Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  1997-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1128/AAC.41.3.600PMID 9056000PMCID PMC163758
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid.

  1996influential reference
• Compensatory ahpC Gene Expression in Isoniazid-Resistant Mycobacterium tuberculosis

  1996influential reference
• Origin and interstate spread of a New York City multidrug-resistant Mycobacterium tuberculosis clone family.

  1996cited by this paper
• ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex

  1996cited by this paper
• Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis

  1996influential reference
• Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance.

  1996cited by this paper
• Identification of a polymorphic nucleotide in oxyR specific for Mycobacterium bovis

  1996cited by this paper
• Site‐directed mutagenesis of the katG gene of Mycobacterium tuberculosis: effects on catalase–peroxidase activities and isoniazid resistance

  1996cited by this paper
• Molecular mechanisms of isoniazid resistance in Mycobacterium tuberculosis and Mycobacterium bovis

  1995cited by this paper
• Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic.

  1995cited by this paper
• Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative‐stress regulatory gene:implications for sensitivity to isoniazid

  1995cited by this paper
• Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria.

  1995cited by this paper
• Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing.

  1995cited by this paper
• Missense mutations in the catalase‐peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis

  1995cited by this paper
• Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis.

  1995cited by this paper
• Antimicrobial agent resistance in mycobacteria: molecular genetic insights

  1995cited by this paper
• Is Mycobacterium tuberculosis 15,000 years old?

  1994cited by this paper
• inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.

  1994cited by this paper
• Effects of peroxides on susceptibilities of Escherichia coli and Mycobacterium smegmatis to isoniazid

  1994cited by this paper
• Susceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid

  1993cited by this paper
• Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology

  1993cited by this paper
• Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis

  1993cited by this paper
• Transformation with katG restores isoniazid‐sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations

  1993cited by this paper
• The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis

  1992cited by this paper
• Oxidative stress responses in Escherichia coli and Salmonella typhimurium

  1991cited by this paper
• The global tuberculosis situation and the new control strategy of the World Health Organization.

  1991cited by this paper
• Oxidative stress responses in Escherichia coli and Salmonella typhimurium.

  1991cited by this paper
• Identification and molecular analysis of oxyR-regulated promoters important for the bacterial adaptation to oxidative stress.

  1989cited by this paper
• OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins.

  1989cited by this paper
• Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium.

  1985cited by this paper
• Isoniazid-resistance and catalase activity of tubercle bacilli; a preliminary report.

  1954cited by this paper

• Mutations in oxyR and oxyR-ahpC Interogenic Region in Isoniazid-Resistant Mycobacterium tuberculosis Clinical Isolates from Chongqing, China

  2026influential citation
• A comprehensive evaluation of a novel targeted-sequencing workflow for Mycobacterium species identification and anti-tuberculosis drug-resistance detection

  2025cites this paper
• The ahpC c−54t compensatory mutation is not always a valid surrogate for isoniazid resistance in Mycobacterium tuberculosis

  2025cites this paper
• A Comprehensive Review of Molecular Mechanisms Leading to the Emergence of Multidrug Resistance in Bacteria

  2024cites this paper
• Genomic epidemiology analysis of drug-resistant Mycobacterium tuberculosis distributed in Mexico

  2023cites this paper
• First insights into the phylogenetic diversity of Mycobacterium tuberculosis in Kuwait and evaluation of REBA MTB-MDR assay for rapid detection of MDR-TB

  2022cites this paper
• Molecular characteristics of Mycobacterium tuberculosis drug-resistant isolates from HIV- and HIV+ tuberculosis patients in Russia

  2022cites this paper
• Detection and characterization of mutations in genes related to isoniazid resistance in Mycobacterium tuberculosis clinical isolates from Iran

  2022cites this paper
• Genome analyses of 174 strains of Mycobacterium tuberculosis provide insight into the evolution of drug resistance and reveal potential drug targets

  2021cites this paper
• Significance of the coexistence of non-codon 315 katG, inhA, and oxyR-ahpC intergenic gene mutations among isoniazid-resistant and multidrug-resistant isolates of Mycobacterium tuberculosis: a report of novel mutations

  2021cites this paper
• Molecular Basis of Resistance to First-Line Drugs of Mycobacterium tuberculosis/canettii Strains in Greece

  2021cites this paper
• Prevalence of drug resistance-conferring mutations associated with isoniazid and rifampicin-resistant Mycobacterium tuberculosis in Ethiopia: A systematic review and meta-analysis.

