Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Gastroenterology

• Publication date

  1996-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1053/GAST.1996.V111.PM8690211PMID 8690211
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• New insights into the mode of action of anti-inflammatory drugs

  2005cited by this paper
• Differential measurement of constitutive (COX-1) and inducible (COX-2) cyclooxygenase expression in human umbilical vein endothelial cells using specific immunometric enzyme immunoassays.

  1995cited by this paper
• Intestinal site‐dependent susceptibility to chronic indomethacin in the rat: a morphological and biochemical study

  1995cited by this paper
• Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach

  1995cited by this paper
• Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2 (*)

  1995cited by this paper
• Non-steroidal anti-inflammatory drug-induced gastric damage in experimental animals: underlying pathological mechanisms.

  1995cited by this paper
• c-Kit Ligand Mediates Increased Expression of Cytosolic Phospholipase A, Prostaglandin Endoperoxide Synthase-1, and Hematopoietic Prostaglandin D Synthase and Increased IgE-dependent Prostaglandin D Generation in Immature Mouse Mast Cells (*)

  1995cited by this paper
• Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.

  1995cited by this paper
• Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs.

  1995cited by this paper
• Eicosanoids and the gastrointestinal tract.

  1995cited by this paper
• Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

  1995cited by this paper
• Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

  1995cited by this paper
• Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

  1995cited by this paper
• Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.

  1994cited by this paper
• Regulated expression of prostaglandin endoperoxide synthase-2 by uterine stroma.

  1994cited by this paper
• Regulation of prostaglandin synthase-1 and prostaglandin synthase-2

  1994cited by this paper
• Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo.

  1994cited by this paper
• Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas.

  1994cited by this paper
• Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells.

  1994cited by this paper
• Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.

  1994cited by this paper
• NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro.

  1994cited by this paper
• Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.

  1994cited by this paper
• Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

  1994cited by this paper
• Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

  1994cited by this paper
• Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

  1993cited by this paper
• NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.

  1993cited by this paper
• Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues

  1993cited by this paper
• Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

  1993cited by this paper
• Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells.

  1993cited by this paper
• Prostanoid biosynthesis and mechanisms of action.

  1992cited by this paper
• PGE2 secretion from organ cultured gastric mucosa: correlation with cyclooxygenase activity and endogenous substrate release.

  1992cited by this paper
• Prostaglandins, NSAIDs, and cytoprotection.

  1992cited by this paper
• Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

  1992cited by this paper
• Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles.

  1992cited by this paper
• Prostaglandin H synthase immunoreactivity in human gut

  1991cited by this paper
• Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth factor-1 in human endothelial cells.

  1991cited by this paper
• Prostaglandin E2 formation by rat gastroduodenal tissue following intragastric acid perfusion.

  1990cited by this paper
• Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain.

  1988cited by this paper
• Patterns of prostaglandin synthesis and degradation in isolated superficial and proliferative colonic epithelial cells compared to residual colon.

  1983cited by this paper
• Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa.

  1983cited by this paper
• Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

  1979cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Transcriptome Analysis Reveals Equine Endometrium’s Gene Expression Profile Around Embryo Fixation

  2025cites this paper
• Antacida in der Tiermedizin – ist ein komplementärer Ansatz möglich?

  2024cites this paper
• An overview of recent advancements in anticancer Pt(IV) prodrugs: New smart drug combinations, activation and delivery strategies

  2023cites this paper
• Cellular mechanisms of taste disturbance induced by the non-steroidal anti-inflammatory drug, diclofenac, in mice

  2023cites this paper
• NSAID-Associated Small Intestinal Injury: An Overview From Animal Model Development to Pathogenesis, Treatment, and Prevention

  2022cites this paper
• Spinal revival: The management of lower back pain

  2022cites this paper
• Protective effect of Juglans regia L. (walnut) leaves extract against indomethacin induced gastric mucosal damage in rats

  2022cites this paper
• Celecoxib, a selective cyclooxygenase-2 inhibitor, aggravates radiation-induced intestinal damage in mice

  2021cites this paper
• Conserved and breed-specific differences in the cervical transcriptome of sheep with divergent fertility at the follicular phase of a natural oestrus cycle

  2021cites this paper
• Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: Regulating arachidonic acid metabolism and glycerophospholipid metabolism.

  2020cites this paper
• NSAID–Gut Microbiota Interactions

  2020cites this paper
• Study of Melatonin as Preventive Agent of Gastrointestinal Damage Induced by Sodium Diclofenac

  2020cites this paper
• Different Chemical Structures and Physiological/Pathological Roles of Cyclooxygenases

  2020cites this paper
• Suppression of inflammatory mediators and matrix metalloproteinase (MMP)-13 by Morus alba stem extract and oxyresveratrol in RAW 264.7 cells and C28/I2 human chondrocytes

  2019influential citation
• Induction of COX-1, suppression of COX-2 and pro-inflammatory cytokines gene expression by moringa leaves and its aqueous extract in aspirin-induced gastric ulcer rats

  2019cites this paper
• An Activity-based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells.

