Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Integrative Biology

• Publication date

  2013-07-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1039/c3ib40103kPMID 23817524
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells

  2012cited by this paper
• Up-regulated biglycan expression correlates with the malignancy in human colorectal cancers

  2012cited by this paper
• The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices

  2011cited by this paper
• Tenascin-C Enhances Pancreatic Cancer Cell Growth and Motility and Affects Cell Adhesion through Activation of the Integrin Pathway

  2011cited by this paper
• Biglycan expression correlates with aggressiveness and poor prognosis of gastric cancer

  2011cited by this paper
• Human Embryonic-like ECM (hECM) Stimulates Proliferation and Differentiation in Stem Cells While Killing Cancer Cells.

  2011cited by this paper
• Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation.

  2011cited by this paper
• Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

  2011cited by this paper
• Mesenchymal Stem Cell Transition to Tumor-Associated Fibroblasts Contributes to Fibrovascular Network Expansion and Tumor Progression

  2009cited by this paper
• Direct Evidence of Mesenchymal Stem Cell Tropism for Tumor and Wounding Microenvironments Using In Vivo Bioluminescent Imaging

  2009cited by this paper
• The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells

  2009cited by this paper
• Matrix crosslinking forces tumor progression by enhancing integrin signaling.

  2009cited by this paper
• Estrogen/Estrogen Receptor Alpha Signaling in Mouse Posterofrontal Cranial Suture Fusion

  2009cited by this paper
• Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms

  2009cited by this paper
• Mammary development in the embryo and adult: a journey of morphogenesis and commitment

  2008cited by this paper
• Can cancer be reversed by engineering the tumor microenvironment?

  2008cited by this paper
• A Novel 3D In Vitro Culture Model to Study Stromal–Epithelial Interactions in the Mammary Gland

  2008cited by this paper
• Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

  2007cited by this paper
• Heme-copper/dioxygen adduct formation, properties, and reactivity.

  2007cited by this paper
• Methoxy-substituted TQEN family of fluorescent zinc sensors.

  2006cited by this paper
• Tenascin-C induced signaling in cancer.

  2006cited by this paper
• 6-methylpyridyl for pyridyl substitution tunes the properties of fluorescent zinc sensors of the Zinpyr family.

  2006cited by this paper
• Midrange affinity fluorescent Zn(II) sensors of the Zinpyr family: syntheses, characterization, and biological imaging applications.

  2006cited by this paper
• Zinspy sensors with enhanced dynamic range for imaging neuronal cell zinc uptake and mobilization.

  2006cited by this paper
• Analogues of Zinpyr-1 provide insight into the mechanism of zinc sensing.

  2006cited by this paper
• A sensitive probe for the detection of Zn(II) by time-resolved fluorescence.

  2006cited by this paper
• An OFF-OFF-ON fluorescence sensor for metal ions in stepwise complex formation of 2,3,5,6-tetrakis(2-pyridyl)pyrazine with metal ions.

  2006cited by this paper
• Fluorescence-based zinc ion sensor for zinc ion release from pancreatic cells.

  2006cited by this paper
• A coumarin based fluorescent photoinduced electron transfer cation sensor

  2006cited by this paper
• (67)Zn NMR chemical shifts and electric field gradients in zinc complexes: a quantum chemical investigation.

  2005cited by this paper
• Controlled hydrolysis of lanthanide complexes of the N-donor tripod tris(2-pyridylmethyl)amine versus bisligand complex formation.

  2005cited by this paper
• Selective zinc sensor molecules with various affinities for Zn2+, revealing dynamics and regional distribution of synaptically released Zn2+ in hippocampal slices.

  2005cited by this paper
• Cell migration analyses within fibroblast-derived 3-D matrices.

  2005cited by this paper
• Esterase-activated two-fluorophore system for ratiometric sensing of biological zinc(II).

  2005cited by this paper
• The Coordination Chemistry of Tripodal Tetraamine Ligands

  2005cited by this paper
• QZ1 and QZ2: rapid, reversible quinoline-derivatized fluoresceins for sensing biological Zn(II).