  2021cites this paper
• Drugs against Mycobacterium tuberculosis

  2020cites this paper
• Differential expression of resistant and efflux pump genes in MDR-TB isolates.

  2020cites this paper
• Two Novel katG Mutations Conferring Isoniazid Resistance in Mycobacterium tuberculosis

  2020cites this paper
• Prevalence of drug resistance-conferring mutations associated with isoniazid and rifampicin resistant Mycobacterium tuberculosis in Ethiopia: A systematic review and meta-analysis

  2020cites this paper
• Diagnostic Delays and Treatment Implications for Patients with Isoniazid-Resistant Tuberculosis: A Case Report and Review of the Literature

  2019cites this paper
• PREVALENCE OF MUTATIONS IN MYCOBACTERIUM TUBERCULOSIS GENES CODING RESISTANCE TO ISONIAZID AND RIFAMPICIN IN TUBERCULOSIS PATIENTS FROM DIFFERENT AGE GROUPS

  2019cites this paper
• Detection of resistant strains of tubercle bacilli by gene mutation hybridization

  2019cites this paper
• Распространенность мутаций в генах микобактерий туберкулеза, кодирующих лекарственную устойчивость к изониазиду и рифампицину, у больных туберкулезом в разных возрастных группах

  2019cites this paper
• Detection of Resistant-Associated Mutations and Genetic Profile of Resistance to Rifampicin and Isoniazid among Multi-Drug Resistant Mycobacterium tuberculosis Isolates from Plateau State.

  2019cites this paper
• Significance of Coexisting Mutations on Determination of the Degree of Isoniazid Resistance in Mycobacterium tuberculosis Strains

  2018cites this paper
• The impact of combined gene mutations in inhA and ahpC genes on high levels of isoniazid resistance amongst katG non-315 in multidrug-resistant tuberculosis isolates from China

  2018cites this paper
• A study on mutation in genes associated with rifampicin and isoniazid resistance in Mycobacterium tuberculosis complex using line probe assay

  2018cites this paper
• Using transposon mutagenesis of mycobacterium bovis BCG to identify candidate molecules for novel control approaches for bovine tuberculosis.

  2018cites this paper
• Direct detection of rpoB and katG gene mutations of Mycobacterium tuberculosis in clinical samples

  2017cites this paper
• Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysis

  2017cites this paper
• Mutation as a Molecular Determinant for Isoniazid Resistance in Mycobacterium tuberculosis

  2017cites this paper
• Evolution of Phenotypic and Molecular Drug Susceptibility Testing.

  2017cites this paper
• Host and pathogen genetics associated with pneumococcal meningitis

  2017cites this paper
• DETECTION OF SPECIFIC CAUSES OF TUBERCULOSIS IN THE DAIRY CATTLE OF BANGLADESH AGRICULTURAL UNIVERSITY BY SEQUENCING AND SEQUENCE ANALYSIS

  2017cites this paper
• Chapter 6 References

  2017cites this paper
• Comprehensive Whole-Genome Sequencing and Reporting of Drug Resistance Profiles on Clinical Cases of Mycobacterium tuberculosis in New York State

  2017cites this paper
• Large scale genomic analysis shows no evidence for pathogen adaptation between the blood and cerebrospinal fluid niches during bacterial meningitis

  2017cites this paper
• Comparative accuracy of the REBA MTB MDR and Hain MTBDRplus line probe assays for the detection of multidrug-resistant tuberculosis: A multicenter, non-inferiority study

  2017cites this paper
• Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics.

  2016cites this paper
• The influence of growth conditions on the susceptibility of Mycobacterium tuberculosis to antibiotics

  2016cites this paper
• Large scale genomic analysis shows no evidence for repeated pathogen adaptation during the invasive phase of bacterial meningitis in humans

  2016cites this paper
• Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis.

  2016cites this paper
• Frequency and Distribution of Tuberculosis Resistance-Associated Mutations between Mumbai, Moldova, and Eastern Cape

  2016cites this paper
• Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium tuberculosis: A Systematic Review

  2015cites this paper
• Detection of novel and reported mutations in the rpoB, katG and inhA genes in multidrug-resistant tuberculosis isolates: A hospital-based study.

