Frontline: Optimal T cell activation requires the engagement of CD6 and CD166

No abstract is available for this paper.

• Publication year

  2004

• Venue

  European Journal of Immunology

• Publication date

  2004-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/eji.200424856PMID 15048703
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular interactions mediating T cell antigen recognition.

  2003cited by this paper
• OX52 is the rat homologue of CD6: evidence for an effector function in the regulation of CD5 phosphorylation

  2003cited by this paper
• The Accessory Molecules CD5 and CD6 Associate on the Membrane of Lymphoid T Cells*

  2003cited by this paper
• CD5‐mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain

  2002cited by this paper
• Scavenger receptor cysteine‐rich domains 9 and 11 of WC1 are receptors for the WC1 counter receptor

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• CD6: expression during development, apoptosis and selection of human and mouse thymocytes.

  2002cited by this paper
• Cloning of S4D-SRCRB, a new soluble member of the group B scavenger receptor cysteine-rich family (SRCR-SF) mapping to human Chromosome 7q11.23

  2002cited by this paper
• Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

  2001cited by this paper
• Molecular Basis for the Homophilic Activated Leukocyte Cell Adhesion Molecule (ALCAM)-ALCAM Interaction*

  2001influential reference
• The Identification and Characterization of a Ligand for Bovine CD51

  2001cited by this paper
• Identification of the haemoglobin scavenger receptor

  2001cited by this paper
• CD5 signal transduction: positive or negative modulation of antigen receptor signaling.

  2000cited by this paper
• Evidence for the expression of a second CD6 ligand by synovial fibroblasts.

  2000cited by this paper
• Soluble CD86 is a costimulatory molecule for human T lymphocytes.

  2000cited by this paper
• Cell surface receptors and their ligands: In vitro analysis of CD6‐CD166 interactions

  2000cited by this paper
• Dynamic regulation of activated leukocyte cell adhesion molecule-mediated homotypic cell adhesion through the actin cytoskeleton.

  2000influential reference
• Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity.

  2000cited by this paper
• Negative regulation of CD4 lineage development and responses by CD5.

  1999cited by this paper
• Dependence of T Cell Antigen Recognition on the Dimensions of an Accessory Receptor–Ligand Complex

  1999cited by this paper
• An influence of CD5 on the selection of CD4‐lineage T cells

  1999cited by this paper
• Interaction of recombinant and natural soluble CD5 forms with an alternative cell surface ligand

  1999cited by this paper
• CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

  1998cited by this paper
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  1998cited by this paper
• Structural analysis of the CD5 antigen--expression, disulphide bond analysis and physical characterisation of CD5 scavenger receptor superfamily domain 1.

  1998cited by this paper
• The leucocyte Antigen FactsBook (2nd edn)

  1998cited by this paper
• CD6-ligand interactions: a paradigm for SRCR domain function?

  1997cited by this paper
• Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms.

  1997cited by this paper
• CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes.

  1997cited by this paper
• Characterization of mouse CD6 with novel monoclonal antibodies which enhance the allogeneic mixed leukocyte reaction

  1996influential reference
• The Amino-terminal Immunoglobulin-like Domain of Activated Leukocyte Cell Adhesion Molecule Binds Specifically to the Membrane-proximal Scavenger Receptor Cysteine-rich Domain of CD6 with a 1:1 Stoichiometry*

  1996influential reference
• CD5-Mediated Negative Regulation of Antigen Receptor-Induced Growth Signals in B-1 B Cells

  1996cited by this paper
• Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes

  1996cited by this paper
• Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand

  1995influential reference
• The Membrane-proximal Scavenger Receptor Cysteine-rich Domain of CD6 Contains the Activated Leukocyte Cell Adhesion Molecule Binding Site (*)

  1995influential reference
• Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells

  1995cited by this paper
• A role for CD5 in TCR-mediated signal transduction and thymocyte selection.

  1995cited by this paper
• The anti-CD6 mAb, IOR-T1, defined a new epitope on the human CD6 molecule that induces greater responsiveness in T cell receptor/CD3-mediated T cell proliferation.

  1994cited by this paper
• Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59.

  1994cited by this paper
• Activation of human T cells through CD6: functional effects of a novel anti-CD6 monoclonal antibody and definition of four epitopes of the CD6 glycoprotein.

  1993cited by this paper
• The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins

  1991cited by this paper
• Expression of antibody genes in nonlymphoid mammalian cells

  1991cited by this paper
• High level expression in Chinese hamster ovary cells of soluble forms of CD4 T lymphocyte glycoprotein including glycosylation variants.

  1990cited by this paper
• Anti-T12, an anti-CD6 monoclonal antibody, can activate human T lymphocytes.

  1989cited by this paper
• A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

  1988cited by this paper

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• Serum ALCAM is a potential novel non-invasive marker for predicting the progression of IgA nephropathy

  2025cites this paper
• Defining the functional role and potential as an immunotherapeutic target of ALCAM in neuroblastoma.

  2025cites this paper
• Aberrant Lower CD6 Expression on Peripheral B Cells Associated With Liver/Kidney Injury and Autoantibody Production of Systemic Lupus Erythematosus Patients

  2025cites this paper
• Ligands of CD6: roles in the pathogenesis and treatment of cancer

  2025cites this paper
• Cellular responses to neoadjuvant FOLFOX6-bevacizumab treatment in colorectal cancers analyzed by single-cell transcriptome analysis.

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• AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine

  2024cites this paper
• Twin study identifies early immunological and metabolic dysregulation of CD8+ T cells in multiple sclerosis

  2024cites this paper
• The CD6 interactome orchestrates ligand-independent T cell inhibitory signaling

  2024influential citation
• Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer.

  2024cites this paper
• The CD318/CD6 axis limits type 1 diabetes islet autoantigen-specific human T cell activation.

  2024cites this paper
• A CD6 homolog of Nile tilapia (Oreochromis niloticus) conserved binding bacteria involved in the regulation of Streptococcus agalactiae induced inflammation.

  2024cites this paper
• CD6 and Its Interacting Partners: Newcomers to the Block of Cancer Immunotherapies

  2023influential citation
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway

  2023cites this paper
• Activated leukocyte cell adhesion molecule on human oligodendrocytes mediates CD4 T cell adhesion.

  2023cites this paper
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  2021cites this paper
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  2020cites this paper
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