  2005cited by this paper
• A ratiometric fluorescence probe for selective visual sensing of Zn2+.

  2005cited by this paper
• Development and Characterization of a Progressive Series of Mammary Adenocarcinoma Cell Lines Derived from the C3(1)/SV40 Large T-antigen Transgenic Mouse Model

  2004cited by this paper
• The small leucine‐rich proteoglycan biglycan modulates BMP‐4‐induced osteoblast differentiation

  2004cited by this paper
• Membrane-permeable and -impermeable sensors of the Zinpyr family and their application to imaging of hippocampal zinc in vivo.

  2004cited by this paper
• The stroma as a crucial target in rat mammary gland carcinogenesis

  2004cited by this paper
• Fluorescent detection of zinc in biological systems: recent development on the design of chemosensors and biosensors

  2004cited by this paper
• ZP8, a neuronal zinc sensor with improved dynamic range; imaging zinc in hippocampal slices with two-photon microscopy.

  2004cited by this paper
• Synthesis and spectroscopy of micro-oxo (O(2)(-))-bridged heme/non-heme diiron complexes: models for the active site of nitric oxide reductase.

  2004cited by this paper
• Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts

  2004cited by this paper
• Illuminating zinc in biological systems.

  2004cited by this paper
• Synthesis and characterization of zinc sensors based on a monosubstituted fluorescein platform.

  2004cited by this paper
• The zinspy family of fluorescent zinc sensors: syntheses and spectroscopic investigations.

  2004cited by this paper
• Detection of zinc ions by differential circularly polarized fluorescence excitation.

  2004cited by this paper
• Origins of ‘on–off’ fluorescent behavior of 8-hydroxyquinoline containing chemosensors

  2004cited by this paper
• Emission ratiometric imaging of intracellular zinc: design of a benzoxazole fluorescent sensor and its application in two-photon microscopy.

  2004cited by this paper
• Heparan sulphate proteoglycans modulate fibroblast growth factor-2 binding through a lipid raft-mediated mechanism.

  2004cited by this paper
• Bone marrow stroma inhibits proliferation and apoptosis in leukemic cells through gap junction-mediated cell communication

  2003cited by this paper
• Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction.

  2003cited by this paper
• Zinc takes the center stage: its paradoxical role in Alzheimer's disease.

  2003cited by this paper
• A novel two-fluorophore approach to ratiometric sensing of Zn(2+).

  2003cited by this paper
• C3v symmetric receptors show high selectivity and high affinity for phosphate.

  2003cited by this paper
• The prion protein and neuronal zinc homeostasis.

  2003cited by this paper
• Solid-State 67Zn NMR spectroscopic studies and ab initio molecular orbital calculations on a synthetic analogue of carbonic anhydrase.

  2003cited by this paper
• Selective detection of zinc ions with novel luminescent lanthanide probes.

  2003cited by this paper
• Geometry-dependent phosphodiester hydrolysis catalyzed by binuclear copper complexes.

  2003cited by this paper
• Circular dichroism imaging microscopy: application to enantiomorphous twinning in biaxial crystals of 1,8-dihydroxyanthraquinone.

  2003cited by this paper
• ZP4, an improved neuronal Zn2+ sensor of the Zinpyr family.

  2003cited by this paper
• Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors

  2003cited by this paper
• 細胞内金属元素の分布異常からみた神経細胞の変性--アルツハイマー病を例として (特集 放射光による微量元素分析と生命科学・医学への応用)

  2003cited by this paper
• Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation.

  2003cited by this paper
• Two faces of zinc in the brain

  2003cited by this paper
• Luminescent lanthanide complexes with stereocontrolled tris(2-pyridylmethyl)amine ligands: chirality effects on lanthanide complexation and luminescence properties.

  2003cited by this paper
• A novel, cell-permeable, fluorescent probe for ratiometric imaging of zinc ion.

