Nucleic acid separations using superficially porous silica particles

Highlights • Superficially porous silica particles enable high resolution separation of nucleic acids.• The pore size of the C18 superficially porous silica particles significantly effects resolution.• Optimum separations of small oligonucleotides obtained with 80 Å pore sizes.• Optimum resolution of oligonucleotides (>19 mers) was observed with pore sizes of 150 Å.• Improved resolution of larger dsDNA/RNA molecules was achieved with pore sizes of 400 Å

• Publication year

  2016

• Venue

  Journal of Chromatography A

• Publication date

  2016-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.chroma.2016.02.057PMID 26948761PMCID 4801196
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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