  2015cites this paper
• Genome sequence comparisons of serial multi-drug-resistant Mycobacterium tuberculosis isolates over 21 years of infection in a single patient

  2015cites this paper
• Investigation of Ser315 Substitutions within katG Gene in Isoniazid-Resistant Clinical Isolates of Mycobacterium tuberculosis from South India

  2015cites this paper
• FOR WHO Non-inferiority Evaluation of Nipro NTM + MDRTB and Hain GenoType MTBDRplus V 2 line probe assays

  2015cites this paper
• The impacto of the oxidative stress response on tacrolimus production by S. Tsukubaensis NRRL 18488

  2015cites this paper
• Molecular identification of mycobacterium bovis from Post-Mortem inspected cattle at the abattoir and slaughter houses in Bauchi State, Nigeria.

  2015cites this paper
• ANTI-TUBERCULOSIS DRUG RESISTANCE SURVEILLANCE

  2015cites this paper
• Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities

  2014cites this paper
• Impact of isoniazid resistance on virulence of global and south Indian clinical isolates of Mycobacterium tuberculosis.

  2014cites this paper
• Detection of mutations associated with isoniazid resistance in multidrug-resistant Mycobacterium tuberculosis clinical isolates.

  2014cites this paper
• Molecular genetic analysis of Isoniazid-resistant strains of Mycobacterium tuberculosis circulating in the Saratov region

  2013cites this paper
• Early detection and group-specific identification of Mycobacterium tuberculosis strains by method of single-nucleotide polymorphism analysis with hairpin primers

  2013cites this paper
• Evaluation of Mycobacterium tuberculosis drug susceptibility in clinical specimens from Nigeria using genotype MTBDRplus and MTBDRsl assays.

  2013cites this paper
• Adaptation and evolution of drug-resistant Mycobacterium tuberculosis

  2013cites this paper
• Experimental evolution as an efficient tool to dissect adaptive paths to antibiotic resistance.

  2013cites this paper
• Identification of Mycobacterium Species and Mycobacterium tuberculosis Complex Resistance Determinants by Use of PCR-Electrospray Ionization Mass Spectrometry

  2013cites this paper
• Utility of GenoType MTBDRplus assay in rapid diagnosis of multidrug resistant tuberculosis at a tertiary care centre in India.

  2012cites this paper
• Polymorphism in the RD 1 locus and its effect on downstream genes among South Indian clinical isolates of Mycobacterium tuberculosis

  2012cites this paper
• Synthesis, Characterization and Biological Activities of 2-Decylsulfonylacetamide Derivatives

  2012cites this paper
• Molecular Biological Techniques for Detection of Multidrug Resistant Tuberculosis (MDR) and Extremely Drug Resistant Tuberculosis (XDR) in Clinical Isolates of Mycobacterium tuberculosis

  2012influential citation
• Phenotypic and genotypic characteristics of drug resistance in Mycobacterium tuberculosis isolates from pediatric population of Chennai, India.

  2012cites this paper
• Polymorphism in the RD1 locus and its effect on downstream genes among South Indian clinical isolates of Mycobacterium tuberculosis.

  2012cites this paper
• Identification of Mycobacterium tuberculosis complex based on amplification and sequencing of the oxyR pseudogene from stored Ziehl-Neelsen-stained sputum smears in Brazil.

  2011cites this paper
• Drug-Resistance in Mycobacterium Tuberculosis: Molecular Basis and Genotypic Detection

  2011cites this paper
• Direct detection of isoniazid-resistant Mycobacterium tuberculosis in respiratory specimens by multiplex allele-specific polymerase chain reaction.

  2011cites this paper
• GenoType® MTBDRplus compared with conventional drug-susceptibility testing of Mycobacterium tuberculosis in a low-resistance locale.

  2011cites this paper
• Detection of Isoniazid-Resistant Clinical isolates of Mycobacterium tuberculosis from India using Ser315Thr marker by Comparison of molecular methods

  2011cites this paper
• Susceptibility Test Methods: Mycobacteria, Nocardia, and Other Actinomycetes*

  2011cites this paper
• Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand.

