Targeting the PI3K and MAPK pathways to treat Kaposi’s sarcoma-associated herpes virus infection and pathogenesis

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Expert opinion on therapeutic targets

• Publication date

  2007-04-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1517/14728222.11.5.589PMID 17465719
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An essential role of ERK signalling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus.

  2006cited by this paper
• Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae.

  2006influential reference
• Transcriptional Regulation of the Kaposi's Sarcoma-Associated Herpesvirus K15 Gene

  2006cited by this paper
• PI3K and RAC signalling in leukocyte and cancer cell migration.

  2006cited by this paper
• Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies.

  2006cited by this paper
• V600E B‐Rafはその安定性にHsp90シャペロンを要求し,Hsp90阻害剤への応答として分解される

  2006cited by this paper
• Regulation of cellular functions by the ERK5 signalling pathway.

  2006cited by this paper
• Aspects of Growth Hormone and Insulin-Like Growth Factor-I Related to Neuroprotection, Regeneration, and Functional Plasticity in the Adult Brain

  2006cited by this paper
• KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2.

  2006cited by this paper
• A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.

  2006cited by this paper
• Handicapping the Race to Develop Inhibitors of the Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway

  2006cited by this paper
• Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.

  2006cited by this paper
• Small molecular weight inhibitors of stress-activated and mitogen-activated protein kinases.

  2006cited by this paper
• BRAF mutation predicts sensitivity to MEK inhibition

  2006cited by this paper
• The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target.

  2006cited by this paper
• Raf kinase inhibitor protein regulation of raf and MAPK signaling.

  2006cited by this paper
• V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors.

  2006cited by this paper
• Analyzing phosphoinositides and their interacting proteins

  2006cited by this paper
• KSHV RTA induces a transcriptional repressor, HEY1 that represses rta promoter.

  2006cited by this paper
• Raf/MEK/ERK signalling triggers reactivation of Kaposi's sarcoma-associated herpesvirus latency.

  2006cited by this paper
• The Isoflavone Equol Mediates Rapid Vascular Relaxation

  2006cited by this paper
• Alternative and accessory pathways in the regulation of IFN-beta-mediated gene expression.

  2005cited by this paper
• A phase II trial of R115777, an oral farnesyl transferase inhibitor, in patients with advanced urothelial tract transitional cell carcinoma

  2005cited by this paper
• Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants.

  2005cited by this paper
• Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery.

  2005cited by this paper
• Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes.

  2005cited by this paper
• B-Raf-dependent expression of vascular endothelial growth factor-A in Kaposi sarcoma-associated herpesvirus-infected human B cells.

  2005cited by this paper
• Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation.

  2005influential reference
• Raf and VEGF: emerging therapeutic targets in Kaposi's sarcoma-associated herpesvirus infection and angiogenesis in hematopoietic and nonhematopoietic tumors

  2005influential reference
• N-methyl-D-aspartate (NMDA) and the regulation of mitogen-activated protein kinase (MAPK) signaling pathways: a revolving neurochemical axis for therapeutic intervention?

  2005cited by this paper
• The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes.

  2005cited by this paper
• A Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 ORF50 Deletion Mutant Is Defective for Reactivation of Latent Virus and DNA Replication

  2005cited by this paper
• Raf kinase as a target for anticancer therapeutics

  2005cited by this paper
• Functional implications of altered subcellular localization of PELP1 in breast cancer cells.

  2005cited by this paper
• Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration.

  2005cited by this paper
• Kaposi's Sarcoma-Associated Herpesvirus Induction of AP-1 and Interleukin 6 during Primary Infection Mediated by Multiple Mitogen-Activated Protein Kinase Pathways

  2005cited by this paper
• Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells.

  2005cited by this paper
• Cellular prostatic acid phosphatase: a protein tyrosine phosphatase involved in androgen-independent proliferation of prostate cancer.

  2005cited by this paper
• Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways

  2005cited by this paper
• AIDS related viruses, their association with leukemia, and Raf signaling.

