Action at a Distance: Systemically Administered Adult Stem/Progenitor Cells (MSCs) Reduce Inflammatory Damage to the Cornea Without Engraftment and Primarily by Secretion of TNF‐α Stimulated Gene/Protein 6

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Stem Cells

• Publication date

  2011-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/stem.708PMID 21837654
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages.

  2011cited by this paper
• Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs)

  2010cited by this paper
• Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

  2010cited by this paper
• Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury

  2010cited by this paper
• Why should mesenchymal stem cells (MSCs) cure autoimmune diseases?

  2010cited by this paper
• Mesenchymal stem cells for acute lung injury: preclinical evidence.

  2010cited by this paper
• Congenic Mesenchymal Stem Cell Therapy Reverses Hyperglycemia in Experimental Type 1 Diabetes

  2010cited by this paper
• Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1.

  2010cited by this paper
• Why are MSCs therapeutic? New data: new insight

  2009cited by this paper
• Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

  2009cited by this paper
• Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6.

  2009cited by this paper
• Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury.

  2009cited by this paper
• Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide.

  2008cited by this paper
• Mesenchymal stem cells in health and disease

  2008cited by this paper
• Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses

  2008cited by this paper
• The Anti‐Inflammatory and Anti‐Angiogenic Role of Mesenchymal Stem Cells in Corneal Wound Healing Following Chemical Injury

  2008cited by this paper
• Immunomodulatory properties of mesenchymal stromal cells.

  2007cited by this paper
• Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury

  2007cited by this paper
• Anti-Inflammation Role for Mesenchymal Stem Cells Transplantation in Myocardial Infarction

  2007cited by this paper
• Mesenchymal stem cells as trophic mediators

  2006cited by this paper
• Mesenchymal stem cell transplantation in a rabbit corneal alkali burn model: engraftment and involvement in wound healing

  2006cited by this paper
• Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.

  2006cited by this paper
• Reconstruction of Chemically Burned Rat Corneal Surface by Bone Marrow–Derived Human Mesenchymal Stem Cells

  2006cited by this paper
• Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice

  2006cited by this paper
• TSG-6: a pluripotent inflammatory mediator?

  2006cited by this paper
• A Crosstalk Between Myeloma Cells and Marrow Stromal Cells Stimulates Production of DKK1 and Interleukin‐6: A Potential Role in the Development of Lytic Bone Disease and Tumor Progression in Multiple Myeloma

  2006cited by this paper
• Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice.

  2004cited by this paper
• Inhibitory Effects of TSG‐6 Link Module on Leukocyte–Endothelial Cell Interactions In Vitro and In Vivo

  2004cited by this paper
• Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14.

  2004cited by this paper
• TSG-6: a multifunctional protein associated with inflammation

  2003cited by this paper
• The Link Module from Human TSG-6 Inhibits Neutrophil Migration in a Hyaluronan- and Inter-α-inhibitor-independent Manner*

  2002cited by this paper
• Mesenchymal Stem Cells

  2002cited by this paper
• A Novel Allelic Variant of the Human TSG-6 Gene Encoding an Amino Acid Difference in the CUB Module

  2002cited by this paper
• Anti-inflammatory and chondroprotective effect of TSG-6 (tumor necrosis factor-alpha-stimulated gene-6) in murine models of experimental arthritis.

  2001cited by this paper
• Granules of the Human Neutrophilic Polymorphonuclear Leukocyte

  1997cited by this paper
• Granules of the human neutrophilic polymorphonuclear leukocyte.

  1997cited by this paper
• Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration.

  1996cited by this paper
• Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts.

  1993cited by this paper
• Mesenchymal Stem Cells

  1991cited by this paper
• Molecular Analysis of Primitive Hematopoietic Cell Proliferation Control Mechanisms a

  1991cited by this paper
• Stromal stem cells: marrow-derived osteogenic precursors.

  1988cited by this paper
• Fibroblast precursors in normal and irradiated mouse hematopoietic organs.

  1976cited by this paper

• Cell and Gene Therapy in Equine Ocular Disease

  2026cites this paper
• Donor adipose-derived stromal cells are vasoprotectant but unable to revert acute rejection in rodent vascularized composite allotransplants

  2025cites this paper
• Irradiated umbilical cord mesenchymal stem cell-coated high oxygen-permeable hydrogel lenses inhibit corneal inflammation and neovascularization after corneal alkali burns

  2025cites this paper
• Bone marrow- versus adipose tissue-derived mesenchymal stem cells for corneal failure in an experimental model of limbal stem cell deficiency.

