The regulative effect and repercussion of probiotics and prebiotics on osteoporosis: involvement of brain-gut-bone axis

Abstract Osteoporosis (OP) is a systemic disease characterized by decreased bone mass and degeneration of bone microstructure. In recent years, more and more researches have focused on the close relationship between gut microbiota (GM) and the occurrence and progression of OP, and the regulation of probiotics and prebiotics on bone metabolism has gradually become a research hotspot. Based on the influence of brain-gut-bone axis on bone metabolism, this review expounds the potential mechanisms of probiotics and prebiotics on OP from next perspectives: regulation of intestinal metabolites, regulation of intestinal epithelial barrier function, involvement of neuromodulation, involvement of immune regulation and involvement of endocrine regulation, so as to provide a novel and promising idea for the prevention and treatment of OP in the future.

• Publication year

  2022

• Venue

  Critical reviews in food science and nutrition

• Publication date

  2022-03-02

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1080/10408398.2022.2047005PMID 35234534
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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