  2019cites this paper
• Expression of cyclooxygenase 2 in oral submucous fibrosis: An immunohistochemical pilot study

  2019cites this paper
• Investigation of the effects of centrally injected nesfatin-1 on the hypothalamic cyclooxygenase and lipoxygenase enzymes using western blotting

  2019cites this paper
• Lack of Small Intestinal Dysbiosis Following Long-Term Selective Inhibition of Cyclooxygenase-2 by Rofecoxib in the Rat

  2019cites this paper
• Enzymatic Research Having Pharmaceutical Significance

  2018cites this paper
• Cardiorenal Safety of OTC Analgesics

  2018cites this paper
• Maintenance use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) and prostate cancer risk

  2018cites this paper
• Selected Molecular Mechanisms Involved in the Parasite–Host System Hymenolepis diminuta–Rattus norvegicus

  2018cites this paper
• Comparative Microbiome Signatures and Short-Chain Fatty Acids in Mouse, Rat, Non-human Primate, and Human Feces

  2018cites this paper
• Comparative Anti-Arthritic Study of Cassia fistula with Naproxen in Rheumatoid Arthritis Murine Model

  2018cites this paper
• A study of two major challenges in prostate cancer : effective chemo-prevention and overcoming resistance to hormonal and chemotherapy

  2018cites this paper
• Molecular Signaling in Tumorigenesis of Gastric Cancer

  2018cites this paper
• The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis

  2018cites this paper
• Effects of nonselective and selective cyclooxygenase inhibitors on the contractions of isolated bronchial smooth muscle in the horse

  2018cites this paper
• A Carrier-Free Nanostructure Based on Platinum(IV) Prodrug Enhances Cellular Uptake and Cytotoxicity.

  2018cites this paper
• Investigations on Antioxidant, Antiproliferative and COX‐2 Inhibitory Potential of Alkaloids from Anthocephalus cadamba (Roxb.) Miq. Leaves

  2017cites this paper
• Gastroprotective potential of hydro-alcoholic extract of Pattanga (Caesalpinia sappan Linn.).

  2017cites this paper
• Interactions between nitric oxide and hydrogen sulfide generating systems in gastric mucosa under condition of the combined action of stress and NDAIDs

  2017cites this paper
• H. pylori infection increases gastric mucosal COX2 and mTOR expression in chronic gastritis: Implications for cancer progression?

  2017cites this paper
• Deciphering the mechanism behind the varied binding activities of COXIBs through Molecular Dynamic Simulations, MM-PBSA binding energy calculations and per-residue energy decomposition studies

  2017cites this paper
• Analgesic efficacy of celecoxib in patients after oral surgery: special reference to time to onset of analgesia and duration of analgesic effect

  2016cites this paper
• Molecular and Experimental Basis for COX Inhibition in Cancer

  2016cites this paper
• Non-steroidal anti-inflammatory drug-induced colopathy: A Case series

  2016cites this paper
• Curcumin ameliorates Ethanol induced Gastric Mucosal Erosion in Rats via alleviation of Oxidative Stress and Regulation of Pro-Inflammatory Cytokines and NF-kappa B activation

  2016cites this paper
• The inflammatory effect of infection with Hymenolepis diminuta via the increased expression and activity of COX-1 and COX-2 in the rat jejunum and colon.

  2016cites this paper
• Physiological and molecular responses in the pulp associated with early inflammatory process

  2016cites this paper
• Targeting arachidonic acid pathway by natural products for cancer prevention and therapy.

  2016cites this paper
• Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations.

  2016cites this paper
• the rat stomach: effects of aging and ulcers Cyclooxygenase-1 and an alternatively spliced mRNA in

  2016cites this paper
• Biochemical and epidemiological investigations of non-steroidal anti-inflammatory drug usage and related side effects in equids

  2016cites this paper
• Metformin does not reduce markers of cell proliferation in esophageal tissues of patients with Barrett's esophagus.

  2015cites this paper
• Design and synthesis of new non-steroidal anti-inflammatory drugs with anti-cancer activity on colon rectal cancer cell lines HCT-116 and Caco-2

  2015cites this paper
• Regulatory mechanism of the gastric hyperemic response following barrier disruption: roles of cyclooxygenase-1, the prostaglandin E2/EP1 receptor and sensory neurons.

  2015cites this paper
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Induced Dyspepsia.

  2015cites this paper
• Model‐based prediction of the acute and long‐term safety profile of naproxen in rats

  2015cites this paper
• New Insights into the Mechanism of Action of Aspirin in the Prevention of Colorectal Neoplasia.

  2015cites this paper
• NSAID-Induced Small Intestinal Damage - Roles of Various Pathogenic Factors

  2015cites this paper
• Anti-diabetic and Anti-inflammatory Potential of the Edible Brown Alga Hizikia Fusiformis

  2015cites this paper
• Immunomodulation by interleukin-10 overexpressing mesenchymal stem cells for cartilage repair in osteoarthritis

  2015cites this paper
• Variable responses of human and non-human primate gut microbiomes to a Western diet

  2015cites this paper
• November 2014 PeriOperative Use of Injectable Rimadyl ® ( carprofen )

  2014cites this paper
• Importance of cyclooxygenase‐1/prostacyclin in modulating gastric mucosal integrity under stress conditions

  2014cites this paper
• Impact of non-steroidal anti-inflammatory drugs on gastrointestinal cancers: current state-of-the science.

