Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Cell

• Publication date

  1995-01-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0092-8674(95)90401-8PMID 7834738
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transcriptional regulation by extracellular signals: mechanisms and specificity.

  1995cited by this paper
• Calcium signaling.

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• MAP kinase pathways in yeast: for mating and more.

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