  2025cites this paper
• Therapeutic Efficacy and Mechanisms of Mesenchymal Stem Cells and Their Exosomes in the Treatment of Ocular Graft-Versus-Host Disease

  2025cites this paper
• Improving the Wound Healing Process: Pivotal role of Mesenchymal stromal/stem Cells and Immune Cells

  2025cites this paper
• Biomedical Application of MSCs in Corneal Regeneration and Repair

  2025cites this paper
• Immunomodulatory Delivery Materials for Tissue Repair

  2025cites this paper
• Cell therapy in the cornea: the emerging role of microenvironment.

  2024cites this paper
• Molecular and Cellular Mechanisms of the Therapeutic Effect of Mesenchymal Stem Cells and Extracellular Vesicles in Corneal Regeneration

  2024cites this paper
• Healing the Cornea: Exploring the Therapeutic Solutions Offered by MSCs and MSC-derived EVs.

  2024cites this paper
• Mesenchymal vs. Epithelial Extracellular Vesicles in Corneal Epithelial Repair, Apoptosis, and Immunomodulation: an in vitro study.

  2024cites this paper
• Adipose-derived mesenchymal stromal cells alleviate intestinal fibrosis: The role of tumor necrosis factor-stimulated gene 6 protein.

  2024cites this paper
• Activation of Toll-like receptor 2 promotes mesenchymal stem/stromal cell-mediated immunoregulation and angiostasis through AKR1C1

  2024cites this paper
• Mesenchymal stem cells derived from CHIR99021 and TGF‑β induction remained on the colicomentum and improved cardiac function of a rat model of acute myocardium infarction

  2024cites this paper
• Impact of adipose-derived stem cells on aortic tensile strength in a model of abdominal aortic aneurysm

  2023cites this paper
• A Bioengineering‐Regenerative Medicine Approach for Ocular Surface Reconstruction Using a Functionalized Native Cornea‐Derived Bio‐Scaffold

  2023cites this paper
• Immunomodulation by mesenchymal stem cells during osteogenic differentiation: Clinical implications during bone regeneration.

  2023cites this paper
• Applications of mesenchymal stem cells in ocular surface diseases: sources and routes of delivery

  2023cites this paper
• Illustrative Potency Assay Examples from Approved Therapies.

  2023cites this paper
• Canine adipose tissue-derived MSCs engineered with mRNA to overexpress TSG-6 and enhance the anti-inflammatory effects in canine macrophages

  2023cites this paper
• Interaction between Mesenchymal Stem Cells and Immune Cells during Bone Injury Repair

  2023cites this paper
• Mesenchymal Stem Cells and Exosomes: A Novel Therapeutic Approach for Corneal Diseases

  2023influential citation
• Forthcoming complications in recovered COVID-19 patients with COPD and asthma; possible therapeutic opportunities

  2022cites this paper
• Mesenchymal Stromal Cell–Based Therapy for Dry Eye: Current Status and Future Perspectives

  2022cites this paper
• Antifibrotic TSG-6 Expression Is Synergistically Increased in Both Cells during Coculture of Mesenchymal Stem Cells and Macrophages via the JAK/STAT Signaling Pathway

  2022cites this paper
• Current and Emerging Therapies for Limbal Stem Cell Deficiency

  2022cites this paper
• Modulation of the Immune System Promotes Tissue Regeneration

  2022cites this paper
• Mesenchymal Stem Cell–Immune Cell Interaction and Related Modulations for Bone Tissue Engineering

  2022influential citation
• Extracellular Vesicles in Corneal Fibrosis/Scarring

  2022cites this paper
• The link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease.

  2021cites this paper
• Induction of M2‐Type Macrophage Differentiation for Bone Defect Repair via an Interpenetration Network Hydrogel with a GO‐Based Controlled Release System

  2021cites this paper
• Imaging Stem Cell-Based Myocardial Vasculoprotection

  2021cites this paper
• Subconjunctival injection of mesenchymal stem cells for corneal failure due to limbal stem cell deficiency: state of the art

  2021cites this paper
• Differential immunomodulation of human Mesenchymal Stromal Cells from various sources in an inflammation mimetic milieu.

