PAX6 and SOX2‐dependent regulation of the Sox2 enhancer N‐3 involved in embryonic visual system development

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Genes to Cells

• Publication date

  2007-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2443.2007.01114.xPMID 17825048
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Deep mutational scanning quantifies DNA binding and predicts clinical outcomes of PAX6 variants

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• Robust Genetic Analysis of the X-Linked Anophthalmic (Ie) Mouse

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• Congenital and Inherited Cataracts

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• Genetic association study of SOX2 gene polymorphisms with high myopia in a Chinese population

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• Sox2 gene regulation via the D1 enhancer in embryonic neural tube and neural crest by the combined action of SOX2 and ZIC2

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• Congenital and Hereditary Cataracts: Epidemiology and Genetics

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• Recurrent heterozygous PAX6 missense variants cause severe bilateral microphthalmia via predictable effects on DNA–protein interaction

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• The Spectrum of PAX6 Mutations and Genotype-Phenotype Correlations in the Eye

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• Recurrent heterozygous PAX6 missense variants cause severe bilateral microphthalmia via predictable effects on DNA–protein interaction

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• In Vivo Evaluation of PAX6 Overexpression and NMDA Cytotoxicity to Stimulate Proliferation in the Mouse Retina

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• Identification and expression of transcription factor sox2 in large yellow croaker Larimichthys crocea.

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• Nasal and otic placode specific regulation of Sox2 involves both activation by Sox-Sall4 synergism and multiple repression mechanisms.

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• Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo

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• Enhancer Analyses Using Chicken Embryo Electroporation.

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• Cyclin-Dependent Kinase-Dependent Phosphorylation of Sox2 at Serine 39 Regulates Neurogenesis

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• Explorer Discovery and assessment of conserved Pax 6 target genes and enhancers

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• Genes relacionados con microftalmia y anoftalmia hereditarias.

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• Genetic causes of optic nerve hypoplasia

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• Molecular basis for the genome engagement by Sox proteins.

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• The eye development of Astyanax cavefish

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• Genes expressed in mouse cortical progenitors are enriched in Pax, Lhx, and Sox transcription factor putative binding sites.

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• Systems Biology of Transcription Regulation

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• Multiple Roles for SOX2 in Eye Development

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• Regulation of Sox2 via Many Enhancers of Distinct Specificities

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• SOX2–Partner Factor Interactions and Enhancer Regulation

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• Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development

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• Sixteen additional enhancers associated with the chicken Sox2 locus outside the central 50‐kb region

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• DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors

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• A trans-Regulatory Code for the Forebrain Expression of Six3.2 in the Medaka Fish*

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• Activation of Six1 Expression in Vertebrate Sensory Neurons

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• Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line

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• The cellular and molecular mechanisms of vertebrate lens development

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• Molecular and Cellular Complexity of Glioma Highlights on the Double-Edged-Sword of Infiltration Versus Proliferation

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• Enhancer identification in mouse embryonic stem cells using integrative modeling of chromatin and genomic features

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• SOX2 is required for adult human muller stem cell survival and maintenance of progenicity in vitro.

  2011cites this paper
• Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro

  2011cites this paper
• Identifying Tissue Specific Distal Regulatory Sequences in the Mouse Genome

  2011cites this paper
• B1 and B2 Sox gene expression during neural plate development in chicken and mouse embryos: Universal versus species‐dependent features

  2011cites this paper
• Discovery and assessment of conserved Pax6 target genes and enhancers.

  2011cites this paper
• The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates.

  2011cites this paper
• Characterization of New Otic Enhancers of the Pou3f4 Gene Reveal Distinct Signaling Pathway Regulation and Spatio-Temporal Patterns

  2010cites this paper
• SOX-partner code for cell specification: Regulatory target selection and underlying molecular mechanisms.

  2010cites this paper
• Pax2 coordinates epithelial morphogenesis and cell fate in the inner ear

  2010cites this paper
• Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage.

  2010cites this paper
• Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR.

  2010cites this paper
• Regulation of Sox2 in the pre‐placodal cephalic ectoderm and central nervous system by enhancer N‐4

  2010cites this paper
• Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination

  2010cites this paper
• Strategies for Locus-Wide Identification and Systematic Analysis of Enhancers Using Chicken Embryo Electroporation

  2009cites this paper
• Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis

  2009influential citation
• Role of SoxB1 transcription factors in development

  2009influential citation
• Evolution of non-coding regulatory sequences involved in the developmental process: Reflection of differential employment of paralogous genes as highlighted by Sox2 and group B1 Sox genes

  2009cites this paper
• Pax6 is essential for lens fiber cell differentiation

  2009cites this paper
• Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of Group B1 Sox genes

  2009cites this paper
• Detailed ophthalmologic evaluation of 43 individuals with PAX6 mutations.

  2009cites this paper
• Multiple evolutionarily conserved enhancers control expression of Eya1

  2008cites this paper
• Having it both ways: Sox protein function between conservation and innovation

  2008cites this paper
• Dissection of chick genomic regulatory regions.

  2008cites this paper
• Shedding light on developmental gene regulation through the lens

  2008cites this paper
• The role of SOX proteins in normal pituitary development.

  2008cites this paper
• NEUROGENESIS IN THE VERTEBRATE CNS

  2008cites this paper
• Regulation of neurogenesis in the vertebrate CNS

  2008cites this paper
• Computational approaches to finding and analyzing cis-regulatory elements.

  2008cites this paper
• Molecular links among the causative genes for ocular malformation: Otx2 and Sox2 coregulate Rax expression

  2008influential citation
• Enhancer analysis by chicken embryo electroporation with aid of genome comparison

  2008cites this paper
• Index

  2007cites this paper