Ubiquinone Synthesis in Mitochondrial and Microsomal Subcellular Fractions of Pneumocystis spp.: Differential Sensitivities to Atovaquone

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Eukaryotic Cell

• Publication date

  2005-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/EC.4.8.1483-1492.2005PMID 16087753PMCID PMC1214522
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pneumocystis.

  2014cited by this paper
• Determination of coenzyme Q biosynthesis in cultured cells without the necessity for lipid extraction.

  2005cited by this paper
• The role of ubiquinone in Caenorhabditis elegans longevity.

  2005cited by this paper
• The essential functions of coenzyme Q

  2004cited by this paper
• Metabolism and function of coenzyme Q.

  2004influential reference
• Measurement of reduced and oxidized coenzyme Q9 and coenzyme Q10 levels in mouse tissues by HPLC with coulometric detection.

  2004cited by this paper
• The AtPPT1 gene encoding 4-hydroxybenzoate polyprenyl diphosphate transferase in ubiquinone biosynthesis is required for embryo development in Arabidopsis thaliana

  2004cited by this paper
• Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana.

  2004cited by this paper
• Molecular Basis for Atovaquone Resistance in Pneumocystis jirovecii Modeled in the Cytochrome bc1Complex of Saccharomyces cerevisiae*

  2004cited by this paper
• Antioxidant and prooxidant properties of mitochondrial Coenzyme Q.

  2004cited by this paper
• Cardiolipin Domains in Bacillus subtilis Marburg Membranes

  2004cited by this paper
• Recapitulation in Saccharomyces cerevisiae of Cytochrome b Mutations Conferring Resistance to Atovaquone in Pneumocystis jiroveci

  2003cited by this paper
• Evidence that Biosynthesis of Individual Ubiquinone Homologs in Pneumocystis carinii is Under Homolog‐Specific Negative Feedback (Product) Control

  2003cited by this paper
• Molecular Basis for Atovaquone Binding to the Cytochrome bc1 Complex*

  2003cited by this paper
• Ubiquinone biosynthesis in rat liver peroxisomes.

  2002cited by this paper
• Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q

  2002cited by this paper
• Ubiquinone Is Necessary for Caenorhabditis elegansDevelopment at Mitochondrial and Non-mitochondrial Sites*

  2002cited by this paper
• Is Pneumocystis a Plant?

  2002cited by this paper
• Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass

  2002cited by this paper
• Do sterols reduce proton and sodium leaks through lipid bilayers?

  2001cited by this paper
• Cardiolipin binds nonyl acridine orange by aggregating the dye at exposed hydrophobic domains on bilayer surfaces

  2001cited by this paper
• HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma.

  2001cited by this paper
• New insights into transmission, diagnosis, and drug treatment of Pneumocystis carinii pneumonia.

  2001cited by this paper
• Pneumocystis carinii f. sp. carinii Synthesizes De Novo Four Homologs of Ubiquinone

  2001influential reference
• New Nomenclature for the Genus Pneumocystis

  2001cited by this paper
• The multiple functions of coenzyme Q.

  2001cited by this paper
• Pneumocystis carinii cytochrome b mutations are associated with atovaquone exposure in patients with AIDS.

  2001cited by this paper
• Characterization of cytochrome b from Toxoplasma gondii and Q(o) domain mutations as a mechanism of atovaquone-resistance.

  2000cited by this paper
• The existence of a lysosomal redox chain and the role of ubiquinone.

  2000cited by this paper
• Effects of Atovaquone and Diospyrin-Based Drugs on the Cellular ATP of Pneumocystis carinii f. sp.carinii

  2000cited by this paper
• Visualization of Phospholipid Domains inEscherichia coli by Using the Cardiolipin-Specific Fluorescent Dye 10-N-Nonyl Acridine Orange

  2000cited by this paper
• Effects of Atovaquone and Diospyrin-Based Drugs on Ubiquinone Biosynthesis in Pneumocystis carinii Organisms

  2000cited by this paper
• Phenotypes of Fission Yeast Defective in Ubiquinone Production Due to Disruption of the Gene for p-Hydroxybenzoate Polyprenyl Diphosphate Transferase

  2000cited by this paper
• Subcellular localization of plastoquinone and ubiquinone synthesis in spinach cells.

  2000cited by this paper
• Ubiquinone. Biosynthesis of quinone ring and its isoprenoid side chain. Intracellular localization.

  2000cited by this paper
• Regulation of the plasma membrane potential in Pneumocystis carinii.

  2000cited by this paper
• Staining of mitochondrial membranes with 10-nonyl acridine orange, MitoFluor Green, and MitoTracker Green is affected by mitochondrial membrane potential altering drugs.

  2000cited by this paper
• Pathways for proton release during ubihydroquinone oxidation by the bc(1) complex.

  1999cited by this paper
• Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation.

  1999cited by this paper
• Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives.

  1999cited by this paper
• Resistance mutations reveal the atovaquone‐binding domain of cytochrome b in malaria parasites

  1999cited by this paper
• Pro- and antioxidant functions of quinones in mammalian cells.

  1999cited by this paper
• Continuous axenic cultivation of Pneumocystis carinii.

  1999cited by this paper
• Cell Wall Antigens of Pneumocystis carinii Trophozoites and Cysts: Purification and Carbohydrate Analysis of these Glycoproteins

  1998cited by this paper
• Mutations in the cytochrome b gene of Plasmodium berghei conferring resistance to atovaquone.

