CD5 signal transduction: positive or negative modulation of antigen receptor signaling.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Critical Reviews in Immunology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1615/CRITREVIMMUNOL.V20.I4.30PMID 11100806
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Pseudo-immunoreceptor Tyrosine-based Activation Motif of CD5 Mediates Its Inhibitory Action on B-cell Receptor Signaling*

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• CD5 Costimulation Up-Regulates the Signaling to Extracellular Signal-Regulated Kinase Activation in CD4+CD8+ Thymocytes and Supports Their Differentiation to the CD4 Lineage1

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• CD5 Is A Potential Selecting Ligand for B-Cell Surface Immunoglobulin: A Possible Role in Maintenance and Selective Expansion of Normal and Malignant B Cells

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• Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts1

  2000cited by this paper
• CD5 Negatively Regulates the T-Cell Antigen Receptor Signal Transduction Pathway: Involvement of SH2-Containing Phosphotyrosine Phosphatase SHP-1

  1999cited by this paper
• Identification of a natural soluble form of human CD5.

  1999cited by this paper
• Negative regulation of CD4 lineage development and responses by CD5.

  1999cited by this paper
• Negative regulation of antigen receptor‐mediated signaling by constitutive asociation of CD5 with the SHP‐1 protein tyrosine phosphatase in B‐1 B cells

  1999cited by this paper
• The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.

  1999cited by this paper
• Interaction of recombinant and natural soluble CD5 forms with an alternative cell surface ligand

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• Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes.

  1999cited by this paper
• Several Different Cell Surface Molecules Control Negative Selection of Medullary Thymocytes

  1999cited by this paper
• Signaling through CD5 involves acidic sphingomyelinase, protein kinase C-zeta, mitogen-activated protein kinase kinase, and c-Jun NH2-terminal kinase.

  1999cited by this paper
• Differential CD5-dependent regulation of CD5-associated CK2 activity in mature and immature T cells: implication on TCR/CD3-mediated activation.

  1998cited by this paper
• Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

  1998cited by this paper
• Regulation of Casein Kinase 2 by Direct Interaction with Cell Surface Receptor CD5*

  1998cited by this paper
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• Thymocyte activation induces the association of the proto‐oncoprotein c‐cbl and ras GTPase‐ activating protein with CD5

  1998cited by this paper
• CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

  1998cited by this paper
• Human CD5 signaling and constitutive phosphorylation of C-terminal serine residues by casein kinase II.

  1998cited by this paper
• Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha.

  1998cited by this paper
• Signaling through CD5 Activates a Pathway Involving Phosphatidylinositol 3-Kinase, Vav, and Rac1 in Human Mature T Lymphocytes

  1998cited by this paper
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  1998cited by this paper
• Interaction of the CD5 cytoplasmic domain with the Ca2+ /calmodulin‐dependent kinase IIδ

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• The cytoplasmic domain of CD5 mediates both TCR/CD3-dependent and -independent diacylglycerol production.

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  1997cited by this paper
• The Ca2+/Calmodulin-dependent Kinase Type IV Is Involved in the CD5-mediated Signaling Pathway in Human T Lymphocytes*

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• Thymocyte activation induces the association of phosphatidylinositol 3‐kinase and pp120 with CD5

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• In vivo association of CD5 with tyrosine-phosphorylated ZAP-70 and p21 phospho-zeta molecules in human CD3+ thymocytes.

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• Molecular linkage of the mouse CD5 and CD6 genes.

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• Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3-Kinase Association (*)

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• Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

  1996cited by this paper
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• Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.

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• Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

  1996cited by this paper
• Native soluble CD5 delivers a costimulatory signal to resting human B lymphocytes.

  1996cited by this paper
• Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes

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• CD5 is a potential selecting ligand for B cell surface immunoglobulin framework region sequences

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• Multiple pathways originate at the Fas/APO‐1 (CD95) receptor: sequential involvement of phosphatidylcholine‐specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.

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• Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

  1995cited by this paper
• Anti-immunoglobulin M activates nuclear calcium/calmodulin-dependent protein kinase II in human B lymphocytes

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• Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

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• PKC zeta is a molecular switch in signal transduction of TNF‐alpha, bifunctionally regulated by ceramide and arachidonic acid.

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• Analysis of the Role of Protein Kinase C-α, -ϵ, and -ζ in T Cell Activation (*)

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• Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells

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• A role for CD5 in TCR-mediated signal transduction and thymocyte selection.

  1995cited by this paper
• CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

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• CD5 B cells, a fetal B cell lineage.

  1994cited by this paper
• Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

  1994cited by this paper
• Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

  1994cited by this paper
• The SRCR superfamily: a family reminiscent of the Ig superfamily.

  1994cited by this paper
• Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids.

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• CD5 is associated with the human B cell antigen receptor complex

  1994cited by this paper
• lnterleukin-2 transcriptional block by multifunctional Ca2+/ calmodulin kinase

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• p56lck phosphorylation by Ca2+/calmodulin-dependent protein kinase type II.

  1994cited by this paper
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• The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck

  1994cited by this paper
• Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

  1993cited by this paper
• Association of an activation inducible serine kinase activity with CD5.

  1993cited by this paper
• Simultaneous ligation of CD5 and CD28 on resting T lymphocytes induces T cell activation in the absence of T cell receptor/CD3 occupancy.

  1993cited by this paper
• Physical association of CD5 and the T cell receptor/CD3 antigen complex on the surface of human T lymphocytes

  1993cited by this paper
• Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72).

  1992cited by this paper
• CD5 is phosphorylated on tyrosine after stimulation of the T-cell antigen receptor complex.

  1992cited by this paper
• Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.

  1992cited by this paper
• CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.

  1992cited by this paper
• Intracellular events involved in CD5-induced human T cell activation and proliferation.

  1992cited by this paper
• Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.

  1992cited by this paper
• The B-cell surface protein CD72/Lyb-2 is the ligand for CDS

  1991cited by this paper
• Induction of human T cell proliferation by a monoclonal antibody to CD5.

  1991cited by this paper
• Immobilized anti‐CD5 together with prolonged activation of protein kinase C induce interleukin 2‐dependent T cell growth: evidence for signal transduction through CD5

  1991cited by this paper
• Phosphorylation-mediated changes in the electrophoretic mobility of CD5 molecules.

  1990cited by this paper
• Stimulation of CD5 enhances signal transduction by the T cell antigen receptor.

  1990cited by this paper
• Antigen receptor tail clue

  1989cited by this paper
• In vivo and in vitro phosphorylation of murine lymphocyte differentiation antigen CD5.

  1989cited by this paper
• Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5).

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• CD5 antibodies increase intracellular ionized calcium concentration in T cells.

  1987cited by this paper
• Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1

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