Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1999-02-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.96.3.1002PMID 9927683PMCID PMC15340
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• pRB plays an essential role in cell cycle arrest induced by DNA damage.

  1998cited by this paper
• Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

  1998cited by this paper
• p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells

  1998cited by this paper
• Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein.

  1997cited by this paper
• Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb.

  1997cited by this paper
• Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.

  1997cited by this paper
• Role of the Rb/E2F pathway in cell growth control

  1997cited by this paper
• The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.

  1997cited by this paper
• When Checkpoints Fail Review

  1997cited by this paper
• Differential Phosphorylation of the Retinoblastoma Protein by G1/S Cyclin-dependent Kinases*

  1997cited by this paper
• Cyclin-dependent Kinases Are Inactivated by a Combination of p21 and Thr-14/Tyr-15 Phosphorylation after UV-induced DNA Damage*

  1996cited by this paper
• The consensus motif for phosphorylation by cyclin D1‐Cdk4 is different from that for phosphorylation by cyclin A/E‐Cdk2.

  1996cited by this paper
• UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints.

  1996cited by this paper
• p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

  1995cited by this paper
• Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

  1995cited by this paper
• Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

  1995cited by this paper
• Radiation-induced cell cycle arrest compromised by p21 deficiency

  1995cited by this paper
• Requirement for tyrosine phosphorylation of Cdk4 in Gl arrest induced by ultraviolet irradiation

  1995cited by this paper
• Mechanism of active transcriptional repression by the retinoblastoma protein

  1995cited by this paper
• Inhibition of ras-induced proliferation and cellular transformation by p16INK4

  1995cited by this paper
• Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

  1995cited by this paper
• Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity

  1995cited by this paper
• Direct transcriptional repression by pRB and its reversal by specific cyclins

  1995cited by this paper
• D-type cyclin-dependent kinase activity in mammalian cells

  1994cited by this paper
• Identification of G1 kinase activity for cdk6, a novel cyclin D partner

  1994cited by this paper
• p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

  1994cited by this paper
• p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

  1994cited by this paper
• Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

  1993cited by this paper
• p21 is a universal inhibitor of cyclin kinases

  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

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• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
• Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.

  1993cited by this paper
• Regulation of retinoblastoma protein functions by ectopic expression of human cyclins.

  1992cited by this paper
• The retinoblastoma gene and gene product.

  1992cited by this paper
• A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.

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• p53, guardian of the genome

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• Adenovirus E1A targets key regulators of cell proliferation.

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• Retinoblastoma protein switches the E2F site from positive to negative element

  1992cited by this paper
• The retinoblastoma gene and gene product.

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• Cancer. p53, guardian of the genome.

  1992cited by this paper
• Participation of p53 protein in the cellular response to DNA damage.

  1991cited by this paper
• The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

  1991cited by this paper

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