  1998cited by this paper
• Sequence polymorphisms in the Pneumocystis carinii cytochrome b gene and their association with atovaquone prophylaxis failure.

  1998cited by this paper
• Genetic Evidence for Coenzyme Q Requirement in Plasma Membrane Electron Transport

  1998cited by this paper
• In-vitro activity of atovaquone, sulphamethoxazole and dapsone alone and combined with inhibitors of dihydrofolate reductase and macrolides against Pneumocystis carinii.

  1997cited by this paper
• Cloning and characterization of the

  1996cited by this paper
• Composition of Pneumocystis carinii Neutral Lipids and Identification of Coenzyme Q10 as the Major Ubiquinone Homolog

  1996cited by this paper
• Ion pair formation between basic residues at 144 of the Cyt b polypeptide and the ubiquinones at the Qo site of the Cyt bc1 complex.

  1995cited by this paper
• Relationship between the endoplasmic reticulum-Golgi membrane system and ubiquinone biosynthesis.

  1995cited by this paper
• Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family

  1995cited by this paper
• Cloning and Characterization of an ATPase Gene from Pneumocystis carinii which Closely Resembles Fungal H+ ATPases

  1995cited by this paper
• The role of atovaquone tablets in treating Pneumocystis carinii pneumonia.

  1995cited by this paper
• Coenzyme Q homologs in parasitic protozoa as targets for chemotherapeutic attack.

  1994cited by this paper
• Copyright � 1995, American Society for Microbiology Effects of Atovaquone and Other Inhibitors on

  1994cited by this paper
• Detection of ubiquinone in parasitic and free-living protozoa, including species devoid of mitochondria.

  1994cited by this paper
• ATOVAQUONE: A Review

  1993cited by this paper
• Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes.

  1993cited by this paper
• Biosynthesis of ubiquinone and plastoquinone in the endoplasmic reticulum-Golgi membranes of spinach leaves.

  1993cited by this paper
• Characterization of Pneumocystis carinii Preparations Developed for Lipid Analysis

  1993influential reference
• Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3-hydroxy-1,4-naphthoquinone (566C80).

  1992cited by this paper
• Requirement for coenzyme Q in plasma membrane electron transport.

  1992cited by this paper
• 566C80, an antimalarial hydroxynaphthoquinone with broad spectrum: experimental activity against opportunistic parasitic infections of AIDS patients.

  1991cited by this paper
• Chloroquine-sensitive transplasmalemma electron transport in Tetrahymena pyriformis: a hypothesis for control of parasite protozoa through transmembrane redox.

  1991cited by this paper
• Open-label efficacy and safety trial of 42 days of 566C80 for Pneumocystis carinii pneumonia in AIDS patients.

  1991cited by this paper
• Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.

  1991cited by this paper
• 566C80, an antimalarial hydroxynaphthoquinone with broad spectrum: experimental activity against opportunistic parasitic infections of AIDS patients.

  1991influential reference
• Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver.

  1990cited by this paper
• Analysis of Pneumocystis carinii cyst wall. II. Sugar composition.

  1990cited by this paper
• Ultrastructural studies of Pneumocystis carinii.

  1989cited by this paper
• Ubiquinone biosynthesis by the microsomal fraction from rat liver.

  1987cited by this paper
• Biosynthesis of ubiquinone.

  1983cited by this paper
• Alternate routes for ubiquinone biosynthesis in rats.

  1977cited by this paper
• 3-Polyprenyl-4-hydroxybenzoate synthesis in the inner membrane of mitochondria from p-hydroxybenzoate and isopentenylpyrophosphate. A demonstration of isoprenoid synthesis in rat liver mitochondria.

  1972cited by this paper
• Ubiquinone from rat liver Golgi apparatus fractions.

  1970cited by this paper
• THE INTRACELLULAR LOCALIZATION OF PORPHYRINS.

  1964cited by this paper
• Distribution of Coenzyme Q in Rat Liver Cell Fractions

  1961cited by this paper
• Pneumocystis carinii pneumonia.

  1960cited by this paper
• [The biosynthesis of ubiquinone].

  1958cited by this paper
• [121] Succinic dehydrogenase

  1955cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Drug repurposing of Mito-Atovaquone for cancer treatment.

  2023cites this paper
• Challenges and Perspectives in Malaria Treatment

  2017influential citation
• Regulation of coenzyme Q biosynthesis through nutritional and pharmacological interventions

  2017cites this paper
• Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts

  2016cites this paper
• Caracterização de múltiplos polimorfismos de Pneumocystis Jirovecii por multiplex-PCR/Single base extension

  2013cites this paper
• Agents antimicrobiens ciblant le complexe III de la chaîne respiratoire mitochondriale : caractérisation de nouveaux inhibiteurs et étude du développement des résistances

  2012cites this paper
• Trypanosoma brucei solanesyl-diphosphate synthase localizes to the mitochondrion.

  2012cites this paper
• Molecular & Biochemical Parasitology

  2012cites this paper
• Biochemical research elucidating metabolic pathways in Pneumocystis.

  2010cites this paper
• Inhibitors of the mitochondrial electron transport chain and de novo pyrimidine biosynthesis as antimalarials: The present status.

  2010cites this paper
• Hydroxylation of demethoxy-Q 6 constitutes a control point in yeast coenzyme Q 6

  2009cites this paper
• Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis

  2008cites this paper
• Ubiquinone Synthesis and its Regulation in Pneumocystis carinii

  2006cites this paper
• Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa

  2006cites this paper