  2021cites this paper
• Goals and Challenges of Stem Cell-Based Therapy for Corneal Blindness Due to Limbal Deficiency

  2021cites this paper
• Application of mesenchymal stem cells in corneal regeneration.

  2021cites this paper
• Vitamin E and hCG enhance the immunomodulatory properties of LPS-induced mesenchymal stem/stromal cells

  2021cites this paper
• Effects of different detergent-containing children's toothpastes on the viability, osteogenic and chondrogenic differentiation of human dental periodontal ligament stem cells and gingival stem cells in vitro.

  2021cites this paper
• MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism

  2021cites this paper
• Mesenchymal stromal cells for the treatment of ocular autoimmune diseases.

  2021cites this paper
• Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry

  2021cites this paper
• Genetically-Modified Stem Cell in Regenerative Medicine and Cancer Therapy; A New Era.

  2021cites this paper
• Retinal Lineage Therapeutic Specific Effect of Human Orbital and Abdominal Adipose-Derived Mesenchymal Stem Cells

  2021cites this paper
• Dental pulp–derived stem cells inhibit osteoclast differentiation by secreting osteoprotegerin and deactivating AKT signalling in myeloid cells

  2021cites this paper
• Role of prostaglandin E2 in allogeneic mesenchymal stem cell therapy for cardiac repair.

  2021cites this paper
• Therapeutic effect of secretome from TNF-α stimulated mesenchymal stem cells in an experimental model of corneal limbal stem cell deficiency.

  2021cites this paper
• Safety and feasibility of subconjunctival injection of mesenchymal stem cells for acute severe ocular burns: A single-arm study.

  2021cites this paper
• Hypothermically Stored Adipose-Derived Mesenchymal Stromal Cell Alginate Bandages Facilitate Use of Paracrine Molecules for Corneal Wound Healing

  2020cites this paper
• Subconjunctival injection of tumor necrosis factor-α pre-stimulated bone marrow-derived mesenchymal stem cells enhances anti-inflammation and anti-fibrosis in ocular alkali burns

  2020cites this paper
• Vitamin E Pretreatment of Mesenchymal Stem Cells: The Interplay of Oxidative Stress and Inflammation

  2020cites this paper
• A Rapid Method for Analysis of cDNA Synthesis Using Ion-Pair Reversed-Phase High Performance Liquid Chromatography

  2020cites this paper
• Comprehensive Molecular Profiles of Functionally Effective MSC-Derived Extracellular Vesicles in Immunomodulation.

  2020cites this paper
• Immunoregulatory properties of mesenchymal stem cells and their application in immunotherapy

  2020cites this paper
• Therapeutic Effects of Lyophilized Conditioned-Medium Derived from Corneal Mesenchymal Stromal Cells on Corneal Epithelial Wound Healing

  2020cites this paper
• Multifunctional nanoparticles in stem cell therapy for cellular treating of kidney and liver diseases.

  2020cites this paper
• Oral Mesenchymal Stem/Progenitor Cells: The Immunomodulatory Masters

  2020cites this paper
• A Phase I Study to Evaluate Two Doses of Wharton’s Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease

  2020cites this paper
• Mesenchymal stem cells alleviate liver injury induced by chronic-binge ethanol feeding in mice via release of TSG6 and suppression of STAT3 activation

  2020cites this paper
• Mesenchymal Stem Cells Beyond Regenerative Medicine

  2020cites this paper
• Current Trends and Future Perspective of Mesenchymal Stem Cells and Exosomes in Corneal Diseases

  2019cites this paper
• The therapeutic application of mesenchymal stem cells at the ocular surface.

  2019influential citation
• Therapeutic efficacy of different routes of mesenchymal stem cell administration in corneal injury.

  2019cites this paper
• The Effect of Chyle Fat Injection on Human Hypertrophic Scars in an Animal Model: A New Strategy for the Treatment of Hypertrophic Scars

  2019cites this paper
• Nomenclature and heterogeneity: consequences for the use of mesenchymal stem cells in regenerative medicine

  2019cites this paper
• Mussel-Inspired Nanostructures Potentiate the Immunomodulatory Properties and Angiogenesis of Mesenchymal Stem Cells.