  2014cites this paper
• ANTI-ARTHRITIC ACTIVITY OF EUPHORBIA THYMIFOLIA LINN

  2014cites this paper
• Efficacy and Safety of some Medical Herbs on Gastric Ulcer Induced by Aspirin in Rats

  2014cites this paper
• Role of cyclooxygenase-2 in intestinal injury in neonatal rats.

  2014cites this paper
• At the Bedside: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer

  2014cites this paper
• Estudio farmacológico de la modulación del receptor 5-HT2b de serotonina por inhibidores selectivos de la COX-2 (celecoxib y valdecoxib) y fluoxetina

  2013cites this paper
• ASP6537, a novel highly selective cyclooxygenase-1 inhibitor, exerts potent antithrombotic effect without "aspirin dilemma".

  2013cites this paper
• Pharmacokinetics and pharmacodynamics of some NSAIDs in horses: A pharmacological, biochemical and forensic study

  2013cites this paper
• Effects of a novel herbal formulation JSK on acute spinal cord injury in rats

  2013cites this paper
• Pharmacology in the musculoskeletal system

  2013cites this paper
• Dillapiole, Isolated from Peperomia pellucida, Shows Gastroprotector Activity against Ethanol-Induced Gastric Lesions in Wistar Rats

  2013cites this paper
• Role of cyclooxygenase-2 in gastric cancer development and progression.

  2013cites this paper
• DNA damage, p53, Ki-67 and COX-2 expression in rat tongue cells exposed to nandrolone decanoate

  2013cites this paper
• Research on the Effectiveness of Transferring Skills with the Use of E-Learning in the Precision of Blood Pressure Measurement Conducted by Pharmacists

  2012cites this paper
• Cyklooksygenaza-2 i jej rola w kancerogenezie

  2012cites this paper
• Synergic Effect of NSAID and Gastric Acid on Superoxide-Anion Production in Stomach

  2012cites this paper
• Tocotrienols as possible treatments for obesity

  2012cites this paper
• Roles of EP4 Receptors in Protective and Healing-Promoting Effects of Prostaglandin E2 on NSAID-Induced Small Intestinal Damage

  2012cites this paper
• Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility.

  2012cites this paper
• Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system.

  2012cites this paper
• COX-2 as a molecular target of colon cancer chemoprevention: Promise and reality

  2012cites this paper
• Hyperbaric oxygen therapy reduces COX-2 expression in a dimethylhydrazine-induced rat model of colorectal carcinogenesis.

  2012cites this paper
• Bean concentrates and inflammation reduction

  2012cites this paper
• Effect of COX-2 inhibitor lumiracoxib and the TNF-α antagonist etanercept on TNBS-induced colitis in Wistar rats

  2012cites this paper
• ESTUDO DA SEGURANÇA DA DOSE TERAPÊUTICA ORAL DO FIROCOXIB EM EQUINOS

  2012cites this paper
• Novel regulators of human gonadal development

  2012cites this paper
• Managing the adverse effects of nonsteroidal anti-inflammatory drugs

  2011cites this paper
• The impact of cyclooxygenase inhibition on duodenal motility and mucosal alkaline secretion in anaesthetized rats

  2011cites this paper
• Ulcerogenic Effects of NSAIDs on Gastric Mucosa: Comparison between Selective and Non-Selective Cox2 Inhibitors; Indomethacin VS Rofecoxib

  2011cites this paper
• Immunomodulatory activity of fucoidan against aspirin-induced gastric mucosal damage in rats.

  2011cites this paper
• Investigation into the immuno-therapeutic potential of melanocortin peptides on activated chondrocytes

  2011cites this paper
• Regulatory mechanism of duodenal bicarbonate secretion: Roles of endogenous prostaglandins and nitric oxide.

  2011cites this paper
• Characterization of microRNAs regulating cyclooxygenase-2 gene expression

  2011cites this paper
• NITROGEN OXIDE RELEASING PRODRUGS AS ANTIINFLAMMATORY, ANTICANCER AND CARDIOPROTECTIVE AGENTS

  2011cites this paper
• Biosilicate® and low‐level laser therapy improve bone repair in osteoporotic rats

  2011cites this paper
• Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation

  2011cites this paper
• Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia.

  2011cites this paper
• Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.

  2011cites this paper
• Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs

  2011cites this paper
• Effects of celecoxib in young rats: Histopathological changes in tissues and alterations of oxidative stress/antioxidant defense system

  2011cites this paper
• The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine

  2011cites this paper
• Prostaglandins and Other Lipid Mediators eview nti-inflammatory drugs , eicosanoids and the annexin A 1 / FPR 2 nti-inflammatory system amia

  2011cites this paper
• Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.

  2010cites this paper