Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization.

  1998cited by this paper
• DNA end-joining catalyzed by human cell-free extracts.

  1998cited by this paper
• Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

  1998cited by this paper
• Chemotactic Properties of Angiopoietin-1 and -2, Ligands for the Endothelial-specific Receptor Tyrosine Kinase Tie2*

  1998cited by this paper
• Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy.

  1998cited by this paper
• Endogenous regulation of angiogenesis in the rat aorta model. Role of vascular endothelial growth factor.

  1997cited by this paper
• Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site*

  1997cited by this paper
• Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

  1997cited by this paper
• p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

  1997cited by this paper
• Blood vessel formation: what is its molecular basis?

  1996cited by this paper
• Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

  1996cited by this paper
• Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.

  1996cited by this paper
• Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.

  1996cited by this paper
• Vascular endothelial growth factor, a specific regulator of angiogenesis

  1996cited by this paper
• GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase.

  1995cited by this paper
• [MAP kinase module: role in the control of cell proliferation].

  1995cited by this paper
• Angiogenesis in cancer, vascular, rheumatoid and other disease

  1995cited by this paper
• Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.

  1995cited by this paper
• Angiogenic role of endogenous basic fibroblast growth factor released by rat aorta after injury.

  1993cited by this paper
• Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.

  1992cited by this paper
• Identification of a new endothelial cell growth factor receptor tyrosine kinase.

  1991cited by this paper
• Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

  1990cited by this paper
• Growth of microvessels in serum-free matrix culture of rat aorta. A quantitative assay of angiogenesis in vitro.

  1990cited by this paper

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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2018cites this paper
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  2004cites this paper
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  2004cites this paper
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