  2002cited by this paper
• The rhodafluor family. An initial study of potential ratiometric fluorescent sensors for Zn2+.

  2002cited by this paper
• Cancer as a disease of epithelial-mesenchymal interactions and extracellular matrix regulation.

  2002cited by this paper
• Solid-state (67)zn NMR spectroscopy in bioinorganic chemistry. Spectra of four- and six-coordinate zinc pyrazolylborate complexes obtained by management of proton relaxation rates with a paramagnetic dopant.

  2002cited by this paper
• Cu(I/II) redox control of molecular conformation and shape in chiral tripodal ligands: binary exciton-coupled circular dichroic states.

  2002cited by this paper
• Improvement and biological applications of fluorescent probes for zinc, ZnAFs.

  2002cited by this paper
• Bis(μ‐oxo)dimetal “Diamond” Cores in Copper and Iron Complexes Relevant to Biocatalysis

  2002cited by this paper
• Phenotypic Effects of Biglycan Deficiency Are Linked to Collagen Fibril Abnormalities, Are Synergized by Decorin Deficiency, and Mimic Ehlers‐Danlos‐Like Changes in Bone and Other Connective Tissues

  2002cited by this paper
• Zinc and disease of the brain

  2001cited by this paper
• Brain copper, iron, magnesium, zinc, calcium, sulfur and phosphorus storage in Wilson's disease.

  2001cited by this paper
• Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis

  2001cited by this paper
• Chemistry of zinc(II) fluorophore sensors

  2001cited by this paper
• Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution.

  2001cited by this paper
• Specific recognition of chiral amino alcohols via lanthanide coordination chemistry: structural optimization of lanthanide tris(beta-diketonates) toward effective circular dichroism/fluorescence probing.

  2001cited by this paper
• Zinc biochemistry, physiology, and homeostasis – recent insights and current trends

  2001cited by this paper
• Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines.

  2001cited by this paper
• Chirality technology in metal separation : Stereochemical design of Ag+ ion-specific ionophores for practical membrane separation

  2000cited by this paper
• Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.

  2000cited by this paper
• Novel Zinc Fluorescent Probes Excitable with Visible Light for Biological Applications We thank Prof. E. Kimura and Prof. T. Koike for advice on the chemistry of macrocyclic polyamines.

  2000cited by this paper
• Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains.

  2000cited by this paper
• The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression to carcinoma

  2000cited by this paper
• Estrogen Receptor Alpha in Human Breast Cancer: Occurrence and Significance

  2000cited by this paper
• The capacity of connective tissue stromas to sustain myelopoiesis depends both upon the growth factors and the local intercellular environment

  2000cited by this paper
• Highly Zinc-Selective Fluorescent Sensor Molecules Suitable for Biological Applications

  2000cited by this paper
• A New Cell-Permeable Fluorescent Probe for Zn2+

  2000cited by this paper
• The structural and mechanical complexity of cell-growth control

  1999cited by this paper
• A Calcium-Sensitive Magnetic Resonance Imaging Contrast Agent

  1999cited by this paper
• In vitro growth inhibition of ovarian cancer cells by decorin: synergism of action between decorin and carboplatin.

  1999cited by this paper
• cis-Dihydroxylation of Olefins by a Non-Heme Iron Catalyst: A Functional Model for Rieske Dioxygenases.

  1999cited by this paper
• Aqueous Coordination Chemistry of Quinoline-Based Fluorescence Probes for the Biological Chemistry of Zinc

  1999cited by this paper
• Fluorescence-Detected Exciton-Coupled Circular Dichroism: Scope and Limitation in Structural Studies of Organic Molecules

  1999cited by this paper
• Influence of Coordination Geometry upon Copper(II/I) Redox Potentials. Physical Parameters for Twelve Copper Tripodal Ligand Complexes

  1999cited by this paper

• Proteoglycans in Breast Cancer: Friends and Foes

  2025cites this paper
• A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction

  2025cites this paper
• The end of the genetic paradigm of cancer

  2025cites this paper
• Analyses of hypoxia-related risk factors and clinical relevance in breast cancer

  2024cites this paper
• The Proteoglycans Biglycan and Decorin Protect Cardiac Cells against Irradiation-Induced Cell Death by Inhibiting Apoptosis

  2024cites this paper
• Biglycan and reduced glycolysis are associated with breast cancer cell dormancy in the brain

  2023cites this paper
• Transforming cancer cells for long-term living with cancer: An inspiring new approach.