  2010cites this paper
• Rapid Differentiation of Mycobacterium tuberculosis and M. bovis by High-Resolution Melt Curve Analysis

  2010cites this paper
• The role of the efflux mechanisms in multidrug resistance in Mycobacterium tuberculosis

  2010cites this paper
• Molecular characterization of mycobacterial species isolated from tuberculosis lesions seen in bovine carcasses at post mortem: a case study of three abattoirs in the Accra Region of Ghana.

  2010cites this paper
• Resistant mutants of Mycobacterium tuberculosis selected in vitro do not reflect the in vivo mechanism of isoniazid resistance

  2009cites this paper
• Performance Assessment of the GenoType MTBDRplus Test and DNA Sequencing in Detection of Multidrug-Resistant Mycobacterium tuberculosis

  2009cites this paper
• Detección de mutaciones en los Genes rpoB y katG asociados a resistencia en cepas de Mycobacterium tuberculosis de Bolivia

  2009cites this paper
• Molecular Analysis of Isoniazid Resistance in Different Genotypes of Mycobacterium tuberculosis Isolates from Iran

  2008cites this paper
• Molecular analysis of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from India.

  2008cites this paper
• Synthesis and in vitro antimycobacterial activity of 3-substituted 5-hydroxy-5-trifluoro[chloro]methyl-4,5-dihydro-1H-1-(isonicotinoyl) pyrazoles.

  2008cites this paper
• Mycobacterial Antimicrobial Resistance

  2008cites this paper
• Evaluation of the GenoType MTBDRplus Assay for Rifampin and Isoniazid Susceptibility Testing of Mycobacterium tuberculosis Strains and Clinical Specimens

  2007cites this paper
• Drug susceptibility of Spanish Mycobacterium tuberculosis complex isolates from animals.

  2007cites this paper
• A novel genotypic test for rapid detection of multidrug‐resistant Mycobacterium tuberculosis isolates by a multiplex probe array

  2007cites this paper
• The genetic portrait of an outbreak strain.

  2006cites this paper
• The use of macroarrays for the identification of MDR Mycobacterium tuberculosis.

  2006cites this paper
• Use of Genotype MTBDR Assay for Molecular Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Clinical Strains Isolated in Italy

  2006cites this paper
• Population Genetics Study of Isoniazid Resistance Mutations and Evolution of Multidrug-Resistant Mycobacterium tuberculosis

  2006cites this paper
• Evaluation of the CombiChip Mycobacteria Drug-Resistance detection DNA chip for identifying mutations associated with resistance to isoniazid and rifampin in Mycobacterium tuberculosis.

  2006cites this paper
• Multidrug-resistant tuberculosis.

  2006cites this paper
• Evidenziazione molecolare di resistenza di Mycobacterium tuberculosis complex a rifampicina e isoniazide

  2006cites this paper
• Multidrug-resistant tuberculosis: a menace that threatens to destabilize tuberculosis control.

  2006cites this paper
• Disequilibrium in Distribution of Resistance Mutations among Mycobacterium tuberculosis Beijing and Non-Beijing Strains Isolated from Patients in Germany

  2005cites this paper
• Rifampicin and isoniazid resistance mutations in Mycobacterium tuberculosis strains isolated from patients in Kazakhstan.

  2005cites this paper
• Evaluation of hybridisation on oligonucleotide microarrays for analysis of drug-resistant Mycobacterium tuberculosis.

  2005cites this paper
• Use of fluorescence resonance energy transfer for rapid detection of isoniazid resistance in Mycobacterium tuberculosis clinical isolates.

  2005cites this paper
• Molecular Analysis of Isoniazid-Resistant Mycobacterium tuberculosis Isolates from England and Wales Reveals the Phylogenetic Significance of the ahpC −46A Polymorphism

  2005influential citation
• Use of the Genotype MTBDR Assay for Rapid Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Complex Isolates

  2005cites this paper
• Drug Resistance Evolution of a Mycobacterium tuberculosis Strain from a Noncompliant Patient

  2005cites this paper
• Risk factors associated with isoniazid resistance in tuberculosis

  2005cites this paper
• OxyR mediated compensatory expression between ahpC and katA and the significance of ahpC in protection from hydrogen peroxide in Xanthomonas campestris.

  2005cites this paper