  2019cites this paper
• Biological functions of mesenchymal stem cells and clinical implications

  2019cites this paper
• Designer Stem Cells: Genome Engineering and the Next Generation of Cell‐Based Therapies

  2019cites this paper
• Mesenchymal stromal cells for ocular surface repair

  2019cites this paper
• Remote transplantation of human adipose-derived stem cells induces regression of cardiac hypertrophy by regulating the macrophage polarization in spontaneously hypertensive rats

  2019cites this paper
• Mesenchymal Stem Cell Functionalization for Enhanced Therapeutic Applications

  2019cites this paper
• Extracellular vesicles derived from human Wharton’s jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

  2019cites this paper
• Salmonella enhances osteogenic differentiation in adipose-derived mesenchymal stem cells

  2019cites this paper
• Cell Therapy Using Extraocular Mesenchymal Stem Cells

  2019cites this paper
• MSC: immunoregulatory effects, roles on neutrophils and evolving clinical potentials.

  2019cites this paper
• The secretome of adipose-derived mesenchymal stem cells attenuates epithelial–mesenchymal transition in human corneal epithelium

  2019cites this paper
• Efficacy of 3D Culture Priming is Maintained in Human Mesenchymal Stem Cells after Extensive Expansion of the Cells

  2019cites this paper
• Principal Criteria for Evaluating the Quality, Safety and Efficacy of hMSC-Based Products in Clinical Practice: Current Approaches and Challenges

  2019cites this paper
• Harnessing the mesenchymal stem cell secretome for regenerative urology

  2019cites this paper
• Fibrosis: Shared Lessons From the Lens and Cornea

  2019cites this paper
• Corneal Regeneration: Use of Extracorneal Stem Cells

  2019cites this paper
• Absence of Therapeutic Benefit of the Anti-Inflammatory Protein TSG-6 for Corneal Alkali Injury in a Rat Model

  2019cites this paper
• Intraarticularly-Injected Mesenchymal Stem Cells Stimulate Anti-Inflammatory Molecules and Inhibit Pain Related Protein and Chondrolytic Enzymes in a Monoiodoacetate-Induced Rat Arthritis Model

  2018cites this paper
• Humoral factors secreted from adipose tissue-derived mesenchymal stem cells ameliorate atherosclerosis in Ldlr−/− mice

  2018cites this paper
• The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke

  2018cites this paper
• The Role of TNF-α induced MSCs on Suppressive Inflammation by Increasing TGF-β and IL-10

  2018cites this paper
• Gene and Cell Delivery for Intervertebral Disc Degeneration

  2018cites this paper
• FAK- and YAP/TAZ dependent mechanotransduction pathways are required for enhanced immunomodulatory properties of adipose-derived mesenchymal stem cells induced by aligned fibrous scaffolds.

  2018cites this paper
• TSG-6 released from intraperitoneally injected canine adipose tissue-derived mesenchymal stem cells ameliorate inflammatory bowel disease by inducing M2 macrophage switch in mice

  2018cites this paper
• Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning

  2018cites this paper
• Cornea‐Derived Mesenchymal Stromal Cells Therapeutically Modulate Macrophage Immunophenotype and Angiogenic Function

  2018cites this paper
• Marrow Adiposity and Hematopoiesis in Aging and Obesity: Exercise as an Intervention

  2018cites this paper
• Synergistic antibacterial effect of co-administering adipose-derived mesenchymal stromal cells and Ophiophagus hannahl-amino acid oxidase in a mouse model of methicillin-resistant Staphylococcus aureus-infected wounds

  2017cites this paper
• Comparison of the anti-inflammatory effects of induced pluripotent stem cell-derived and bone marrow-derived mesenchymal stromal cells in a murine model of corneal injury.

  2017cites this paper
• Corneal Defects and Stem Cell Therapeutics

  2017cites this paper
• Questions and Challenges in the Development of Mesenchymal Stromal/Stem Cell-Based Therapies in Veterinary Medicine

  2017cites this paper
• Mesenchymal stem cells in idiopathic pulmonary fibrosis

  2017cites this paper
• Therapeutic Effect of Human Adipose Tissue‐Derived Mesenchymal Stem Cells in Experimental Corneal Failure Due to Limbal Stem Cell Niche Damage

  2017cites this paper
• Rationale and Design of the ARREST Trial Investigating Mesenchymal Stem Cells in the Treatment of Small AAA

  2017cites this paper
• Eminent Sources of Adult Mesenchymal Stem Cells and Their Therapeutic Imminence

  2017cites this paper