  2005cited by this paper
• Tyrosine kinase activity and remodelling of the actin cytoskeleton are co‐temporally required for degranulation by cytotoxic T lymphocytes

  2005cited by this paper
• KAPOSI'S SARCOMA–ASSOCIATED HERPESVIRUS: Clinical, Diagnostic, and Epidemiological Aspects

  2005cited by this paper
• Targeted Deletion of mek5 Causes Early Embryonic Death and Defects in the Extracellular Signal-Regulated Kinase 5/Myocyte Enhancer Factor 2 Cell Survival Pathway

  2005cited by this paper
• Alternative and Accessory Pathways in the Regulation of IFN-β-Mediated Gene Expression

  2005cited by this paper
• Inhibition of PI3K/Akt signaling: an emerging paradigm for targeted cancer therapy.

  2005cited by this paper
• Ras initiates phosphatidyl-inositol-3-kinase (PI3K)/PKB mediated signalling pathways in untransformed human peripheral blood T lymphocytes.

  2005cited by this paper
• Mind‐Body Medicine: Stress and Its Impact on Overall Health and Longevity

  2005cited by this paper
• Early and sustained expression of latent and host modulating genes in coordinated transcriptional program of KSHV productive primary infection of human primary endothelial cells.

  2005cited by this paper
• Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction.

  2005cited by this paper
• Rapid inhibition of MAPK signaling and anti-proliferation effect via JAK/STAT signaling by interferon-alpha in hepatocellular carcinoma cell lines.

  2005influential reference
• A Network of Immediate Early Gene Products Propagates Subtle Differences in Mitogen-Activated Protein Kinase Signal Amplitude and Duration

  2004cited by this paper
• The KSHV G protein-coupled receptor signals via multiple pathways to induce transcription factor activation in primary effusion lymphoma cells

  2004cited by this paper
• Phosphorylation of p38 MAPK and its downstream targets in SARS coronavirus-infected cells

  2004cited by this paper
• The RAF proteins take centre stage

  2004cited by this paper
• Role for Raf in the entry of viruses associated with AIDS (review).

  2004cited by this paper
• Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer.

  2004cited by this paper
• Virokines in the Pathogenesis of Cancer: Focus on Human Herpesvirus 8

  2004cited by this paper
• ORC, MCM, and Histone Hyperacetylation at the Kaposi's Sarcoma-Associated Herpesvirus Latent Replication Origin

  2004cited by this paper
• Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes.

  2004influential reference
• Synergy between PI3K/Akt and Raf/MEK/ERK Pathways in IGF-1R Mediated Cell Cycle Progression and Prevention of Apoptosis in Hematopoietic Cells

  2004cited by this paper
• Targeting the mitogen-activated protein kinase cascade to treat cancer

  2004cited by this paper
• PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane

  2004cited by this paper
• Vascular endothelial growth factor as a target for anticancer therapy.

  2004cited by this paper
• Opposite long-term regulation of c-Myc and p27Kip1 through overactivation of Raf-1 and the MEK/ERK module in proliferating human choroidal melanoma cells

  2003cited by this paper
• Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1

  2003cited by this paper
• High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.

  2003cited by this paper
• Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR.

  2003cited by this paper
• Mammalian transcription factor LSF is a target of ERK signaling

  2003cited by this paper
• Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer.

  2003cited by this paper
• Regulation of Raf through Phosphorylation and N Terminus-C Terminus Interaction*

  2003cited by this paper
• Role of Raf in Vascular Protection from Distinct Apoptotic Stimuli

  2003cited by this paper
• Therapeutic potential of phosphoinositide 3-kinase inhibitors.

  2003cited by this paper
• BRAF mutation in papillary thyroid carcinoma.

  2003cited by this paper
• Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation

  2003cited by this paper
• Mechanisms of regulating the Raf kinase family.

  2003influential reference
• Phase II study of CGP 69846A (ISIS 5132) in recurrent epithelial ovarian cancer: an NCIC clinical trials group study (NCIC IND.116).

  2003cited by this paper
• Phosphorylation of Raf-1 by p21-activated Kinase 1 and Src Regulates Raf-1 Autoinhibition*

  2003cited by this paper
• Integrin α3β1 (CD 49c/29) Is a Cellular Receptor for Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8) Entry into the Target Cells

  2002cited by this paper
• Untying the regulation of the Raf-1 kinase.

  2002cited by this paper
• AP-1 as a regulator of cell life and death

  2002cited by this paper
• Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects

  2002cited by this paper
• Kaposi's sarcoma and other manifestations of human herpesvirus 8.

  2002cited by this paper
• Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome.