  2023cites this paper
• Deep learning neural network image analysis of immunohistochemical protein expression reveals a significantly reduced expression of biglycan in breast cancer

  2023cites this paper
• Proteoglycans in breast cancer, identification and characterization by LC‐MS/MS assisted proteomics approach: A review

  2023cites this paper
• The multifaceted role of Matricellular Proteins in health and cancer, as biomarkers and therapeutic targets.

  2022cites this paper
• Dynamically softened substrate regulates malignancy of breast tumor cells

  2021cites this paper
• Mechanical Pressure Driving Proteoglycan Expression in Mammographic Density: a Self-perpetuating Cycle?

  2021cites this paper
• Remaining true to one’s identity

  2021cites this paper
• Distinct phenotypes of cancer cells on tissue matrix gel

  2020cites this paper
• Tumor reversion and Embryo morphogenetic factors.

  2020cites this paper
• Three-Dimensional Models as a New Frontier for Studying the Role of Proteoglycans in the Normal and Malignant Breast Microenvironment

  2020cites this paper
• Biglycan as a potential diagnostic and prognostic biomarker in multiple human cancers

  2020cites this paper
• Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine

  2020cites this paper
• Tumor Reversion Induced by Embryo and Oocyte Extracts

  2020cites this paper
• The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer

  2019cites this paper
• Tumor-dependent Effects of Proteoglycans and Various Glycosaminoglycan Synthesizing Enzymes and Sulfotransferases on Patients' Outcome.

  2019cites this paper
• Proteoglycans as miscommunication biomarkers for cancer diagnosis.

  2019cites this paper
• Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells

  2019cites this paper
• Active Fraction from Embryo Fish Extracts Induces Reversion of the Malignant Invasive Phenotype in Breast Cancer through Down-Regulation of TCTP and Modulation of E-cadherin/β-catenin Pathway

  2019cites this paper
• Stromal directives can control cancer

  2019cites this paper
• Macromolecule-Network Electrostatics Controlling Delivery of the Biotherapeutic Cell Modulator TIMP-2.

  2018cites this paper
• Fish protein extract enhances clinical response to salvage chemotherapy in colon cancer patients

  2018cites this paper
• Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery.

  2017cites this paper
• Unravelling the complexity of signalling networks in cancer: A review of the increasing role for computational modelling.

  2017cites this paper
• Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance

  2016cites this paper
• Matricellular proteins as regulators of cancer metastasis to bone.

  2016cites this paper
• Control of cancer formation by intrinsic genetic noise and microenvironmental cues

  2015cites this paper
• Insights into the key roles of proteoglycans in breast cancer biology and translational medicine.

  2015cites this paper
• Studies on artificial and extracellular matrix protein-rich surfaces as regulators of cell growth and differentiation

  2015cites this paper
• A Combined Shotgun and Targeted Mass Spectrometry Strategy for Breast Cancer Biomarker Discovery.

  2015cites this paper
• Engineered in vitro disease models.

  2015cites this paper
• Aberrant cell and basement membrane architecture contribute to sidestream smoke-induced choroidal endothelial dysfunction.

  2014cites this paper
• Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment.

  2014cites this paper
• Stromal regulation of embryonic and postnatal mammary epithelial development and differentiation.

  2014cites this paper
• A potential mechanism for extracellular matrix induction of breast cancer cell normality

  2014cites this paper
• Biomimetic tissue-engineered systems for advancing cancer research: NCI Strategic Workshop report.

  2014cites this paper