  2002cited by this paper
• Kaposi's Sarcoma Biology

  2002cited by this paper
• ERK5 MAPK Regulates Embryonic Angiogenesis and Acts as a Hypoxia-sensitive Repressor of Vascular Endothelial Growth Factor Expression*

  2002cited by this paper
• Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259

  2002cited by this paper
• Cyclic AMP Blocks Cell Growth through Raf-1-Dependent and Raf-1-Independent Mechanisms

  2002cited by this paper
• Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: a National Cancer Institute of Canada clinical trials group study.

  2002cited by this paper
• Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases

  2002cited by this paper
• Integrin alpha3beta1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells.

  2002cited by this paper
• The biology of Kaposi's sarcoma.

  2001cited by this paper
• Biology of Kaposi's sarcoma.

  2001cited by this paper
• KSR: a MAPK scaffold of the Ras pathway?

  2001cited by this paper
• Activation of the c-fos enhancer by the Erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites

  2000cited by this paper
• Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

  2000cited by this paper
• Monoclonality or oligoclonality of human herpesvirus 8 terminal repeat sequences in Kaposi's sarcoma and other diseases.

  2000cited by this paper
• Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.

  2000cited by this paper
• Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade.

  2000cited by this paper
• Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338.

  2000influential reference
• Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity

  1999cited by this paper

• The important role of TLR2/MyD88/JNK in regulating the pathogenesis and inflammation induced by pseudorabies virus in mice.

  2025cites this paper
• Rutaecarpine attenuates high glucose‐induced damage in AC16 cardiomyocytes by suppressing the MAPK pathway

  2023influential citation
• Oncopeptide MBOP Encoded by LINC01234 Promotes Colorectal Cancer through MAPK Signaling Pathway

  2022cites this paper
• Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus

  2022cites this paper
• RUTIN: A PHARMACOLOGICAL REVIEW

  2018cites this paper
• Chloroquine inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by disrupting mTOR and p38-MAPK activation.

  2016cites this paper
• Viral inhibitors of NKG2D ligands for tumor surveillance

  2016cites this paper
• Identification of pathogenic virus sequences in pancreatic ductal adenocarcinoma

  2016cites this paper
• Kaposi's Sarcoma–Associated Herpesvirus Pathogenesis

  2015cites this paper
• Dynamics of KSHV gene expression during de novo infection and the role of LANA in immune modulation

  2015cites this paper
• Widespread evidence of viral miRNAs targeting host pathways

  2013cites this paper
• Integrated Analyses of Genome-Wide DNA Occupancy and Expression Profiling Identify Key Genes and Pathways Involved in Cellular Transformation by a Marek's Disease Virus Oncoprotein, Meq

  2013cites this paper
• Post-translational modification of VSV glycoprotein , but not JNK 1 inhibition , is the antiviral mechanism of SP 600125 2 3

  2012cites this paper
• Posttranslational Modification of Vesicular Stomatitis Virus Glycoprotein, but Not JNK Inhibition, Is the Antiviral Mechanism of SP600125

  2012cites this paper
• The flavonoids hesperidin and rutin promote neural crest cell survival

  2012cites this paper
• 3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: design, synthesis and biological characterization.

  2012cites this paper
• Virus reactivation: a panoramic view in human infections.

  2011cites this paper
• Phosphorylation of Eukaryotic Translation Initiation Factor 4B (EIF4B) by Open Reading Frame 45/p90 Ribosomal S6 Kinase (ORF45/RSK) Signaling Axis Facilitates Protein Translation during Kaposi Sarcoma-associated Herpesvirus (KSHV) Lytic Replication*

  2011cites this paper
• Hesperidin, a Flavone Glycoside, as Mediator of Neuronal Survival

  2011cites this paper
• Diacylglycerol kinases are essential for hepatocyte growth factor‐dependent proliferation and motility of Kaposi’s sarcoma cells

  2011cites this paper
• Herpesviruses: hijacking the Ras signaling pathway.

  2010cites this paper
• Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways.

  2010cites this paper
• The BH 3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI 3 K / Akt and MEK / ERK 1 / 2 pathways

  2009cites this paper
• Treatment for Kaposi sarcoma herpesvirus: great challenges with promising accomplishments

  2009cites this paper
• Role of cell signaling in poxvirus-mediated foreign gene expression in mammalian cells.

  2009cites this paper
• The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways.

  2009cites this paper